Written at 2014-09-29 15:47:02.213863
MAP - E. coli iAF1260: COMBINED Proline Pyrimidine Biosynthesis 4 2 3 Alternate Carbon Sources Cytosine Tyrosine, Tryptophan, Phenylalanine 2 Purine Biosynthesis Ubiquinone Reduction/Oxidation Glycerophosphodiester phosphodiesterase Biotin Menaquinone Thiamin Ubiquinol 2 NAD/NADP Metabolism outer core 2 Oxidative Stress colanic acid precursors (M-antigen) Enterochelin Triphosphatase Xanthosine 2 Lower Glycolysis (see Central Metabolism Map) Spermidine Alanine, Leucine and Valine 3 Riboflavin AMINO ACID METABOLISM Common Antigen 2 2 3 Transhydrogenase Carbonate pseudogene (insertion) 2 Fatty Acid Biosynthesis 2 3 2 Glutamate and Glutamine Fatty Acid Oxidation Arginine periplasm Isoprenoid Thymidine 4 2 3 Lysine 0.5 or TCA Cycle 8 Threonine Heme Biosynthesis Mid Glycolysis Pentose Phosphate Pathway Serine and Glycine ATP 2 Upper Glycolysis O-antigen Nucleotide Metabolism Isoleucine dead end 5 extracellular space 2 Guanine 3 2 Converted to GLX lipid A Demethymenaquinone Reduction/Oxidation O-antigen (potential) dead end Inorganic Ion Transport 0.5 Vitamin B12 tRNA Charging 3 Enterobacterial Folate Cysteine Glutathione CoA Menaquinone Reduction/Oxidation methionine synthase ATP Maintenance acutal sulfur donor unknown Adenosine Aspartate and Asparagine enterobacterial common antigen 1 Synthase Phospholipids 2 cytoplasm Cofactor Biosynthesis Nitrite Reductase methionine salvage pathway taken from B. subtilis 2 Methionine Inosine Putrescine 3 2 Other Reactions inner core Diphosphatase Nucleotide Salvage thiL Uracil Vitamin B6 0.5 2 dead end Histidine Metabolism 2 HEPK2 RNDR4b GGPTRCS ALAALAr ADNK1 GGGABADr CPPPGO2 RNTR2c VALabcpp IDONtex PPNCL2 MME HEPT3 GLYCtex DGMPtex NTD6pp NDPK7 HEPT4 2AGPA181tipp EAR100y HOPNTAL GUAt2pp MLTGY2pp FORt2pp ACtex SUCptspp FEROpp ASPTRS NADH5 FE3DCITabcpp ASAD GLYtex MDRPD DSERDHr HEPT2 CA2t3pp GF6PTA ECAP1pp PRPPS NTP12 EDTXS1 ECOAH2 UDPKAAT MOAT TMPK BPNT PTPATi URAt2pp FRD2 MDH UPP3S PSSA161 SBTptspp AAMYLpp FEENTERtex GLYC3Pt6pp NODOx XYLI2 INDOLEt2rpp NO3R1pp 3HAD140 THRA2i DGK1 PGSA120 26DAHtex MLTG2 ALLPI OP4ENH MECDPS HPYRI UAGDP NACODA PAPA180pp TMK TRPS2 ADSS 2AGPEAT120 GALBDtex GLCP OMPHHX3 NTD9pp GAMAN6Ptex XYLUtex 2AGPG120tipp D-LACtex MANtex NTD2pp ACHBS GPDDA4pp GAMtex FORtex GALabcpp PGPP161 3NTD9pp NTRIR2x ACONIs PE181abcpp HPYRRy FEOXAMR1 EAR180y ICDHyr MAN6PI GALCTND UAGPT3 GALt2pp GLYC3Ptex CYSSADS SUCCtex 2AGPGAT120 PACALDtex PYDXNK DPCOAK HEMEOS GBBTNtex PGLYCP SPODMpp PYDXK PPAKr AACTOOR TPRDCOAS PTHRpp TAUDO NADH9 DMPPS HPPPNt2rpp G3PSabcpp 2AGPEAT180 CYTK1 23DAPPAt2pp 14GLUCANtexi UDPGALM XYLUt2pp TDECOAI SERD_D PGMT GLU5K GLYBabcpp PGSA141 4HOXPACDtex FADRx2 ASNNpp ARBTNR1 MLDEP2pp ACANTHAT 3HCINNMH ADOCBLabcpp LPLIPAL2A120 COLIPAtex DHCINDO MG2tex LYXtex GLYCLTt4pp OMCDC CYSDDS XYLK PSSA141 ALPATG160pp OMPHHX CYSDS GUI1 FACOAE60 HYD2pp HMBS ACCOAL GLUDy GLUN FEENTERR1 MNtex PERD MTHFD GLUTRR PLIPA2G181pp CHORS DSERtex UM3PL PAPA160 PTRCtex MG2uabcpp GPDDA2 TRPS1 UDPGPpp PSP_L VALTRS ARBt3ipp NI2t3pp ADNtex ALAabcpp FUMt2_2pp PLIPA2E181pp GLCtexi GLCptspp TUNGSabcpp FRULYStex ASCBPL FA100ACPHi ACALD MDDEP2pp 3OAR160 NTD7pp DSBAO2 CRNt7pp ACACtex ALAGLUE PGPP141pp PLIPA1G161pp HXPRT URIDK2r XAND PGCD ECA4COLIPAtex HPPK2 RNTR4c ASP1DC FRUptspp CBL1tonex DDPGALA PYDAMK GUI2 HACD8i FALDtpp ADK3 MALTPTtexi H2O2tex MMETt2pp ASPabcpp TKT1 CU2tex 3OAR180 GLYC3Ptex EDTXS4 TUNGStex PPC CLPNH181pp GAPD 2AGPG180tipp 2AGPEAT141 GLCtex MNLptspp PLIPA1G181pp FACOAL161t2pp AGPAT181 HDCOAI MOAT3C SPODM PDX5PS NADPPPS LEUt2rpp ASNN GLNTRS CYTDH G3PD7 NDPK1 G1SAT ALCD2x THRt2pp AMALT3 KAS14 DATPHs PROabcpp G3PCtex GLYCTO3 DHAD2 SOTA PLIPA2E140pp PGAMT HG2abcpp GLCptspp SELNPS AMAOTr ASCBtex THRtex SHCHF CYSTL PAPA141pp CBMKr 3HPPPNH ACOLIPAtex ACLS AGPAT161 DCYTt2pp LPLIPAL1G181pp THMDt2rpp PAPSR2 R5PP UACGAMPpp PUNP5 NTD9 5DGLCNtex ACKr PPGPPDP LCADi PFK_2 BALAt2pp PPCDC 3OAR100 FACOAL181t2pp NNAM CYTK2 TDSR2 FECRMR3 NAtex URIH ECOAH1 GTHOr DHORD5 METTRS ACSERtex BUTSO3tex UPPRT MCTP1Bpp DHAD1 URDGLYCD CRNCDH GLCTR3 PROGLYabcpp ECAP3pp LIPAabcpp TRDR TRE6PP NI2tex ATPPRT ARAI NAMNPP GLCATr G6PDH2r MOAT2 MPTG2 DMSOR1 PPPNtex ALAtex LPLIPAL1A140pp PSP_Lpp MALTtexi AAMYL MAN6Ptex METSOXR1 PPCSCT L-LACtex THRPtex MICITD PLIPA1E141pp Kt2pp DADK PPND S7PI URAtex KDOCT2 PPALtex O16GLCT1 ACONTa DMSOR1pp THRt2rpp L-LACt2rpp NTD11 GUAtpp 3NTD4pp MALDt2_2pp 2AGPG141tipp PRFGS Kt3pp LPLIPAL1A180pp MDDCP3pp DHAtex O2tpp ACPS1 FALGTHLs MNt2pp SGSAD 23CAMPtex ANHGMtex PPPNDO HPYRRx GCALDD LPLIPAL1A141pp TYMtex INSK XYLtex CHLt2pp UDCPDPpp 23PDE2pp 2AGPGAT181 23CUMPtex PG180abcpp BSORy HYD1pp MANptspp GTHOXtex THRAi ACOAD6f RNDR3b PPA PPBNGS GLYC3Pabcpp METDtex PSD161 FE3HOXR2 FACOAL120t2pp CFAS180E NTD8 AGMH O16AP2pp EAR141x ARGtex PPS 3HAD120 GALS3 HCINNMt2rpp ABUTt2pp CYStex GMHEPPA PLIPA1A140pp EAR121x NTPP5 FRULYSK ALDD3y SSALy O2tex 3OAR181 TPI GTPtex PGPP141 AMPMS2 H2Stex NMNtex NMNN CLt3_2pp L-LACtex NI2tpp URIt2rpp UAAGDS CLPNS141pp DXPS CDAPPA141 CGLYtex 12DGR160tipp EAR140y CTBTCAL2 ORPT PLIPA1G180pp FECRMexs DNMPPA PE180abcpp HSTPT RNDR3 KARA1 SPMDAT1 HCYSMT PGM MALt2_3pp RNDR4 DGSNtex 3HAD100 COBALT2abcpp ATPM PIt2rpp G3PIabcpp PGSA160 LYStex ADMDC G2PPpp OCTDPS DKMPPD3 DOPAtex THD2pp TRPS3 ARGTRS CU1Opp FRUtex TYRTRS NMNPtpp SO3tex EAR40y ARBTNtex NADH10 BUTCT G5SADs 23PDE4pp UPLA4FNF R5PPpp DCYTD G3PAT160 GLYOX3 DKGLCNR2y RIBabcpp COLIPAabcpp FE3Ri GND IDONt2rpp CPGNtonex ASNTRS FACOAE161 TKT2 AGPAT141 PHYTSpp PROt4pp HXCT MDDCP5pp DHBD NTPP10 TAGURr DALAt2pp ACALDtpp FEOXAMtonex TARTRt7pp FDMO GLYCK2 3GMPtex EAR40x FBP LPLIPAL2A160 4PEPTtex DM_HMFURN SHK3Dr GLCDpp HPPPNDO CLPNH120pp CDAPPA120 ALATA_L2 PSD160 GLCP2 G3PD2 AGPAT120 ACMANAtex CRNabcpp PGPP180pp ASNS1 MAN6PI ACONTb ADOCBIK HIStex TREHpp TYRPtex UGMDDS AGPAT160 PSSA120 SHCHD2 GLYt2pp GARFT G1Ptex F6PA RNTR3c CYTDt2pp IDOND2 TMAOR1 SKMt2pp FACOAE181 NNDPR 12DGR181tipp FE3DCITtonex MLTP2 LEUTAi HISTD RMPA MCITD GLCUR1Ptex PYAM5PO INSt2rpp PYRt2rpp PLIPA1E181pp 3OAS100 CD2t3pp GALUi FEENTERtonex DPR DUMPtex GTHRDtex ACSERtpp HACD1i FECRMtonex PUNP6 ALCD2x LPLIPAL2A161 MTRPOX ILETA VPAMT GLYCtpp ACMUMptspp AP5AH AIRC3 O2Stex DDPA SUCRtex ACt4pp G1PTT GTHS MOHMT MDDCP1pp ADPT CDAPPA180 GLUtex CHLtex DAPtex THRabcpp FLVR LCTStpp DHDPS CU2tpp PTRCORNt7pp TDPDRR DUTPDP L-LACt2rpp ORNDC PSD140 GLUSy ALAR PAPA160pp G6Pt6_2pp ACACt2pp 2AGPGAT160 DSBDR 2DGULRx G3PCabcpp RMI MLDCP1App CINNDO DRPA TRPt2rpp MDDEP1pp AMPTASECG ACACCT LYSDC BUTt2rpp FBA ACNML KDOPS 3HAD180 CPGNUtex GPDDA3pp CYStpp PLIPA2E120pp NTPP7 TYROXDApp O16GLCT2 LSERDHr GLYCAtex GALCTD 3NTD7pp GLCt2pp UGLYCH GMPR URItex TREH PSSA160 PG141abcpp NO3t7pp ALLTNtex ADA H2tpp MOBDtex LIPAtex ALAALAtex IPPMIa DTMPK DDGLCNt2rpp PSCLYSt2pp 3OAS180 CAt6pp RNDR1 DMSOR2pp CBIAT PROTRS AADDGT TALA NADPHQR2 UPPDC1 SHCHCS2 LCARR PLIPA1A160pp THMtex AACPS8 AGM4PA GLCNtex ALLTNt2rpp FE2tex 3UMPtex KAT5 GLBRAN2 ARBTNabcpp GSNt2pp CLPNH180pp XYLt2pp FA80ACPHi UDPG4E ECAP2pp NAt3_2pp MGSA MALTabcpp G3PItex AM3PA GLYCTO4 UREAtpp SGDS NPHS F6Pt6_2pp MCITS PG160abcpp L-LACD3 HACD2i GSPMDS ADPRDP PMANM ACtex EDA NMNAT RIBtex DAPabcpp ALAt4pp ALDD2x SUCCt2_2pp GALCTLO THYMt3pp EAR120x THRt4pp ARBabcpp DINSt2pp UAMAS TRPTRS GMHEPAT GF6PTA MALDDH THIORDXi HEXt2rpp PPPNt2rpp DHPPD GLTPD MMM2 PLIPA1G140pp XYLtex ARGDC PNTOt4pp FTHFD GLUPRT NTPP4 CLPNH141pp FEOXAMR3 DM_OXAM DMSOR2 DHCIND OMMBLHX3 ENTERES2 LPLIPAL1E180pp Zn2tex AGM4PCPpp E4PD HCYSMT2 RIBabcpp MELIBt2pp LPLIPAL1E120pp 23CCMPtex ASCBptspp GLYCDx GLCS1 CYSS SUCBZS PLIPA2G180pp METSOX1abcpp LPLIPAL1G120pp MG2tpp PETNT181pp ADEtex GTPHs PSD180 NAt3_1p5pp 2AGPG160tipp ACOATA AGM4Pt2pp UAGDP SFGTHi GAL1PPpp PMPK ACOAD2f PLIPA2A180pp AMMQLT8 FDMO4 NTD7 PRAMPC CHORM AOBUTDs EAR160x ARGDCpp ALDD2y GLYCDx N2Otpp PUNP4 F6PP ALPATE160pp ADNt2rpp NTD10pp NOtex OPHHX Ktex CO2tpp OCTAtex Kabcpp TYRtex TDPADGAT XTSNtex XYLt2pp MCPST CDAPPA160 NHFRBO HYPOE LYSabcpp NDPK8 AACPS5 RNDR1b PYDXPP LCTSt3ipp PSSA181 HCO3E PNTOtex PRPPS PGPP181 3KGK GALCTNLtex INSt2pp GLCabcpp H2SO FACOAL140t2pp ACGK AACPS1 SERTRS MLDCP3App PSD181 UREAtex CBLAT MANAO OMPDC FECRMabcpp LIPAHTex DKGLCNR1 KAT2 FRUpts2pp CYTDtex SUCCtex NADPHQR3 ILETRS NO3R2pp GTHRDabc2pp FRUURt2rpp FEOXAMR2 2AGPA180tipp TREptspp EAR120y ACOAD8f ACALD NO3R1bpp NTPP2 ASPK URIK2 PYK SPMDabcpp 23PDE7pp CPGNR3 CD2tex NTD12 ACGAM1PPpp P5CD 3HAD80 HEPT1 GPDDA3 CO2tex DGSNt2pp PYNP2r GGPTRCO PAPA140pp PANTS OMBZLM AMPtex UAGAAT NDPK4 NDPK6 ALAt2pp LPLIPAL1A120pp ASPO6 GPDDA4 PRATPP LDH_D2 SO2tex ALDD2y GLYCLTDx NADN FCLPA A5PISO CRNCAL2 GK1 2AGPE181tipp AHCYSNS EAR181y FACOAE140 PGP141abcpp NTPTP1 COBALT2t3pp DAGK140 PSERtex AM4PCP GLCRAL IMPD ICHORT PLIPA1A161pp FUCtex AKGDH O16AP3pp O16GALFT ADK4 DKMPPD RBFSb ME1 RBFK DCMPtex GLYCAt2rpp ENTERES DMATT HSDy ASPTA PE141abcpp GDMANE THMDt2pp 2DGLCNRy QULNS UACMAMO THRD_L MLTP1 K2L4Atex DAPE PHEt2rpp HDCAtexi FACOAL100t2pp CTPS2 GLYBtex GLYCtex PG120abcpp GLYK 12DGR141tipp KDOPP GLCRt2rpp PLIPA2E160pp OHPHM POX DASYN141 GLUabcpp G3PD5 PFK CBItonex GALTtex PA180abcpp CA2tex XTSNt2rpp NTRIR3pp PHETRS SELCYSS HEX4 FRULYSE PGSA161 XYLabcpp FORtppi LGTHL MLTGY3pp UDCPPtppi 3OAR40 MTHFR2 NTD10 ETHSO3tex KAT4 TTDCEAtexi AGMHE UM4PCP PE120abcpp RIBtex MACPD PTRCabcpp EAR161y CDAPPA181 AACPS3 GRXR NH4tpp 23CGMPtex PSERT NTPP1 ACOTA PPCK G3PD2 ARBTNexs GAL1Ptex O16A4Lpp PLIPA2A141pp FMNAT ALDD4 TAURabcpp TDSK PLIPA1E161pp HISTP GLGC URIH MLDEP1pp G6Pt6_2pp FACOAL60t2pp MMETtex MECDPDH2 3OAR141 AB6PGH SULFACtex HISabcpp OCDCAtexi AGt3 DM_4HBA CLPNH140pp QMO3 CDAPPA140 12PPDRtpp EAR80y THYMtex H2tex 3OAS80 PGP160abcpp RBFSa EAR60x PLIPA1G120pp DB4PS TRPAS2 GLYC3Pabcpp HACD7i HEX1 ECOAH8 PLIPA1E140pp FDMO2 DTMPtex MSO3abcpp DHAtpp VALtex ACM6PH FRUptspp 12DGR161tipp PDH CPGNUtpp DAPDC 2DGULRy GART PLIPA1G160pp ECOAH5 ALLK UDPGD IGPDH NNATr LPLIPAL1G161pp ACGAM1Ptex LCTStex ME2 FE3HOXexs DHDPRy AMANAPEr NTD11pp FECRMUtex 2AGPE161tipp ISETACtex TARTRtex CFAS160G ACGALtex GLUR CYSabcpp FACOAE100 ISETACabcpp CLIPAtex 4PEPTabcpp FEENTERtpp PLIPA1G141pp EDD DSERt2pp AGPR SERTRS2 PLIPA2A161pp UAGCVT EAR180x ALCD19 GLUt2rpp CYSTRS MALTHXabcpp ACMANAptspp LPLIPAL1A161pp ALLULPE H2SO ACt2rpp ETHAAL MALTTRtexi XYLK PROD2 GTPDPDP ALATA_L GLYK GUAPRT CITtex OBTFL PMANM PAPA180 DAGK161 PGP161abcpp CYTD PLIPA1E160pp ARBt2rpp 2AGPEAT181 ARBTNR3 FFSD APRAUR DADA ICHORS ENLIPAtex SPMS ZN2abcpp 3OAS161 PGPP181pp ASPt2pp PGP180abcpp AMANK FECRMR1 FE2t2pp GLCRD INStex ACGAL1Ptex DHNAOT4 ASNabcpp MAN1PT2 TSULabcpp AACPS9 HEX1 GALURt2rpp MTHFC PLIPA2G160pp 5DOAN PACCOAL PGP181abcpp PUNP3 ALLTAMH HXAtex GLYCtpp GAM6Pt6_2pp ETOHt2rpp 2AGPGAT141 GLYALDtex R1PK METSOXR2 PLIPA2G161pp ILEt2rpp PACALDt2rpp FUCtpp NO2t2rpp FDH5pp CITL DASYN140 GLYALDtpp PNTK EDTXS2 UAPGR MPTG 4PCP PRMICI CSND PHETA1 NNDMBRT HACD5i 3HAD40 INDOLEtex DHAPT AGMt2pp MALTHXtexi HBZOPT PG140abcpp AM4PA CRNDt2rpp GLCTR1 PAPA120pp FHL PGSA140 RMNtex GAMptspp FEENTERabcpp AGM3PA MLTG1 GPDDA5 PE161abcpp ASPCT ACMUMtex AGM4PApp 2AGPE140tipp FECRMUtpp SERASr MDDCP2pp GMPS2 AGM4PCP QMO2 ETHAt2pp CPGNexs PPNDH L-LACD2 MN6PP 3OAS140 LIPACabcpp ANPRT ALR4x DURIPP CLPNS161pp PG161abcpp LEUabcpp ARBtex GMAND DADNt2pp SPMDtex ADK1 FE2tpp LCARR ASNtex EAR160y KG6PDC ECOAH4 GLYCLTt4pp NTP11 DHFS FRULYSt2pp FALDH2 FEOXAMexs FUMtex MCOATA METtex CBPS GALtex PLIPA1E120pp PA161abcpp XYLK2 PUNP1 3OAR140 NTP3pp FE3DHBZR INSTtex DAGK181 LPLIPAL1E161pp ADOCBLS FRUURtex ALR2 DALAtex RBP4E ARGAGMt7pp THDPS MALS DHPTDCs MINOHPtexi HOMt2pp XANtex TRPtex EAR80x FACOAE120 AGM4PH THZPSN CLPNS180pp ASO3tex PMDPHT CRNCBCT NI2abcpp NTD12pp 3CMPtex G5SD LEUTRS DSBAO1 TMDPP AGM3Pt2pp UDPG4E DSBGGT NTP1 ODECOAI XYLI1 NTD6 5DGLCNR CPPPGO FACOAE80 EX_34dhpac(e) MCITL2 FUMt2_3pp LYSt3pp CRNt2rpp PROGLYtex AACPS2 2AGPG161tipp FLDR XANtpp HKNDDH SERt2rpp TRE6PH TYRPpp PHEMEtiex METOX2s 23PDE9pp MALtex XANt2pp NTD1 PSSA180 SDPDS 12PPDStpp ULA4NFT EAR121y COBALT2tpp CMPtex CRNBTCT PLIPA2G120pp 3OAR120 ZN2t3pp NTRIR4pp HYD3pp ULA4Ntppi PPALtpp AGDC SARCOX ACALDtex GALURtex AGM3PApp DMQMT 2AGPE120tipp GLYCTO2 SUCOAS DXYLK IDOND OAADC G3PAT181 MELIBtex GLYCLTt2rpp PLIPA2E161pp PLIPA2A140pp ICHORSi IGPS CBMKr GLDBRAN2 GHMT2r FALDtex UDPGLCURtex ACS TREtex MOBDabcpp PLIPA2A160pp FDH4pp UM4PL AGMtex NTPP8 GALCTtex PDXPP ACOAD7f PUNP2 GALCTt2rpp PGPP120pp NO3tex TYRTA SULFACabcpp ACCOAC PPPGO FE2abcpp 2AGPEAT140 MAN6Pt6_2pp T2DECAI PAPPT3 2MAHMP ALAALAabcpp URIt2pp ACPS1 DAPAL UAG2E NTD8pp UNK3 DASYN181 ACGS RMK INSH 2AGPEAT160 5DOAN XMPtex GLNabcpp NTPP6 G3PStex CFAS160E MLTG4 4PCPpp GLCNt2rpp CPGNR1 PGI ASPT NADTRHD FACOAE180 FEOXAMUtpp CTBTt2rpp ACOAD5f NMNDA LYXI ASPt2_2pp LPADSS CU1abcpp ADCS ASR LALGP SUCCt3pp MLTGY4pp SHSL1 DOGULNR ECA4OALpp GLCURtex GTPCII2 KAS15 CUtex 3PEPTabcpp XYLI1 NADH17pp UACGAMtex CLPNH161pp CRNtex FA140ACPHi PTRCTA GP4GH PGPP120 IPMD SERAT FA120ACPHi IPPMIb G3PAT161 ACOAD1f GLYC2Ptex 3HAD141 3OAR60 PA160abcpp TSULtex 2AGPA161tipp ANHMK DHAPT ECOAH7 RNTR1c DHPTPE 12DGR140tipp 2AGPG140tipp FADRx AGPAT180 CYTBO3_4pp O16AUNDtpp ALAALAD GPDDA1 HDCEAtexi GLCptspp LYSt2pp KAT3 RBK HYXNtpp DHFR CMPN NDPK5 PE140abcpp CLPNS140pp NTPP11 LALDO2x FEENTERR2 TGBPA HSST UPLA4FNT GLYC3Pt6pp MEPCT 2DGLCNRx PRASCSi PDX5POi NTD4pp FMNRx2 UPP3MT PGL ASO3t8pp GLCRtex CTBTabcpp CYANST DCYTtex EDTXS3 BTS4 IMPtex GLYCLTtex PHEtex PIuabcpp AMALT4 L-LACD2 G3PAT120 GLYCK GLCURt2rpp ALLabcpp NADPHQR4 LPLIPAL1G141pp CLPNH160pp HG2tex UDPACGALtex RNDR2b PSD141 RBK 5DGLCNt2rpp SUCFUMtpp ETHAtex GLUt4pp KARA2 O16AP1pp AMPN CYSDtex DM_AACALD ASPt2_3pp GLUABUTt7pp LIPAHT2ex MLDCP1Bpp LPLIPAL1A160pp ILEabcpp MLDCP2App TYRt2rpp URAt2rpp ADD PSSA140 DNTPPA ASNt2rpp ADCL PGP140abcpp NADH18pp METSOX1tex 2AGPGAT140 AGM3PH RZ5PP O16AT ZNabcpp ACGAL1PPpp LALDO2x X5PL3E TMAOR1pp MTRI AMPTASEPG FE3DHBZSabcpp URIC DURIK1 GLUTRS DCTPD RBK_L1 DINStex FLVRx G3PT LPLIPAL1E181pp DHPS2 PLIPA2A181pp LPLIPAL1G160pp 42A12BOOXpp ACONMT NTD3 NTD4 METDabcpp PGSA180 MN2t3pp CAT PTRCt2pp ADNCYC CSNt2pp MNLtex PGSA181 FRD3 2AGPE160tipp ALATRS GLCtex SERD_L PGPP140pp ILEtex LCARS GPDDA5pp HETZK MDH2 DHNPA2 LPLIPAL1A181pp EAR141y FE3HOXR1 PETNT161pp DAAD NOtpp CHRPL ALATA_D2 GUR1PPpp PAPA140 3OAS181 MDDEP4pp DASYN120 CU2abcpp AGMT MDH3 PRAGSr G3PGabcpp SADT2 PPPGO3 ENO 3OAS60 OCDCEAtexi ADSK RNDR2 CBL1abcpp COBALT2tex FA161ACPHi OPHBDC HCINNMtex PGPP161pp CGLYabcpp ADEt2rpp LPLIPAL1E140pp 2AGPG181tipp PSCLYStex FDMO3 HMPK1 3OAR121 SSALx 3OAS160 H2St1pp 3HAD60 NTP3 PA181abcpp UHGADA GALKr OMMBLHX GPDDA1pp GALCTNt2pp PGPP160 ATHRDHr FCLK FRUpts2pp CRNDabcpp DIMPtex HXAND BETALDHx HACD4i LDH_D UGLCURPpp PA140abcpp FECRMR2 D-LACt2pp UDPGALPpp 34dhpactex SDPTA CYTDK2 EAR60y 3OAS121 PSCVT NTP10 HPPPNtex K2L4Aabcpp ADOCBLtonex SERt4pp LPLIPAL1G140pp ACGAtex NTPP9 DURIt2pp SERtex ABUTD EAR161x THRS GLYCLTt2rpp AACPS4 ORNtex THRD CLtex GUAtex NDPK3 ACOAD4f MMCD SULabcpp GTPCI OPHHX3 GTHRDabcpp R5Ptex DAGK141 NH4tex N2Otex GSNK CLPNS160pp TMDK1 2AGPA160tipp ACALDtpp FACOAE160 LPLIPAL2A141 AMALT2 AACPS7 GSPMDA LEUtex NTPTP2 TDPDRE AICART FE3HOXR3 ARGSS NADS1 ASPO4 METSOX2abcpp NTD2 CLPNS120pp 2AGPE180tipp PE160abcpp ETHSO3abcpp ARGORNt7pp THMDtex FACOAE141 ACALDtex OXAMTC DM_5DRIB SUCDi PGP120abcpp MLTG5 LA4NTpp MCTP1App HSK VALt2rpp DKGLCNR2x PEAMNtex GALT1 AMALT1 METOX1s ACNAMtex CHLabcpp HISTRS SBTPD ORNabcpp FACOAL80t2pp PDE1 PGPP160pp IPDDI CRNt8pp NTP5 3AMPtex PLIPA1A181pp HYXNtex ARBTNR2 NDPK2 FE3DHBZStonex SHKK SO2tpp OCBT SULRi F6Ptex MLTGY1pp FE3abcpp TDPAGTA L-LACD3 AIRC2 SKMtex CSNtex PROtex MANGLYCtex GLUNpp AST ARBTNtonex MALTATr GLNS METAT ADSL1r 3HAD160 DDGLCNtex NTD5pp TDPGDH G6PP FE3HOXabcpp DXPRIi G3PAT141 NODOy GOFUCR PRAIi 2AGPGAT180 3HAD181 NTPP3 FE3HOXUtpp FMNRx PAPA181 MALTPTabcpp G6Ptex DADNtex ALTRH HG2t3pp RMNtpp PFL LPLIPAL2A140 PAPA161 ADNt2pp MANGLYCptspp MELIBt3ipp EAR181x CYTDt2rpp BSORx MDDEP3pp GLYOX 2AGPE141tipp GLYAT FE3HOXtonex UGLT RHCCE GALCTNtex PAPA141 3HAD121 PUNP7 TRSARr ALDD2x DAGK120 2AGPEAT161 CD2abcpp GLYCLTDy TMPPP PPM2 CITt7pp GDPMNH OHPBAT ATPS4rpp PTA2 MN2tpp PLIPA2G140pp MTAN G6PDA CYTBDpp DHBS PLIPA2E180pp DHBSH METS ANS LPLIPAL1E141pp ECOAH3 LPLIPAL1E160pp SUCBZL UACGALPpp DHORTS ARGSL XPPT TMAOR2pp 23DAPPAtex GLUDC PLIPA1A141pp ADSL2r PPAtex GALTptspp SUCCt2_3pp ACGAMT UMPK HACD6i MCTP2App THRTRS GLXCL 4HTHRS ADNUC AKGtex GLYt4pp XYLabcpp CDAPPA161 12DGR180tipp MG2t3_2pp METSOX2tex DAGK180 ACACT1r GSNtex FCI FEENTERexs CLPNS181pp PGAMT CBIuabcpp FEOXAMUtex MALt2_2pp 2AGPA120tipp ARBTNtpp GAM6Pt6_2pp PSD120 CRNDCAL2 12DGR120tipp NMNt7pp EAR100x MALTptspp GGGABAH HEX7 PDX5PO2 VALTA METabcpp ENTCS RPE NTD3pp CD2tpp PPA2 TTDCAtexi DASYN160 ASPO3 LACZpp UMPtex ZN2tpp DBTS G3PEtex PLIPA2E141pp O16A4COLIPAtex GDPMNP MSO3tex PLIPA1A120pp NO2tex BUTSO3abcpp NO3R2bpp CS IPPS THMabcpp PEAMNOpp ABTA MLTG3 CYSabc2pp TMDS FE2t3pp PRAIS IG3PS GLUCYS GTPDPK MANPGH PAPA161pp FRULYSDG UDPGDC 3OAR80 2AGPA141tipp NTD5 AGPAT140 GLYCLTtex INOSTt4pp ETOHtex DASYN180 UDPGALtex G3PAT140 G3PGtex ECOAH6 G1PPpp GLYTRS ACNAMt2pp FA160ACPHi UDCPDP FE3HOXUtex UAMAGS NI2uabcpp MALTTRabcpp ASNS2 12PPDStex GDPtex FACOAL160t2pp TMAOR2 FACOAL141t2pp TAURtex ALLTN LPLIPAL2A181 NAt3pp PAPSR DAGK160 RPI GUAD DAMPtex HKNTDH CPGNR2 ALLtex TDSR1 ACONMT OXGDC2 LACZ PAPA120 ARGabcpp 3OAS141 IPDPS HACD3i ARGt3pp UDPGtex UGLT CDPMEK DDGALK PG181abcpp MDDCP4pp PYRtex 2AGPA140tipp CYSDabcpp PLIPA2G141pp PA120abcpp 3HAD161 GDPDPK LPLIPAL2A180 ASPtex 14GLUCANabcpp CYTBD2pp FA141ACPHi PGMT SBTtex GMHEPK FRUK PA141abcpp G1PACT FEENTERR3 PHEMEabcpp AKGt2rpp TARTD A5PISO GNK MALDtex SO4tex PLIPA1A180pp ICL FRUK ATPHs DASYN161 DHQTi GLYBt2pp CUt3 KAT1 G3PEabcpp GPDDA2pp GALKr DSBCGT NTD1pp FACOAL180t2pp LYSTRS BUTtex RHAT1 ABUTtex MI1PP FE3tex UDCPDPS GLCTR2 MNNH GLYCL CRNCAR IMPC MALTTTRtexi CFAS180G LYXt2pp G6Ptex AOXSr ACGAptspp BALAtex FMETTRS ACBIPGT ACONIs 2AGPGAT161 SADH ACODA PGPP140 PGK GLCt2pp AACPS6 U23GAAT PLIPA1E180pp G3PAT180 3PEPTtex DURItex GALM2pp GHMT2r LPLIPAL1G180pp DHPPDA2 G1PACT AP4AH FUM FDMO6 LADGMDH PPAt4pp G3PD6 PAPA181pp NADDP TDP BETALDHy ASPO5 GLNtex ACOAD3f PLIPA2A120pp PTAr FEOXAMabcpp MLTP3 ECAtpp GMPtex GRTT HEPK1 USHD TRE6PS PGPP180 3OAR161 R15BPK CPGNabcpp ACGAMK DDGLK 3OAS120 NADK HISt2rpp GTHRDHpp EAR140x XTSNH MLDCP2Bpp P5CR INDOLEt2pp DHORD2 ALDD19x ACMAMUT NADH16pp 12PPDRtex MTRK 3NTD2pp DHQS GLYCK SPMDAT2 CADVtpp GALCTNLt2pp PROt2rpp FCLT MALTTTRabcpp PPM HOMtex M1PD DDCAtexi h2o glyc3p[p] imp[e] ap5a din[p] 12ppd-S[p] h[p] pi na1 glc-D[p] his-L[e] gdp nadph h h2o[p] 23dhbzs h2o na1 h2o[p] psclys[p] atp oxam fad tdecoa fe2[e] met-L[e] co2[p] uamag h 1agpe181[p] nadh h2o h2o accoa no3[p] adp o2 tungs[p] h nadph kdo2lipid4L h[p] mal-D[e] nh4 g3pe[p] ctbt glu-L glcn[p] trnaarg 3gmp[e] atp nmn[e] h hdd2coa amp o2 ade[p] pa140[p] uamr amet h 2agpg180 nad h h csn[e] adp nadph pyr nh4 co2 h2o pi coa glyc-R atp dmbzid h2o[p] h2o 12dgr180 26dap-M h2o coa nadph fuc-L[e] pi ac[p] h2o nad 4ampm h2o2 h2o atp ACP h2o[p] 23dappa[e] glyc3p[p] pi 5mtr so3 h 2agpg181 h2o[p] h[e] trp-L pan4p h atp g3pe[p] for h nadp h h h2o[p] coa dhap h2o h2o[p] h pi pi o2 2agpg141[p] 2amsa pep nadph h adp h pi[p] h coa adp gln-L h udcpp[p] h2o frulys coa nadp adp g1p rbflvrd adp h2o glyc3p h h dd2coa gam6p atp h2o[p] h acon-C h adp fadh2 anhgm3p[p] adp h2o atp h f6p ade nadh ACP na1[p] h2o h[p] cobalt2[p] ppi colipa[e] h2o adn h h nadh h h[p] h nadp h2o asp-L h h h[p] atp h h pi[p] 2agpg180[p] trdox h h2o[p] nadh no3[p] h nad h[p] thr-L[p] thmpp phe-L 23dappa[p] h h2o h2o h fmnh2 amp nh4 h2o h2o2 g3p atp fum pe180 2hdecg3p[p] pe141[p] pi nad ala-L[e] h[p] pi h r1p h atp h pi indole[p] h h ppi agm[e] adp 2agpg140 lipa[e] phe-L[e] h 5drib 4hba g3pg[p] orn[p] atp g3p xu5p-D pi 5drib sucgsa ump[e] pep maltttr h[p] k[p] maltttr[e] gly h2o atp h2o h[p] h2o h pi pi[p] h2o asp-L ru5p-D adp adprib atp malttr[p] ru5p-D h amp h phphhlipa arbtn pep 2agpg160[p] ACP nadh ala-B[e] h2o[p] glu-L h h2o h nadph pi[p] pi h g3pg[p] nadh air co2 ser-D h sbt-D[e] h[p] ichor h atp ppi ACP trp-L h2o2 arbtn[e] myrsACP ppi g6p n2o h2o 3hcvac11eACP gdpmann udp o2[p] h h2o atp melib[p] h h2o[p] cmp adp atp tmao mql8 3pg h2o pi adp ACP nadp h2o h h2o ppi h[p] h2o adp 12dgr140 akg h amp fum dcmp[e] for[p] h2o atp coa nh4[p] o2 histrna dhnpt h2o[p] pgp161[p] but2eACP h h e4p h uagmda trdrd h 4ppan h2o[p] h o2 ddcaACP succoa h nadp atp gthrd pe161 h2o 2agpg120 h h2o mlthf h[p] glyclt h2o[p] adp h h[p] h2o h sertrna(sec) h h ps140 trdrd so4[p] h dsbdox ppi etha[p] fum atp fad lyx-L[p] fadh2 pi h2o adp h2o h xan nadp nadh atp nadph h2o[p] ctp succ[p] frulysp h h aragund mn2[e] h h2o[p] nadph o2 glu-L h[p] glu5p h accoa h2o2[p] h nad adp atp nh4[p] pi 4abz cdpdodec11eg udp arbt6p cys-D h2o o2[p] 5mthf co2 o16a3und[p] oaa trdox atp ins glyc 2agpg120[p] h2o[p] h h accoa ACP ser-L amp[p] pep h2o pyr acgam6p accoa accoa dha[p] pi pi atp gmhep7p co2 h[p] pi[p] h h2o[p] cdpdhdecg gln-L[e] fcl-L glc-D h adp h2o trnagln h nh4 glyc2p[e] h pyr dtbt nad atp asptrna dmpp acgam h[p] phe-L[p] h h2o accoa pep micit h2o[p] 4abut atp na1 co2 ppi atp gly mthgxl 2dmmq8 thf atp h ade adp pyr h h pyr h2o acald[e] 2agpg141 atp adp pi nh4 atp atp h h[p] h[p] but[e] nad h h2o ade[e] h gal1p nadph h h dopa[e] pi co2 h2o imacp dnad 3hoctACP atp gly atp trdox nad h2o nad 2dmmql8 pep h[p] h lac-L[e] amet gicolipa h[p] adocbl[p] 3oocoa leu-L akg ACP 2dr5p ppi alltt atp fe3[e] adp h pi[p] 3dhgulnp eig3p ppi pi malACP acmum6p atp q8 h[p] ahcys chor co2 o2 atp atp anhgm[p] h kdolipid4 h2o h[p] anhgm4p[p] pi h[p] 2dhp g6p[p] g6p h 4hoxpacd[p] crn[p] h amp h[p] h2o 5apru melib h pi[p] co2 q8h2 ACP amp h2o asn-L adp atp h h2o[p] h pheme[e] pa180 o2 1hdec9eg3p phaccoa mlthf xmp[p] 2shchc enter[e] h rib-D malt so3 h2o[p] gthox[e] r5p nadph h2o met-D amp h2o octeACP ahcys ppi glc-D[e] cpe180 h h prpp 5mdr1p pi 12dgr160 glyclt[e] h2o o2[p] h h h ribflv t3c9palmeACP pi acgam1p[p] ppi fadh2 h g3pg[p] h atp h2o 23cump[p] nadph gtp h pheme[p] tagur r5p trnasecys adp h pi thdp h[p] atp h h atp grxox o2 3dhguln xu5p-L h duri h adp h cmp h atp gam1p o2 atp h h pi[p] nadph adp h[p] succ h nad h2o co2 h h2o[p] fldox coa ppi h phom pydxn udpLa4o h h[p] csn[p] co2 h2o fldrd ocdcea[p] h h adp pi asn-L ppi adp g3pg[p] pa160 o2[p] co2 h atp ahcys lys-L[e] pro-L[p] h r15bp o2[p] ppi hdca h2o h co2[p] co2 pi h2o2 xmp h[p] h2o pi glyc3p rib-D co2 atp atp h co2 co2 h nadh amp atp accoa progly glu-L dhpppn oxur udcpdp[p] dpcoa tyr-L murein3px3p[p] glyc-R glu-L acnam fe3hox[e] atp succ amp h[p] glcur h2o[p] ppgpp sulfac[p] h[p] leutrna gln-L hxa[e] pi 2agpe120 na1[p] urea[p] ttdca ocdca[p] ppi pi[p] h2o[p] h2o atp fe3[e] dha cystrna h ser-L cobalt2[e] dgmp pi taur[p] h2o o2 pg120 h2o ac h atp pi 2pg adp lald-L adp gly h no adp h2o coa h h h nh4 nadh h nadh glu1sa h[p] glu-L rbflvrd glu-D accoa h[p] h2o[p] acorn coa adp 3ocddec5eACP cit[e] fadh2 h2o atp LalaDgluMdapDala 1agpe180[p] h adp h2o gar ggbutal 3hhdcoa h2o[p] h[p] atp o16aund udp h fe2 h h[p] akg pi fadh2 h[p] fpram adp ACP fum nadh fmn h[p] h2o hom-L[p] o16a4colipa[p] glcur[p] 2h3oppan h h2o[p] amp ura[p] ACP h2o dhpmp gam6p nad udcpdp[p] adp h h2o h pi h ac h nadph fe3hox-un[e] 3hpppn ppi h2o[p] progly[e] pi[p] h2o succ pi cmp pi h2s g6p h2o nadph h[p] pep mqn8 h2o fmnh2 nadh ac co2 h2o2 adp nadp nadh h atp h fald co2 nadh h2o g3pg[p] pi h h pi fad pi[p] dad-5 dmso[p] nadh h2o[p] h2o ni2[e] atp h h[p] h gbbtn[p] h h2o h2o2[p] nad fecrm[p] tartr-L asp-L h urdglyc 23ddhb adp 4abut[e] hg2[p] 2tdecg3p h lcts[e] h[p] 12dgr141[p] co2 nadp lac-L h2o ttdca[p] h pi adp malttr ump h2o 2tdec7eg3p[p] h[p] pi h2o udp pg161[p] pi h 12dgr120[p] 3sala cbl1[e] h2o datp dscl nh4[e] pi h[p] h2o nadh h[p] acgal[e] dcmp pi atp glc-D atp ppi h h co2 h pi h ahcys indole[e] adp adp h2o h2o glyclt[p] h mi1p-D ppi h g3pg[p] atp h metsox-S-L[p] ppi pgp120[p] h h2o cd2 selnp ser-D[p] eca2und[p] h2o[p] hdcoa h2o[p] acmum[e] amp adp udp adp h[p] h2o cmp 3hhexACP h[p] h2o acald nad btcoa adocbip dsbdox ppi but adp h h 1odec11eg3p[p] no2[p] co2 fald[p] h2o hdca[e] co2 glyb[e] fum[p] 2omhmbl h2o nad alltn[p] dad-2 2dr1p adp acald h2o atp o2 h2o mthgxl glc-D gmp glyc3p[e] h amp atp atp gmhep1p 23dhbzs db4p h2o[p] nadh amp gtp 4pasp clpn140[p] co2 atp h h[p] 3mob acald[p] myrsACP 3htdcoa atp nadh h2o atp pa160[p] akg[e] o2 cbi prbamp xtsn[p] h fad indole ppi atp h co2 lipidX h2o h[p] nad pi h[p] h nh4 ppi amp nadh h[p] h adp h lac-L[e] h h pi td2coa na1[p] coa o2s h h2o[p] h nadp h co2 ttdcea[e] ahcys nadph pi etoh[p] alpp[p] sucsal glc-D pi h nadh h atp murein4px4px4p[p] h galt[p] skm nadph atp thm nad udpg pi h2o h h f6p pi acon-T aso3 nh4 h2o nadp amp nadp amp pe140[p] ttdca[e] h2o hdca[e] coa rbflvrd atp adp 1agpg160[p] glu-L h nad cmp h h2o pi eca4und[p] nadh h2o coa malthx[p] acgam[p] h2o[p] h adp pi h nadp h2o[p] coa h ACP adp amp uacgam h ala-D[p] fe3hox-un lcts[p] h dctp h2o h adp h[p] h[p] atp nadp h2o h2o h trdox h murein5px4p[p] h atp octdp pyr adp adphep-LD atp h2o[p] udpglcur 1hdec9eg3p[p] ppi pi adp o2 h h h2o co2 h2o nadh akg ile-L[p] tyr-L h tma[p] glu-L sbzcoa adp glc-D nadp nad h2o acser[p] h2o 4hthr co2 na1[p] q8h2 adp h dhf atp h fecrm-un[e] glu-L glyc3p grxrd h pi chol[p] h2o[p] atp pyr h[p] h[p] ca2[p] atp prpp nadp amp ocdca[e] nadph grxrd f6p 13dpg h 5dglcn[e] coa ac nad pram tre dhptd atp adp gmp fe2 h 2tpr3dpcoa h2o co2 cit[p] nh4 adp h ppi pe140 amp h2o nad h r5p h atp pi[p] nad trnaile trdrd adpglc h2o h2o 12dgr161 xyl-D[e] h[p] h cys-L accoa udp h2o adp fe3[e] ACP h2o adp 3mop acgam1p[e] atp h glcn atp h2o h nad mnl[e] nadp nadp nadh h[p] udpglcur[p] atp atp coa atp ppi h2o h h acmana[p] h oaa atp adp sertrna h asp-L[e] 3amp[p] nac man[e] phthr thr-L atp h h nh4 h nad din[e] h um4p gly[p] trnamet pi 3ocpalm9eACP no2[p] fum xylu-L[e] uLa4n[p] adp cbi[e] dkmpp ACP pi amet pi h2o h2o pppi ttdca nadp h2o ACP nadp ppi h h2o h[p] h gtp[p] ACP pacald[e] aicar h2o[p] atp h h h2o co2 glc-D[e] fecrm-un h[p] na1 h[p] h 15dap[e] dhap h[p] h akg fe3dhbzs[e] sucglu cinnm gbbtn atp h peamn[p] g1p[e] lac-D h 1odec11eg3p h h h[p] h2o h adp h adp ACP dgmp[p] glyc[e] h2o atp fad enlipa[e] h[p] glx f1p ppi h pi 12dgr140[p] pi accoa mg2 imp h[p] ala-D pi ppi man1p lac-L[p] ppi pi h2o orot5p adp h2o atp amp amp ppi feoxam[e] minohp[e] ade mql8 h h2o mql8 34hpp nadph pi cdpdhdec9eg h[p] tmrs2eACP pyr 2ahbut ggagicolipa imp h2o h2o pi h2o[p] h nadph grxox 1agpe161[p] gbbtn[e] 12dgr160[p] glcur1p[e] adp adp pi[p] 2ombzl atp hxan[e] h h h h2s[e] ump alaala[e] h atp nac pi atp 3hpppn[p] nadph h h[p] glu-L[e] h nadp adp h2o[p] frulys[p] pi arab-L[e] co2 pe181[p] nadh h h LalaDglu actACP h2o2[p] alltn ribflv h adphep-DD pser-L[e] h cmp[p] gdptp malt pgp180[p] nadp pi atp coa nadh glyc[p] 3c3hmp h2o nad h2o h2o lac-D gsn[e] pyr h amp seln h pi ser-L for atp adp n2o[p] adp ddcacoa thf h glu-L ppi amp h2o 1agpg161[p] no2 h glx h h mal-L[p] h thym[p] adp atp h[p] nh4 succ orn 12dgr141 adp ru5p-D h2o adp ctp coa damp[e] pacald adp dsbcox[p] nadph h2o maltttr[p] h[p] atp g3p atp atp coa h h2o h2o h2o nad so2 crn atp ala-L fe3[p] fald pgp160 man6p udcpdp[p] nadh ppal[e] h2o gua kphphhlipa atp fru[p] 1ddecg3p na1[p] adp pyr h[p] ocdcaACP 2pglyc h h dca t3c11vaceACP h h[p] h h h butso3[p] h etha[e] nadp h2o o16a4und[p] pep aso3[e] h2o[p] dump[e] glc-D trdrd h[p] h acgal[p] h[p] h2o h galct-D[p] h[p] h ppi tpalm2eACP h h h2o h2o[p] amp glu-L acmum[p] h[p] nad coa acac[e] h nadp pi h atp pi adp all-D[e] h adp pi pi nad pgp160[p] ni2 h zn2[p] h nh4 ara5p 12ppd-R[e] uri h2o grxox glc-D gly h2o h h h h2o 5prdmbz h2o tcynt ppi acon-C pi uama 3ooctdACP h2o o2 co2 pydx5p ocdcea[e] fe3 so3[e] h pppi nadph amp nadh dttp ile-L 2omph h2o h hco3 h2o h2o h[p] h2o[p] aicar thym atp adp 2agpe120[p] h[p] ugmd h2o[p] h2o h2o h[p] ACP malt glu-L h h f6p h h[p] pg180[p] fe3[e] so3[p] h fadh2 pa140 rbflvrd ctp h[p] h utp coa clpn180[p] ppi h pi h h2o arab-L[p] h2o no3 3ump[e] adp amp h[p] h dadp udcpp paps h[p] coa xtsn[e] pi gmhep17bp adp nh4 6pgl h2o glutrna pi co2 nh4[p] h[p] atp nadph nadp h ppi h h[p] isetac h pi trnatyr pi fum[p] h[p] ppi co2 h[p] hkndd 4abut dcacoa ahcys h h2o[p] dimp h atp coa h2o pi h man galctn-L cmp h nicrnt accoa metsox-S-L[e] atp glc-D lac-D[e] glycogen nadph h lald-D na1[p] nadph cu[e] pi[p] nadp pi h2o h cgly[p] coa h2o h2o2[e] nh4[p] atp udpg g3pi[p] imp[p] leu-L[p] h[p] h[p] nh4 uaagmda amp[e] h nadh ppi accoa h[p] succ adp pi[p] hdcea[e] pmtcoa dca[p] ppi ala-D 4ppcys atp h fuc-L coa 1odecg3p[p] tym[p] h2o[p] h glyc3p atp h[p] pi h2o h2o nadph ppi fe2 q8h2 nadh adp ppi co2 nadph h[p] pg181 h2o h[p] udpacgal[p] glc-D[p] ala-D[e] betald atp h h pi h2o ppi h2o aact pi h h[p] h2s sbt-D[p] g1p[p] nad h o16aund[p] atp nadph g1p h amp udp h[p] 26dap-M[e] g1p h[p] 2mcacn acnam[p] nad h2o 6pgc h dcamp ACP atp g6p[p] h pi fad no3 adp na1 h 3pg nh4[p] hmbil pppn[p] gdpmann pi so2[e] h h[p] trnahis h2o nadh h2o[p] adp odecoa adp nadp h[p] nadh pro-L[e] glcn[p] 3hoctaACP h h2o atp glyc3p[p] h udp nadh cdpdtdecg q8 h2o gsn atp h2o[p] 4mop h2o h2o galctn-D[e] adp h2o[p] h h2o[p] cgly[e] pi acald[p] h h2o[p] atp h adp cd2[p] h2o[p] pi h h ahcys h[p] glyc-R[p] ascb6p h2o h amp h2o succ glyc3p eca4colipa[e] nadp cpgn-un[e] h adp u3aga h2o[p] 2obut 12dgr120 atp h2o o16a2und[p] ppi h pi[p] h[p] cl feoxam[p] h h[p] h[p] h h2o gln-L[p] uLa4n h2o h2o h ACP ppi prlp atp succ[p] glytrna adp h h[p] adp dhap h gp4g coa atp 23dhdp ptrc[e] gly ppi h h2o atp ascb-L[p] h2o atp lipa ppi h2o nadph acald[e] fe2 unagamu pi co2 co2 h coa h 2agpe180[p] pi[p] atp pi[p] h ahcys all6p ppi h2o nadph adp ohpb adp tmao coa h2o[p] thymd[e] ump[p] for h h apoACP adp od2coa fldrd g3pe[p] h h frulys[e] pep h[p] aso3[p] h2o[p] h etoh nadph h2o cmp ACP cpgn-un atp agdpcbi met-D[p] ag[e] coa mnl1p adp ade h2o[p] occoa nadp atp adp h2o[p] adp gal[p] o2 f6p atp atp pyam5p h[p] ppi nad pi sucr[p] met-L ACP pyr nadp atp 5aizc grxrd utp h pep ps160 accoa h2o h atp ahcys pi h atp pi pi[p] h2o[p] h2o h2o atp nadph h[p] fad nadh h2o nadh amp gcald dtdprmn 2dhguln nadh h2o h2o[p] citr-L h h nadh nadh dms[p] pgp181[p] h h 2dh3dgal 23cump[e] h2o h2o[p] aspsa q8h2 nadh ddca fe3[e] h2o coa pi h akg o2 nh4 ppi pi pi ump[p] adp mobd g3pi h g3ps[e] pep h adp h pi pyr h[p] atp asp-L h[p] pe161[p] pi h ppi nad glx hg2[e] h adp h2o trdox ca2[e] dms[p] cmp h[p] acgam6p h 2ddglcn h2o h2o atp h 12ppd-S glu5sa h[p] pi adp gln-L h2o fdp h no3 glyclt fe3dcit[e] h grxox fe2 nadph h adp gal pyr nadh adp malt h 1agpg140[p] atp o2 nad atp h2o atp atp h atp h2o[p] 3hcinnm[p] adp prpp glx h 1agpg180[p] h h[p] co2 ppi agm h2o pyr aconm mal-D[p] hemeO h2o h h h h h2o h2o h h h h[p] 3c4mop hg2 fe3[e] h udcpdp[p] lipa_cold h[p] colipa[p] h2o atp nadh glu-L h idon-L[p] nadh dtmp h2o[p] o2 h2o glc-D[p] fe3dhbzs h2o butACP h nad h2o hdcea glyc3p[p] glc-D ptrc[p] 2dh3dgal6p h2o[e] pg161 amp h atp co2 adp glcr[e] h2o adp alaala[p] pi ppi h2o atp glyc3p[p] h2o udcpp[p] h2o[p] ser-L h murein5p3p[p] gthrd h2o dgmp[e] Sfglutth h[p] h[p] nadh pro-L ppi amp fldrd thymd uri pi adp nad udcpdp[p] fmnh2 ACP 1agpe140[p] ribflv h2o mal-L pep dgtp h[p] hdca[e] h glyc3p[p] pi 4abut[p] atp pi[p] for thmmp tma[p] atp gdpofuc nad prbatp atp mqn8 fru[e] rib-D[p] btal adp h2o h h2o adp alaala[p] malthp atp atp glcr pi cmp[e] h murein4p3p[p] pi xyl-D[p] udpg glntrna fe3hox nadh g6p[e] h2o nadh ser-L tungs h thf glu-L h adp h2o nadph h hxa amp glyc h h2o glyc[e] atp h2o xtsn h2o atp h2o amet h2o h2o spmd[p] ethso3[e] ACP adp pi spmd[e] alltn[e] dhna ACP pi h2o dxyl5p h ppi h 2mcit atp amp nad h ac trnaala h2o h2o val-L[p] h2o na1 h2o asp-L[p] succoa udpLa4n atp thf h[p] hlipa sucorn 5dh4dglc nad h[p] h no2[e] h agm[p] h rbflvrd h pi pg160 nadph h h2o pi 12ppd-R h2o acanth h h[p] scl co2 h h h nad nadp nadp acetol nadp h2o[p] h2o hdd2coa h[p] atp nad dcmp[p] h glcur1p[p] r5p ppi atp nad nad glyb[p] gthox[p] nadh r5p[p] adp h[p] h2o adp tungs[e] udp galct-D[e] h atp fmn h2o pi pyr uacgam[e] cbp adp frdp h2o h2o h2o[p] h trnatrp tyr-L[e] atp glyclt gtp h2o h2o feenter[e] h protrna fe2 h rib-D nadh h feenter[p] h val-L h2o[p] nad h prpp suc6p udpglcur[e] kdo ctbtcoa fmnh2 fldox pser-L nadh nadh adp nadh tartr-L[p] nh4 na1[p] h[p] dmso h2o h[p] pser-L[p] tre[e] r1p h2o gal1p fmnh2 dump[p] h uacmam h2o pyr man1p glyc3p[p] h[p] nadh h h[p] glu-L h ala-D[p] 3ocvac11eACP so4 adp fmn ala-D tdecoa pyr hacolipa[e] mql8 ppi imp h2o pi cdp amp adp ACP coa crn-D asp-L 2cpr5p no2 pi h2o tsul[e] nadph 26dap-M[p] rib-D[p] adp h[p] nadh pyr h2o pi h h2o ppi udp coa his-L[p] h h nad amp atp pi pyr[p] h2o coa h h h2 h atp h h[p] dhap h[p] h[p] cmp atp h2o pi acglc-D h nadp h ac[p] pe120[p] ppi glyc[p] cit h2o h nadph f6p h hom-L pi[p] pi h fad cmp urea[e] t3c5ddeceACP pi h2 nh4 atp h gggagicolipa h2o adp amp hkntd nh4 coa N1aspmd h h h grxrd pg140 h h2o 14glucan[p] fruur[e] h h h h atp ppi nadh tmao[p] cys-L[e] h2o nad h2o[p] nadh nad btnso h ala-B itp h[p] h[p] pe180[p] nh4 pi[p] h2o ACP atp pi h2o[p] nadh h h2o h h 2hdecg3p h pi h[p] nadph 5aprbu h ser-D[e] h his-L h2o h h2o atp nh4 h amet tyrp[e] dtmp[e] 3oddcoa h2o h atp pi amp h2o butso3 h 2dr1p o2 h h na1[p] co2 dutp h2o[p] ACP h[p] atp h nadp xtp co2 h2o lys-L dhor-S adp h h met-D[e] adp h h2o[p] pi h2o pyr b2coa h acgam1p atp cpe160 h h adp mg2[p] atp h h[p] pi[p] h h h2o glyc[p] h acnam[e] pi gcald g3pc[e] h udp h2o dc2coa succ[e] adp glyc3p h2o trdrd ACP ppi q8h2 h 3php 4hoxpacd[e] galct-D h2o[p] o2[p] ppi dmso[p] crncoa trnapro glyc-R[e] o2 dsbdrd atp LalaDgluMdapDala[p] 3cmp[e] pi h 2ommbl h[p] h h2o adp asp-L nad nh4 coa cl[e] h2o ppal pi h2o h pi h o2s[p] atp atp co2 amp ac atp nadph h h[p] t3c7mrseACP h2o ppi lys-L h[p] ppi h2o nadph coa dsbaox[p] nad h acglu h ppi 3hdcoa h h ppi ppbng pgp141 arbtn-fe3 uri[p] 14glucan[e] h[p] udpgal h[p] h 2oph atp fe2 h h coa h2o h2o acser[e] malcoa amet h2o h akg gam[e] nad ctbt[p] nh4 h ile-L trdox f1p 12dgr161[p] fe2 5mthf h2o h[p] h h pi h skm5p 2tdec7eg3p h h[p] h2o h[p] glu-L 34dhpac[p] ac h2o accoa amp tddec2eACP h2o so4[e] succ h2o[p] rib-D 2dr1p met-L pg120[p] udcpdp ahcys nad pyr pep g3pe[p] nad ppi glu-L 3hmrsACP adp gam[p] h2o h2[p] h2o pi h[p] ppi glu-D atp g3pc for nadh nmn[p] fadh2 g6p h2o2 na1[e] nh4 pyr nadh malthx[e] h adp dimp[e] h2o[p] h lac-D[p] h pi pi adp maltpt h[p] amp h gal-bD[p] sbt6p allul6p glu-L 2agpe141 h[p] h nadh pap pi[p] glyclt[p] h[p] h 4mhetz adp h2o[p] nadp h h val-L[e] h atp nadph nadph h h2o damp[p] h h2o 5dglcn mal-L[e] pa161[p] coa pi[p] h2o[p] atp nadh h2o galctn-D glu-L nadh h h2o h2o h[p] thf h co2 fe2 adp pep h2o accoa coa h2o h2o[p] h2o cbl1[p] atp ppi h2o[p] fe2 pi akg h nadh h atp mqn8 h cbasp h2o pep nad hdcea[p] h2o icolipa etha h mso3 h pi h2o glu-L pi h2o[p] h nadp h sarcs ala-D[p] h q8 dann uLa4fn dmso progly[p] fad malthx pi g3pe[p] 2dmmql8 pyr gal1p[e] malt[p] pep h[p] co2 na1[p] manglyc[e] 3ohcoa h h n2o[e] ps141 pep nadh h2o atp h[p] pi g3pe[e] tmao[p] h2o co2[e] lcts ala-L co2 o2 atp dcacoa nadh adp h[p] h2o atp acgal1p[e] coa pi[p] h tyrp[p] atp h[p] h glu-L atp tdcoa 1agpg181[p] h2o atp hxcoa mlthf ac lyx-L[e] clpn161[p] nadph thex2eACP atp h2o[p] histd ala-D[p] glu-L[p] 3mob h2o nadh cys-D[p] pi nadp nadp h adp atp h g1p fad unaga co2 h pi so3 pi amet thmpp co2 lipidA pyr amp pacald[p] h h sheme h h2o pi pi glc-D[p] adp ascb-L[e] g3pe[p] h taur[e] h adprib ACP 23dhmp gln-L h h2o nad co2 h[p] h h2o[p] maltpt[e] argsuc h[p] murein3px4p[p] h2o mana ppi 12ppd-R coa 3hpalmACP h2o acmanap h2o[p] h[p] atp h2o sucr[e] h2o arbtn-fe3[p] ala-D h2o h h o2 feoxam lyx-L h adp h2o crn-D nad uri co2 pa141[p] h pe181[p] h h[p] gmp cytd[e] 5aop pi adp gua[p] atp glyald h h2o pi h[p] h[p] h2o 12dgr161[p] pg141[p] h h o2 h atp ac udpgal h2o h[p] pi nh4 eca4colipa[p] h2o h adn[e] rib-D[e] h2o atp ppi pran lipa_cold[e] h mqn8 for h h[p] na1 atp ppi h2o pyr h amet atp pi h nadp kdo8p adp all-D gthrd arg-L pyr h h h pi dsbgox[p] adp pyr camp amp rib-D[e] h2o fad atp gthrd[p] atp h2o[p] h2o h[p] fmnh2 adp no3[e] metsox-R-L[p] for pnto-R[p] nadp h h[p] ppi nadp 2agpe161[p] pgp140[p] fmnh2 h2o pi tyr-L[p] aso4 h2o no3 h2o adp ctp h hxan h akg h2o murein5px4px4p[p] atp adp h2o succ o2 pyr[e] amp man6pglyc atp h[p] nadp mlthf ppi pnto-R adp h h nad 3gmp[p] glc-D h[p] 2obut xmp[e] trp-L[p] h2o[p] h[p] r1p atp ni2[p] trdrd adp h fadh2 h2o xu5p-D 2agpe160[p] ACP coa nadph co2 alatrna r1p h2o coa 2p4c2me pep pi h2o nh4 2dr1p coa xylu-L nadh nadph atp nadph g1p amp h h2o so4 pheme so3 h h2o h2o[p] dad-2[e] gdp h[p] taur 5dglcn[p] nad gln-L coa glyc3p[p] h2o 1tdec7eg3p ru5p-L ca2 pi h[p] h2o h2o amp mnl[p] h mettrna h gdpddman h h2o h[p] pro-L pi h2o[p] h2o pi[p] dttp pi pg140[p] h2o co2 ppi atp h2o h h na1 h h dcyt adp h adp cyan h[p] nadph atp glyc3p[p] co2 6pgc u23ga h h[p] cyst-L ser-L h2o nadp pyr ac[e] alaala atp nadph h2o[p] akg h[p] h h[p] 2agpg181[p] nadh glu-L glucys 2dhglcn eca3und[p] h ppi hdcea q8h2 ac[e] tyrtrna nadph h2o h ppi ser-L[e] h cytd adp ser-L[p] nad xyl-D[p] met-L for tre[p] h h h atp 1odecg3p for[p] glyc[p] skm[e] atp fad h2o 3hbcoa adocbl h adp h h[p] nad udcpp atp atp tag6p-D h h2o pi nadph h atp h2o nad nad fldox adp nadph ala-B[p] orn[e] adp adp h h2o chor h2o 23dhb h[p] pi ppi ppi h kdo2lipid4p ser-L h atp h ACP h nadph metsox-R-L mso3[p] h[p] pi pi fe2 asntrna h nadh nad h[p] h2o o2 h amp h2o nadp h[p] mlthf h pi co2 prpp gmp[e] pi psclys[e] h 23dappa pgp141[p] sulfac anhm4p h2o[p] pi akg h2o amet ins[e] glu-L pyr ragund amp 2agpg161[p] h2o h[p] dtdp h ppi h[p] nadh no2 prpp acon-T 2agpe140[p] atp h h h pi[p] h cdpdodecg fe2 gmp[p] ppi h2o udpgal[e] adp adp acolipa[p] nad h h2o[p] h2o adp h atp f6p[e] pi pi glyclt glu-L met-L 10fthf mqn8 h atp h na1 trdrd gtp pe160 h2o lac-L no2[p] pi[p] ppi enlipa[p] orn[p] h h2o[p] LalaDgluMdap[e] h2o h2o h h pyr adp h asn-L[p] h2o ppi atp pi h h nadp ala-L h2o h adp h2o[p] ddcaACP ppi h[p] h2o asp-L h h[p] adp h[p] gthox h cbi[p] pi[p] adp f6p ctp feenter kdo2lipid4[p] h2o[p] h h2o h g6p fmnh2 udcpdp[p] murein5p5p[p] 3ump[p] h h2o coa h2o h2o[p] nadh nadph atp h2o atp adp nadph nh4 cmp pi h h2o[p] fe2 pg141 h toctd2eACP nad octa[e] atp pi h2o[p] ppi h2o[p] h h h2o h2o[p] mql8 h udpg[p] fe2 inost[p] udpg[e] atp pi nadp pi anhgm4p ppap adp ppi adp h h nadh ppi h h2o h nad ckdo atp nh4 ade thrp[p] ACP acg5sa ppi h2o[e] fe2 gam6p[p] lystrna amp h2o succoa xdp h coa 3ohdcoa h h2o[p] nadp nadh h2o h h h2o h2o h adp pep mqn8 r5p atp h udcpp h2o h ps120 pi gam1p h[p] trp-L[e] cpppg3 acmum6p h2o h2o 2ippm h adp pi pppi fad g6p glcn[e] nad ribflv h atp o2[e] nadph h2o fum glu-L h na1 pi ile-L[e] fmn pi akg gly[e] h2o[p] 2hdec9eg3p h2o 1agpe160[p] pi[p] h2o nadh h2o h[p] co2 h acgal1p[p] hx2coa enter h[p] atp ahdt h2 h2o2 ACP atp h h2o h2o h adp fecrm pi glu-L h[p] pi nadp h2o idon-L h2o h[p] nadh h2o atp adp nh4 ctp adp nadh urea h2o akg h2o h h o2 ps180 nh4 h2o clpn181[p] no[p] h2o nadph cobalt2 murein5p5p5p[p] pi nh4[p] amob ncam glc-D 3odcoa ump[p] h2o[p] h arbtn-fe3[e] mqn8 h amp nadh h malttr[e] u3hga h2o glyb h2o amp nadp h h2o[p] h2o nadh glu-L h2o[p] no[e] h2o2[p] g3p pgp120 pydam pi h[p] nh4 h2o2 h dcyt[p] ac atp h[p] 12ppd-R[p] g1p nad amp adp pi 2agpe141[p] atp arg-L[p] mn2[p] fmnh2 h[p] pi[p] fald 2odecg3p[p] ipdp 23doguln 23cgmp[e] ala-D h2o pi pppn atp nadh h2o[p] h2o[p] h[p] nad cys-L[p] nadp pep h[p] mercppyr h2o 1ddecg3p[p] ribflv 2agpe140 pyr g3pg[e] nad h2o h[p] 3amp[e] co2 nadh h[p] h coa nh4 ttdcea thym[e] h2o h2o2 fmnh2 h2o 4ahmmp anhm3p h2o[p] op4en h2o cmp h mql8 h2o co2 h pe141 g3p pi aacoa ACP 4adcho ACP cmp h val-L h[p] o2 adp acmana[e] atp akg 4abut trnaglu h2o[p] 23dhmb glyc[p] h h h[p] nad ssaltpp 10fthf pi nad ppi nadh h h atp nadh h2o adp h[p] cmp pi[p] h h[p] h atp pi cys-L amp dhap pyr h2o co2 cu2[e] atp atp pi o16a4colipa[e] h atp adp h[p] cddec5eACP pi oaa manglyc[p] atp ppi glyc[p] lald-D 26dap-LL h pi[p] h dgsn 3psme grxox ser-L[p] fldox ACP 2dmmq8 succoa pyr h adp h k[e] succ amp fadh2 spmd pi h lac-L gln-L ump nadph ditp melib[e] pi h pi[p] 2pg trnaser murein4px4p[p] h h h2o h h h h h h2o h2o atp adp h h2o leu-L[e] h nadp xan fru h[p] h cit nh4 atp h 3dhsk pgp180 pi[p] atp adp for h2o[p] h2o h nadph lac-L ppi h xylu-D h[p] h2o h h gthrd atp fadh2 adp csn pi[p] ala-D[p] ethso3 adp h[p] cmp arab-L pdx5p nh4 murein3p3p[p] h atp dtdpglu h g3pg adp nad 2dr1p coa lipa[p] h pi amp prpp pant-R h[p] mobd[p] unagamuf q8h2 h2o pyr adp h 2kmb h[p] ppa[e] h adp adp h h2o h adp cpg160 metsox-R-L[e] dxyl adp nad atp h h2o fe2 g6p nadp h atp h2o cpgn pyr g3pe lipidAds adp atp h2o[p] ACP acgam[e] 2agpe161 aconm h dsbgrd[p] h dump colipa h[p] ggptrc h pep stcoa pi h 3hdecACP 5caiz h[p] h[p] h h2o2 h[p] h h athr-L h2o h2o[p] ppi 2agpe180 pi atp inost glyc[p] h2o h2o[p] adp pg181[p] cmp galur[p] nadh asp-L 10fthf h2o h atp nh4 tyr-L nadh nadp toct2eACP tym[e] h[p] ppi uppg3 r1p 12dgr181[p] h2o[p] ins[p] co2 pi h h h etoh[e] trnacys amp h co2 4h2opntn h h rdmbzi fdp pi 2agpg161 h 3hpppn[e] amet rbflvrd thf nadp h 23ccmp[e] anhgm3p h ribflv ala-L[p] glu-L[p] h cpg180 atp h h h2o pi ppcoa f6p atp adp adp atp thf pi atp nad nadh nad acolipa[e] h h[p] h na1 glyc2p[p] amp ttdcea[p] atp h[p] ppi h nadh nadph dgsn[e] akg atp h h[p] udpg nadph h h ala-L pi adp adp h2o adp xyl-D fc1p adp pi h2o[p] pi nh4 h2o pi h[p] h h2o[p] pi co2 h2o[p] h ppi h2o fldox h h h[p] mobd[e] glu-L adp h[p] h[p] atp h cbp pep h h pi[p] nadp ocdca ptrc succ rib-D h h2o pyr accoa h duri[p] h[p] h2o 3opalmACP h2o no2[p] gtp uaccg nadph octa adp 3ocmrs7eACP h2o ru5p-D h pyr fprica h adp pi[p] adocbi mso3[e] nadh nadp ACP adp nad air nad amp h acg5p amp h atp 2ohph acmalt h 1pyr5c h2o atp h2o atp h h2o octa[p] h pi h LalaDgluMdap[p] h 2agpg160 glyald[e] na1 h ACP malt[e] h gdp adp h2o atp h2o adp h[p] alac-S tartr-L[e] mal-D h h2o[p] ppi thymd[p] h[p] adp odecoa atp nadh ura g3pe[p] h[p] coa nad h2o adp 3ooctACP pi malt6p h2o galctn-D[p] 3hddcoa h2o h2o[p] LalaDgluMdapDala[e] akg o2[p] adp atp atp 2odec11eg3p atp thrp[e] adp 2hdec9eg3p[p] h[p] h2o co2 adp h[p] ppi h adp h2o pi adp nadp nad amp atp hom-L coa quln 2mahmp pi fldrd h pi dms co2 pi[p] fe2 nadh atp nad h ptrc co2 adp atp h h2o h2o ppi gdp atp Nmtrp sl26da nh4[p] h h2o succ thf pi h lipa_cold[p] 1agpg120[p] pi pac fadh2 glu-L h2o rbflvrd h2s pi pi[p] ppa[p] atp nadh dudp for 3dhq h2o hxa[p] pi h[p] adp fe3hox-un[p] adp h2o 15dap h g3pg[p] gln-L prpp uacmamu h glyclt[e] h2s[p] h2o[p] h dtmp[p] nadh 12dgr181 atp atp thm[e] hxcoa fmn h2o[p] but[p] nadph pi h myrsACP ala-D[p] h h nad 3c2hmp h coa gdpfuc h2o[p] amp 15dap[p] h nad thrtrna mg2[e] h 2ddecg3p[p] fe2 2me4p cmp ump[p] 3haACP ugmda urate h h2o dha nh4[p] 2tdecg3p[p] atp tsul galctn-L[p] h[p] halipa[e] adp h h2o h[p] ddca[p] tsul[p] fe2 atp h h h h2o[p] h ppi glu-L grxrd fad h ocdcea cys-L 4hbz damp o2 adp acmana nadh s7p adp amp adp h[p] h ddca[e] h2o2 dtdp4d6dg h coa pi anth atp h udp amet rib-D dad-5 h2o h2o no2 pi coa glc-D h gtp pphn h 5mdru1p acald h pi h glc-D[p] h[p] h2mb4p inost[e] h h dtdp succoa h h[p] h[p] ppi nadph accoa h2o pa181 atp dsbaox[p] h2o h ppi h2o 2aobut pi[p] ala-D[p] ACP man[p] atp nad coa 2agpe160 atp skm[p] hdca[p] 3hcinnm[e] fad h2o h2o[p] adp 3cmp[p] isetac[e] h2o ala-D[p] 4per nad h adp gal ppi dsbdrd h[p] 8aonn h2o lys-L nad h h nadh coa rmn apoACP h2o ppi h nicrnt h2o h2o[p] h2o[p] fecrm-un[p] cys-L 2odecg3p amp succ[p] h grdp h atp h h cytd[p] h trdrd adp sectrna f6p ppi h udpgalfur akg argtrna h2o[p] h2o acac icit 2dmmql8 atp nadp h tdec2eACP trnaasp coa nadp g3p h[p] pi nadp gthox ppi bglycogen h[p] adp gthox 2agpe181[p] amet h h[p] h h[p] o2s alaala[p] hqn cenchddd leu-L h[p] h2o h atp atp uacgam[p] trdox h2o h2o[p] ps181 gua[e] nad atp glc-D h h2o[p] nadph mmet[e] h2o cpgn[e] glyc[p] h nad pi ethso3[p] crn-D[p] lpp[p] nadph h ACP na1 h[p] h h2[e] ACP h glx h2o xylu-L[p] h pg180 atp gtspmd nad h2o[p] ppi 25drapp atp h2o2 kdo2lipid4 h pi palmACP atp ACP h nadp ppi pppi h[p] h glc-D nadp h2o coa h h2o no2 nadph h glu-L fruur h pi adp h2o2 phetrna cu[p] nad fadh2 h2o[p] pi glyc3p fadh2 h pe161[p] h adp adp h 6hmhptpp adp 3omrsACP pi h enter atp adp 3oddecACP nad h gam6p[e] h2o pyr clpn160[p] pi pi nmn gln-L h2o h2o hom-L[e] atp fmn clpn120[p] ru5p-L galctn-L[e] h nad rmn[p] co2 thr-L glyc3p[p] nad ppi h atp h2o atp h2o nad h h2o[p] adp xmp man6p atp h2o udpg fe3dhbzs[p] h2o grxrd malt lac-D h2o dhcinnm mn2 4mpetz accoa h2o glu-L atp anhgm[e] h pe181 g1p[p] amet g3pi[e] h2o[p] h2o ala-D h h akg 1hdecg3p[p] h h nadph udp h2o atp atp g6p 4r5au h 5mta h2o h2o[p] valtrna for[e] ala-D[p] atp pyr fecrm[e] pi glcur[e] udpg pydx atp h acald ppi h lcts h2o h2o[p] orot adp pi acald rib-D atp succ h adp pe120 h pi h[p] h pi h 3hodcoa glyclt 12ppd-S[e] fmn cmp h2o[p] fe2 4c2me accoa pep 2ddg6p adp h[p] h h2o[p] pep adp h pi adp ag h h2o[p] for[p] minohp[p] gln-L nad h pi atp agm[p] pgp161 nadh h ametam h[e] h ala-D[p] pppg9 fad h h[p] fe2 din gdp[p] ppi h h glx h adp h pi fum pyr h ppi nad 2ddglcn[p] h h 2agpe181 gdp 3otdcoa ACP h pgp181 glc-D iletrna nh4 ala-D[p] adp pi LalaDgluMdap h2o atp co2 ACP pi pi h2o adp 2odec11eg3p[p] adp h nadph atp adp o2 h2o tre6p r5p cmp dad-2[p] h[p] h glu-L 1agpe120[p] pi ala-L na1[p] pi gal-bD[e] h h glyc o2s nadh h[p] nad nh4 nad atp h2o gtp h h atp nadph hpyr ppi ppa mql8 h2o 2dr1p h h2o co2 nadh lys-L[p] h h2o glyc3p[p] h h pi ppi h 3pg adp atp fad h[p] pi gal1p[p] h[p] atp udpg ctp pi pi pi h idon-L[e] ppi fgam adp gthrd[p] h2o phhlipa h atp amp h amp xyl-D pi[p] prpp pi h pmcoa h udpgalfur nadp coa co2 h2o h[p] adp g3ps h h2o h fmn glu-L amp 1tdec7eg3p[p] h h2o[p] fum[e] h actp glcr[p] h2o[p] pppn[e] h2o nad pi duri[e] xan[e] 2ddecg3p acac[p] ac adp h nadph h pi q8 1agpe141[p] h[p] co2 nh4 nh4 pi[p] h atp adn[p] 10fthf h amp nad co2 dgsn[p] h hco3 h nadph fadh2 h2o h2o nadp nad 1agpg141[p] h[p] h2o[p] h2o g1p h h atp h2o[p] h[p] nadph k adp h[p] pa120[p] cpgn-un[p] h h2o nadp cechddd hexACP h2o aacoa atp urate h tma r5p iasp h nadh adp utp h rhcys ocACP h2o[p] cgly pi h2o[p] cbp n8aspmd arg-L[p] nadp h[p] ppi pe160[p] pi[p] pyr nadh h2o[p] h h pi nadp zn2 pi[p] h ctp akg adp h pi man6p[p] atp ala-D[p] h2o rml dsbard[p] so4 23dhba fmnh2 nadh LalaLglu co2 h[p] ahcys h pppi h2o e4p fmettrna amet zn2[e] pi h dsbard[p] atp lac-L[p] adp nad h2o atp h2o nad h[p] nadph e4p h atp h[p] ala-D h[p] amp oc2coa h2o ribflv h2o[p] aps nadh h met-L nadp maltpt[p] cpgn[p] ump[p] peamn[e] h dtdp4aaddg co2 h[p] nadph 10fthf glu-L his-L trnagly psclys pi pi dtdprmn pa120 adocbl[e] h2o[p] ppi h2o cgly[p] h h2o atp pa141 dhmptp akg h2o h2o h2o[p] h[p] 1tdecg3p[p] adp pi nadh h adp garagund akg mmet[p] h2o atp atp atp h2o arg-L atp feoxam-un pi adp h2o h ump atp prpp pa161 h[p] 3hocoa h tma h nadp h pi atp h glu-L lgt-S dmlz 23camp[p] sucarg pi[p] btal amp h xyl-D[e] h2o h co2 gthrd[e] galt[e] coa so2 nh4 pyr trdox 1hdecg3p chol xu5p-L g3p trnaasn atp adp h adp adp na1[p] h adp h[p] ura tagdp-D arg-L[e] pyr h atp glyc[p] h2o[p] no2[p] ala-L nadph h2o 23camp[e] gam6p h h2o[p] h2o thr-L[e] h2o atp atp g3pc[p] co2 h[p] amp nadph 3ophb atp crnDcoa h[e] g6p h pi[p] nadh ppi phe-L h h2o r1p ACP 3hhcoa h[p] h2o murein4p4p[p] h[p] ac h2o q8 o2 adp pi h[p] h2o coa dhap nadh dtdp4d6dm pyr nad h atp adp anhgm coa pi[p] coa nadp h[p] gg4abut glu-L amp atp atp nadph h s dtdp4aaddg atp pi atp gtp[e] ppi adp fe3[e] hco3 metsox-S-L nh4 atp h2o h2o[p] h2o trptrna h h nh4 pi[p] atp h h h[p] prfp h[p] h2o pap nadph glu-L amp isetac[p] dhap h h prpp h2o aacald nad g3ps[p] h adp adp h2o h[p] cys-D[e] nh4 pi atp ppi gln-L atp ala-L o2 h[p] dopa[p] cd2[e] h atp pi dtdp4addg h h2o h2o[p] h2o[p] uacgam o2 dhpt pi h gmp 12dgr180[p] h[p] rmn[e] cbl1 ppp9 h 4abutn fe2 ppi h h2o[p] h no3[p] nadh ctp h methf o2s[e] galt1p atp glyc3p[p] dhap h glc-D h nadp na1[p] gua[p] adp h h2o udpgal[p] h acser cdec3eACP cys-L cmp glyc3p[e] 2dda7p trnalys h h adp h2o h h idp thm[p] ppi pgp140 h pi pi 2agpg140[p] h2o[p] 6hmhpt 3hcmrs7eACP atp ps161 12dgr181[p] h2o pi dhap h[p] btn 2mecdp co2 pi h[p] h2s nad fald[e] h2o ppi bbtcoa nad orn h seramp h nad co2 nadp coa h murein5p4p[p] feoxam-un[e] nadp pi h h[p] cmp h2o rbl-L tdeACP h[p] fe3dcit[p] 2ddglcn[e] adp nadh co2 udpLa4fn enter[p] pi h2o h h2o glyald[p] h h hdeACP hdeACP fldrd gdp pyr pa180[p] h atp h2o[p] h2o nad h[p] h pnto-R[e] dxyl5p nadh udcpdp g3pg[p] xylu-D pi nadh ump[p] cl[p] h2o h2o fmn ara5p fadh2 no3 pi adp gal[e] fum h nad dha[e] ura[e] adp adp r5p adp fad glyc[p] adp hco3 h2o q8 glyc3p nadph h2o g6p[e] ctp atp ahcys pi coa h2o[p] fruur[p] dimp[p] alltn 3hmrsACP coa pyr rib-D adp nad pi pi pi atp trnathr udpg coa fald h[p] pi pyr nadp h suchms atp o2 murein5px3p[p] trnaval nadph h2o[p] amp adp fuc-L[p] hmgth h f6p pep cu2 atp pap 3ohexACP acgam1p nadp pi adp h[p] h2o h2o h rml1p h[p] adp amp uri[e] nadp ppi butso3[e] adp h pi o2 3oodcoa h ctp fmn 25aics xu5p-D h2o glyc-R pi dhf arbtn[p] sucbz asn-L[e] h met-L[p] h2o[p] hhlipa dcyt[e] atp h sl2a6o amet glyc3p adp pi cmp pyr pi amp cmp co2 nad dsbcrd[p] nadh h2o[p] ppi atp h2o pi atp h 23cgmp[p] h2o[p] for so3 adp na1[p] fmn h o2 h[p] ala-L h2o[p] unagamuf[p] acACP cmp nadp mmet udpacgal[e] pi h pi h h h hmfurn atp didp 34dhpac[e] 3hcddec5eACP nadp btcoa pi hphhlipa h[p] pi 3ig3p nadp h2o acald ACP gln-L h2o[p] 1tdecg3p h crn[e] r5p[e] h2o[p] mmcoa-R h h2o[p] h ump h cmp pyr h2o[p] amp h[p] g3pe[p] atp nad o2s[p] 3hcpalm9eACP h2o[p] amp succ[e] gdp[e] nadph h[p] h h atp murein4px4p4p[p] h[p] kdo2lipid4[e] utp nad atp h fum fmn for ACP pi gln-L h2o 3hddecACP anhm h pyr ddca adp nad h2o atp h[p] man6p[e] nadh h2o ade h aact nadh h grxox h atp nadp atp h h2o h nadh ppi h[p] h dcaACP nadp nad fe3hox[p] gfgaragund h h cdpdtdec7eg atp nadh nad h gsn[p] atp accoa h2o[p] glx etoh 4abut[p] fadh2 h h2o atp h 26dap-M amp h[e] feoxam-un[p] pi clpn141[p] adp f6p[p] h2o 3odecACP galur sulfac[e] adp altrn h glyc[p] gagicolipa h2o hisp gdp h h g6p h2o cu2[p] pi[p] glyc3p[p] pa181[p] uacgam atp h2o[p] nadh nadh h2o h[p] h ppi 26dap-M 25dkglcn atp h[p] dtdp h co2 adp glu-L succ[p] o2 ACP h h h h pi h pi ACP ppi h pi[p] cdpdddecg h2o[p] atp h[p] h2o fe2[p] amp ap4a h h akg 3hcinnm cmp h2o adp ppi atp adp h2o dms h[p] adp pep h2o h h2o h2o h fru[p] trnaleu 14glucan h[p] h hcys-L nad all-D[p] dcdp ptrc ppal[p] ppi akg[p] h2o h2o h2 chol[e] h2o h adp fadh2 h2o cu h2o mmcoa-S adp h[p] h atp ppi so2[p] pi 2ddg6p succ adp pg160[p] nadp h ACP pi pi dgdp h[p] pi h h h2o adp h nadph amet h2o h2o trnaphe nh4 pi phpyr nadh atp atp trdrd gthrd h atp h2o h pyr atp h2o 23ccmp[p] o2 h oaa h galur[e] s7p nadh h[p] h2o hxan[p] thf fmnh2 nadh pi cmp fadh2 glyc3p[p] xan[p] crn-D[p] nad trdox
Exchange reactions:

Sub SystemReaction NameReaction IDReactionLBUBReaction Flux
ExchangeH+ exchangeEX_h_e ⇋ h_e-100010009.5e+02
ExchangeO2 exchangeEX_o2_e ⇋ o2_e-100010002.9e+02
ExchangeCO2 exchangeEX_co2_e ⇋ co2_e-100010002e+02
ExchangeAmmonia exchangeEX_nh4_e ⇋ nh4_e-1000100053
ExchangePhosphate exchangeEX_pi_e ⇋ pi_e-100010004.8
ExchangeSulfate exchangeEX_so4_e ⇋ so4_e-100010001.2
ExchangeK+ exchangeEX_k_e ⇋ k_e-100010000.96
ExchangeFe2+ exchangeEX_fe2_e ⇋ fe2_e-100010000.079
ExchangeMg exchangeEX_mg2_e ⇋ mg2_e-100010000.043
ExchangeCalcium exchangeEX_ca2_e ⇋ ca2_e-100010000.026
ExchangeChloride exchangeEX_cl_e ⇋ cl_e-100010000.026
ExchangeCu2+ exchangeEX_cu2_e ⇋ cu2_e-100010000.0035
ExchangeMn2+ exchangeEX_mn2_e ⇋ mn2_e-100010000.0034
ExchangeZinc exchangeEX_zn2_e ⇋ zn2_e-100010000.0017
ExchangeNi2+ exchangeEX_ni2_e ⇋ ni2_e-100010000.0016
ExchangeMolybdate exchangeEX_mobd_e ⇋ mobd_e-100010000.00064
ExchangeCo2+ exchangeEX_cobalt2_e ⇋ cobalt2_e-100010000.00012
ExchangeSink needed to allow S-Adenosyl-4-methylthio-2-oxobutanoate to leave systemDM_AMOBamob_c ⇋ 010009.9e-06
Exchangemethanol exchangeEX_meoh_emeoh_e ⇋ 010009.9e-06
ExchangeSink needed to allow p-Cresol to leave systemDM_4CRSOL4crsol_c ⇋ 010000.0011
ExchangeSink needed to allow 5'-deoxyribose to leave systemDM_5DRIB5drib_c ⇋ 010000.0011
ExchangeSink needed to allow (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran to leave systemDM_MTHTHFmththf_c ⇋ 010000.0022
ExchangeE. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9
ExchangePRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c0100036
ExchangeH2O exchangeEX_h2o_eh2o_e ⇋ -100010009.3e+02
Exchangefree_eREDnad_c ⇋ nadh_c010001e+03

Metabolite name: 10-Formyltetrahydrofolate
Metabolite ID: 10fthf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate Metabolismmethenyltetrahydrofolate cyclohydrolaseMTHFCmethf_c + h2o_c ⇋ h_c + 10fthf_c-100010004.94.9
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide formyltransferaseGARFT10fthf_c + gar_c ⇋ fgam_c + thf_c + h_c-100010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolecarboxamide formyltransferaseAICART10fthf_c + aicar_c ⇋ fprica_c + thf_c-100010002.7-2.7

Metabolite name: 1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)
Metabolite ID: 12dgr120_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0)
Metabolite ID: 12dgr140_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: 12dgr141_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0)
Metabolite ID: 12dgr160_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: 12dgr161_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
Metabolite ID: 12dgr180_c
Compartment: c


Metabolite name: 1,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: 12dgr181_c
Compartment: c


Metabolite name: (R)-Propane-1,2-diol
Metabolite ID: 12ppd_R_c
Compartment: c


Metabolite name: (S)-Propane-1,2-diol
Metabolite ID: 12ppd_S_c
Compartment: c


Metabolite name: 3-Phospho-D-glyceroyl phosphate
Metabolite ID: 13dpg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisphosphoglycerate kinasePGKatp_c + 3pg_c ⇋ 13dpg_c + adp_c-100010007171
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-1000100071-71

Metabolite name: 1,4-dihydroxy-2-napthoyl-CoA
Metabolite ID: 14dhncoa_c
Compartment: c


Metabolite name: 1,4-alpha-D-glucan
Metabolite ID: 14glucan_c
Compartment: c


Metabolite name: 1,5-Diaminopentane
Metabolite ID: 15dap_c
Compartment: c


Metabolite name: 1-dodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1ddecg3p_c
Compartment: c


Metabolite name: 1-hexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1hdec9eg3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:1)G3PAT161hdeACP_c + glyc3p_c ⇋ ACP_c + 1hdec9eg3p_c010000.370.37
Glycerophospholipid Metabolism1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)AGPAT161hdeACP_c + 1hdec9eg3p_c ⇋ ACP_c + pa161_c010000.37-0.37

Metabolite name: 1-hexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1hdecg3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:0)G3PAT160palmACP_c + glyc3p_c ⇋ ACP_c + 1hdecg3p_c010000.310.31
Glycerophospholipid Metabolism1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)AGPAT160palmACP_c + 1hdecg3p_c ⇋ ACP_c + pa160_c010000.31-0.31

Metabolite name: 1-octadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1odec11eg3p_c
Compartment: c


Metabolite name: 1-octadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1odecg3p_c
Compartment: c


Metabolite name: 1-Pyrroline-5-carboxylate
Metabolite ID: 1pyr5c_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline MetabolismL-glutamate 5-semialdehyde dehydratase (spontaneous)G5SADsglu5sa_c ⇋ 1pyr5c_c + h_c + h2o_c010001.11.1
Arginine and Proline Metabolismpyrroline-5-carboxylate reductaseP5CR1pyr5c_c + 2 h_c + nadph_c ⇋ nadp_c + pro_L_c010001.1-1.1

Metabolite name: 1-tetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1tdec7eg3p_c
Compartment: c


Metabolite name: 1-tetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1tdecg3p_c
Compartment: c


Metabolite name: 2,3-diaminopropionate
Metabolite ID: 23dappa_c
Compartment: c


Metabolite name: 2,3-Dihydro-2,3-dihydroxybenzoate
Metabolite ID: 23ddhb_c
Compartment: c


Metabolite name: 2,3-dehydroadipyl-CoA
Metabolite ID: 23dhacoa_c
Compartment: c


Metabolite name: 2,3-Dihydroxybenzoate
Metabolite ID: 23dhb_c
Compartment: c


Metabolite name: (2,3-Dihydroxybenzoyl)adenylate
Metabolite ID: 23dhba_c
Compartment: c


Metabolite name: 2,3-dihydroxybenzoylserine
Metabolite ID: 23dhbzs_c
Compartment: c


Metabolite name: 2,3-Dihydrodipicolinate
Metabolite ID: 23dhdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismdihydrodipicolinate synthaseDHDPSpyr_c + aspsa_c ⇋ h_c + 2 h2o_c + 23dhdp_c010001.81.8
Threonine and Lysine Metabolismdihydrodipicolinate reductase (NADPH)DHDPRy23dhdp_c + h_c + nadph_c ⇋ nadp_c + thdp_c010001.8-1.8

Metabolite name: (R)-2,3-Dihydroxy-3-methylbutanoate
Metabolite ID: 23dhmb_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)KARA1h_c + alac_S_c + nadph_c ⇋ 23dhmb_c + nadp_c-100010004.34.3
Valine, Leucine, and Isoleucine Metabolismdihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)DHAD123dhmb_c ⇋ h2o_c + 3mob_c010004.3-4.3

Metabolite name: (R)-2,3-Dihydroxy-3-methylpentanoate
Metabolite ID: 23dhmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2-Acetolactate)KARA22ahbut_c + h_c + nadph_c ⇋ 23dhmp_c + nadp_c-100010001.41.4
Valine, Leucine, and Isoleucine MetabolismDihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)DHAD223dhmp_c ⇋ 3mop_c + h2o_c010001.4-1.4

Metabolite name: 2,3-Dioxo-L-gulonate
Metabolite ID: 23doguln_c
Compartment: c


Metabolite name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
Metabolite ID: 25aics_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisadenylosuccinate lyaseADSL2r25aics_c ⇋ aicar_c + fum_c-100010002.2-2.2

Metabolite name: 2,5-diketo-D-gluconate
Metabolite ID: 25dkglcn_c
Compartment: c


Metabolite name: 2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate
Metabolite ID: 25drapp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesisdiaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)DHPPDA2h_c + 25drapp_c + h2o_c ⇋ 5apru_c + nh4_c010000.0022-0.0022

Metabolite name: LL-2,6-Diaminoheptanedioate
Metabolite ID: 26dap_LL_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismsuccinyl-diaminopimelate desuccinylaseSDPDSsl26da_c + h2o_c ⇋ succ_c + 26dap_LL_c010001.81.8
Threonine and Lysine Metabolismdiaminopimelate epimeraseDAPE26dap_LL_c ⇋ 26dap_M_c-100010001.8-1.8

Metabolite name: meso-2,6-Diaminoheptanedioate
Metabolite ID: 26dap_M_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismdiaminopimelate epimeraseDAPE26dap_LL_c ⇋ 26dap_M_c-100010001.81.8
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.14-0.14
Threonine and Lysine Metabolismdiaminopimelate decarboxylaseDAPDCh_c + 26dap_M_c ⇋ co2_c + lys_L_c010001.7-1.7

Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0)
Metabolite ID: 2agpe120_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0)
Metabolite ID: 2agpe140_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)
Metabolite ID: 2agpe141_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)
Metabolite ID: 2agpe160_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)
Metabolite ID: 2agpe161_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)
Metabolite ID: 2agpe180_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)
Metabolite ID: 2agpe181_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)
Metabolite ID: 2agpg120_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)
Metabolite ID: 2agpg140_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)
Metabolite ID: 2agpg141_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)
Metabolite ID: 2agpg160_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)
Metabolite ID: 2agpg161_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)
Metabolite ID: 2agpg180_c
Compartment: c


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)
Metabolite ID: 2agpg181_c
Compartment: c


Metabolite name: (S)-2-Aceto-2-hydroxybutanoate
Metabolite ID: 2ahbut_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism2-aceto-2-hydroxybutanoate synthaseACHBSpyr_c + 2obut_c + h_c ⇋ 2ahbut_c + co2_c010001.41.4
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2-Acetolactate)KARA22ahbut_c + h_c + nadph_c ⇋ 23dhmp_c + nadp_c-100010001.4-1.4

Metabolite name: 2-Aminomalonate semialdehyde
Metabolite ID: 2amsa_c
Compartment: c


Metabolite name: L-2-Amino-3-oxobutanoate
Metabolite ID: 2aobut_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycine and Serine MetabolismL-threonine dehydrogenaseTHRDnad_c + thr_L_c ⇋ nadh_c + h_c + 2aobut_c010001.3e+021.3e+02
Glycine and Serine Metabolismglycine C-acetyltransferaseGLYATcoa_c + 2aobut_c ⇋ gly_c + accoa_c-100010001.3e+02-1.3e+02

Metabolite name: 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
Metabolite ID: 2cpr5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismphosphoribosylanthranilate isomerase (irreversible)PRAIipran_c ⇋ 2cpr5p_c010000.280.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismindole-3-glycerol-phosphate synthaseIGPS2cpr5p_c + h_c ⇋ co2_c + 3ig3p_c + h2o_c010000.28-0.28

Metabolite name: 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
Metabolite ID: 2dda7p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-deoxy-D-arabino-heptulosonate 7-phosphate synthetaseDDPAe4p_c + h2o_c + pep_c ⇋ 2dda7p_c + pi_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate synthaseDHQS2dda7p_c ⇋ pi_c + 3dhq_c010001.9-1.9

Metabolite name: 2-dodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2ddecg3p_c
Compartment: c


Metabolite name: 2-Dehydro-3-deoxy-D-gluconate 6-phosphate
Metabolite ID: 2ddg6p_c
Compartment: c


Metabolite name: 2-Dehydro-3-deoxy-D-gluconate
Metabolite ID: 2ddglcn_c
Compartment: c


Metabolite name: 2-Dehydro-3-deoxy-D-galactonate
Metabolite ID: 2dh3dgal_c
Compartment: c


Metabolite name: 2-Dehydro-3-deoxy-D-galactonate 6-phosphate
Metabolite ID: 2dh3dgal6p_c
Compartment: c


Metabolite name: 2-Dehydro-L-gulonate
Metabolite ID: 2dhguln_c
Compartment: c


Metabolite name: 2-Dehydropantoate
Metabolite ID: 2dhp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-methyl-2-oxobutanoate hydroxymethyltransferaseMOHMT3mob_c + mlthf_c + h2o_c ⇋ thf_c + 2dhp_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesis2-dehydropantoate 2-reductaseDPR2dhp_c + h_c + nadph_c ⇋ pant_R_c + nadp_c010000.0028-0.0028

Metabolite name: 2-Demethylmenaquinone 8
Metabolite ID: 2dmmq8_c
Compartment: c


Metabolite name: 2-Demethylmenaquinol 8
Metabolite ID: 2dmmql8_c
Compartment: c


Metabolite name: 2-Deoxy-D-ribose 1-phosphate
Metabolite ID: 2dr1p_c
Compartment: c


Metabolite name: 2-Deoxy-D-ribose 5-phosphate
Metabolite ID: 2dr5p_c
Compartment: c


Metabolite name: [2Fe-1S] desulfurated iron-sulfur cluster
Metabolite ID: 2fe1s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-06-9.9e-06

Metabolite name: [2Fe-2S] iron-sulfur cluster
Metabolite ID: 2fe2s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] TransferI2FE2STiscu_2fe2s_c + 4 h_c ⇋ iscu_c + 2fe2s_c010000.000140.00014
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-06-9.9e-06
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.00013

Metabolite name: 2-Hydroxy-3-oxopropanoate
Metabolite ID: 2h3oppan_c
Compartment: c


Metabolite name: 2-hexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2hdec9eg3p_c
Compartment: c


Metabolite name: 2-hexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2hdecg3p_c
Compartment: c


Metabolite name: 2-Isopropylmaleate
Metabolite ID: 2ippm_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate hydrataseIPPMIb3c3hmp_c ⇋ h2o_c + 2ippm_c-100010002.22.2
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrataseIPPMIa2ippm_c + h2o_c ⇋ 3c2hmp_c-100010002.2-2.2

Metabolite name: 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
Metabolite ID: 2mahmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisphosphomethylpyrimidine kinasePMPK4ampm_c + atp_c ⇋ 2mahmp_c + adp_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate diphosphorylaseTMPPP4mpetz_c + 2mahmp_c + h_c ⇋ thmmp_c + ppi_c010000.0011-0.0011

Metabolite name: cis-2-Methylaconitate
Metabolite ID: 2mcacn_c
Compartment: c


Metabolite name: 2-Methylcitrate
Metabolite ID: 2mcit_c
Compartment: c


Metabolite name: 2-C-methyl-D-erythritol 4-phosphate
Metabolite ID: 2me4p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose reductoisomeraseDXPRIidxyl5p_c + h_c + nadph_c ⇋ 2me4p_c + nadp_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseMEPCT2me4p_c + h_c + ctp_c ⇋ 4c2me_c + ppi_c010000.012-0.012

Metabolite name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
Metabolite ID: 2mecdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseMECDPS2p4c2me_c ⇋ 2mecdp_c + cmp_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.012-0.012

Metabolite name: 2-Oxobutanoate
Metabolite ID: 2obut_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine MetabolismL-threonine deaminaseTHRD_Lthr_L_c ⇋ 2obut_c + nh4_c010001.41.4
Valine, Leucine, and Isoleucine Metabolism2-aceto-2-hydroxybutanoate synthaseACHBSpyr_c + 2obut_c + h_c ⇋ 2ahbut_c + co2_c010001.4-1.4

Metabolite name: 2-octadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2odec11eg3p_c
Compartment: c


Metabolite name: 2-octadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2odecg3p_c
Compartment: c


Metabolite name: 2-Octaprenyl-6-hydroxyphenol
Metabolite ID: 2ohph_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis2-Octaprenylphenol hydroxylaseOPHHX0.5 o2_c + 2oph_c ⇋ 2ohph_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011

Metabolite name: 2-Octaprenyl-6-methoxy-1,4-benzoquinol
Metabolite ID: 2ombzl_c
Compartment: c


Metabolite name: 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol
Metabolite ID: 2omhmbl_c
Compartment: c


Metabolite name: 2-Octaprenyl-3-methyl-6-methoxy- 1,4-benzoquinol
Metabolite ID: 2ommbl_c
Compartment: c


Metabolite name: 2-Octaprenyl-6-methoxyphenol
Metabolite ID: 2omph_c
Compartment: c


Metabolite name: 2-Octaprenylphenol
Metabolite ID: 2oph_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisOctaprenyl-hydroxybenzoate decarboxylaseOPHBDCh_c + 3ophb_c ⇋ 2oph_c + co2_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis2-Octaprenylphenol hydroxylaseOPHHX0.5 o2_c + 2oph_c ⇋ 2ohph_c010000.0011-0.0011

Metabolite name: 2-oxepin-2(3H)-ylideneacetyl-CoA
Metabolite ID: 2oxpaccoa_c
Compartment: c


Metabolite name: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Metabolite ID: 2p4c2me_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseCDPMEK4c2me_c + atp_c ⇋ 2p4c2me_c + h_c + adp_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseMECDPS2p4c2me_c ⇋ 2mecdp_c + cmp_c010000.012-0.012

Metabolite name: D-Glycerate 2-phosphate
Metabolite ID: 2pg_c
Compartment: c


Metabolite name: 2-Phosphoglycolate
Metabolite ID: 2pglyc_c
Compartment: c


Metabolite name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate
Metabolite ID: 2sephchc_c
Compartment: c


Metabolite name: 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
Metabolite ID: 2shchc_c
Compartment: c


Metabolite name: 2-tetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2tdec7eg3p_c
Compartment: c


Metabolite name: 2-tetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2tdecg3p_c
Compartment: c


Metabolite name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA
Metabolite ID: 2tpr3dpcoa_c
Compartment: c


Metabolite name: 3-(4-Hydroxyphenyl)pyruvate
Metabolite ID: 34hpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydrogenasePPNDnad_c + pphn_c ⇋ nadh_c + co2_c + 34hpp_c010000.680.68
Tyrosine, Tryptophan, and Phenylalanine Metabolismtyrosine transaminaseTYRTA34hpp_c + glu_L_c ⇋ tyr_L_c + akg_c-100010000.68-0.68

Metabolite name: 3',5'-Cyclic GMP
Metabolite ID: 35cgmp_c
Compartment: c


Metabolite name: 3-Aminoacrylate
Metabolite ID: 3amac_c
Compartment: c


Metabolite name: 3-Carboxy-2-hydroxy-4-methylpentanoate
Metabolite ID: 3c2hmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrataseIPPMIa2ippm_c + h2o_c ⇋ 3c2hmp_c-100010002.22.2
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrogenaseIPMDnad_c + 3c2hmp_c ⇋ nadh_c + h_c + 3c4mop_c010002.2-2.2

Metabolite name: 3-Carboxy-3-hydroxy-4-methylpentanoate
Metabolite ID: 3c3hmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.22.2
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate hydrataseIPPMIb3c3hmp_c ⇋ h2o_c + 2ippm_c-100010002.2-2.2

Metabolite name: 3-Carboxy-4-methyl-2-oxopentanoate
Metabolite ID: 3c4mop_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrogenaseIPMDnad_c + 3c2hmp_c ⇋ nadh_c + h_c + 3c4mop_c010002.22.2
Valine, Leucine, and Isoleucine Metabolism2-Oxo-4-methyl-3-carboxypentanoate decarboxylationOMCDC3c4mop_c + h_c ⇋ co2_c + 4mop_c010002.2-2.2

Metabolite name: 3-Dehydro-L-gulonate
Metabolite ID: 3dhguln_c
Compartment: c


Metabolite name: 3-keto-L-gulonate-6-phosphate
Metabolite ID: 3dhgulnp_c
Compartment: c


Metabolite name: 3-Dehydroquinate
Metabolite ID: 3dhq_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate synthaseDHQS2dda7p_c ⇋ pi_c + 3dhq_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate dehydratase, irreversibleDHQTi3dhq_c ⇋ h2o_c + 3dhsk_c010001.9-1.9

Metabolite name: 3-Dehydroshikimate
Metabolite ID: 3dhsk_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate dehydratase, irreversibleDHQTi3dhq_c ⇋ h2o_c + 3dhsk_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate dehydrogenaseSHK3Drh_c + 3dhsk_c + nadph_c ⇋ skm_c + nadp_c-100010001.9-1.9

Metabolite name: [3Fe-4S] damaged iron-sulfur cluster
Metabolite ID: 3fe4s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.0190.038
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster repairFESRfe2_c + 3fe4s_c ⇋ 4fe4s_c010000.038-0.038

Metabolite name: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
Metabolite ID: 3haACP_c
Compartment: c


Metabolite name: (3S)-3-Hydroxyadipyl-CoA
Metabolite ID: 3hadpcoa_c
Compartment: c


Metabolite name: (S)-3-Hydroxybutanoyl-CoA
Metabolite ID: 3hbcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)HACD1nadh_c + aacoa_c + h_c ⇋ 3hbcoa_c + nad_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)ECOAH13hbcoa_c ⇋ h2o_c + b2coa_c-100010001.8-1.8

Metabolite name: (R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]
Metabolite ID: 3hcddec5eACP_c
Compartment: c


Metabolite name: 3-hydroxycinnamic acid
Metabolite ID: 3hcinnm_c
Compartment: c


Metabolite name: (R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]
Metabolite ID: 3hcmrs7eACP_c
Compartment: c


Metabolite name: (R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]
Metabolite ID: 3hcpalm9eACP_c
Compartment: c


Metabolite name: (R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]
Metabolite ID: 3hcvac11eACP_c
Compartment: c


Metabolite name: (S)-3-Hydroxydecanoyl-CoA
Metabolite ID: 3hdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)HACD4nadh_c + h_c + 3odcoa_c ⇋ 3hdcoa_c + nad_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)ECOAH43hdcoa_c ⇋ h2o_c + dc2coa_c-100010001.8-1.8

Metabolite name: (S)-3-Hydroxydodecanoyl-CoA
Metabolite ID: 3hddcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)HACD53oddcoa_c + h_c + nadh_c ⇋ nad_c + 3hddcoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)ECOAH53hddcoa_c ⇋ h2o_c + dd2coa_c-100010001.8-1.8

Metabolite name: (R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
Metabolite ID: 3hddecACP_c
Compartment: c


Metabolite name: (R)-3-Hydroxydecanoyl-[acyl-carrier protein]
Metabolite ID: 3hdecACP_c
Compartment: c


Metabolite name: (S)-3-Hydroxyhexanoyl-CoA
Metabolite ID: 3hhcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)HACD2nadh_c + 3ohcoa_c + h_c ⇋ nad_c + 3hhcoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)ECOAH23hhcoa_c ⇋ h2o_c + hx2coa_c-100010001.8-1.8

Metabolite name: (S)-3-Hydroxyhexadecanoyl-CoA
Metabolite ID: 3hhdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)HACD7nadh_c + 3ohdcoa_c + h_c ⇋ 3hhdcoa_c + nad_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)ECOAH73hhdcoa_c ⇋ h2o_c + hdd2coa_c-100010001.4-1.4

Metabolite name: (R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
Metabolite ID: 3hhexACP_c
Compartment: c


Metabolite name: (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
Metabolite ID: 3hmrsACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)3OAR1403omrsACP_c + h_c + nadph_c ⇋ nadp_c + 3hmrsACP_c-100010000.380.38
Lipopolysaccharide Biosynthesis / RecyclingUDP-N-acetylglucosamine acyltransferaseUAGAATuacgam_c + 3hmrsACP_c ⇋ ACP_c + u3aga_c-100010000.19-0.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferaseU23GAAT3hmrsACP_c + u3hga_c ⇋ ACP_c + h_c + u23ga_c010000.19-0.19

Metabolite name: (S)-3-Hydroxyoctanoyl-CoA
Metabolite ID: 3hocoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)HACD3nadh_c + h_c + 3oocoa_c ⇋ nad_c + 3hocoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)ECOAH33hocoa_c ⇋ h2o_c + oc2coa_c-100010001.8-1.8

Metabolite name: (R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
Metabolite ID: 3hoctACP_c
Compartment: c


Metabolite name: (R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
Metabolite ID: 3hoctaACP_c
Compartment: c


Metabolite name: (S)-3-Hydroxyoctadecanoyl-CoA
Metabolite ID: 3hodcoa_c
Compartment: c


Metabolite name: R-3-hydroxypalmitoyl-[acyl-carrier protein]
Metabolite ID: 3hpalmACP_c
Compartment: c


Metabolite name: 3-Hydroxypropanoate
Metabolite ID: 3hpp_c
Compartment: c


Metabolite name: 3-(3-hydroxy-phenyl)propionate
Metabolite ID: 3hpppn_c
Compartment: c


Metabolite name: (S)-3-Hydroxytetradecanoyl-CoA
Metabolite ID: 3htdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)HACD63otdcoa_c + nadh_c + h_c ⇋ nad_c + 3htdcoa_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)ECOAH63htdcoa_c ⇋ td2coa_c + h2o_c-100010001.4-1.4

Metabolite name: C'-(3-Indolyl)-glycerol 3-phosphate
Metabolite ID: 3ig3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismindole-3-glycerol-phosphate synthaseIGPS2cpr5p_c + h_c ⇋ co2_c + 3ig3p_c + h2o_c010000.280.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismtryptophan synthase (indoleglycerol phosphate)TRPS1ser_L_c + 3ig3p_c ⇋ g3p_c + trp_L_c + h2o_c010000.28-0.28

Metabolite name: 3-Methyl-2-oxobutanoate
Metabolite ID: 3mob_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismdihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)DHAD123dhmb_c ⇋ h2o_c + 3mob_c010004.34.3
Cofactor and Prosthetic Group Biosynthesis3-methyl-2-oxobutanoate hydroxymethyltransferaseMOHMT3mob_c + mlthf_c + h2o_c ⇋ thf_c + 2dhp_c010000.0028-0.0028
Valine, Leucine, and Isoleucine Metabolismvaline transaminaseVALTA3mob_c + glu_L_c ⇋ akg_c + val_L_c-100010002.1-2.1
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.2-2.2

Metabolite name: (S)-3-Methyl-2-oxopentanoate
Metabolite ID: 3mop_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine MetabolismDihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)DHAD223dhmp_c ⇋ 3mop_c + h2o_c010001.41.4
Valine, Leucine, and Isoleucine Metabolismisoleucine transaminaseILETAglu_L_c + 3mop_c ⇋ ile_L_c + akg_c-100010001.4-1.4

Metabolite name: 3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]
Metabolite ID: 3ocddec5eACP_c
Compartment: c


Metabolite name: 3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]
Metabolite ID: 3ocmrs7eACP_c
Compartment: c


Metabolite name: 3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]
Metabolite ID: 3ocpalm9eACP_c
Compartment: c


Metabolite name: 3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]
Metabolite ID: 3ocvac11eACP_c
Compartment: c


Metabolite name: 3-Oxodecanoyl-CoA
Metabolite ID: 3odcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (octanoyl-CoA) (r)ACACT4roccoa_c + accoa_c ⇋ 3odcoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)HACD4nadh_c + h_c + 3odcoa_c ⇋ 3hdcoa_c + nad_c-100010001.8-1.8

Metabolite name: 3-Oxododecanoyl-CoA
Metabolite ID: 3oddcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (decanoyl-CoA) (r)ACACT5raccoa_c + dcacoa_c ⇋ 3oddcoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)HACD53oddcoa_c + h_c + nadh_c ⇋ nad_c + 3hddcoa_c-100010001.8-1.8

Metabolite name: 3-Oxododecanoyl-[acyl-carrier protein]
Metabolite ID: 3oddecACP_c
Compartment: c


Metabolite name: 3-Oxodecanoyl-[acyl-carrier protein]
Metabolite ID: 3odecACP_c
Compartment: c


Metabolite name: 3-Oxohexanoyl-CoA
Metabolite ID: 3ohcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (butanoyl-CoA) (r)ACACT2rbtcoa_c + accoa_c ⇋ coa_c + 3ohcoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)HACD2nadh_c + 3ohcoa_c + h_c ⇋ nad_c + 3hhcoa_c-100010001.8-1.8

Metabolite name: 3-Oxohexadecanoyl-CoA
Metabolite ID: 3ohdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)ACACT7rtdcoa_c + accoa_c ⇋ coa_c + 3ohdcoa_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)HACD7nadh_c + 3ohdcoa_c + h_c ⇋ 3hhdcoa_c + nad_c-100010001.4-1.4

Metabolite name: 3-Oxohexanoyl-[acyl-carrier protein]
Metabolite ID: 3ohexACP_c
Compartment: c


Metabolite name: 3-Oxotetradecanoyl-[acyl-carrier protein]
Metabolite ID: 3omrsACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.380.38
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)3OAR1403omrsACP_c + h_c + nadph_c ⇋ nadp_c + 3hmrsACP_c-100010000.38-0.38

Metabolite name: 3-Oxooctanoyl-CoA
Metabolite ID: 3oocoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)ACACT3rhxcoa_c + accoa_c ⇋ coa_c + 3oocoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)HACD3nadh_c + h_c + 3oocoa_c ⇋ nad_c + 3hocoa_c-100010001.8-1.8

Metabolite name: 3-Oxooctanoyl-[acyl-carrier protein]
Metabolite ID: 3ooctACP_c
Compartment: c


Metabolite name: 3-Oxooctadecanoyl-[acyl-carrier protein]
Metabolite ID: 3ooctdACP_c
Compartment: c


Metabolite name: 3-Oxooctadecanoyl-CoA
Metabolite ID: 3oodcoa_c
Compartment: c


Metabolite name: 3-Oxohexadecanoyl-[acyl-carrier protein]
Metabolite ID: 3opalmACP_c
Compartment: c


Metabolite name: 3-Octaprenyl-4-hydroxybenzoate
Metabolite ID: 3ophb_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisHydroxybenzoate octaprenyltransferaseHBZOPT4hbz_c + octdp_c ⇋ 3ophb_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisOctaprenyl-hydroxybenzoate decarboxylaseOPHBDCh_c + 3ophb_c ⇋ 2oph_c + co2_c010000.0011-0.0011

Metabolite name: 3-Oxotetradecanoyl-CoA
Metabolite ID: 3otdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)ACACT6rddcacoa_c + accoa_c ⇋ coa_c + 3otdcoa_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)HACD63otdcoa_c + nadh_c + h_c ⇋ nad_c + 3htdcoa_c-100010001.4-1.4

Metabolite name: 3-oxo-5,6-dehydrosuberyl-CoA
Metabolite ID: 3oxdhscoa_c
Compartment: c


Metabolite name: 3-Phospho-D-glycerate
Metabolite ID: 3pg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c010003671
Glycolysis/Gluconeogenesisphosphoglycerate kinasePGKatp_c + 3pg_c ⇋ 13dpg_c + adp_c-1000100071-71

Metabolite name: 3-Phosphohydroxypyruvate
Metabolite ID: 3php_c
Compartment: c


Metabolite name: 5-O-(1-Carboxyvinyl)-3-phosphoshikimate
Metabolite ID: 3psme_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-phosphoshikimate 1-carboxyvinyltransferasePSCVTskm5p_c + pep_c ⇋ 3psme_c + pi_c-100010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolismchorismate synthaseCHORS3psme_c ⇋ chor_c + pi_c010001.9-1.9

Metabolite name: 3-Sulfino-L-alanine
Metabolite ID: 3sala_c
Compartment: c


Metabolite name: 4-Aminobutanoate
Metabolite ID: 4abut_c
Compartment: c


Metabolite name: 4-Aminobutanal
Metabolite ID: 4abutn_c
Compartment: c


Metabolite name: 4-Aminobenzoate
Metabolite ID: 4abz_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis4-aminobenzoate synthaseADCL4adcho_c ⇋ h_c + 4abz_c + pyr_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydropteroate synthaseDHPS26hmhptpp_c + 4abz_c ⇋ dhpt_c + ppi_c010000.0033-0.0033

Metabolite name: 4-amino-4-deoxychorismate
Metabolite ID: 4adcho_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis4-amino-4-deoxychorismate synthaseADCSchor_c + gln_L_c ⇋ 4adcho_c + glu_L_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesis4-aminobenzoate synthaseADCL4adcho_c ⇋ h_c + 4abz_c + pyr_c010000.0033-0.0033

Metabolite name: 4-Amino-5-hydroxymethyl-2-methylpyrimidine
Metabolite ID: 4ahmmp_c
Compartment: c


Metabolite name: 4-Amino-2-methyl-5-phosphomethylpyrimidine
Metabolite ID: 4ampm_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisphosphomethylpyrimidine kinasePMPK4ampm_c + atp_c ⇋ 2mahmp_c + adp_c010000.0011-0.0011

Metabolite name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Metabolite ID: 4c2me_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseMEPCT2me4p_c + h_c + ctp_c ⇋ 4c2me_c + ppi_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseCDPMEK4c2me_c + atp_c ⇋ 2p4c2me_c + h_c + adp_c010000.012-0.012

Metabolite name: p-Cresol
Metabolite ID: 4crsol_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Sink needed to allow p-Cresol to leave systemDM_4CRSOL4crsol_c ⇋ 010000.0011-0.0011

Metabolite name: [4Fe-4S] iron-sulfur cluster
Metabolite ID: 4fe4s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster repairFESRfe2_c + 3fe4s_c ⇋ 4fe4s_c010000.0380.038
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] TransferI4FE4STiscu_4fe4s_c + 4 h_c ⇋ iscu_c + 4fe4s_c010000.00130.0013
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0013
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.019-0.038

Metabolite name: 4-Hydroxy-2-oxopentanoate
Metabolite ID: 4h2opntn_c
Compartment: c


Metabolite name: 4-Hydroxybenzoate
Metabolite ID: 4hbz_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisChorismate pyruvate lyaseCHRPLchor_c ⇋ 4hbz_c + pyr_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisHydroxybenzoate octaprenyltransferaseHBZOPT4hbz_c + octdp_c ⇋ 3ophb_c + ppi_c010000.0011-0.0011

Metabolite name: 4-Hydroxy-L-threonine
Metabolite ID: 4hthr_c
Compartment: c


Metabolite name: 4-Methyl-5-(2-hydroxyethyl)-thiazole
Metabolite ID: 4mhetz_c
Compartment: c


Metabolite name: 4-Methyl-2-oxopentanoate
Metabolite ID: 4mop_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolism2-Oxo-4-methyl-3-carboxypentanoate decarboxylationOMCDC3c4mop_c + h_c ⇋ co2_c + 4mop_c010002.22.2
Valine, Leucine, and Isoleucine Metabolismleucine transaminase (irreversible)LEUTAiglu_L_c + 4mop_c ⇋ leu_L_c + akg_c010002.2-2.2

Metabolite name: 4-Methyl-5-(2-phosphoethyl)-thiazole
Metabolite ID: 4mpetz_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate diphosphorylaseTMPPP4mpetz_c + 2mahmp_c + h_c ⇋ thmmp_c + ppi_c010000.0011-0.0011

Metabolite name: 4-Phospho-L-aspartate
Metabolite ID: 4pasp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismaspartate kinaseASPKasp_L_c + atp_c ⇋ 4pasp_c + adp_c-100010001.3e+021.3e+02
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+02-1.3e+02

Metabolite name: 4-Phospho-D-erythronate
Metabolite ID: 4per_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisErythronate 4-phosphate (4per) dehydrogenasePERDnad_c + 4per_c ⇋ nadh_c + h_c + ohpb_c-100010000.0011-0.0011

Metabolite name: D-4'-Phosphopantothenate
Metabolite ID: 4ppan_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesispantothenate kinasePNTKpnto_R_c + atp_c ⇋ h_c + 4ppan_c + adp_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.0028-0.0028

Metabolite name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
Metabolite ID: 4ppcys_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenoylcysteine decarboxylasePPCDC4ppcys_c + h_c ⇋ co2_c + pan4p_c010000.0028-0.0028

Metabolite name: 4-(1-D-Ribitylamino)-5-aminouracil
Metabolite ID: 4r5au_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSb2 dmlz_c ⇋ 4r5au_c + ribflv_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesispyrimidine phosphatasePMDPHTh2o_c + 5aprbu_c ⇋ pi_c + 4r5au_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSadb4p_c + 4r5au_c ⇋ dmlz_c + pi_c + 2 h2o_c010000.0044-0.0044

Metabolite name: 5,6-dihydrouracil
Metabolite ID: 56dura_c
Compartment: c


Metabolite name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
Metabolite ID: 5aizc_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylase (mutase rxn)AIRC35caiz_c ⇋ 5aizc_c-100010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.2-2.2

Metabolite name: 5-Amino-4-oxopentanoate
Metabolite ID: 5aop_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisglutamate-1-semialdehyde aminotransferaseG1SATglu1sa_c ⇋ 5aop_c-100010000.0180.018
Cofactor and Prosthetic Group Biosynthesisporphobilinogen synthasePPBNGS2 5aop_c ⇋ 2 h2o_c + ppbng_c + h_c010000.0088-0.018

Metabolite name: 5-Amino-6-(5'-phosphoribitylamino)uracil
Metabolite ID: 5aprbu_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis5-amino-6-(5-phosphoribosylamino)uracil reductaseAPRAURnadph_c + h_c + 5apru_c ⇋ nadp_c + 5aprbu_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesispyrimidine phosphatasePMDPHTh2o_c + 5aprbu_c ⇋ pi_c + 4r5au_c010000.0022-0.0022

Metabolite name: 5-Amino-6-(5'-phosphoribosylamino)uracil
Metabolite ID: 5apru_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisdiaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)DHPPDA2h_c + 25drapp_c + h2o_c ⇋ 5apru_c + nh4_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesis5-amino-6-(5-phosphoribosylamino)uracil reductaseAPRAURnadph_c + h_c + 5apru_c ⇋ nadp_c + 5aprbu_c010000.0022-0.0022

Metabolite name: 5-phosphoribosyl-5-carboxyaminoimidazole
Metabolite ID: 5caiz_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylase (mutase rxn)AIRC35caiz_c ⇋ 5aizc_c-100010002.2-2.2

Metabolite name: 5-Dehydro-D-gluconate
Metabolite ID: 5dglcn_c
Compartment: c


Metabolite name: 5-Dehydro-4-deoxy-D-glucarate
Metabolite ID: 5dh4dglc_c
Compartment: c


Metabolite name: 5'-deoxyribose
Metabolite ID: 5drib_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis5'-deoxyadenosine nuclosidase5DOANdad_5_c + h2o_c ⇋ 5drib_c + ade_c010000.00110.0011
Sink needed to allow 5'-deoxyribose to leave systemDM_5DRIB5drib_c ⇋ 010000.0011-0.0011

Metabolite name: 5-Formyltetrahydrofolate
Metabolite ID: 5fthf_c
Compartment: c


Metabolite name: 5-Methylthioadenosine
Metabolite ID: 5mta_c
Compartment: c


Metabolite name: 5-Methyltetrahydrofolate
Metabolite ID: 5mthf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate Metabolism5,10-methylenetetrahydrofolate reductase (NADH)MTHFR2nadh_c + mlthf_c + 2 h_c ⇋ nad_c + 5mthf_c010000.760.76
Methionine Metabolismmethionine synthaseMETShcys_L_c + 5mthf_c ⇋ h_c + met_L_c + thf_c010000.76-0.76

Metabolite name: 5-Methylthio-D-ribose
Metabolite ID: 5mtr_c
Compartment: c


Metabolite name: N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
Metabolite ID: 5prdmbz_c
Compartment: c


Metabolite name: 6-hydroxymethyl dihydropterin
Metabolite ID: 6hmhpt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisdihydroneopterin aldolase reversibleDHNPA2rdhnpt_c ⇋ 6hmhpt_c + gcald_c-100010000.00330.0033
Cofactor and Prosthetic Group Biosynthesis6-hydroxymethyl-dihydropterin pyrophosphokinaseHPPK26hmhpt_c + atp_c ⇋ 6hmhptpp_c + h_c + amp_c010000.0033-0.0033

Metabolite name: 6-hydroxymethyl-dihydropterin pyrophosphate
Metabolite ID: 6hmhptpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis6-hydroxymethyl-dihydropterin pyrophosphokinaseHPPK26hmhpt_c + atp_c ⇋ 6hmhptpp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydropteroate synthaseDHPS26hmhptpp_c + 4abz_c ⇋ dhpt_c + ppi_c010000.0033-0.0033

Metabolite name: 6-Phospho-D-gluconate
Metabolite ID: 6pgc_c
Compartment: c


Metabolite name: 6-phospho-D-glucono-1,5-lactone
Metabolite ID: 6pgl_c
Compartment: c


Metabolite name: 8-Amino-7-oxononanoate
Metabolite ID: 8aonn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis8-amino-7-oxononanoate synthaseAOXSr2pimACP_c + ala_L_c ⇋ ACP_c + co2_c + 8aonn_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesisadenosylmethionine-8-amino-7-oxononanoate transaminaseAMAOTramet_c + 8aonn_c ⇋ dann_c + amob_c-100010009.9e-06-9.9e-06

Metabolite name: acyl carrier protein
Metabolite ID: ACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.380.38
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:1)G3PAT161hdeACP_c + glyc3p_c ⇋ ACP_c + 1hdec9eg3p_c010000.370.37
Glycerophospholipid Metabolism1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)AGPAT161hdeACP_c + 1hdec9eg3p_c ⇋ ACP_c + pa161_c010000.370.37
Glycerophospholipid Metabolism1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)AGPAT160palmACP_c + 1hdecg3p_c ⇋ ACP_c + pa160_c010000.310.31
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:0)G3PAT160palmACP_c + glyc3p_c ⇋ ACP_c + 1hdecg3p_c010000.310.31
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferaseU23GAAT3hmrsACP_c + u3hga_c ⇋ ACP_c + h_c + u23ga_c010000.190.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-N-acetylglucosamine acyltransferaseUAGAATuacgam_c + 3hmrsACP_c ⇋ ACP_c + u3aga_c-100010000.190.19
Cofactor and Prosthetic Group Biosynthesis8-amino-7-oxononanoate synthaseAOXSr2pimACP_c + ala_L_c ⇋ ACP_c + co2_c + 8aonn_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-069.9e-06
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.38-0.38
Membrane Lipid MetabolismMalonyl-CoA-ACP transacylaseMCOATAACP_c + malcoa_c ⇋ coa_c + malACP_c-100010000.38-0.38
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.63-0.63
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.74-0.74

Metabolite name: L-alanine-D-glutamate
Metabolite ID: LalaDglu_c
Compartment: c


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate
Metabolite ID: LalaDgluMdap_c
Compartment: c


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine
Metabolite ID: LalaDgluMdapDala_c
Compartment: c


Metabolite name: L-alanine-L-glutamate
Metabolite ID: LalaLglu_c
Compartment: c


Metabolite name: N1-Acetylspermidine
Metabolite ID: N1aspmd_c
Compartment: c


Metabolite name: N-Methyltryptophan
Metabolite ID: Nmtrp_c
Compartment: c


Metabolite name: S-Formylglutathione
Metabolite ID: Sfglutth_c
Compartment: c


Metabolite name: Aminoacetaldehyde
Metabolite ID: aacald_c
Compartment: c


Metabolite name: Acetoacetyl-CoA
Metabolite ID: aacoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA C-acetyltransferaseACACT1r2 accoa_c ⇋ aacoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)HACD1nadh_c + aacoa_c + h_c ⇋ 3hbcoa_c + nad_c-100010001.8-1.8

Metabolite name: Aminoacetone
Metabolite ID: aact_c
Compartment: c


Metabolite name: Acetate
Metabolite ID: ac_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismacetylornithine deacetylaseACODAacorn_c + h2o_c ⇋ ac_c + orn_c010001.51.5
Cysteine Metabolismcysteine synthaseCYSSacser_c + h2s_c ⇋ ac_c + cys_L_c + h_c010001.21.2
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-acetylglucosamine deacetylaseUHGADAh2o_c + u3aga_c ⇋ ac_c + u3hga_c010000.190.19
Pyruvate Metabolismacetate kinaseACKrac_c + atp_c ⇋ actp_c + adp_c-100010002.9-2.9

Metabolite name: Acetyl-ACP
Metabolite ID: acACP_c
Compartment: c


Metabolite name: Acetoacetate
Metabolite ID: acac_c
Compartment: c


Metabolite name: Acetaldehyde
Metabolite ID: acald_c
Compartment: c


Metabolite name: N-Acetylanthranilate
Metabolite ID: acanth_c
Compartment: c


Metabolite name: Acetyl-CoA
Metabolite ID: accoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycine and Serine Metabolismglycine C-acetyltransferaseGLYATcoa_c + 2aobut_c ⇋ gly_c + accoa_c-100010001.3e+021.3e+02
Pyruvate MetabolismphosphotransacetylasePTArcoa_c + actp_c ⇋ pi_c + accoa_c-100010002.92.9
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.0033-0.0033
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.38-0.38
Cell Envelope Biosynthesisglucosamine-1-phosphate N-acetyltransferaseG1PACTgam1p_c + accoa_c ⇋ coa_c + h_c + acgam1p_c010000.47-0.47
Cysteine Metabolismserine O-acetyltransferaseSERATaccoa_c + ser_L_c ⇋ acser_c + coa_c-100010001.2-1.2
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)ACACT7rtdcoa_c + accoa_c ⇋ coa_c + 3ohdcoa_c-100010001.4-1.4
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)ACACT6rddcacoa_c + accoa_c ⇋ coa_c + 3otdcoa_c-100010001.4-1.4
Arginine and Proline MetabolismN-acetylglutamate synthaseACGSglu_L_c + accoa_c ⇋ coa_c + h_c + acglu_c010001.5-1.5
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (decanoyl-CoA) (r)ACACT5raccoa_c + dcacoa_c ⇋ 3oddcoa_c + coa_c-100010001.8-1.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)ACACT3rhxcoa_c + accoa_c ⇋ coa_c + 3oocoa_c-100010001.8-1.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (butanoyl-CoA) (r)ACACT2rbtcoa_c + accoa_c ⇋ coa_c + 3ohcoa_c-100010001.8-1.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (octanoyl-CoA) (r)ACACT4roccoa_c + accoa_c ⇋ 3odcoa_c + coa_c-100010001.8-1.8
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.2-2.2
Membrane Lipid Metabolismacetyl-CoA C-acetyltransferaseACACT1r2 accoa_c ⇋ aacoa_c + coa_c-100010001.8-3.5
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.3-5.3
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+02-1e+02

Metabolite name: Acetol
Metabolite ID: acetol_c
Compartment: c


Metabolite name: N-Acetyl-L-glutamyl 5-phosphate
Metabolite ID: acg5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismacetylglutamate kinaseACGKatp_c + acglu_c ⇋ adp_c + acg5p_c010001.51.5
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.5-1.5

Metabolite name: N-Acetyl-L-glutamate 5-semialdehyde
Metabolite ID: acg5sa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.51.5
Arginine and Proline Metabolismacetylornithine transaminaseACOTAacg5sa_c + glu_L_c ⇋ acorn_c + akg_c-100010001.5-1.5

Metabolite name: N-Acetyl-D-glucosamine
Metabolite ID: acgam_c
Compartment: c


Metabolite name: N-Acetyl-D-glucosamine 1-phosphate
Metabolite ID: acgam1p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisglucosamine-1-phosphate N-acetyltransferaseG1PACTgam1p_c + accoa_c ⇋ coa_c + h_c + acgam1p_c010000.470.47
Cell Envelope BiosynthesisUDP-N-acetylglucosamine diphosphorylaseUAGDPutp_c + h_c + acgam1p_c ⇋ ppi_c + uacgam_c010000.47-0.47

Metabolite name: N-Acetyl-D-glucosamine 6-phosphate
Metabolite ID: acgam6p_c
Compartment: c


Metabolite name: 6-Acetyl-D-glucose
Metabolite ID: acglc_D_c
Compartment: c


Metabolite name: N-Acetyl-L-glutamate
Metabolite ID: acglu_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline MetabolismN-acetylglutamate synthaseACGSglu_L_c + accoa_c ⇋ coa_c + h_c + acglu_c010001.51.5
Arginine and Proline Metabolismacetylglutamate kinaseACGKatp_c + acglu_c ⇋ adp_c + acg5p_c010001.5-1.5

Metabolite name: Acetyl-maltose
Metabolite ID: acmalt_c
Compartment: c


Metabolite name: N-Acetyl-D-mannosamine
Metabolite ID: acmana_c
Compartment: c


Metabolite name: N-Acetyl-D-mannosamine 6-phosphate
Metabolite ID: acmanap_c
Compartment: c


Metabolite name: N-acetylmuramate 6-phosphate
Metabolite ID: acmum6p_c
Compartment: c


Metabolite name: N-Acetylneuraminate
Metabolite ID: acnam_c
Compartment: c


Metabolite name: cis-Aconitate
Metabolite ID: acon_C_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Citric Acid Cycleaconitase (half-reaction A, Citrate hydro-lyase)ACONTacit_c ⇋ h2o_c + acon_C_c-100010005.35.3
Citric Acid Cycleaconitase (half-reaction B, Isocitrate hydro-lyase)ACONTbacon_C_c + h2o_c ⇋ icit_c-100010005.3-5.3

Metabolite name: trans-Aconitate
Metabolite ID: acon_T_c
Compartment: c


Metabolite name: E-3-carboxy-2-pentenedioate 6-methyl ester
Metabolite ID: aconm_c
Compartment: c


Metabolite name: N2-Acetyl-L-ornithine
Metabolite ID: acorn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismacetylornithine transaminaseACOTAacg5sa_c + glu_L_c ⇋ acorn_c + akg_c-100010001.51.5
Arginine and Proline Metabolismacetylornithine deacetylaseACODAacorn_c + h2o_c ⇋ ac_c + orn_c010001.5-1.5

Metabolite name: O-Acetyl-L-serine
Metabolite ID: acser_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismserine O-acetyltransferaseSERATaccoa_c + ser_L_c ⇋ acser_c + coa_c-100010001.21.2
Cysteine Metabolismcysteine synthaseCYSSacser_c + h2s_c ⇋ ac_c + cys_L_c + h_c010001.2-1.2

Metabolite name: Acetoacetyl-ACP
Metabolite ID: actACP_c
Compartment: c


Metabolite name: Acetyl phosphate
Metabolite ID: actp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pyruvate Metabolismacetate kinaseACKrac_c + atp_c ⇋ actp_c + adp_c-100010002.92.9
Pyruvate MetabolismphosphotransacetylasePTArcoa_c + actp_c ⇋ pi_c + accoa_c-100010002.9-2.9

Metabolite name: Adenine
Metabolite ID: ade_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine MetabolismS-adenosylhomocysteine nucleosidaseAHCYSNSh2o_c + ahcys_c ⇋ ade_c + rhcys_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesis5'-deoxyadenosine nuclosidase5DOANdad_5_c + h2o_c ⇋ 5drib_c + ade_c010000.00110.0011
Nucleotide Salvage Pathwaypurine-nucleoside phosphorylase (Adenosine)PUNP1ade_c + r1p_c ⇋ pi_c + adn_c-100010000.0033-0.0033

Metabolite name: Adenosine
Metabolite ID: adn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaypurine-nucleoside phosphorylase (Adenosine)PUNP1ade_c + r1p_c ⇋ pi_c + adn_c-100010000.00330.0033
Nucleotide Salvage Pathwayadenosine kinaseADNK1adn_c + atp_c ⇋ adp_c + h_c + amp_c010000.0033-0.0033

Metabolite name: Adenosyl cobinamide
Metabolite ID: adocbi_c
Compartment: c


Metabolite name: Adenosyl cobinamide phosphate
Metabolite ID: adocbip_c
Compartment: c


Metabolite name: Adenosylcobalamin
Metabolite ID: adocbl_c
Compartment: c


Metabolite name: ADP
Metabolite ID: adp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwayadenylate kinaseADK1atp_c + amp_c ⇋ 2 adp_c-100010001.6e+023.1e+02
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.92.7e+02
Threonine and Lysine Metabolismaspartate kinaseASPKasp_L_c + atp_c ⇋ 4pasp_c + adp_c-100010001.3e+021.3e+02
Threonine and Lysine Metabolismhomoserine kinaseHSKhom_L_c + atp_c ⇋ phom_c + adp_c + h_c010001.3e+021.3e+02
Glycolysis/Gluconeogenesisphosphoglycerate kinasePGKatp_c + 3pg_c ⇋ 13dpg_c + adp_c-100010007171
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c010003636
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.98.9
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:GDP)NDPK1atp_c + gdp_c ⇋ adp_c + gtp_c-100010003.83.8
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.13.1
Pyruvate Metabolismacetate kinaseACKrac_c + atp_c ⇋ actp_c + adp_c-100010002.92.9
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.62.6
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.22.2
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:UDP)NDPK2udp_c + atp_c ⇋ adp_c + utp_c-100010002.12.1
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate kinaseSHKKskm_c + atp_c ⇋ skm5p_c + adp_c + h_c010001.91.9
Nucleotide Salvage PathwayUMP kinaseUMPKatp_c + ump_c ⇋ udp_c + adp_c-100010001.91.9
Arginine and Proline Metabolismacetylglutamate kinaseACGKatp_c + acglu_c ⇋ adp_c + acg5p_c010001.51.5
Cysteine Metabolismadenylyl-sulfate kinaseADSKatp_c + aps_c ⇋ paps_c + adp_c + h_c010001.21.2
Nucleotide Salvage Pathwayguanylate kinase (GMP:ATP)GK1gmp_c + atp_c ⇋ adp_c + gdp_c-100010001.21.2
Arginine and Proline Metabolismglutamate 5-kinaseGLU5Kglu_L_c + atp_c ⇋ adp_c + glu5p_c010001.11.1
Nucleotide Salvage Pathwaycytidylate kinase (CMP)CYTK1cmp_c + atp_c ⇋ cdp_c + adp_c-100010000.890.89
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:CDP)NDPK3cdp_c + atp_c ⇋ adp_c + ctp_c-100010000.890.89
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.790.79
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.380.38
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.230.23
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.140.14
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dGDP)NDPK5atp_c + dgdp_c ⇋ dgtp_c + adp_c-100010000.130.13
Nucleotide Salvage PathwaydTMP kinaseDTMPKdtmp_c + atp_c ⇋ adp_c + dtdp_c-100010000.130.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dTDP)NDPK4dtdp_c + atp_c ⇋ adp_c + dttp_c-100010000.130.13
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.10.1
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingTetraacyldisaccharide 4'kinaseTDSKlipidAds_c + atp_c ⇋ adp_c + h_c + lipidA_c010000.0960.096
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseCDPMEK4c2me_c + atp_c ⇋ 2p4c2me_c + h_c + adp_c010000.0120.012
Nucleotide Salvage Pathwayadenosine kinaseADNK1adn_c + atp_c ⇋ adp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesispantothenate kinasePNTKpnto_R_c + atp_c ⇋ h_c + 4ppan_c + adp_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisdephospho-CoA kinaseDPCOAKdpcoa_c + atp_c ⇋ coa_c + adp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group BiosynthesisNAD kinaseNADKnad_c + atp_c ⇋ nadp_c + adp_c + h_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesisriboflavin kinaseRBFKatp_c + ribflv_c ⇋ adp_c + h_c + fmn_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisphosphomethylpyrimidine kinasePMPK4ampm_c + atp_c ⇋ 2mahmp_c + adp_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate kinaseTMPKthmmp_c + atp_c ⇋ adp_c + thmpp_c010000.00110.0011
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.000640.00064
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-069.9e-06
Oxidative Phosphorylationpolyphosphate kinasePPKrppi_c + adp_c ⇋ atp_c + pi_c-1000100017-17
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+02-9.8e+02

Metabolite name: ADPglucose
Metabolite ID: adpglc_c
Compartment: c


Metabolite name: ADP-D-glycero-D-manno-heptose
Metabolite ID: adphep_DD_c
Compartment: c


Metabolite name: ADP-L-glycero-D-manno-heptose
Metabolite ID: adphep_LD_c
Compartment: c


Metabolite name: ADPribose
Metabolite ID: adprib_c
Compartment: c


Metabolite name: silver
Metabolite ID: ag_c
Compartment: c


Metabolite name: Adenosine-GDP-cobinamide
Metabolite ID: agdpcbi_c
Compartment: c


Metabolite name: Agmatine
Metabolite ID: agm_c
Compartment: c


Metabolite name: S-Adenosyl-L-homocysteine
Metabolite ID: ahcys_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen methyltransferaseUPP3MTuppg3_c + 2 amet_c ⇋ dscl_c + 2 ahcys_c + h_c010000.00110.0022
Cofactor and Prosthetic Group BiosynthesisMalonyl-CoA methyltransferaseMALCOAMTamet_c + malcoa_c ⇋ ahcys_c + malcoame_c010009.9e-069.9e-06
Methionine MetabolismS-adenosylhomocysteine nucleosidaseAHCYSNSh2o_c + ahcys_c ⇋ ade_c + rhcys_c010000.0022-0.0022

Metabolite name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
Metabolite ID: ahdt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase IGTPCIh2o_c + gtp_c ⇋ ahdt_c + for_c + h_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin triphosphate pyrophosphataseDNTPPAahdt_c + h2o_c ⇋ ppi_c + dhpmp_c + h_c010000.0033-0.0033

Metabolite name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
Metabolite ID: aicar_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisadenylosuccinate lyaseADSL2r25aics_c ⇋ aicar_c + fum_c-100010002.22.2
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.470.47
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolecarboxamide formyltransferaseAICART10fthf_c + aicar_c ⇋ fprica_c + thf_c-100010002.7-2.7

Metabolite name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
Metabolite ID: air_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.22.2
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.0011-0.0011
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.2-2.2

Metabolite name: 2-Oxoglutarate
Metabolite ID: akg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alanine and Aspartate Metabolismaspartate transaminaseASPTAglu_L_c + oaa_c ⇋ akg_c + asp_L_c-100010001.4e+021.4e+02
Citric Acid Cycleisocitrate dehydrogenase (NADP)ICDHyrnadp_c + icit_c ⇋ akg_c + nadph_c + co2_c-100010005.35.3
Alanine and Aspartate MetabolismL-alanine transaminaseALATA_Lpyr_c + glu_L_c ⇋ ala_L_c + akg_c-100010002.92.9
Valine, Leucine, and Isoleucine Metabolismleucine transaminase (irreversible)LEUTAiglu_L_c + 4mop_c ⇋ leu_L_c + akg_c010002.22.2
Valine, Leucine, and Isoleucine Metabolismvaline transaminaseVALTA3mob_c + glu_L_c ⇋ akg_c + val_L_c-100010002.12.1
Threonine and Lysine Metabolismsuccinyldiaminopimelate transaminaseSDPTAglu_L_c + sl2a6o_c ⇋ sl26da_c + akg_c-100010001.81.8
Arginine and Proline Metabolismacetylornithine transaminaseACOTAacg5sa_c + glu_L_c ⇋ acorn_c + akg_c-100010001.51.5
Valine, Leucine, and Isoleucine Metabolismisoleucine transaminaseILETAglu_L_c + 3mop_c ⇋ ile_L_c + akg_c-100010001.41.4
Tyrosine, Tryptophan, and Phenylalanine Metabolismphenylalanine transaminasePHETA1glu_L_c + phpyr_c ⇋ phe_L_c + akg_c-100010000.910.91
Tyrosine, Tryptophan, and Phenylalanine Metabolismtyrosine transaminaseTYRTA34hpp_c + glu_L_c ⇋ tyr_L_c + akg_c-100010000.680.68
Histidine Metabolismhistidinol-phosphate transaminaseHSTPTimacp_c + glu_L_c ⇋ akg_c + hisp_c010000.470.47
Cofactor and Prosthetic Group BiosynthesisO-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferaseOHPBATglu_L_c + ohpb_c ⇋ akg_c + phthr_c-100010000.00110.0011
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+02-1.6e+02

Metabolite name: beta-Alanine
Metabolite ID: ala_B_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisaspartate 1-decarboxylaseASP1DCasp_L_c + h_c ⇋ ala_B_c + co2_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.0028-0.0028

Metabolite name: D-Alanine
Metabolite ID: ala_D_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alanine and Aspartate Metabolismalanine racemaseALARala_L_c ⇋ ala_D_c-100010000.210.21
Transport, Inner MembraneD-alanine transport in via proton symport (periplasm)DALAt2ppala_D_p + h_p ⇋ ala_D_c + h_c010000.0680.068
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.14-0.27

Metabolite name: L-Alanine
Metabolite ID: ala_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alanine and Aspartate MetabolismL-alanine transaminaseALATA_Lpyr_c + glu_L_c ⇋ ala_L_c + akg_c-100010002.92.9
Cofactor and Prosthetic Group BiosynthesisISC Cysteine desulfurationICYSDSiscs_c + cys_L_c ⇋ ala_L_c + iscssh_c010000.00890.0089
Cofactor and Prosthetic Group Biosynthesis8-amino-7-oxononanoate synthaseAOXSr2pimACP_c + ala_L_c ⇋ ACP_c + co2_c + 8aonn_c010009.9e-06-9.9e-06
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.14-0.14
Alanine and Aspartate Metabolismalanine racemaseALARala_L_c ⇋ ala_D_c-100010000.21-0.21
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-2.5

Metabolite name: D-Alanyl-D-alanine
Metabolite ID: alaala_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.14-0.14

Metabolite name: (S)-2-Acetolactate
Metabolite ID: alac_S_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismacetolactate synthaseACLSh_c + 2 pyr_c ⇋ alac_S_c + co2_c010004.34.3
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)KARA1h_c + alac_S_c + nadph_c ⇋ 23dhmb_c + nadp_c-100010004.3-4.3

Metabolite name: L-Alanyl-tRNA(Ala)
Metabolite ID: alatrna_c
Compartment: c


Metabolite name: D-Allose
Metabolite ID: all_D_c
Compartment: c


Metabolite name: D-Allose 6-phosphate
Metabolite ID: all6p_c
Compartment: c


Metabolite name: Allantoin
Metabolite ID: alltn_c
Compartment: c


Metabolite name: Allantoate
Metabolite ID: alltt_c
Compartment: c


Metabolite name: Allulose 6-phosphate
Metabolite ID: allul6p_c
Compartment: c


Metabolite name: D-Altronate
Metabolite ID: altrn_c
Compartment: c


Metabolite name: S-Adenosyl-L-methionine
Metabolite ID: amet_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.00440.0044
Cofactor and Prosthetic Group Biosynthesisadenosylmethionine-8-amino-7-oxononanoate transaminaseAMAOTramet_c + 8aonn_c ⇋ dann_c + amob_c-100010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisMalonyl-CoA methyltransferaseMALCOAMTamet_c + malcoa_c ⇋ ahcys_c + malcoame_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.0011-0.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen methyltransferaseUPP3MTuppg3_c + 2 amet_c ⇋ dscl_c + 2 ahcys_c + h_c010000.0011-0.0022

Metabolite name: S-Adenosylmethioninamine
Metabolite ID: ametam_c
Compartment: c


Metabolite name: S-Adenosyl-4-methylthio-2-oxobutanoate
Metabolite ID: amob_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisadenosylmethionine-8-amino-7-oxononanoate transaminaseAMAOTramet_c + 8aonn_c ⇋ dann_c + amob_c-100010009.9e-069.9e-06
Sink needed to allow S-Adenosyl-4-methylthio-2-oxobutanoate to leave systemDM_AMOBamob_c ⇋ 010009.9e-06-9.9e-06

Metabolite name: AMP
Metabolite ID: amp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+021.4e+02
Histidine Metabolismphosphoribosylpyrophosphate synthetasePRPPSatp_c + r5p_c ⇋ amp_c + h_c + prpp_c-100010004.64.6
Purine and Pyrimidine Biosynthesisadenylsuccinate lyaseADSL1rdcamp_c ⇋ amp_c + fum_c-100010001.51.5
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.51.5
Cysteine Metabolism3',5'-bisphosphate nucleotidaseBPNTpap_c + h2o_c ⇋ amp_c + pi_c010001.21.2
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.21.2
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.21.2
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.740.74
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.630.63
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.380.38
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.0180.018
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.0110.011
Nucleotide Salvage Pathwayadenosine kinaseADNK1adn_c + atp_c ⇋ adp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesis6-hydroxymethyl-dihydropterin pyrophosphokinaseHPPK26hmhpt_c + atp_c ⇋ 6hmhptpp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.00280.0028
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.00240.0024
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdenum cofactor synthaseBMOCOSmptamp_c + moco_c ⇋ bmoco_c + cu2_c + amp_c010000.00060.0006
Nucleotide Salvage Pathwayadenylate kinaseADK1atp_c + amp_c ⇋ 2 adp_c-100010001.6e+02-1.6e+02

Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
Metabolite ID: anhgm_c
Compartment: c


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide
Metabolite ID: anhgm3p_c
Compartment: c


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide
Metabolite ID: anhgm4p_c
Compartment: c


Metabolite name: 1,6-anhydrous-N-Acetylmuramate
Metabolite ID: anhm_c
Compartment: c


Metabolite name: 1,6-anhydrous-N-Acetylmuramyl-tripeptide
Metabolite ID: anhm3p_c
Compartment: c


Metabolite name: 1,6-anhydrous-N-Acetylmuramyl-tetrapeptide
Metabolite ID: anhm4p_c
Compartment: c


Metabolite name: Anthranilate
Metabolite ID: anth_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.280.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate phosphoribosyltransferaseANPRTprpp_c + anth_c ⇋ ppi_c + pran_c010000.28-0.28

Metabolite name: P1,P4-Bis(5'-adenosyl) tetraphosphate
Metabolite ID: ap4a_c
Compartment: c


Metabolite name: P1,P5-Bis(5'-adenosyl) pentaphosphate
Metabolite ID: ap5a_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C12:0)
Metabolite ID: apg120_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C14:0)
Metabolite ID: apg140_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C14:1)
Metabolite ID: apg141_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C16:0)
Metabolite ID: apg160_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C16:1)
Metabolite ID: apg161_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C18:0)
Metabolite ID: apg180_c
Compartment: c


Metabolite name: acyl phosphatidylglycerol (n-C18:1)
Metabolite ID: apg181_c
Compartment: c


Metabolite name: apoprotein [acyl carrier protein]
Metabolite ID: apoACP_c
Compartment: c


Metabolite name: 1-Aminopropan-2-ol
Metabolite ID: appl_c
Compartment: c


Metabolite name: Adenosine 5'-phosphosulfate
Metabolite ID: aps_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.21.2
Cysteine Metabolismadenylyl-sulfate kinaseADSKatp_c + aps_c ⇋ paps_c + adp_c + h_c010001.2-1.2

Metabolite name: D-Arabinose 5-phosphate
Metabolite ID: ara5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alternate Carbon Metabolismarabinose-5-phosphate isomeraseA5PISOru5p_D_c ⇋ ara5p_c-100010000.190.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy -D-manno-octulosonic -acid 8-phosphate synthaseKDOPSara5p_c + pep_c + h2o_c ⇋ kdo8p_c + pi_c010000.19-0.19

Metabolite name: L-Arabinose
Metabolite ID: arab_L_c
Compartment: c


Metabolite name: O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate
Metabolite ID: aragund_c
Compartment: c


Metabolite name: Arbutin 6-phosphate
Metabolite ID: arbt6p_c
Compartment: c


Metabolite name: aerobactin minus Fe3
Metabolite ID: arbtn_c
Compartment: c


Metabolite name: Aerobactin
Metabolite ID: arbtn_fe3_c
Compartment: c


Metabolite name: L-Arginine
Metabolite ID: arg_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismargininosuccinate lyaseARGSLargsuc_c ⇋ arg_L_c + fum_c-100010001.51.5
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.5

Metabolite name: N(omega)-(L-Arginino)succinate
Metabolite ID: argsuc_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.51.5
Arginine and Proline Metabolismargininosuccinate lyaseARGSLargsuc_c ⇋ arg_L_c + fum_c-100010001.5-1.5

Metabolite name: L-Arginyl-tRNA(Arg)
Metabolite ID: argtrna_c
Compartment: c


Metabolite name: L-ascorbate-6-phosphate
Metabolite ID: ascb6p_c
Compartment: c


Metabolite name: L-Asparagine
Metabolite ID: asn_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.21.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.2

Metabolite name: L-Asparaginyl-tRNA(Asn)
Metabolite ID: asntrna_c
Compartment: c


Metabolite name: arsenite
Metabolite ID: aso3_c
Compartment: c


Metabolite name: arsenate
Metabolite ID: aso4_c
Compartment: c


Metabolite name: L-Aspartate
Metabolite ID: asp_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alanine and Aspartate Metabolismaspartate transaminaseASPTAglu_L_c + oaa_c ⇋ akg_c + asp_L_c-100010001.4e+021.4e+02
Cofactor and Prosthetic Group Biosynthesisaspartate 1-decarboxylaseASP1DCasp_L_c + h_c ⇋ ala_B_c + co2_c010000.0028-0.0028
Cofactor and Prosthetic Group BiosynthesisL-aspartate oxidaseASPO6o2_c + asp_L_c ⇋ h_c + iasp_c + h2o2_c010000.011-0.011
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.2-1.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.2
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.5-1.5
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.5-1.5
Purine and Pyrimidine Biosynthesisaspartate carbamoyltransferaseASPCTcbp_c + asp_L_c ⇋ h_c + pi_c + cbasp_c010001.6-1.6
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.2-2.2
Threonine and Lysine Metabolismaspartate kinaseASPKasp_L_c + atp_c ⇋ 4pasp_c + adp_c-100010001.3e+02-1.3e+02

Metabolite name: L-Aspartate 4-semialdehyde
Metabolite ID: aspsa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+021.3e+02
Threonine and Lysine Metabolismdihydrodipicolinate synthaseDHDPSpyr_c + aspsa_c ⇋ h_c + 2 h2o_c + 23dhdp_c010001.8-1.8
Threonine and Lysine Metabolismhomoserine dehydrogenase (NADPH)HSDyaspsa_c + nadph_c + h_c ⇋ hom_L_c + nadp_c-100010001.3e+02-1.3e+02

Metabolite name: L-Aspartyl-tRNA(Asp)
Metabolite ID: asptrna_c
Compartment: c


Metabolite name: L-Allo-threonine
Metabolite ID: athr_L_c
Compartment: c


Metabolite name: adenosine thiamine triphosphate
Metabolite ID: athtp_c
Compartment: c


Metabolite name: ATP
Metabolite ID: atp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+029.8e+02
Oxidative Phosphorylationpolyphosphate kinasePPKrppi_c + adp_c ⇋ atp_c + pi_c-100010001717
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-06-9.9e-06
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.00064-0.00064
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate kinaseTMPKthmmp_c + atp_c ⇋ adp_c + thmpp_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisphosphomethylpyrimidine kinasePMPK4ampm_c + atp_c ⇋ 2mahmp_c + adp_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisFMN adenylyltransferaseFMNATh_c + atp_c + fmn_c ⇋ fad_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisriboflavin kinaseRBFKatp_c + ribflv_c ⇋ adp_c + h_c + fmn_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesismolybdopterin adenylyltransferaseMPTATmpt_c + h_c + atp_c ⇋ mptamp_c + ppi_c010000.0012-0.0012
Cofactor and Prosthetic Group BiosynthesisNAD kinaseNADKnad_c + atp_c ⇋ nadp_c + adp_c + h_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthase sulfurylaseMPTSSmoadcoo_c + h_c + atp_c ⇋ ppi_c + moadamp_c010000.0024-0.0024
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesispantetheine-phosphate adenylyltransferasePTPATih_c + atp_c + pan4p_c ⇋ ppi_c + dpcoa_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesispantothenate kinasePNTKpnto_R_c + atp_c ⇋ h_c + 4ppan_c + adp_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesisdephospho-CoA kinaseDPCOAKdpcoa_c + atp_c ⇋ coa_c + adp_c + h_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesis6-hydroxymethyl-dihydropterin pyrophosphokinaseHPPK26hmhpt_c + atp_c ⇋ 6hmhptpp_c + h_c + amp_c010000.0033-0.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.0033-0.0033
Nucleotide Salvage Pathwayadenosine kinaseADNK1adn_c + atp_c ⇋ adp_c + h_c + amp_c010000.0033-0.0033
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.0044-0.0044
Nucleotide Salvage Pathwaynicotinate-nucleotide adenylyltransferaseNNATrnicrnt_c + h_c + atp_c ⇋ ppi_c + dnad_c-100010000.011-0.011
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.011-0.011
Cofactor and Prosthetic Group Biosynthesis4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseCDPMEK4c2me_c + atp_c ⇋ 2p4c2me_c + h_c + adp_c010000.012-0.012
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.012-0.012
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.018-0.018
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.096-0.096
Lipopolysaccharide Biosynthesis / RecyclingTetraacyldisaccharide 4'kinaseTDSKlipidAds_c + atp_c ⇋ adp_c + h_c + lipidA_c010000.096-0.096
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.096-0.096
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.1-0.1
Nucleotide Salvage PathwaydTMP kinaseDTMPKdtmp_c + atp_c ⇋ adp_c + dtdp_c-100010000.13-0.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dTDP)NDPK4dtdp_c + atp_c ⇋ adp_c + dttp_c-100010000.13-0.13
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.13-0.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dGDP)NDPK5atp_c + dgdp_c ⇋ dgtp_c + adp_c-100010000.13-0.13
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.14-0.14
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.14-0.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.14-0.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.14-0.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.14-0.14
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.23-0.23
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.38-0.38
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.38-0.38
Histidine MetabolismATP phosphoribosyltransferaseATPPRTatp_c + prpp_c ⇋ prbatp_c + ppi_c010000.47-0.47
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.63-0.63
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.74-0.74
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.79-0.79
Nucleotide Salvage Pathwaycytidylate kinase (CMP)CYTK1cmp_c + atp_c ⇋ cdp_c + adp_c-100010000.89-0.89
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:CDP)NDPK3cdp_c + atp_c ⇋ adp_c + ctp_c-100010000.89-0.89
Arginine and Proline Metabolismglutamate 5-kinaseGLU5Kglu_L_c + atp_c ⇋ adp_c + glu5p_c010001.1-1.1
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.2-1.2
Nucleotide Salvage Pathwayguanylate kinase (GMP:ATP)GK1gmp_c + atp_c ⇋ adp_c + gdp_c-100010001.2-1.2
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.2-1.2
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.2-1.2
Cysteine Metabolismadenylyl-sulfate kinaseADSKatp_c + aps_c ⇋ paps_c + adp_c + h_c010001.2-1.2
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.5-1.5
Arginine and Proline Metabolismacetylglutamate kinaseACGKatp_c + acglu_c ⇋ adp_c + acg5p_c010001.5-1.5
Nucleotide Salvage PathwayUMP kinaseUMPKatp_c + ump_c ⇋ udp_c + adp_c-100010001.9-1.9
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate kinaseSHKKskm_c + atp_c ⇋ skm5p_c + adp_c + h_c010001.9-1.9
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:UDP)NDPK2udp_c + atp_c ⇋ adp_c + utp_c-100010002.1-2.1
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.2-2.2
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.6-2.6
Pyruvate Metabolismacetate kinaseACKrac_c + atp_c ⇋ actp_c + adp_c-100010002.9-2.9
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.1-3.1
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:GDP)NDPK1atp_c + gdp_c ⇋ adp_c + gtp_c-100010003.8-3.8
Histidine Metabolismphosphoribosylpyrophosphate synthetasePRPPSatp_c + r5p_c ⇋ amp_c + h_c + prpp_c-100010004.6-4.6
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.9-8.9
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c0100036-36
Glycolysis/Gluconeogenesisphosphoglycerate kinasePGKatp_c + 3pg_c ⇋ 13dpg_c + adp_c-1000100071-71
Threonine and Lysine Metabolismhomoserine kinaseHSKhom_L_c + atp_c ⇋ phom_c + adp_c + h_c010001.3e+02-1.3e+02
Threonine and Lysine Metabolismaspartate kinaseASPKasp_L_c + atp_c ⇋ 4pasp_c + adp_c-100010001.3e+02-1.3e+02
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+02-1.4e+02
Nucleotide Salvage Pathwayadenylate kinaseADK1atp_c + amp_c ⇋ 2 adp_c-100010001.6e+02-1.6e+02
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-2.7e+02

Metabolite name: Crotonoyl-CoA
Metabolite ID: b2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)ECOAH13hbcoa_c ⇋ h2o_c + b2coa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (butanoyl-CoA)ACOAD1fb2coa_c + fadh2_c ⇋ fad_c + btcoa_c-100010001.8-1.8

Metabolite name: gamma-butyrobetainyl-CoA
Metabolite ID: bbtcoa_c
Compartment: c


Metabolite name: Betaine aldehyde
Metabolite ID: betald_c
Compartment: c


Metabolite name: branching glycogen
Metabolite ID: bglycogen_c
Compartment: c


Metabolite name: bis-molybdenum cofactor
Metabolite ID: bmoco_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisbis-molybdenum cofactor synthaseBMOCOSmptamp_c + moco_c ⇋ bmoco_c + cu2_c + amp_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthase (single GDP)BMOGDS1bmoco_c + h_c + gtp_c ⇋ bmoco1gdp_c + ppi_c010000.0006-0.0006

Metabolite name: bis-molybdopterin mono-guanine dinucleotide
Metabolite ID: bmoco1gdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthase (single GDP)BMOGDS1bmoco_c + h_c + gtp_c ⇋ bmoco1gdp_c + ppi_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthaseBMOGDS2bmoco1gdp_c + h_c + gtp_c ⇋ ppi_c + bmocogdp_c010000.0006-0.0006

Metabolite name: bis-molybdopterin guanine dinucleotide
Metabolite ID: bmocogdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthaseBMOGDS2bmoco1gdp_c + h_c + gtp_c ⇋ ppi_c + bmocogdp_c010000.00060.0006
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0006

Metabolite name: Butanal
Metabolite ID: btal_c
Compartment: c


Metabolite name: Butanoyl-CoA
Metabolite ID: btcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (butanoyl-CoA)ACOAD1fb2coa_c + fadh2_c ⇋ fad_c + btcoa_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (butanoyl-CoA) (r)ACACT2rbtcoa_c + accoa_c ⇋ coa_c + 3ohcoa_c-100010001.8-1.8

Metabolite name: Biotin
Metabolite ID: btn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-069.9e-06
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-9.9e-06

Metabolite name: d-biotin d-sulfoxide
Metabolite ID: btnso_c
Compartment: c


Metabolite name: Butyrate (n-C4:0)
Metabolite ID: but_c
Compartment: c


Metabolite name: But-2-enoyl-[acyl-carrier protein]
Metabolite ID: but2eACP_c
Compartment: c


Metabolite name: Butyryl-ACP (n-C4:0ACP)
Metabolite ID: butACP_c
Compartment: c


Metabolite name: butanesulfonate
Metabolite ID: butso3_c
Compartment: c


Metabolite name: tungsten bispterin cofactor
Metabolite ID: bwco_c
Compartment: c


Metabolite name: tungsten bispterin cofactor mono-guanine dinucleotide
Metabolite ID: bwco1gdp_c
Compartment: c


Metabolite name: tungsten bispterin cofactor guanine dinucleotide
Metabolite ID: bwcogdp_c
Compartment: c


Metabolite name: Calcium
Metabolite ID: ca2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismcalcium / sodium antiporter (1:1)CAt6ppca2_p + na1_c ⇋ na1_p + ca2_c-100010000.0260.026
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.026

Metabolite name: cAMP
Metabolite ID: camp_c
Compartment: c


Metabolite name: N-Carbamoyl-L-aspartate
Metabolite ID: cbasp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisaspartate carbamoyltransferaseASPCTcbp_c + asp_L_c ⇋ h_c + pi_c + cbasp_c010001.61.6
Purine and Pyrimidine BiosynthesisdihydroorotaseDHORTSh_c + cbasp_c ⇋ dhor_S_c + h2o_c-100010001.6-1.6

Metabolite name: Cobinamide
Metabolite ID: cbi_c
Compartment: c


Metabolite name: Cob(I)alamin
Metabolite ID: cbl1_c
Compartment: c


Metabolite name: Carbamate
Metabolite ID: cbm_c
Compartment: c


Metabolite name: Carbamoyl phosphate
Metabolite ID: cbp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.13.1
Arginine and Proline Metabolismornithine carbamoyltransferaseOCBTcbp_c + orn_c ⇋ citr_L_c + h_c + pi_c-100010001.5-1.5
Purine and Pyrimidine Biosynthesisaspartate carbamoyltransferaseASPCTcbp_c + asp_L_c ⇋ h_c + pi_c + cbasp_c010001.6-1.6

Metabolite name: Cadmium
Metabolite ID: cd2_c
Compartment: c


Metabolite name: cis-dodec-5-enoyl-[acyl-carrier protein] (n-C12:1)
Metabolite ID: cddec5eACP_c
Compartment: c


Metabolite name: cis-dec-3-enoyl-[acyl-carrier protein] (n-C10:1)
Metabolite ID: cdec3eACP_c
Compartment: c


Metabolite name: 7-deaza-7-carboxyguanine
Metabolite ID: cdg_c
Compartment: c


Metabolite name: CDP
Metabolite ID: cdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaycytidylate kinase (CMP)CYTK1cmp_c + atp_c ⇋ cdp_c + adp_c-100010000.890.89
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:CDP)NDPK3cdp_c + atp_c ⇋ adp_c + ctp_c-100010000.89-0.89

Metabolite name: CDP-1,2-didodecanoylglycerol
Metabolite ID: cdpdddecg_c
Compartment: c


Metabolite name: CDP-1,2-dihexadec-9-enoylglycerol
Metabolite ID: cdpdhdec9eg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:1)DASYN161pa161_c + ctp_c + h_c ⇋ ppi_c + cdpdhdec9eg_c010000.370.37
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:1)PSSA161cdpdhdec9eg_c + ser_L_c ⇋ cmp_c + ps161_c + h_c010000.37-0.37

Metabolite name: CDP-1,2-dihexadecanoylglycerol
Metabolite ID: cdpdhdecg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:0)DASYN160pa160_c + ctp_c + h_c ⇋ ppi_c + cdpdhdecg_c010000.310.31
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:0)PSSA160cdpdhdecg_c + ser_L_c ⇋ ps160_c + cmp_c + h_c010000.31-0.31

Metabolite name: CDP-1,2-dioctadec-11-enoylglycerol
Metabolite ID: cdpdodec11eg_c
Compartment: c


Metabolite name: CDP-1,2-dioctadecanoylglycerol
Metabolite ID: cdpdodecg_c
Compartment: c


Metabolite name: CDP-1,2-ditetradec-7-enoylglycerol
Metabolite ID: cdpdtdec7eg_c
Compartment: c


Metabolite name: CDP-1,2-ditetradecanoylglycerol
Metabolite ID: cdpdtdecg_c
Compartment: c


Metabolite name: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol
Metabolite ID: cechddd_c
Compartment: c


Metabolite name: cis-3-(3-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
Metabolite ID: cenchddd_c
Compartment: c


Metabolite name: Cys-Gly
Metabolite ID: cgly_c
Compartment: c


Metabolite name: Choline
Metabolite ID: chol_c
Compartment: c


Metabolite name: chorismate
Metabolite ID: chor_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismchorismate synthaseCHORS3psme_c ⇋ chor_c + pi_c010001.91.9
Cofactor and Prosthetic Group BiosynthesisChorismate pyruvate lyaseCHRPLchor_c ⇋ 4hbz_c + pyr_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis4-amino-4-deoxychorismate synthaseADCSchor_c + gln_L_c ⇋ 4adcho_c + glu_L_c010000.0033-0.0033
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.28-0.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismchorismate mutaseCHORMchor_c ⇋ pphn_c010001.6-1.6

Metabolite name: diacetylchitobiose-6-phosphate
Metabolite ID: chtbs6p_c
Compartment: c


Metabolite name: trans-Cinnamate
Metabolite ID: cinnm_c
Compartment: c


Metabolite name: Citrate
Metabolite ID: cit_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.35.3
Citric Acid Cycleaconitase (half-reaction A, Citrate hydro-lyase)ACONTacit_c ⇋ h2o_c + acon_C_c-100010005.3-5.3

Metabolite name: L-Citrulline
Metabolite ID: citr_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismornithine carbamoyltransferaseOCBTcbp_c + orn_c ⇋ citr_L_c + h_c + pi_c-100010001.51.5
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.5-1.5

Metabolite name: CMP-3-deoxy-D-manno-octulosonate
Metabolite ID: ckdo_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate cytidylyltransferaseKDOCT2ctp_c + kdo_c ⇋ ckdo_c + ppi_c010000.190.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOAT2ckdo_c + kdolipid4_c ⇋ h_c + cmp_c + kdo2lipid4_c010000.096-0.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOATckdo_c + lipidA_c ⇋ kdolipid4_c + cmp_c + h_c010000.096-0.096

Metabolite name: Chloride
Metabolite ID: cl_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismchloride transport out via proton antiport (2:1) (periplasm)CLt3_2pph_c + 2 cl_p ⇋ h_p + 2 cl_c010000.0130.026
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.026

Metabolite name: CMP
Metabolite ID: cmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:1)PSSA161cdpdhdec9eg_c + ser_L_c ⇋ cmp_c + ps161_c + h_c010000.370.37
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:0)PSSA160cdpdhdecg_c + ser_L_c ⇋ ps160_c + cmp_c + h_c010000.310.31
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOATckdo_c + lipidA_c ⇋ kdolipid4_c + cmp_c + h_c010000.0960.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOAT2ckdo_c + kdolipid4_c ⇋ h_c + cmp_c + kdo2lipid4_c010000.0960.096
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseMECDPS2p4c2me_c ⇋ 2mecdp_c + cmp_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.00280.0028
Nucleotide Salvage Pathwaycytidylate kinase (CMP)CYTK1cmp_c + atp_c ⇋ cdp_c + adp_c-100010000.89-0.89

Metabolite name: CO2
Metabolite ID: co2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneCO2 transporter via diffusion (periplasm)CO2tppco2_p ⇋ co2_c-100010002e+022e+02
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c010006363
Citric Acid Cycleisocitrate dehydrogenase (NADP)ICDHyrnadp_c + icit_c ⇋ akg_c + nadph_c + co2_c-100010005.35.3
Valine, Leucine, and Isoleucine Metabolismacetolactate synthaseACLSh_c + 2 pyr_c ⇋ alac_S_c + co2_c010004.34.3
Valine, Leucine, and Isoleucine Metabolism2-Oxo-4-methyl-3-carboxypentanoate decarboxylationOMCDC3c4mop_c + h_c ⇋ co2_c + 4mop_c010002.22.2
Threonine and Lysine Metabolismdiaminopimelate decarboxylaseDAPDCh_c + 26dap_M_c ⇋ co2_c + lys_L_c010001.71.7
Purine and Pyrimidine Biosynthesisorotidine-5'-phosphate decarboxylaseOMPDCh_c + orot5p_c ⇋ co2_c + ump_c010001.61.6
Valine, Leucine, and Isoleucine Metabolism2-aceto-2-hydroxybutanoate synthaseACHBSpyr_c + 2obut_c + h_c ⇋ 2ahbut_c + co2_c010001.41.4
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydratasePPNDHh_c + pphn_c ⇋ phpyr_c + co2_c + h2o_c010000.910.91
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydrogenasePPNDnad_c + pphn_c ⇋ nadh_c + co2_c + 34hpp_c010000.680.68
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.380.38
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:1)PSD161ps161_c + h_c ⇋ co2_c + pe161_c010000.370.37
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:0)PSD160h_c + ps160_c ⇋ pe160_c + co2_c010000.310.31
Tyrosine, Tryptophan, and Phenylalanine Metabolismindole-3-glycerol-phosphate synthaseIGPS2cpr5p_c + h_c ⇋ co2_c + 3ig3p_c + h2o_c010000.280.28
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose 5-phosphate synthaseDXPSpyr_c + g3p_c + h_c ⇋ dxyl5p_c + co2_c010000.0140.014
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen decarboxylase (uroporphyrinogen III)UPPDC1uppg3_c + 4 h_c ⇋ cpppg3_c + 4 co2_c010000.00110.0044
Cofactor and Prosthetic Group Biosynthesisaspartate 1-decarboxylaseASP1DCasp_L_c + h_c ⇋ ala_B_c + co2_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenoylcysteine decarboxylasePPCDC4ppcys_c + h_c ⇋ co2_c + pan4p_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.00110.0022
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisOctaprenyl-hydroxybenzoate decarboxylaseOPHBDCh_c + 3ophb_c ⇋ 2oph_c + co2_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis8-amino-7-oxononanoate synthaseAOXSr2pimACP_c + ala_L_c ⇋ ACP_c + co2_c + 8aonn_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-06-9.9e-06
UnassignedHCO3 equilibration reactionHCO3Eco2_c + h2o_c ⇋ h_c + hco3_c-100010002.6-2.6
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.1-3.1
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c0100036-36
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+02-1e+02
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+02-1.4e+02

Metabolite name: Coenzyme A
Metabolite ID: coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+021e+02
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.35.3
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.22.2
Threonine and Lysine Metabolismtetrahydrodipicolinate succinylaseTHDPSthdp_c + h2o_c + succoa_c ⇋ coa_c + sl2a6o_c010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acetyltransferaseACACT1r2 accoa_c ⇋ aacoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (octanoyl-CoA) (r)ACACT4roccoa_c + accoa_c ⇋ 3odcoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (decanoyl-CoA) (r)ACACT5raccoa_c + dcacoa_c ⇋ 3oddcoa_c + coa_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)ACACT3rhxcoa_c + accoa_c ⇋ coa_c + 3oocoa_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (butanoyl-CoA) (r)ACACT2rbtcoa_c + accoa_c ⇋ coa_c + 3ohcoa_c-100010001.81.8
Arginine and Proline MetabolismN-acetylglutamate synthaseACGSglu_L_c + accoa_c ⇋ coa_c + h_c + acglu_c010001.51.5
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)ACACT7rtdcoa_c + accoa_c ⇋ coa_c + 3ohdcoa_c-100010001.41.4
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)ACACT6rddcacoa_c + accoa_c ⇋ coa_c + 3otdcoa_c-100010001.41.4
Cysteine Metabolismserine O-acetyltransferaseSERATaccoa_c + ser_L_c ⇋ acser_c + coa_c-100010001.21.2
Methionine Metabolismhomoserine O-succinyltransferaseHSSThom_L_c + succoa_c ⇋ suchms_c + coa_c010000.760.76
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecenoate)FACOAE161hdcoa_c + h2o_c ⇋ coa_c + hdcea_c + h_c010000.740.74
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecanoate)FACOAE160pmtcoa_c + h2o_c ⇋ coa_c + h_c + hdca_c010000.630.63
Cell Envelope Biosynthesisglucosamine-1-phosphate N-acetyltransferaseG1PACTgam1p_c + accoa_c ⇋ coa_c + h_c + acgam1p_c010000.470.47
Membrane Lipid MetabolismMalonyl-CoA-ACP transacylaseMCOATAACP_c + malcoa_c ⇋ coa_c + malACP_c-100010000.380.38
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (dodecanoate)FACOAE120ddcacoa_c + h2o_c ⇋ coa_c + ddca_c + h_c010000.380.38
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdephospho-CoA kinaseDPCOAKdpcoa_c + atp_c ⇋ coa_c + adp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-069.9e-06
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0028
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.6-2.6
Pyruvate MetabolismphosphotransacetylasePTArcoa_c + actp_c ⇋ pi_c + accoa_c-100010002.9-2.9
Glycine and Serine Metabolismglycine C-acetyltransferaseGLYATcoa_c + 2aobut_c ⇋ gly_c + accoa_c-100010001.3e+02-1.3e+02

Metabolite name: Co2+
Metabolite ID: cobalt2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismcobalt transport in via permease (no H+)COBALT2tppcobalt2_p ⇋ cobalt2_c010000.000120.00012
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.00012

Metabolite name: core oligosaccharide lipid A
Metabolite ID: colipa_c
Compartment: c


Metabolite name: cyclopropane phosphatidylethanolamine (dihexadec-9,10-cyclo-anoyl, n-C16:0 cyclo)
Metabolite ID: cpe160_c
Compartment: c


Metabolite name: cyclopropane phosphatidylethanolamine (dioctadec-11,12-cyclo-anoyl, n-C18:0 cyclo)
Metabolite ID: cpe180_c
Compartment: c


Metabolite name: cyclopropane phosphatidylglycerol (dihexadec-9,10-cyclo-anoyl, n-C16:0 cyclo)
Metabolite ID: cpg160_c
Compartment: c


Metabolite name: cyclopropane phosphatidylglycerol (dioctadec-11,12-cyclo-anoyl, n-C18:0 cyclo)
Metabolite ID: cpg180_c
Compartment: c


Metabolite name: coprogen
Metabolite ID: cpgn_c
Compartment: c


Metabolite name: coprogen unloaded (no Fe(III))
Metabolite ID: cpgn_un_c
Compartment: c


Metabolite name: 6-carboxy-5,6,7,8-tetrahydropterin
Metabolite ID: cph4_c
Compartment: c


Metabolite name: cyclic pyranopterin monophosphate
Metabolite ID: cpmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesiscyclic pyranopterin monophosphate synthaseCPMPSgtp_c + h2o_c ⇋ ppi_c + cpmp_c010000.00120.0012
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.0012-0.0012

Metabolite name: Coproporphyrinogen III
Metabolite ID: cpppg3_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen decarboxylase (uroporphyrinogen III)UPPDC1uppg3_c + 4 h_c ⇋ cpppg3_c + 4 co2_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.0011-0.0011

Metabolite name: L-Carnitine
Metabolite ID: crn_c
Compartment: c


Metabolite name: D-Carnitine
Metabolite ID: crn_D_c
Compartment: c


Metabolite name: D-carnitinyl-CoA
Metabolite ID: crnDcoa_c
Compartment: c


Metabolite name: L-Carnitinyl-CoA
Metabolite ID: crncoa_c
Compartment: c


Metabolite name: Cytosine
Metabolite ID: csn_c
Compartment: c


Metabolite name: crotonobetaine
Metabolite ID: ctbt_c
Compartment: c


Metabolite name: crotonobetainyl-CoA
Metabolite ID: ctbtcoa_c
Compartment: c


Metabolite name: CTP
Metabolite ID: ctp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:CDP)NDPK3cdp_c + atp_c ⇋ adp_c + ctp_c-100010000.890.89
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.790.79
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseMEPCT2me4p_c + h_c + ctp_c ⇋ 4c2me_c + ppi_c010000.012-0.012
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.13-0.13
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate cytidylyltransferaseKDOCT2ctp_c + kdo_c ⇋ ckdo_c + ppi_c010000.19-0.19
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:0)DASYN160pa160_c + ctp_c + h_c ⇋ ppi_c + cdpdhdecg_c010000.31-0.31
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:1)DASYN161pa161_c + ctp_c + h_c ⇋ ppi_c + cdpdhdec9eg_c010000.37-0.37
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.66

Metabolite name: Cu+
Metabolite ID: cu_c
Compartment: c


Metabolite name: Cu2+
Metabolite ID: cu2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismcopper transport in via permease (no H+)CU2tppcu2_p ⇋ cu2_c010000.00350.0035
Cofactor and Prosthetic Group Biosynthesisbis-molybdenum cofactor synthaseBMOCOSmptamp_c + moco_c ⇋ bmoco_c + cu2_c + amp_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.0012-0.0012
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0035

Metabolite name: Hydrogen cyanide
Metabolite ID: cyan_c
Compartment: c


Metabolite name: Cyanate
Metabolite ID: cynt_c
Compartment: c


Metabolite name: D-Cysteine
Metabolite ID: cys_D_c
Compartment: c


Metabolite name: L-Cysteine
Metabolite ID: cys_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismcysteine synthaseCYSSacser_c + h2s_c ⇋ ac_c + cys_L_c + h_c010001.21.2
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.0028-0.0028
Cofactor and Prosthetic Group BiosynthesisISC Cysteine desulfurationICYSDSiscs_c + cys_L_c ⇋ ala_L_c + iscssh_c010000.0089-0.0089
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.45
Methionine MetabolismO-succinylhomoserine lyase (L-cysteine)SHSL1cys_L_c + suchms_c ⇋ cyst_L_c + h_c + succ_c010000.76-0.76

Metabolite name: L-Cystathionine
Metabolite ID: cyst_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine MetabolismO-succinylhomoserine lyase (L-cysteine)SHSL1cys_L_c + suchms_c ⇋ cyst_L_c + h_c + succ_c010000.760.76
Methionine Metabolismcystathionine b-lyaseCYSTLcyst_L_c + h2o_c ⇋ pyr_c + hcys_L_c + nh4_c010000.76-0.76

Metabolite name: L-Cysteinyl-tRNA(Cys)
Metabolite ID: cystrna_c
Compartment: c


Metabolite name: Cytidine
Metabolite ID: cytd_c
Compartment: c


Metabolite name: Deoxyadenosine
Metabolite ID: dad_2_c
Compartment: c


Metabolite name: 5'-Deoxyadenosine
Metabolite ID: dad_5_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis5'-deoxyadenosine nuclosidase5DOANdad_5_c + h2o_c ⇋ 5drib_c + ade_c010000.0011-0.0011

Metabolite name: dADP
Metabolite ID: dadp_c
Compartment: c


Metabolite name: dAMP
Metabolite ID: damp_c
Compartment: c


Metabolite name: 7,8-Diaminononanoate
Metabolite ID: dann_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisadenosylmethionine-8-amino-7-oxononanoate transaminaseAMAOTramet_c + 8aonn_c ⇋ dann_c + amob_c-100010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-06-9.9e-06

Metabolite name: dATP
Metabolite ID: datp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.130.13
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.13

Metabolite name: 3,4-dihydroxy-2-butanone 4-phosphate
Metabolite ID: db4p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3,4-Dihydroxy-2-butanone-4-phosphate synthaseDB4PSru5p_D_c ⇋ db4p_c + for_c + h_c010000.00440.0044
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSadb4p_c + 4r5au_c ⇋ dmlz_c + pi_c + 2 h2o_c010000.0044-0.0044

Metabolite name: trans-Dec-2-enoyl-CoA
Metabolite ID: dc2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)ECOAH43hdcoa_c ⇋ h2o_c + dc2coa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (decanoyl-CoA)ACOAD4fdc2coa_c + fadh2_c ⇋ dcacoa_c + fad_c-100010001.8-1.8

Metabolite name: Decanoate (n-C10:0)
Metabolite ID: dca_c
Compartment: c


Metabolite name: Decanoyl-ACP (n-C10:0ACP)
Metabolite ID: dcaACP_c
Compartment: c


Metabolite name: Decanoyl-CoA (n-C10:0CoA)
Metabolite ID: dcacoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (decanoyl-CoA)ACOAD4fdc2coa_c + fadh2_c ⇋ dcacoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (decanoyl-CoA) (r)ACACT5raccoa_c + dcacoa_c ⇋ 3oddcoa_c + coa_c-100010001.8-1.8

Metabolite name: N6-(1,2-Dicarboxyethyl)-AMP
Metabolite ID: dcamp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.51.5
Purine and Pyrimidine Biosynthesisadenylsuccinate lyaseADSL1rdcamp_c ⇋ amp_c + fum_c-100010001.5-1.5

Metabolite name: dCDP
Metabolite ID: dcdp_c
Compartment: c


Metabolite name: dCMP
Metabolite ID: dcmp_c
Compartment: c


Metabolite name: dCTP
Metabolite ID: dctp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.130.13
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.13

Metabolite name: Deoxycytidine
Metabolite ID: dcyt_c
Compartment: c


Metabolite name: trans-Dodec-2-enoyl-CoA
Metabolite ID: dd2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)ECOAH53hddcoa_c ⇋ h2o_c + dd2coa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (dodecanoyl-CoA)ACOAD5fdd2coa_c + fadh2_c ⇋ fad_c + ddcacoa_c-100010001.8-1.8

Metabolite name: Dodecanoate (n-C12:0)
Metabolite ID: ddca_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (dodecanoate)FACOAE120ddcacoa_c + h2o_c ⇋ coa_c + ddca_c + h_c010000.380.38
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.38-0.38

Metabolite name: Dodecanoyl-ACP (n-C12:0ACP)
Metabolite ID: ddcaACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.380.38
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.38-0.38

Metabolite name: Dodecanoyl-CoA (n-C12:0CoA)
Metabolite ID: ddcacoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (dodecanoyl-CoA)ACOAD5fdd2coa_c + fadh2_c ⇋ fad_c + ddcacoa_c-100010001.81.8
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (dodecanoate)FACOAE120ddcacoa_c + h2o_c ⇋ coa_c + ddca_c + h_c010000.38-0.38
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)ACACT6rddcacoa_c + accoa_c ⇋ coa_c + 3otdcoa_c-100010001.4-1.4

Metabolite name: Dodecanoly-phosphate (n-C12:0)
Metabolite ID: ddcap_c
Compartment: c


Metabolite name: dGDP
Metabolite ID: dgdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwayribonucleoside-diphosphate reductase (GDP)RNDR2gdp_c + trdrd_c ⇋ dgdp_c + h2o_c + trdox_c010000.130.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dGDP)NDPK5atp_c + dgdp_c ⇋ dgtp_c + adp_c-100010000.13-0.13

Metabolite name: dGMP
Metabolite ID: dgmp_c
Compartment: c


Metabolite name: Selenodiglutathione
Metabolite ID: dgslnt_c
Compartment: c


Metabolite name: Deoxyguanosine
Metabolite ID: dgsn_c
Compartment: c


Metabolite name: dGTP
Metabolite ID: dgtp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dGDP)NDPK5atp_c + dgdp_c ⇋ dgtp_c + adp_c-100010000.130.13
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.13

Metabolite name: Dihydroxyacetone
Metabolite ID: dha_c
Compartment: c


Metabolite name: Dihydroxyacetone phosphate
Metabolite ID: dhap_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesistriose-phosphate isomeraseTPIg3p_c ⇋ dhap_c-100010002929
Cofactor and Prosthetic Group Biosynthesisquinolinate synthaseQULNSdhap_c + iasp_c ⇋ quln_c + pi_c + 2 h2o_c010000.011-0.011
Alternate Carbon Metabolismglycerol-3-phosphate dehydrogenase (NADP)G3PD2h_c + nadph_c + dhap_c ⇋ glyc3p_c + nadp_c-100010000.69-0.69
Glycolysis/Gluconeogenesisfructose-bisphosphate aldolaseFBAg3p_c + dhap_c ⇋ fdp_c-1000100028-28

Metabolite name: 2,3-dihydroxicinnamic acid
Metabolite ID: dhcinnm_c
Compartment: c


Metabolite name: 7,8-Dihydrofolate
Metabolite ID: dhf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaythymidylate synthaseTMDSmlthf_c + dump_c ⇋ dhf_c + dtmp_c010000.130.13
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate reductaseDHFRh_c + dhf_c + nadph_c ⇋ nadp_c + thf_c-100010000.13-0.13

Metabolite name: dehydroglycine
Metabolite ID: dhgly_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011

Metabolite name: Dihydromonapterin
Metabolite ID: dhmpt_c
Compartment: c


Metabolite name: dihydromonapterin-triphosphate
Metabolite ID: dhmptp_c
Compartment: c


Metabolite name: 1,4-Dihydroxy-2-naphthoate
Metabolite ID: dhna_c
Compartment: c


Metabolite name: Dihydroneopterin
Metabolite ID: dhnpt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin monophosphate dephosphorylaseDNMPPAdhpmp_c + h2o_c ⇋ dhnpt_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydroneopterin aldolase reversibleDHNPA2rdhnpt_c ⇋ 6hmhpt_c + gcald_c-100010000.0033-0.0033

Metabolite name: (S)-Dihydroorotate
Metabolite ID: dhor_S_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine BiosynthesisdihydroorotaseDHORTSh_c + cbasp_c ⇋ dhor_S_c + h2o_c-100010001.61.6
Purine and Pyrimidine Biosynthesisdihydoorotic acid dehydrogenase (quinone8)DHORD2q8_c + dhor_S_c ⇋ orot_c + q8h2_c010001.6-1.6

Metabolite name: Dihydroneopterin monophosphate
Metabolite ID: dhpmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin triphosphate pyrophosphataseDNTPPAahdt_c + h2o_c ⇋ ppi_c + dhpmp_c + h_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin monophosphate dephosphorylaseDNMPPAdhpmp_c + h2o_c ⇋ dhnpt_c + pi_c010000.0033-0.0033

Metabolite name: 3-(2,3-Dihydroxyphenyl)propanoate
Metabolite ID: dhpppn_c
Compartment: c


Metabolite name: Dihydropteroate
Metabolite ID: dhpt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisdihydropteroate synthaseDHPS26hmhptpp_c + 4abz_c ⇋ dhpt_c + ppi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.0033-0.0033

Metabolite name: 4,5-dihydroxy-2,3-pentanedione
Metabolite ID: dhptd_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine MetabolismS-ribosylhomocysteine cleavage enzymeRHCCErhcys_c ⇋ dhptd_c + hcys_L_c010000.00220.0022
Methionine Metabolism4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)DHPTDCs2dhptd_c ⇋ mdhdhf_c010000.0022-0.0022

Metabolite name: 6,7-Dihydropteridine
Metabolite ID: dhptdn_c
Compartment: c


Metabolite name: dIDP
Metabolite ID: didp_c
Compartment: c


Metabolite name: dIMP
Metabolite ID: dimp_c
Compartment: c


Metabolite name: Deoxyinosine
Metabolite ID: din_c
Compartment: c


Metabolite name: dITP
Metabolite ID: ditp_c
Compartment: c


Metabolite name: 5,6-Dimethylbenzimidazole
Metabolite ID: dmbzid_c
Compartment: c


Metabolite name: 6,7-Dimethyl-8-(1-D-ribityl)lumazine
Metabolite ID: dmlz_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSadb4p_c + 4r5au_c ⇋ dmlz_c + pi_c + 2 h2o_c010000.00440.0044
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSb2 dmlz_c ⇋ 4r5au_c + ribflv_c010000.0022-0.0044

Metabolite name: Dimethylallyl diphosphate
Metabolite ID: dmpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisdimethylallyltranstransferaseDMATTdmpp_c + ipdp_c ⇋ grdp_c + ppi_c010000.0014-0.0014

Metabolite name: Dimethyl sulfide
Metabolite ID: dms_c
Compartment: c


Metabolite name: Dimethyl sulfoxide
Metabolite ID: dmso_c
Compartment: c


Metabolite name: Deamino-NAD+
Metabolite ID: dnad_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynicotinate-nucleotide adenylyltransferaseNNATrnicrnt_c + h_c + atp_c ⇋ ppi_c + dnad_c-100010000.0110.011
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.011-0.011

Metabolite name: Dephospho-CoA
Metabolite ID: dpcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesispantetheine-phosphate adenylyltransferasePTPATih_c + atp_c + pan4p_c ⇋ ppi_c + dpcoa_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisdephospho-CoA kinaseDPCOAKdpcoa_c + atp_c ⇋ coa_c + adp_c + h_c010000.0028-0.0028

Metabolite name: fused thiol:disulfide interchange protein (oxidized)
Metabolite ID: dsbdox_c
Compartment: c


Metabolite name: fused thiol:disulfide interchange protein (reduced)
Metabolite ID: dsbdrd_c
Compartment: c


Metabolite name: dihydrosirohydrochlorin
Metabolite ID: dscl_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen methyltransferaseUPP3MTuppg3_c + 2 amet_c ⇋ dscl_c + 2 ahcys_c + h_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin dehydrogenase (NAD)SHCHD2dscl_c + nad_c ⇋ nadh_c + scl_c + h_c010000.0011-0.0011

Metabolite name: Dethiobiotin
Metabolite ID: dtbt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-06-9.9e-06

Metabolite name: dTDP
Metabolite ID: dtdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage PathwaydTMP kinaseDTMPKdtmp_c + atp_c ⇋ adp_c + dtdp_c-100010000.130.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dTDP)NDPK4dtdp_c + atp_c ⇋ adp_c + dttp_c-100010000.13-0.13

Metabolite name: dTDP-4-acetamido-4,6-dideoxy-D-galactose
Metabolite ID: dtdp4aaddg_c
Compartment: c


Metabolite name: dTDP-4-amino-4,6-dideoxy-D-galactose
Metabolite ID: dtdp4addg_c
Compartment: c


Metabolite name: dTDP-4-dehydro-6-deoxy-D-glucose
Metabolite ID: dtdp4d6dg_c
Compartment: c


Metabolite name: dTDP-4-dehydro-6-deoxy-L-mannose
Metabolite ID: dtdp4d6dm_c
Compartment: c


Metabolite name: dTDPglucose
Metabolite ID: dtdpglu_c
Compartment: c


Metabolite name: dTDP-L-rhamnose
Metabolite ID: dtdprmn_c
Compartment: c


Metabolite name: dTMP
Metabolite ID: dtmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaythymidylate synthaseTMDSmlthf_c + dump_c ⇋ dhf_c + dtmp_c010000.130.13
Nucleotide Salvage PathwaydTMP kinaseDTMPKdtmp_c + atp_c ⇋ adp_c + dtdp_c-100010000.13-0.13

Metabolite name: dTTP
Metabolite ID: dttp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:dTDP)NDPK4dtdp_c + atp_c ⇋ adp_c + dttp_c-100010000.130.13
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.13

Metabolite name: dUDP
Metabolite ID: dudp_c
Compartment: c


Metabolite name: dUMP
Metabolite ID: dump_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage PathwaydUTP diphosphataseDUTPDPh2o_c + dutp_c ⇋ ppi_c + dump_c + h_c010000.130.13
Nucleotide Salvage Pathwaythymidylate synthaseTMDSmlthf_c + dump_c ⇋ dhf_c + dtmp_c010000.13-0.13

Metabolite name: Deoxyuridine
Metabolite ID: duri_c
Compartment: c


Metabolite name: dUTP
Metabolite ID: dutp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.130.13
Nucleotide Salvage PathwaydUTP diphosphataseDUTPDPh2o_c + dutp_c ⇋ ppi_c + dump_c + h_c010000.13-0.13

Metabolite name: 1-deoxy-D-xylulose
Metabolite ID: dxyl_c
Compartment: c


Metabolite name: 1-deoxy-D-xylulose 5-phosphate
Metabolite ID: dxyl5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose 5-phosphate synthaseDXPSpyr_c + g3p_c + h_c ⇋ dxyl5p_c + co2_c010000.0140.014
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose reductoisomeraseDXPRIidxyl5p_c + h_c + nadph_c ⇋ 2me4p_c + nadp_c010000.012-0.012

Metabolite name: D-Erythrose 4-phosphate
Metabolite ID: e4p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pentose Phosphate Pathwaytransketolase2TKT2g3p_c + f6p_c ⇋ xu5p_D_c + e4p_c-100010001515
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.0011-0.0011
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-deoxy-D-arabino-heptulosonate 7-phosphate synthetaseDDPAe4p_c + h2o_c + pep_c ⇋ 2dda7p_c + pi_c010001.9-1.9
Pentose Phosphate PathwaytransaldolaseTALAf6p_c + e4p_c ⇋ g3p_c + s7p_c-1000100013-13

Metabolite name: Enoylglutaryl-[acyl-carrier protein] methyl ester
Metabolite ID: egmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester dehydrataseOGMEACPDhgmeACP_c ⇋ h2o_c + egmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylglutaryl-[ACP] methyl ester reductaseEGMEACPRegmeACP_c + h_c + nadph_c ⇋ nadp_c + gmeACP_c010009.9e-06-9.9e-06

Metabolite name: D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate
Metabolite ID: eig3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.470.47
Histidine Metabolismimidazoleglycerol-phosphate dehydrataseIGPDHeig3p_c ⇋ imacp_c + h2o_c010000.47-0.47

Metabolite name: Enterochelin
Metabolite ID: enter_c
Compartment: c


Metabolite name: Enoylpimeloyl-[acyl-carrier protein] methyl ester
Metabolite ID: epmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester dehydrataseOPMEACPDhpmeACP_c ⇋ epmeACP_c + h2o_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylpimeloyl-[ACP] methyl ester reductaseEPMEACPRh_c + epmeACP_c + nadph_c ⇋ nadp_c + pmeACP_c010009.9e-06-9.9e-06

Metabolite name: Ethanolamine
Metabolite ID: etha_c
Compartment: c


Metabolite name: ethanesulfonate
Metabolite ID: ethso3_c
Compartment: c


Metabolite name: Ethanol
Metabolite ID: etoh_c
Compartment: c


Metabolite name: D-Fructose 1-phosphate
Metabolite ID: f1p_c
Compartment: c


Metabolite name: D-Fructose 6-phosphate
Metabolite ID: f6p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisfructose-bisphosphataseFBPh2o_c + fdp_c ⇋ pi_c + f6p_c010002828
Cell Envelope Biosynthesisglutamine-fructose-6-phosphate transaminaseGF6PTAf6p_c + gln_L_c ⇋ gam6p_c + glu_L_c010000.47-0.47
Pentose Phosphate PathwaytransaldolaseTALAf6p_c + e4p_c ⇋ g3p_c + s7p_c-1000100013-13
Pentose Phosphate Pathwaytransketolase2TKT2g3p_c + f6p_c ⇋ xu5p_D_c + e4p_c-1000100015-15

Metabolite name: Flavin adenine dinucleotide oxidized
Metabolite ID: fad_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (decanoyl-CoA)ACOAD4fdc2coa_c + fadh2_c ⇋ dcacoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (butanoyl-CoA)ACOAD1fb2coa_c + fadh2_c ⇋ fad_c + btcoa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexanoyl-CoA)ACOAD2ffadh2_c + hx2coa_c ⇋ hxcoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (dodecanoyl-CoA)ACOAD5fdd2coa_c + fadh2_c ⇋ fad_c + ddcacoa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (octanoyl-CoA)ACOAD3ffadh2_c + oc2coa_c ⇋ occoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (tetradecanoyl-CoA)ACOAD6ftd2coa_c + fadh2_c ⇋ tdcoa_c + fad_c-100010001.41.4
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexadecanoyl-CoA)ACOAD7fhdd2coa_c + fadh2_c ⇋ pmtcoa_c + fad_c-100010000.630.63
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] ReductionI4FE4SRiscu_2fe2s2_c + 2 h_c + fadh2_c ⇋ fad_c + iscu_4fe4s_c010000.00130.0013
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.00130.0013
Cofactor and Prosthetic Group BiosynthesisFMN adenylyltransferaseFMNATh_c + atp_c + fmn_c ⇋ fad_c + ppi_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Cofactor and Prosthetic Group BiosynthesisFAD reductaseFADRxnadh_c + fad_c + h_c ⇋ nad_c + fadh2_c0100011-11

Metabolite name: Flavin adenine dinucleotide reduced
Metabolite ID: fadh2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisFAD reductaseFADRxnadh_c + fad_c + h_c ⇋ nad_c + fadh2_c010001111
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] ReductionI4FE4SRiscu_2fe2s2_c + 2 h_c + fadh2_c ⇋ fad_c + iscu_4fe4s_c010000.0013-0.0013
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.0013-0.0013
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.0014-0.0014
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexadecanoyl-CoA)ACOAD7fhdd2coa_c + fadh2_c ⇋ pmtcoa_c + fad_c-100010000.63-0.63
Membrane Lipid Metabolismacyl-CoA dehydrogenase (tetradecanoyl-CoA)ACOAD6ftd2coa_c + fadh2_c ⇋ tdcoa_c + fad_c-100010001.4-1.4
Membrane Lipid Metabolismacyl-CoA dehydrogenase (octanoyl-CoA)ACOAD3ffadh2_c + oc2coa_c ⇋ occoa_c + fad_c-100010001.8-1.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (decanoyl-CoA)ACOAD4fdc2coa_c + fadh2_c ⇋ dcacoa_c + fad_c-100010001.8-1.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexanoyl-CoA)ACOAD2ffadh2_c + hx2coa_c ⇋ hxcoa_c + fad_c-100010001.8-1.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (dodecanoyl-CoA)ACOAD5fdd2coa_c + fadh2_c ⇋ fad_c + ddcacoa_c-100010001.8-1.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (butanoyl-CoA)ACOAD1fb2coa_c + fadh2_c ⇋ fad_c + btcoa_c-100010001.8-1.8

Metabolite name: Formaldehyde
Metabolite ID: fald_c
Compartment: c


Metabolite name: L-Fuculose 1-phosphate
Metabolite ID: fc1p_c
Compartment: c


Metabolite name: L-fuculose
Metabolite ID: fcl_L_c
Compartment: c


Metabolite name: D-Fructose 1,6-bisphosphate
Metabolite ID: fdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisfructose-bisphosphate aldolaseFBAg3p_c + dhap_c ⇋ fdp_c-100010002828
Glycolysis/Gluconeogenesisfructose-bisphosphataseFBPh2o_c + fdp_c ⇋ pi_c + f6p_c0100028-28

Metabolite name: Fe2+
Metabolite ID: fe2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismiron (+2) transport in via permease (no H+)FE2tppfe2_p ⇋ fe2_c010000.0790.079
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin ferrochelataseSHCHFscl_c + fe2_c ⇋ sheme_c + 3 h_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisFerrochelataseFCLTppp9_c + fe2_c ⇋ 2 h_c + pheme_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.0013-0.0026
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.0014-0.0028
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.033
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster repairFESRfe2_c + 3fe4s_c ⇋ 4fe4s_c010000.038-0.038

Metabolite name: Fe3+
Metabolite ID: fe3_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.0190.038
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.038

Metabolite name: ferric 2,3-dihydroxybenzoylserine
Metabolite ID: fe3dhbzs_c
Compartment: c


Metabolite name: Fe(III)hydroxamate
Metabolite ID: fe3hox_c
Compartment: c


Metabolite name: Fe(III)hydoxamate, unloaded
Metabolite ID: fe3hox_un_c
Compartment: c


Metabolite name: Ferrichrome
Metabolite ID: fecrm_c
Compartment: c


Metabolite name: Ferrichrome minus Fe(III)
Metabolite ID: fecrm_un_c
Compartment: c


Metabolite name: Fe-enterobactin
Metabolite ID: feenter_c
Compartment: c


Metabolite name: ferroxamine
Metabolite ID: feoxam_c
Compartment: c


Metabolite name: ferroxamine minus Fe(3)
Metabolite ID: feoxam_un_c
Compartment: c


Metabolite name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
Metabolite ID: fgam_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide formyltransferaseGARFT10fthf_c + gar_c ⇋ fgam_c + thf_c + h_c-100010002.22.2
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.0120.012
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.2-2.2

Metabolite name: Flavodoxin reduced
Metabolite ID: flxr_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Unassignedflavodoxin reductase (NADPH)FLDR22 flxso_c + nadph_c ⇋ h_c + nadp_c + 2 flxr_c010001e+022.1e+02
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.012-0.024
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.13-0.26
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.13-0.26
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.13-0.27
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+02-2.1e+02

Metabolite name: flavodoxin semi oxidized
Metabolite ID: flxso_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+022.1e+02
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.130.27
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.130.26
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.130.26
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.0120.024
Unassignedflavodoxin reductase (NADPH)FLDR22 flxso_c + nadph_c ⇋ h_c + nadp_c + 2 flxr_c010001e+02-2.1e+02

Metabolite name: N-Formylmethionyl-tRNA
Metabolite ID: fmettrna_c
Compartment: c


Metabolite name: FMN
Metabolite ID: fmn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisriboflavin kinaseRBFKatp_c + ribflv_c ⇋ adp_c + h_c + fmn_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisFMN adenylyltransferaseFMNATh_c + atp_c + fmn_c ⇋ fad_c + ppi_c010000.0011-0.0011

Metabolite name: Reduced FMN
Metabolite ID: fmnh2_c
Compartment: c


Metabolite name: Formate
Metabolite ID: for_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3,4-Dihydroxy-2-butanone-4-phosphate synthaseDB4PSru5p_D_c ⇋ db4p_c + for_c + h_c010000.00440.0044
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase IGTPCIh2o_c + gtp_c ⇋ ahdt_c + for_c + h_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.00110.0022
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.012-0.012

Metabolite name: Formyl-CoA
Metabolite ID: forcoa_c
Compartment: c


Metabolite name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
Metabolite ID: fpram_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.2-2.2

Metabolite name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Metabolite ID: fprica_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolecarboxamide formyltransferaseAICART10fthf_c + aicar_c ⇋ fprica_c + thf_c-100010002.72.7
Purine and Pyrimidine BiosynthesisIMP cyclohydrolaseIMPCfprica_c ⇋ imp_c + h2o_c-100010002.7-2.7

Metabolite name: Farnesyl diphosphate
Metabolite ID: frdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisgeranyltranstransferaseGRTTipdp_c + grdp_c ⇋ frdp_c + ppi_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisUndecaprenyl diphosphate synthaseUDCPDPS8 ipdp_c + frdp_c ⇋ 8 ppi_c + udcpdp_c010000.00027-0.00027
Cofactor and Prosthetic Group BiosynthesisOctaprenyl pyrophosphate synthaseOCTDPS5 ipdp_c + frdp_c ⇋ octdp_c + 5 ppi_c010000.0011-0.0011

Metabolite name: D-Fructose
Metabolite ID: fru_c
Compartment: c


Metabolite name: fructoselysine
Metabolite ID: frulys_c
Compartment: c


Metabolite name: fructoselysine Phosphate
Metabolite ID: frulysp_c
Compartment: c


Metabolite name: D-Fructuronate
Metabolite ID: fruur_c
Compartment: c


Metabolite name: L-Fucose
Metabolite ID: fuc_L_c
Compartment: c


Metabolite name: Fumarate
Metabolite ID: fum_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisadenylosuccinate lyaseADSL2r25aics_c ⇋ aicar_c + fum_c-100010002.22.2
Purine and Pyrimidine Biosynthesisadenylsuccinate lyaseADSL1rdcamp_c ⇋ amp_c + fum_c-100010001.51.5
Arginine and Proline Metabolismargininosuccinate lyaseARGSLargsuc_c ⇋ arg_L_c + fum_c-100010001.51.5
Oxidative Phosphorylationsuccinate dehydrogenase (irreversible)SUCDiq8_c + succ_c ⇋ fum_c + q8h2_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisprotoporphyrinogen oxidase (anaerobic)PPPGO3pppg9_c + 3 fum_c ⇋ ppp9_c + 3 succ_c010000.0011-0.0033
Citric Acid CyclefumaraseFUMh2o_c + fum_c ⇋ mal_L_c-100010005.1-5.1

Metabolite name: D-Glucose 1-phosphate
Metabolite ID: g1p_c
Compartment: c


Metabolite name: Glyceraldehyde 3-phosphate
Metabolite ID: g3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-100010007171
Pentose Phosphate PathwaytransaldolaseTALAf6p_c + e4p_c ⇋ g3p_c + s7p_c-100010001313
Tyrosine, Tryptophan, and Phenylalanine Metabolismtryptophan synthase (indoleglycerol phosphate)TRPS1ser_L_c + 3ig3p_c ⇋ g3p_c + trp_L_c + h2o_c010000.280.28
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose 5-phosphate synthaseDXPSpyr_c + g3p_c + h_c ⇋ dxyl5p_c + co2_c010000.014-0.014
Pentose Phosphate Pathwaytransketolase1TKT1g3p_c + s7p_c ⇋ r5p_c + xu5p_D_c-1000100013-13
Pentose Phosphate Pathwaytransketolase2TKT2g3p_c + f6p_c ⇋ xu5p_D_c + e4p_c-1000100015-15
Glycolysis/Gluconeogenesisfructose-bisphosphate aldolaseFBAg3p_c + dhap_c ⇋ fdp_c-1000100028-28
Glycolysis/Gluconeogenesistriose-phosphate isomeraseTPIg3p_c ⇋ dhap_c-1000100029-29

Metabolite name: sn-Glycero-3-phosphocholine
Metabolite ID: g3pc_c
Compartment: c


Metabolite name: sn-Glycero-3-phosphoethanolamine
Metabolite ID: g3pe_c
Compartment: c


Metabolite name: Glycerophosphoglycerol
Metabolite ID: g3pg_c
Compartment: c


Metabolite name: sn-Glycero-3-phospho-1-inositol
Metabolite ID: g3pi_c
Compartment: c


Metabolite name: Glycerophosphoserine
Metabolite ID: g3ps_c
Compartment: c


Metabolite name: D-Glucose 6-phosphate
Metabolite ID: g6p_c
Compartment: c


Metabolite name: galactosyl-glucosyl-inner core oligosaccharide lipid A
Metabolite ID: gagicolipa_c
Compartment: c


Metabolite name: D-Galactose
Metabolite ID: gal_c
Compartment: c


Metabolite name: alpha-D-Galactose 1-phosphate
Metabolite ID: gal1p_c
Compartment: c


Metabolite name: D-Galactarate
Metabolite ID: galct_D_c
Compartment: c


Metabolite name: D-Galactonate
Metabolite ID: galctn_D_c
Compartment: c


Metabolite name: L-Galactonate
Metabolite ID: galctn_L_c
Compartment: c


Metabolite name: Galactitol 1-phosphate
Metabolite ID: galt1p_c
Compartment: c


Metabolite name: D-Galacturonate
Metabolite ID: galur_c
Compartment: c


Metabolite name: D-Glucosamine 1-phosphate
Metabolite ID: gam1p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisphosphoglucosamine mutasePGAMTgam6p_c ⇋ gam1p_c-100010000.470.47
Cell Envelope Biosynthesisglucosamine-1-phosphate N-acetyltransferaseG1PACTgam1p_c + accoa_c ⇋ coa_c + h_c + acgam1p_c010000.47-0.47

Metabolite name: D-Glucosamine 6-phosphate
Metabolite ID: gam6p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisglutamine-fructose-6-phosphate transaminaseGF6PTAf6p_c + gln_L_c ⇋ gam6p_c + glu_L_c010000.470.47
Cell Envelope Biosynthesisphosphoglucosamine mutasePGAMTgam6p_c ⇋ gam1p_c-100010000.47-0.47

Metabolite name: N1-(5-Phospho-D-ribosyl)glycinamide
Metabolite ID: gar_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.22.2
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.012-0.012
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide formyltransferaseGARFT10fthf_c + gar_c ⇋ fgam_c + thf_c + h_c-100010002.2-2.2

Metabolite name: glucosyl-O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate
Metabolite ID: garagund_c
Compartment: c


Metabolite name: gamma-butyrobetaine
Metabolite ID: gbbtn_c
Compartment: c


Metabolite name: Glycolaldehyde
Metabolite ID: gcald_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisdihydroneopterin aldolase reversibleDHNPA2rdhnpt_c ⇋ 6hmhpt_c + gcald_c-100010000.00330.0033
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.0033-0.0033

Metabolite name: GDP
Metabolite ID: gdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.51.5
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.21.2
Nucleotide Salvage Pathwayguanylate kinase (GMP:ATP)GK1gmp_c + atp_c ⇋ adp_c + gdp_c-100010001.21.2
Nucleotide Salvage Pathwayribonucleoside-diphosphate reductase (GDP)RNDR2gdp_c + trdrd_c ⇋ dgdp_c + h2o_c + trdox_c010000.13-0.13
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:GDP)NDPK1atp_c + gdp_c ⇋ adp_c + gtp_c-100010003.8-3.8

Metabolite name: GDP-4-dehydro-6-deoxy-D-mannose
Metabolite ID: gdpddman_c
Compartment: c


Metabolite name: GDP-L-fucose
Metabolite ID: gdpfuc_c
Compartment: c


Metabolite name: GDP-D-mannose
Metabolite ID: gdpmann_c
Compartment: c


Metabolite name: GDP-4-oxo-L-fucose
Metabolite ID: gdpofuc_c
Compartment: c


Metabolite name: Guanosine 3'-diphosphate 5'-triphosphate
Metabolite ID: gdptp_c
Compartment: c


Metabolite name: galactofuranosyl-glucosyl-O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate
Metabolite ID: gfgaragund_c
Compartment: c


Metabolite name: gamma-glutamyl-gamma aminobutyric acid
Metabolite ID: gg4abut_c
Compartment: c


Metabolite name: glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A
Metabolite ID: ggagicolipa_c
Compartment: c


Metabolite name: gamma-glutamyl-gamma-butyraldehyde
Metabolite ID: ggbutal_c
Compartment: c


Metabolite name: glucosyl-glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A
Metabolite ID: gggagicolipa_c
Compartment: c


Metabolite name: gamma-glutamyl-putrescine
Metabolite ID: ggptrc_c
Compartment: c


Metabolite name: gamma-hydroxybutyrate
Metabolite ID: ghb_c
Compartment: c


Metabolite name: glucosyl-inner core oligosaccharide lipid A
Metabolite ID: gicolipa_c
Compartment: c


Metabolite name: D-Glucose
Metabolite ID: glc_D_c
Compartment: c


Metabolite name: D-Gluconate
Metabolite ID: glcn_c
Compartment: c


Metabolite name: D-Glucarate
Metabolite ID: glcr_c
Compartment: c


Metabolite name: D-Glucuronate
Metabolite ID: glcur_c
Compartment: c


Metabolite name: L-Glutamine
Metabolite ID: gln_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.98.9
Cofactor and Prosthetic Group Biosynthesis4-amino-4-deoxychorismate synthaseADCSchor_c + gln_L_c ⇋ 4adcho_c + glu_L_c010000.0033-0.0033
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.28-0.28
Cell Envelope Biosynthesisglutamine-fructose-6-phosphate transaminaseGF6PTAf6p_c + gln_L_c ⇋ gam6p_c + glu_L_c010000.47-0.47
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.47-0.47
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.79-0.79
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.2-1.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.3
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.2-2.2

Metabolite name: L-Glutaminyl-tRNA(Gln)
Metabolite ID: glntrna_c
Compartment: c


Metabolite name: D-Glutamate
Metabolite ID: glu_D_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisglutamate racemaseGLURglu_L_c ⇋ glu_D_c-100010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.14-0.14

Metabolite name: L-Glutamate
Metabolite ID: glu_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+021.6e+02
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.22.2
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.21.2
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.790.79
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.470.47
Cell Envelope Biosynthesisglutamine-fructose-6-phosphate transaminaseGF6PTAf6p_c + gln_L_c ⇋ gam6p_c + glu_L_c010000.470.47
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.280.28
Cofactor and Prosthetic Group Biosynthesis4-amino-4-deoxychorismate synthaseADCSchor_c + gln_L_c ⇋ 4adcho_c + glu_L_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisO-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferaseOHPBATglu_L_c + ohpb_c ⇋ akg_c + phthr_c-100010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.0033-0.0033
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.018-0.018
Cell Envelope Biosynthesisglutamate racemaseGLURglu_L_c ⇋ glu_D_c-100010000.14-0.14
Histidine Metabolismhistidinol-phosphate transaminaseHSTPTimacp_c + glu_L_c ⇋ akg_c + hisp_c010000.47-0.47
Tyrosine, Tryptophan, and Phenylalanine Metabolismtyrosine transaminaseTYRTA34hpp_c + glu_L_c ⇋ tyr_L_c + akg_c-100010000.68-0.68
Tyrosine, Tryptophan, and Phenylalanine Metabolismphenylalanine transaminasePHETA1glu_L_c + phpyr_c ⇋ phe_L_c + akg_c-100010000.91-0.91
Arginine and Proline Metabolismglutamate 5-kinaseGLU5Kglu_L_c + atp_c ⇋ adp_c + glu5p_c010001.1-1.1
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.3
Valine, Leucine, and Isoleucine Metabolismisoleucine transaminaseILETAglu_L_c + 3mop_c ⇋ ile_L_c + akg_c-100010001.4-1.4
Arginine and Proline MetabolismN-acetylglutamate synthaseACGSglu_L_c + accoa_c ⇋ coa_c + h_c + acglu_c010001.5-1.5
Arginine and Proline Metabolismacetylornithine transaminaseACOTAacg5sa_c + glu_L_c ⇋ acorn_c + akg_c-100010001.5-1.5
Threonine and Lysine Metabolismsuccinyldiaminopimelate transaminaseSDPTAglu_L_c + sl2a6o_c ⇋ sl26da_c + akg_c-100010001.8-1.8
Valine, Leucine, and Isoleucine Metabolismvaline transaminaseVALTA3mob_c + glu_L_c ⇋ akg_c + val_L_c-100010002.1-2.1
Valine, Leucine, and Isoleucine Metabolismleucine transaminase (irreversible)LEUTAiglu_L_c + 4mop_c ⇋ leu_L_c + akg_c010002.2-2.2
Alanine and Aspartate MetabolismL-alanine transaminaseALATA_Lpyr_c + glu_L_c ⇋ ala_L_c + akg_c-100010002.9-2.9
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.9-8.9
Alanine and Aspartate Metabolismaspartate transaminaseASPTAglu_L_c + oaa_c ⇋ akg_c + asp_L_c-100010001.4e+02-1.4e+02

Metabolite name: L-Glutamate 1-semialdehyde
Metabolite ID: glu1sa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.0180.018
Cofactor and Prosthetic Group Biosynthesisglutamate-1-semialdehyde aminotransferaseG1SATglu1sa_c ⇋ 5aop_c-100010000.018-0.018

Metabolite name: L-Glutamate 5-phosphate
Metabolite ID: glu5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismglutamate 5-kinaseGLU5Kglu_L_c + atp_c ⇋ adp_c + glu5p_c010001.11.1
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.1-1.1

Metabolite name: L-Glutamate 5-semialdehyde
Metabolite ID: glu5sa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.11.1
Arginine and Proline MetabolismL-glutamate 5-semialdehyde dehydratase (spontaneous)G5SADsglu5sa_c ⇋ 1pyr5c_c + h_c + h2o_c010001.1-1.1

Metabolite name: gamma-L-Glutamyl-L-cysteine
Metabolite ID: glucys_c
Compartment: c


Metabolite name: L-Glutamyl-tRNA(Glu)
Metabolite ID: glutrna_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.0180.018
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.018-0.018

Metabolite name: Glyoxylate
Metabolite ID: glx_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alternate Carbon MetabolismGlycolate oxidaseGLYCTO2q8_c + glyclt_c ⇋ q8h2_c + glx_c010000.00330.0033
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.0033-0.0033

Metabolite name: Glycine
Metabolite ID: gly_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycine and Serine Metabolismglycine C-acetyltransferaseGLYATcoa_c + 2aobut_c ⇋ gly_c + accoa_c-100010001.3e+021.3e+02
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.2-2.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-3
Glycine and Serine Metabolismglycine hydroxymethyltransferase, reversibleGHMT2rgly_c + mlthf_c + h2o_c ⇋ thf_c + ser_L_c-1000100057-57
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c0100063-63

Metabolite name: D-Glyceraldehyde
Metabolite ID: glyald_c
Compartment: c


Metabolite name: Glycine betaine
Metabolite ID: glyb_c
Compartment: c


Metabolite name: Glycerol
Metabolite ID: glyc_c
Compartment: c


Metabolite name: (R)-Glycerate
Metabolite ID: glyc_R_c
Compartment: c


Metabolite name: Glycerol 2-phosphate
Metabolite ID: glyc2p_c
Compartment: c


Metabolite name: Glycerol 3-phosphate
Metabolite ID: glyc3p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alternate Carbon Metabolismglycerol-3-phosphate dehydrogenase (NADP)G3PD2h_c + nadph_c + dhap_c ⇋ glyc3p_c + nadp_c-100010000.690.69
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:0)G3PAT160palmACP_c + glyc3p_c ⇋ ACP_c + 1hdecg3p_c010000.31-0.31
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:1)G3PAT161hdeACP_c + glyc3p_c ⇋ ACP_c + 1hdec9eg3p_c010000.37-0.37

Metabolite name: Glycolate
Metabolite ID: glyclt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.00330.0033
Alternate Carbon MetabolismGlycolate oxidaseGLYCTO2q8_c + glyclt_c ⇋ q8h2_c + glx_c010000.0033-0.0033

Metabolite name: glycogen
Metabolite ID: glycogen_c
Compartment: c


Metabolite name: Glycyl-tRNA(Gly)
Metabolite ID: glytrna_c
Compartment: c


Metabolite name: Glutaryl-[acyl-carrier protein] methyl ester
Metabolite ID: gmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisEnoylglutaryl-[ACP] methyl ester reductaseEGMEACPRegmeACP_c + h_c + nadph_c ⇋ nadp_c + gmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-06-9.9e-06

Metabolite name: D-Glycero-D-manno-heptose 1,7-bisphosphate
Metabolite ID: gmhep17bp_c
Compartment: c


Metabolite name: D-Glycero-D-manno-heptose 1-phosphate
Metabolite ID: gmhep1p_c
Compartment: c


Metabolite name: D-Glycero-D-manno-heptose 7-phosphate
Metabolite ID: gmhep7p_c
Compartment: c


Metabolite name: GMP
Metabolite ID: gmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.21.2
Nucleotide Salvage Pathwayguanylate kinase (GMP:ATP)GK1gmp_c + atp_c ⇋ adp_c + gdp_c-100010001.2-1.2

Metabolite name: P1,P4-Bis(5'-guanosyl) tetraphosphate
Metabolite ID: gp4g_c
Compartment: c


Metabolite name: Geranyl diphosphate
Metabolite ID: grdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisdimethylallyltranstransferaseDMATTdmpp_c + ipdp_c ⇋ grdp_c + ppi_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisgeranyltranstransferaseGRTTipdp_c + grdp_c ⇋ frdp_c + ppi_c010000.0014-0.0014

Metabolite name: glutaredoxin (oxidized)
Metabolite ID: grxox_c
Compartment: c


Metabolite name: glutaredoxin (reduced)
Metabolite ID: grxrd_c
Compartment: c


Metabolite name: Glutathiolselenolate
Metabolite ID: gslnt_c
Compartment: c


Metabolite name: Guanosine
Metabolite ID: gsn_c
Compartment: c


Metabolite name: Oxidized glutathione
Metabolite ID: gthox_c
Compartment: c


Metabolite name: Reduced glutathione
Metabolite ID: gthrd_c
Compartment: c


Metabolite name: GTP
Metabolite ID: gtp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:GDP)NDPK1atp_c + gdp_c ⇋ adp_c + gtp_c-100010003.83.8
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthaseBMOGDS2bmoco1gdp_c + h_c + gtp_c ⇋ ppi_c + bmocogdp_c010000.0006-0.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthase (single GDP)BMOGDS1bmoco_c + h_c + gtp_c ⇋ bmoco1gdp_c + ppi_c010000.0006-0.0006
Cofactor and Prosthetic Group Biosynthesiscyclic pyranopterin monophosphate synthaseCPMPSgtp_c + h2o_c ⇋ ppi_c + cpmp_c010000.0012-0.0012
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.0022-0.0022
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase IGTPCIh2o_c + gtp_c ⇋ ahdt_c + for_c + h_c010000.0033-0.0033
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.1
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.2-1.2
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.5-1.5

Metabolite name: Glutathionylspermidine
Metabolite ID: gtspmd_c
Compartment: c


Metabolite name: Guanine
Metabolite ID: gua_c
Compartment: c


Metabolite name: H+
Metabolite ID: h_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+022.9e+03
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+021.1e+03
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+022.9e+02
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.92.7e+02
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+021.4e+02
Threonine and Lysine Metabolismhomoserine kinaseHSKhom_L_c + atp_c ⇋ phom_c + adp_c + h_c010001.3e+021.3e+02
Glycine and Serine MetabolismL-threonine dehydrogenaseTHRDnad_c + thr_L_c ⇋ nadh_c + h_c + 2aobut_c010001.3e+021.3e+02
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c01000361.1e+02
Unassignedflavodoxin reductase (NADPH)FLDR22 flxso_c + nadph_c ⇋ h_c + nadp_c + 2 flxr_c010001e+021e+02
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.98.9
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.16.2
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.35.3
Citric Acid Cyclemalate dehydrogenaseMDHnad_c + mal_L_c ⇋ nadh_c + h_c + oaa_c-100010005.15.1
Folate Metabolismmethenyltetrahydrofolate cyclohydrolaseMTHFCmethf_c + h2o_c ⇋ h_c + 10fthf_c-100010004.94.9
Inorganic Ion Transport and Metabolismphosphate reversible transport via symport (periplasm)PIt2rpppi_p + h_p ⇋ h_c + pi_c-100010004.84.8
Histidine Metabolismphosphoribosylpyrophosphate synthetasePRPPSatp_c + r5p_c ⇋ amp_c + h_c + prpp_c-100010004.64.6
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.24.4
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.52.9
UnassignedHCO3 equilibration reactionHCO3Eco2_c + h2o_c ⇋ h_c + hco3_c-100010002.62.6
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.22.4
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.22.4
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrogenaseIPMDnad_c + 3c2hmp_c ⇋ nadh_c + h_c + 3c4mop_c010002.22.2
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide formyltransferaseGARFT10fthf_c + gar_c ⇋ fgam_c + thf_c + h_c-100010002.22.2
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate kinaseSHKKskm_c + atp_c ⇋ skm5p_c + adp_c + h_c010001.91.9
Threonine and Lysine Metabolismdihydrodipicolinate synthaseDHDPSpyr_c + aspsa_c ⇋ h_c + 2 h2o_c + 23dhdp_c010001.81.8
Purine and Pyrimidine Biosynthesisaspartate carbamoyltransferaseASPCTcbp_c + asp_L_c ⇋ h_c + pi_c + cbasp_c010001.61.6
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.791.6
Arginine and Proline Metabolismornithine carbamoyltransferaseOCBTcbp_c + orn_c ⇋ citr_L_c + h_c + pi_c-100010001.51.5
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.51.5
Arginine and Proline MetabolismN-acetylglutamate synthaseACGSglu_L_c + accoa_c ⇋ coa_c + h_c + acglu_c010001.51.5
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.471.4
Inorganic Ion Transport and Metabolismsulfate transport in via proton symport (periplasm to cytoplasm)SO4t2ppso4_p + h_p ⇋ h_c + so4_c010001.21.2
Cysteine Metabolismcysteine synthaseCYSSacser_c + h2s_c ⇋ ac_c + cys_L_c + h_c010001.21.2
Cysteine Metabolismadenylyl-sulfate kinaseADSKatp_c + aps_c ⇋ paps_c + adp_c + h_c010001.21.2
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.21.2
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.21.2
Arginine and Proline MetabolismL-glutamate 5-semialdehyde dehydratase (spontaneous)G5SADsglu5sa_c ⇋ 1pyr5c_c + h_c + h2o_c010001.11.1
Inorganic Ion Transport and Metabolismpotassium transport in via proton symport (periplasm)Kt2ppk_p + h_p ⇋ h_c + k_c010000.960.96
Methionine Metabolismmethionine synthaseMETShcys_L_c + 5mthf_c ⇋ h_c + met_L_c + thf_c010000.760.76
Methionine MetabolismO-succinylhomoserine lyase (L-cysteine)SHSL1cys_L_c + suchms_c ⇋ cyst_L_c + h_c + succ_c010000.760.76
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecenoate)FACOAE161hdcoa_c + h2o_c ⇋ coa_c + hdcea_c + h_c010000.740.74
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecanoate)FACOAE160pmtcoa_c + h2o_c ⇋ coa_c + h_c + hdca_c010000.630.63
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.470.47
Histidine Metabolismphosphoribosyl-ATP pyrophosphatasePRATPPprbatp_c + h2o_c ⇋ ppi_c + prbamp_c + h_c010000.470.47
Cell Envelope Biosynthesisglucosamine-1-phosphate N-acetyltransferaseG1PACTgam1p_c + accoa_c ⇋ coa_c + h_c + acgam1p_c010000.470.47
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.380.38
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (dodecanoate)FACOAE120ddcacoa_c + h2o_c ⇋ coa_c + ddca_c + h_c010000.380.38
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:1)PSSA161cdpdhdec9eg_c + ser_L_c ⇋ cmp_c + ps161_c + h_c010000.370.37
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:0)PSSA160cdpdhdecg_c + ser_L_c ⇋ ps160_c + cmp_c + h_c010000.310.31
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.280.28
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.230.23
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferaseU23GAAT3hmrsACP_c + u3hga_c ⇋ ACP_c + h_c + u23ga_c010000.190.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-sugar hydrolaseUSHDu23ga_c + h2o_c ⇋ ump_c + 2 h_c + lipidX_c010000.0960.19
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.140.14
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.140.14
Murein Biosynthesismurein polymerizing transglycosylaseMPTG2 uaagmda_c ⇋ 2 h_c + murein5p5p_p + 2 udcpdp_c010000.0680.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope Biosynthesisundecaprenyl-diphosphataseUDCPDPh2o_c + udcpdp_c ⇋ udcpp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUAGPT3uacgam_c + uagmda_c ⇋ udp_c + h_c + uaagmda_c010000.140.14
Nucleotide Salvage PathwaydUTP diphosphataseDUTPDPh2o_c + dutp_c ⇋ ppi_c + dump_c + h_c010000.130.13
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.10.1
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.0960.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOAT2ckdo_c + kdolipid4_c ⇋ h_c + cmp_c + kdo2lipid4_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingTetraacyldisaccharide 4'kinaseTDSKlipidAds_c + atp_c ⇋ adp_c + h_c + lipidA_c010000.0960.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOATckdo_c + lipidA_c ⇋ kdolipid4_c + cmp_c + h_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingLipid A disaccaride synthaseLPADSSu23ga_c + lipidX_c ⇋ udp_c + h_c + lipidAds_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.0960.096
Transport, Inner MembraneD-alanine transport in via proton symport (periplasm)DALAt2ppala_D_p + h_p ⇋ ala_D_c + h_c010000.0680.068
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinaseCDPMEK4c2me_c + atp_c ⇋ 2p4c2me_c + h_c + adp_c010000.0120.012
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.0110.011
Cofactor and Prosthetic Group BiosynthesisL-aspartate oxidaseASPO6o2_c + asp_L_c ⇋ h_c + iasp_c + h2o2_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesisporphobilinogen synthasePPBNGS2 5aop_c ⇋ 2 h2o_c + ppbng_c + h_c010000.00880.0088
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.00140.0085
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.00130.0077
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.00330.0066
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.00120.006
Cofactor and Prosthetic Group Biosynthesis3,4-Dihydroxy-2-butanone-4-phosphate synthaseDB4PSru5p_D_c ⇋ db4p_c + for_c + h_c010000.00440.0044
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.00220.0044
Nucleotide Salvage Pathwayadenosine kinaseADNK1adn_c + atp_c ⇋ adp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesis4-aminobenzoate synthaseADCL4adcho_c ⇋ h_c + 4abz_c + pyr_c010000.00330.0033
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin triphosphate pyrophosphataseDNTPPAahdt_c + h2o_c ⇋ ppi_c + dhpmp_c + h_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase IGTPCIh2o_c + gtp_c ⇋ ahdt_c + for_c + h_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesis6-hydroxymethyl-dihydropterin pyrophosphokinaseHPPK26hmhpt_c + atp_c ⇋ 6hmhptpp_c + h_c + amp_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin ferrochelataseSHCHFscl_c + fe2_c ⇋ sheme_c + 3 h_c010000.00110.0033
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.00110.0033
Cofactor and Prosthetic Group Biosynthesispantothenate kinasePNTKpnto_R_c + atp_c ⇋ h_c + 4ppan_c + adp_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisdephospho-CoA kinaseDPCOAKdpcoa_c + atp_c ⇋ coa_c + adp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group BiosynthesisNAD kinaseNADKnad_c + atp_c ⇋ nadp_c + adp_c + h_c010000.00220.0022
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.00110.0022
Cofactor and Prosthetic Group BiosynthesisFerrochelataseFCLTppp9_c + fe2_c ⇋ 2 h_c + pheme_c010000.00110.0022
Cofactor and Prosthetic Group Biosynthesisriboflavin kinaseRBFKatp_c + ribflv_c ⇋ adp_c + h_c + fmn_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen methyltransferaseUPP3MTuppg3_c + 2 amet_c ⇋ dscl_c + 2 ahcys_c + h_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisErythronate 4-phosphate (4per) dehydrogenasePERDnad_c + 4per_c ⇋ nadh_c + h_c + ohpb_c-100010000.00110.0011
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin dehydrogenase (NAD)SHCHD2dscl_c + nad_c ⇋ nadh_c + scl_c + h_c010000.00110.0011
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.000640.00064
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-063.9e-05
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-063e-05
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylpimeloyl-[ACP] methyl ester reductaseEPMEACPRh_c + epmeACP_c + nadph_c ⇋ nadp_c + pmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester reductaseOPMEACPRh_c + nadph_c + opmeACP_c ⇋ nadp_c + hpmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester reductaseOGMEACPRogmeACP_c + h_c + nadph_c ⇋ hgmeACP_c + nadp_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylglutaryl-[ACP] methyl ester reductaseEGMEACPRegmeACP_c + h_c + nadph_c ⇋ nadp_c + gmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] TransferI2FE2STiscu_2fe2s_c + 4 h_c ⇋ iscu_c + 2fe2s_c010000.00014-0.00055
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthaseBMOGDS2bmoco1gdp_c + h_c + gtp_c ⇋ ppi_c + bmocogdp_c010000.0006-0.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthase (single GDP)BMOGDS1bmoco_c + h_c + gtp_c ⇋ bmoco1gdp_c + ppi_c010000.0006-0.0006
Cofactor and Prosthetic Group BiosynthesisOctaprenyl-hydroxybenzoate decarboxylaseOPHBDCh_c + 3ophb_c ⇋ 2oph_c + co2_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate diphosphorylaseTMPPP4mpetz_c + 2mahmp_c + h_c ⇋ thmmp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisFMN adenylyltransferaseFMNATh_c + atp_c + fmn_c ⇋ fad_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesismolybdopterin adenylyltransferaseMPTATmpt_c + h_c + atp_c ⇋ mptamp_c + ppi_c010000.0012-0.0012
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.0006-0.0012
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.0014-0.0014
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.0011-0.0022
Cofactor and Prosthetic Group Biosynthesisdiaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)DHPPDA2h_c + 25drapp_c + h2o_c ⇋ 5apru_c + nh4_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesis5-amino-6-(5-phosphoribosylamino)uracil reductaseAPRAURnadph_c + h_c + 5apru_c ⇋ nadp_c + 5aprbu_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthase sulfurylaseMPTSSmoadcoo_c + h_c + atp_c ⇋ ppi_c + moadamp_c010000.0024-0.0024
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] ReductionI4FE4SRiscu_2fe2s2_c + 2 h_c + fadh2_c ⇋ fad_c + iscu_4fe4s_c010000.0013-0.0026
Cofactor and Prosthetic Group Biosynthesis2-dehydropantoate 2-reductaseDPR2dhp_c + h_c + nadph_c ⇋ pant_R_c + nadp_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesisaspartate 1-decarboxylaseASP1DCasp_L_c + h_c ⇋ ala_B_c + co2_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesispantetheine-phosphate adenylyltransferasePTPATih_c + atp_c + pan4p_c ⇋ ppi_c + dpcoa_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenoylcysteine decarboxylasePPCDC4ppcys_c + h_c ⇋ co2_c + pan4p_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen decarboxylase (uroporphyrinogen III)UPPDC1uppg3_c + 4 h_c ⇋ cpppg3_c + 4 co2_c010000.0011-0.0044
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] TransferI4FE4STiscu_4fe4s_c + 4 h_c ⇋ iscu_c + 4fe4s_c010000.0013-0.0051
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.01-0.01
Nucleotide Salvage Pathwaynicotinate-nucleotide adenylyltransferaseNNATrnicrnt_c + h_c + atp_c ⇋ ppi_c + dnad_c-100010000.011-0.011
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.012-0.012
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose reductoisomeraseDXPRIidxyl5p_c + h_c + nadph_c ⇋ 2me4p_c + nadp_c010000.012-0.012
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseMEPCT2me4p_c + h_c + ctp_c ⇋ 4c2me_c + ppi_c010000.012-0.012
Inorganic Ion Transport and Metabolismchloride transport out via proton antiport (2:1) (periplasm)CLt3_2pph_c + 2 cl_p ⇋ h_p + 2 cl_c010000.013-0.013
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose 5-phosphate synthaseDXPSpyr_c + g3p_c + h_c ⇋ dxyl5p_c + co2_c010000.014-0.014
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.018-0.018
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.011-0.022
Transport, Inner MembraneL-proline reversible transport via proton symport (periplasm)PROt2rpph_c + pro_L_c ⇋ pro_L_p + h_p-100010000.026-0.026
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.019-0.038
Inorganic Ion Transport and Metabolismmagnesium (Mg+2) transport in/out via proton antiport (periplasm)MG2t3_2pp2 h_c + mg2_p ⇋ mg2_c + 2 h_p-100010000.043-0.086
Cofactor and Prosthetic Group Biosynthesisdihydrofolate reductaseDHFRh_c + dhf_c + nadph_c ⇋ nadp_c + thf_c-100010000.13-0.13
Cell Envelope BiosynthesisUDP-N-acetylenolpyruvoylglucosamine reductaseUAPGRnadph_c + h_c + uaccg_c ⇋ nadp_c + uamr_c010000.14-0.14
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.13-0.26
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.13-0.26
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.13-0.27
Tyrosine, Tryptophan, and Phenylalanine Metabolismindole-3-glycerol-phosphate synthaseIGPS2cpr5p_c + h_c ⇋ co2_c + 3ig3p_c + h2o_c010000.28-0.28
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:0)PSD160h_c + ps160_c ⇋ pe160_c + co2_c010000.31-0.31
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:0)DASYN160pa160_c + ctp_c + h_c ⇋ ppi_c + cdpdhdecg_c010000.31-0.31
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:1)PSD161ps161_c + h_c ⇋ co2_c + pe161_c010000.37-0.37
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:1)DASYN161pa161_c + ctp_c + h_c ⇋ ppi_c + cdpdhdec9eg_c010000.37-0.37
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)3OAR1403omrsACP_c + h_c + nadph_c ⇋ nadp_c + 3hmrsACP_c-100010000.38-0.38
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.38-0.38
Cell Envelope BiosynthesisUDP-N-acetylglucosamine diphosphorylaseUAGDPutp_c + h_c + acgam1p_c ⇋ ppi_c + uacgam_c010000.47-0.47
Alternate Carbon Metabolismglycerol-3-phosphate dehydrogenase (NADP)G3PD2h_c + nadph_c + dhap_c ⇋ glyc3p_c + nadp_c-100010000.69-0.69
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydratasePPNDHh_c + pphn_c ⇋ phpyr_c + co2_c + h2o_c010000.91-0.91
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.1-1.1
Oxidative Phosphorylationthioredoxin reductase (NADPH)TRDRh_c + trdox_c + nadph_c ⇋ nadp_c + trdrd_c010001.4-1.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)HACD63otdcoa_c + nadh_c + h_c ⇋ nad_c + 3htdcoa_c-100010001.4-1.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)HACD7nadh_c + 3ohdcoa_c + h_c ⇋ 3hhdcoa_c + nad_c-100010001.4-1.4
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2-Acetolactate)KARA22ahbut_c + h_c + nadph_c ⇋ 23dhmp_c + nadp_c-100010001.4-1.4
Valine, Leucine, and Isoleucine Metabolism2-aceto-2-hydroxybutanoate synthaseACHBSpyr_c + 2obut_c + h_c ⇋ 2ahbut_c + co2_c010001.4-1.4
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.5-1.5
Folate Metabolism5,10-methylenetetrahydrofolate reductase (NADH)MTHFR2nadh_c + mlthf_c + 2 h_c ⇋ nad_c + 5mthf_c010000.76-1.5
Purine and Pyrimidine Biosynthesisorotidine-5'-phosphate decarboxylaseOMPDCh_c + orot5p_c ⇋ co2_c + ump_c010001.6-1.6
Purine and Pyrimidine BiosynthesisdihydroorotaseDHORTSh_c + cbasp_c ⇋ dhor_S_c + h2o_c-100010001.6-1.6
Threonine and Lysine Metabolismdiaminopimelate decarboxylaseDAPDCh_c + 26dap_M_c ⇋ co2_c + lys_L_c010001.7-1.7
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)HACD4nadh_c + h_c + 3odcoa_c ⇋ 3hdcoa_c + nad_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)HACD2nadh_c + 3ohcoa_c + h_c ⇋ nad_c + 3hhcoa_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)HACD1nadh_c + aacoa_c + h_c ⇋ 3hbcoa_c + nad_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)HACD3nadh_c + h_c + 3oocoa_c ⇋ nad_c + 3hocoa_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)HACD53oddcoa_c + h_c + nadh_c ⇋ nad_c + 3hddcoa_c-100010001.8-1.8
Threonine and Lysine Metabolismdihydrodipicolinate reductase (NADPH)DHDPRy23dhdp_c + h_c + nadph_c ⇋ nadp_c + thdp_c010001.8-1.8
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate dehydrogenaseSHK3Drh_c + 3dhsk_c + nadph_c ⇋ skm_c + nadp_c-100010001.9-1.9
Arginine and Proline Metabolismpyrroline-5-carboxylate reductaseP5CR1pyr5c_c + 2 h_c + nadph_c ⇋ nadp_c + pro_L_c010001.1-2.2
Valine, Leucine, and Isoleucine Metabolism2-Oxo-4-methyl-3-carboxypentanoate decarboxylationOMCDC3c4mop_c + h_c ⇋ co2_c + 4mop_c010002.2-2.2
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)KARA1h_c + alac_S_c + nadph_c ⇋ 23dhmb_c + nadp_c-100010004.3-4.3
Valine, Leucine, and Isoleucine Metabolismacetolactate synthaseACLSh_c + 2 pyr_c ⇋ alac_S_c + co2_c010004.3-4.3
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.2-6.1
Cofactor and Prosthetic Group BiosynthesisFAD reductaseFADRxnadh_c + fad_c + h_c ⇋ nad_c + fadh2_c0100011-11
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-1000100071-71
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+02-1e+02
Threonine and Lysine Metabolismhomoserine dehydrogenase (NADPH)HSDyaspsa_c + nadph_c + h_c ⇋ hom_L_c + nadp_c-100010001.3e+02-1.3e+02
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+02-1.3e+02
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+02-1.6e+02
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+02-2.3e+03
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+02-2.3e+03

Metabolite name: H2
Metabolite ID: h2_c
Compartment: c


Metabolite name: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Metabolite ID: h2mb4p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.0014-0.0014
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.01-0.01

Metabolite name: H2O
Metabolite ID: h2o_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+029.8e+02
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+025.7e+02
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+021.6e+02
Citric Acid Cycleaconitase (half-reaction A, Citrate hydro-lyase)ACONTacit_c ⇋ h2o_c + acon_C_c-100010005.35.3
Valine, Leucine, and Isoleucine Metabolismdihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)DHAD123dhmb_c ⇋ h2o_c + 3mob_c010004.34.3
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.23.7
Threonine and Lysine Metabolismdihydrodipicolinate synthaseDHDPSpyr_c + aspsa_c ⇋ h_c + 2 h2o_c + 23dhdp_c010001.83.7
Purine and Pyrimidine BiosynthesisIMP cyclohydrolaseIMPCfprica_c ⇋ imp_c + h2o_c-100010002.72.7
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate hydrataseIPPMIb3c3hmp_c ⇋ h2o_c + 2ippm_c-100010002.22.2
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate dehydratase, irreversibleDHQTi3dhq_c ⇋ h2o_c + 3dhsk_c010001.91.9
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)ECOAH13hbcoa_c ⇋ h2o_c + b2coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)ECOAH23hhcoa_c ⇋ h2o_c + hx2coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)ECOAH33hocoa_c ⇋ h2o_c + oc2coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)ECOAH53hddcoa_c ⇋ h2o_c + dd2coa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)ECOAH43hdcoa_c ⇋ h2o_c + dc2coa_c-100010001.81.8
Purine and Pyrimidine BiosynthesisdihydroorotaseDHORTSh_c + cbasp_c ⇋ dhor_S_c + h2o_c-100010001.61.6
Valine, Leucine, and Isoleucine MetabolismDihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)DHAD223dhmp_c ⇋ 3mop_c + h2o_c010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)ECOAH63htdcoa_c ⇋ td2coa_c + h2o_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)ECOAH73hhdcoa_c ⇋ h2o_c + hdd2coa_c-100010001.41.4
Arginine and Proline MetabolismL-glutamate 5-semialdehyde dehydratase (spontaneous)G5SADsglu5sa_c ⇋ 1pyr5c_c + h_c + h2o_c010001.11.1
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydratasePPNDHh_c + pphn_c ⇋ phpyr_c + co2_c + h2o_c010000.910.91
Histidine Metabolismimidazoleglycerol-phosphate dehydrataseIGPDHeig3p_c ⇋ imacp_c + h2o_c010000.470.47
Tyrosine, Tryptophan, and Phenylalanine Metabolismindole-3-glycerol-phosphate synthaseIGPS2cpr5p_c + h_c ⇋ co2_c + 3ig3p_c + h2o_c010000.280.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismtryptophan synthase (indoleglycerol phosphate)TRPS1ser_L_c + 3ig3p_c ⇋ g3p_c + trp_L_c + h2o_c010000.280.28
Nucleotide Salvage Pathwayribonucleoside-diphosphate reductase (GDP)RNDR2gdp_c + trdrd_c ⇋ dgdp_c + h2o_c + trdox_c010000.130.13
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (CTP) (flavodoxin)RNTR3c22 h_c + ctp_c + 2 flxr_c ⇋ dctp_c + h2o_c + 2 flxso_c010000.130.13
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.130.13
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (ATP) (flavodoxin)RNTR1c2atp_c + 2 h_c + 2 flxr_c ⇋ datp_c + 2 flxso_c + h2o_c010000.130.13
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.0190.038
Cofactor and Prosthetic Group Biosynthesisquinolinate synthaseQULNSdhap_c + iasp_c ⇋ quln_c + pi_c + 2 h2o_c010000.0110.022
Cofactor and Prosthetic Group Biosynthesisporphobilinogen synthasePPBNGS2 5aop_c ⇋ 2 h2o_c + ppbng_c + h_c010000.00880.018
Cofactor and Prosthetic Group Biosynthesis2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydrataseMECDPDH52mecdp_c + h_c + 2 flxr_c ⇋ h2mb4p_c + 2 flxso_c + h2o_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.010.01
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSadb4p_c + 4r5au_c ⇋ dmlz_c + pi_c + 2 h2o_c010000.00440.0088
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0022
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen-III synthaseUPP3Shmbil_c ⇋ h2o_c + uppg3_c010000.00220.0022
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0022
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.00110.0022
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.00140.0014
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester dehydrataseOPMEACPDhpmeACP_c ⇋ epmeACP_c + h2o_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester dehydrataseOGMEACPDhgmeACP_c ⇋ h2o_c + egmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisPimeloyl-[ACP] methyl ester esterasePMEACPEh2o_c + pmeACP_c ⇋ pimACP_c + meoh_c010009.9e-06-9.9e-06
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.00064-0.00064
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis5'-deoxyadenosine nuclosidase5DOANdad_5_c + h2o_c ⇋ 5drib_c + ade_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesiscyclic pyranopterin monophosphate synthaseCPMPSgtp_c + h2o_c ⇋ ppi_c + cpmp_c010000.0012-0.0012
Cofactor and Prosthetic Group Biosynthesishydroxymethylbilane synthaseHMBSh2o_c + 4 ppbng_c ⇋ hmbil_c + 4 nh4_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesisdiaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)DHPPDA2h_c + 25drapp_c + h2o_c ⇋ 5apru_c + nh4_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesispyrimidine phosphatasePMDPHTh2o_c + 5aprbu_c ⇋ pi_c + 4r5au_c010000.0022-0.0022
Methionine MetabolismS-adenosylhomocysteine nucleosidaseAHCYSNSh2o_c + ahcys_c ⇋ ade_c + rhcys_c010000.0022-0.0022
Methionine Metabolism(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)MTHTHFSsh2o_c + mdhdhf_c ⇋ mththf_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesis3-methyl-2-oxobutanoate hydroxymethyltransferaseMOHMT3mob_c + mlthf_c + h2o_c ⇋ thf_c + 2dhp_c010000.0028-0.0028
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.0033-0.0033
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.0033-0.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin triphosphate pyrophosphataseDNTPPAahdt_c + h2o_c ⇋ ppi_c + dhpmp_c + h_c010000.0033-0.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin monophosphate dephosphorylaseDNMPPAdhpmp_c + h2o_c ⇋ dhnpt_c + pi_c010000.0033-0.0033
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase IGTPCIh2o_c + gtp_c ⇋ ahdt_c + for_c + h_c010000.0033-0.0033
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.0044-0.0044
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.0022-0.0066
Lipopolysaccharide Biosynthesis / RecyclingUDP-sugar hydrolaseUSHDu23ga_c + h2o_c ⇋ ump_c + 2 h_c + lipidX_c010000.096-0.096
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.096-0.096
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.096-0.096
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.1-0.1
Nucleotide Salvage PathwaydUTP diphosphataseDUTPDPh2o_c + dutp_c ⇋ ppi_c + dump_c + h_c010000.13-0.13
Cell Envelope Biosynthesisundecaprenyl-diphosphataseUDCPDPh2o_c + udcpdp_c ⇋ udcpp_c + h_c + pi_c010000.14-0.14
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate-8-phosphataseKDOPPh2o_c + kdo8p_c ⇋ kdo_c + pi_c010000.19-0.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-acetylglucosamine deacetylaseUHGADAh2o_c + u3aga_c ⇋ ac_c + u3hga_c010000.19-0.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy -D-manno-octulosonic -acid 8-phosphate synthaseKDOPSara5p_c + pep_c + h2o_c ⇋ kdo8p_c + pi_c010000.19-0.19
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.23-0.23
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (dodecanoate)FACOAE120ddcacoa_c + h2o_c ⇋ coa_c + ddca_c + h_c010000.38-0.38
Histidine Metabolismphosphoribosyl-AMP cyclohydrolasePRAMPCprbamp_c + h2o_c ⇋ prfp_c010000.47-0.47
Histidine Metabolismphosphoribosyl-ATP pyrophosphatasePRATPPprbatp_c + h2o_c ⇋ ppi_c + prbamp_c + h_c010000.47-0.47
Histidine Metabolismhistidinol-phosphataseHISTPhisp_c + h2o_c ⇋ histd_c + pi_c010000.47-0.47
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.47-0.47
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecanoate)FACOAE160pmtcoa_c + h2o_c ⇋ coa_c + h_c + hdca_c010000.63-0.63
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecenoate)FACOAE161hdcoa_c + h2o_c ⇋ coa_c + hdcea_c + h_c010000.74-0.74
Methionine Metabolismcystathionine b-lyaseCYSTLcyst_L_c + h2o_c ⇋ pyr_c + hcys_L_c + nh4_c010000.76-0.76
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.79-0.79
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.2-1.2
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.2-1.2
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.2-1.2
Cysteine Metabolism3',5'-bisphosphate nucleotidaseBPNTpap_c + h2o_c ⇋ amp_c + pi_c010001.2-1.2
Arginine and Proline Metabolismacetylornithine deacetylaseACODAacorn_c + h2o_c ⇋ ac_c + orn_c010001.5-1.5
Threonine and Lysine Metabolismsuccinyl-diaminopimelate desuccinylaseSDPDSsl26da_c + h2o_c ⇋ succ_c + 26dap_LL_c010001.8-1.8
Threonine and Lysine Metabolismtetrahydrodipicolinate succinylaseTHDPSthdp_c + h2o_c + succoa_c ⇋ coa_c + sl2a6o_c010001.8-1.8
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-deoxy-D-arabino-heptulosonate 7-phosphate synthetaseDDPAe4p_c + h2o_c + pep_c ⇋ 2dda7p_c + pi_c010001.9-1.9
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.2-2.2
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.2-2.2
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrataseIPPMIa2ippm_c + h2o_c ⇋ 3c2hmp_c-100010002.2-2.2
Valine, Leucine, and Isoleucine Metabolism2-isopropylmalate synthaseIPPS3mob_c + h2o_c + accoa_c ⇋ coa_c + h_c + 3c3hmp_c010002.2-2.2
UnassignedHCO3 equilibration reactionHCO3Eco2_c + h2o_c ⇋ h_c + hco3_c-100010002.6-2.6
Folate Metabolismmethenyltetrahydrofolate cyclohydrolaseMTHFCmethf_c + h2o_c ⇋ h_c + 10fthf_c-100010004.9-4.9
Citric Acid CyclefumaraseFUMh2o_c + fum_c ⇋ mal_L_c-100010005.1-5.1
Citric Acid Cycleaconitase (half-reaction B, Isocitrate hydro-lyase)ACONTbacon_C_c + h2o_c ⇋ icit_c-100010005.3-5.3
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.3-5.3
Glycolysis/Gluconeogenesisfructose-bisphosphataseFBPh2o_c + fdp_c ⇋ pi_c + f6p_c0100028-28
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c0100036-36
Glycine and Serine Metabolismglycine hydroxymethyltransferase, reversibleGHMT2rgly_c + mlthf_c + h2o_c ⇋ thf_c + ser_L_c-1000100057-57
Threonine and Lysine Metabolismthreonine synthaseTHRSh2o_c + phom_c ⇋ pi_c + thr_L_c010001.3e+02-1.3e+02
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+02-1.4e+02
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+02-1.4e+02
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-2.4e+02
Transport, Inner MembraneH2O transport via diffusion (periplasm)H2Otpph2o_c ⇋ h2o_p-100010009.3e+02-9.3e+02

Metabolite name: Hydrogen peroxide
Metabolite ID: h2o2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisL-aspartate oxidaseASPO6o2_c + asp_L_c ⇋ h_c + iasp_c + h2o2_c010000.0110.011
Citric Acid Cyclemalate oxidaseMOXo2_c + mal_L_c ⇋ h2o2_c + oaa_c-100010000.00690.0069
Cofactor and Prosthetic Group Biosynthesispyridoxine 5'-phosphate oxidasePDX5POipdx5p_c + o2_c ⇋ h2o2_c + pydx5p_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisiron-sulfur cluster damage (peroxide, spontaneous)FESD1s2 4fe4s_c + 2 h_c + h2o2_c ⇋ 2 h2o_c + 2 3fe4s_c + 2 fe3_c010000.019-0.019

Metabolite name: Hydrogen sulfide
Metabolite ID: h2s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.21.2
Cysteine Metabolismcysteine synthaseCYSSacser_c + h2s_c ⇋ ac_c + cys_L_c + h_c010001.2-1.2

Metabolite name: Bicarbonate
Metabolite ID: hco3_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
UnassignedHCO3 equilibration reactionHCO3Eco2_c + h2o_c ⇋ h_c + hco3_c-100010002.62.6
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.38-0.38
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.2-2.2

Metabolite name: L-Homocysteine
Metabolite ID: hcys_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolismcystathionine b-lyaseCYSTLcyst_L_c + h2o_c ⇋ pyr_c + hcys_L_c + nh4_c010000.760.76
Methionine MetabolismS-ribosylhomocysteine cleavage enzymeRHCCErhcys_c ⇋ dhptd_c + hcys_L_c010000.00220.0022
Methionine Metabolismmethionine synthaseMETShcys_L_c + 5mthf_c ⇋ h_c + met_L_c + thf_c010000.76-0.76

Metabolite name: Hexadecanoate (n-C16:0)
Metabolite ID: hdca_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecanoate)FACOAE160pmtcoa_c + h2o_c ⇋ coa_c + h_c + hdca_c010000.630.63
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.63-0.63

Metabolite name: Hexadecanoyl-phosphate (n-C16:0)
Metabolite ID: hdcap_c
Compartment: c


Metabolite name: Hexadecenoate (n-C16:1)
Metabolite ID: hdcea_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecenoate)FACOAE161hdcoa_c + h2o_c ⇋ coa_c + hdcea_c + h_c010000.740.74
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.74-0.74

Metabolite name: Hexadecanoyl-phosphate (n-C16:1)
Metabolite ID: hdceap_c
Compartment: c


Metabolite name: Hexadecenoyl-CoA (n-C16:1CoA)
Metabolite ID: hdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-cis-2-trans-enoyl-CoA isomeraseCTECOAI7hdd2coa_c ⇋ hdcoa_c-100010000.740.74
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecenoate)FACOAE161hdcoa_c + h2o_c ⇋ coa_c + hdcea_c + h_c010000.74-0.74

Metabolite name: trans-Hexadec-2-enoyl-CoA
Metabolite ID: hdd2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)ECOAH73hhdcoa_c ⇋ h2o_c + hdd2coa_c-100010001.41.4
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexadecanoyl-CoA)ACOAD7fhdd2coa_c + fadh2_c ⇋ pmtcoa_c + fad_c-100010000.63-0.63
Membrane Lipid Metabolism3-cis-2-trans-enoyl-CoA isomeraseCTECOAI7hdd2coa_c ⇋ hdcoa_c-100010000.74-0.74

Metabolite name: cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)
Metabolite ID: hdeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.740.74
Glycerophospholipid Metabolism1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)AGPAT161hdeACP_c + 1hdec9eg3p_c ⇋ ACP_c + pa161_c010000.37-0.37
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:1)G3PAT161hdeACP_c + glyc3p_c ⇋ ACP_c + 1hdec9eg3p_c010000.37-0.37

Metabolite name: Heme O
Metabolite ID: hemeO_c
Compartment: c


Metabolite name: Hexanoyl-ACP (n-C6:0ACP)
Metabolite ID: hexACP_c
Compartment: c


Metabolite name: Hg2+
Metabolite ID: hg2_c
Compartment: c


Metabolite name: 3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester
Metabolite ID: hgmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester reductaseOGMEACPRogmeACP_c + h_c + nadph_c ⇋ hgmeACP_c + nadp_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester dehydrataseOGMEACPDhgmeACP_c ⇋ h2o_c + egmeACP_c010009.9e-06-9.9e-06

Metabolite name: heptosyl-heptosyl-kdo2-lipidA
Metabolite ID: hhlipa_c
Compartment: c


Metabolite name: L-Histidine
Metabolite ID: his_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.470.47
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.47

Metabolite name: L-Histidinol phosphate
Metabolite ID: hisp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismhistidinol-phosphate transaminaseHSTPTimacp_c + glu_L_c ⇋ akg_c + hisp_c010000.470.47
Histidine Metabolismhistidinol-phosphataseHISTPhisp_c + h2o_c ⇋ histd_c + pi_c010000.47-0.47

Metabolite name: L-Histidinol
Metabolite ID: histd_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismhistidinol-phosphataseHISTPhisp_c + h2o_c ⇋ histd_c + pi_c010000.470.47
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.47-0.47

Metabolite name: L-Histidyl-tRNA(His)
Metabolite ID: histrna_c
Compartment: c


Metabolite name: 2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
Metabolite ID: hkndd_c
Compartment: c


Metabolite name: 2-hydroxy-6-ketononatrienedioate
Metabolite ID: hkntd_c
Compartment: c


Metabolite name: heptosyl-kdo2-lipidA
Metabolite ID: hlipa_c
Compartment: c


Metabolite name: Hydroxymethylbilane
Metabolite ID: hmbil_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesishydroxymethylbilane synthaseHMBSh2o_c + 4 ppbng_c ⇋ hmbil_c + 4 nh4_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen-III synthaseUPP3Shmbil_c ⇋ h2o_c + uppg3_c010000.0022-0.0022

Metabolite name: hydroxymethylglutathione
Metabolite ID: hmgth_c
Compartment: c


Metabolite name: L-Homoserine
Metabolite ID: hom_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismhomoserine dehydrogenase (NADPH)HSDyaspsa_c + nadph_c + h_c ⇋ hom_L_c + nadp_c-100010001.3e+021.3e+02
Methionine Metabolismhomoserine O-succinyltransferaseHSSThom_L_c + succoa_c ⇋ suchms_c + coa_c010000.76-0.76
Threonine and Lysine Metabolismhomoserine kinaseHSKhom_L_c + atp_c ⇋ phom_c + adp_c + h_c010001.3e+02-1.3e+02

Metabolite name: heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA
Metabolite ID: hphhlipa_c
Compartment: c


Metabolite name: 3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester
Metabolite ID: hpmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester reductaseOPMEACPRh_c + nadph_c + opmeACP_c ⇋ nadp_c + hpmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester dehydrataseOPMEACPDhpmeACP_c ⇋ epmeACP_c + h2o_c010009.9e-06-9.9e-06

Metabolite name: Hydroxypyruvate
Metabolite ID: hpyr_c
Compartment: c


Metabolite name: Hydroquinone
Metabolite ID: hqn_c
Compartment: c


Metabolite name: trans-Hex-2-enoyl-CoA
Metabolite ID: hx2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)ECOAH23hhcoa_c ⇋ h2o_c + hx2coa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexanoyl-CoA)ACOAD2ffadh2_c + hx2coa_c ⇋ hxcoa_c + fad_c-100010001.8-1.8

Metabolite name: Hexanoate (n-C6:0)
Metabolite ID: hxa_c
Compartment: c


Metabolite name: Hypoxanthine
Metabolite ID: hxan_c
Compartment: c


Metabolite name: Hexanoyl-CoA (n-C6:0CoA)
Metabolite ID: hxcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexanoyl-CoA)ACOAD2ffadh2_c + hx2coa_c ⇋ hxcoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)ACACT3rhxcoa_c + accoa_c ⇋ coa_c + 3oocoa_c-100010001.8-1.8

Metabolite name: Iminoaspartate
Metabolite ID: iasp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisL-aspartate oxidaseASPO6o2_c + asp_L_c ⇋ h_c + iasp_c + h2o2_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesisquinolinate synthaseQULNSdhap_c + iasp_c ⇋ quln_c + pi_c + 2 h2o_c010000.011-0.011

Metabolite name: Isochorismate
Metabolite ID: ichor_c
Compartment: c


Metabolite name: Isocitrate
Metabolite ID: icit_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Citric Acid Cycleaconitase (half-reaction B, Isocitrate hydro-lyase)ACONTbacon_C_c + h2o_c ⇋ icit_c-100010005.35.3
Citric Acid Cycleisocitrate dehydrogenase (NADP)ICDHyrnadp_c + icit_c ⇋ akg_c + nadph_c + co2_c-100010005.3-5.3

Metabolite name: inner core oligosaccharide lipid A (E coli)
Metabolite ID: icolipa_c
Compartment: c


Metabolite name: L-Idonate
Metabolite ID: idon_L_c
Compartment: c


Metabolite name: IDP
Metabolite ID: idp_c
Compartment: c


Metabolite name: L-Isoleucine
Metabolite ID: ile_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismisoleucine transaminaseILETAglu_L_c + 3mop_c ⇋ ile_L_c + akg_c-100010001.41.4
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.4

Metabolite name: L-Isoleucyl-tRNA(Ile)
Metabolite ID: iletrna_c
Compartment: c


Metabolite name: 3-(Imidazol-4-yl)-2-oxopropyl phosphate
Metabolite ID: imacp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismimidazoleglycerol-phosphate dehydrataseIGPDHeig3p_c ⇋ imacp_c + h2o_c010000.470.47
Histidine Metabolismhistidinol-phosphate transaminaseHSTPTimacp_c + glu_L_c ⇋ akg_c + hisp_c010000.47-0.47

Metabolite name: IMP
Metabolite ID: imp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine BiosynthesisIMP cyclohydrolaseIMPCfprica_c ⇋ imp_c + h2o_c-100010002.72.7
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.2-1.2
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.5-1.5

Metabolite name: Indole
Metabolite ID: indole_c
Compartment: c


Metabolite name: myo-Inositol
Metabolite ID: inost_c
Compartment: c


Metabolite name: Inosine
Metabolite ID: ins_c
Compartment: c


Metabolite name: Isopentenyl diphosphate
Metabolite ID: ipdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.010.01
Cofactor and Prosthetic Group BiosynthesisgeranyltranstransferaseGRTTipdp_c + grdp_c ⇋ frdp_c + ppi_c010000.0014-0.0014
Cofactor and Prosthetic Group BiosynthesisdimethylallyltranstransferaseDMATTdmpp_c + ipdp_c ⇋ grdp_c + ppi_c010000.0014-0.0014
Cofactor and Prosthetic Group BiosynthesisUndecaprenyl diphosphate synthaseUDCPDPS8 ipdp_c + frdp_c ⇋ 8 ppi_c + udcpdp_c010000.00027-0.0022
Cofactor and Prosthetic Group BiosynthesisOctaprenyl pyrophosphate synthaseOCTDPS5 ipdp_c + frdp_c ⇋ octdp_c + 5 ppi_c010000.0011-0.0055

Metabolite name: IscS sulfur acceptor protein
Metabolite ID: iscs_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.00140.0028
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.00130.0026
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.00240.0024
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisISC Cysteine desulfurationICYSDSiscs_c + cys_L_c ⇋ ala_L_c + iscssh_c010000.0089-0.0089

Metabolite name: IscS with bound sulfur
Metabolite ID: iscssh_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC Cysteine desulfurationICYSDSiscs_c + cys_L_c ⇋ ala_L_c + iscssh_c010000.00890.0089
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.0024-0.0024
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.0013-0.0026
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.0014-0.0028

Metabolite name: IscU scaffold protein
Metabolite ID: iscu_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] TransferI4FE4STiscu_4fe4s_c + 4 h_c ⇋ iscu_c + 4fe4s_c010000.00130.0013
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] TransferI2FE2STiscu_2fe2s_c + 4 h_c ⇋ iscu_c + 2fe2s_c010000.000140.00014
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.0014-0.0014

Metabolite name: IscU with bound [2Fe-2S] cluster
Metabolite ID: iscu_2fe2s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] SynthesisI2FE2SS2 fe2_c + iscu_c + fadh2_c + 2 iscssh_c ⇋ 6 h_c + iscu_2fe2s_c + fad_c + 2 iscs_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] regenerationI2FE2SR2fe1s_c + iscssh_c + iscu_c ⇋ iscs_c + iscu_2fe2s_c + 4 h_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] TransferI2FE2STiscu_2fe2s_c + 4 h_c ⇋ iscu_c + 2fe2s_c010000.00014-0.00014
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.0013-0.0013

Metabolite name: IscU with two bound [2Fe-2S] clusters
Metabolite ID: iscu_2fe2s2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [2Fe-2S] Synthesis III2FE2SS22 fe2_c + 2 iscssh_c + iscu_2fe2s_c + fadh2_c ⇋ fad_c + 2 iscs_c + 6 h_c + iscu_2fe2s2_c010000.00130.0013
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] ReductionI4FE4SRiscu_2fe2s2_c + 2 h_c + fadh2_c ⇋ fad_c + iscu_4fe4s_c010000.0013-0.0013

Metabolite name: IscU with bound [4Fe-4S] cluster
Metabolite ID: iscu_4fe4s_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] ReductionI4FE4SRiscu_2fe2s2_c + 2 h_c + fadh2_c ⇋ fad_c + iscu_4fe4s_c010000.00130.0013
Cofactor and Prosthetic Group BiosynthesisISC [4Fe-4S] TransferI4FE4STiscu_4fe4s_c + 4 h_c ⇋ iscu_c + 4fe4s_c010000.0013-0.0013

Metabolite name: Isethionic acid
Metabolite ID: isetac_c
Compartment: c


Metabolite name: ITP
Metabolite ID: itp_c
Compartment: c


Metabolite name: potassium
Metabolite ID: k_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismpotassium transport in via proton symport (periplasm)Kt2ppk_p + h_p ⇋ h_c + k_c010000.960.96
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.96

Metabolite name: 3-Deoxy-D-manno-2-octulosonate
Metabolite ID: kdo_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate-8-phosphataseKDOPPh2o_c + kdo8p_c ⇋ kdo_c + pi_c010000.190.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate cytidylyltransferaseKDOCT2ctp_c + kdo_c ⇋ ckdo_c + ppi_c010000.19-0.19

Metabolite name: KDO(2)-lipid IV(A)
Metabolite ID: kdo2lipid4_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOAT2ckdo_c + kdolipid4_c ⇋ h_c + cmp_c + kdo2lipid4_c010000.0960.096
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.096-0.096

Metabolite name: KDO(2)-lipid IV(A) with laurate
Metabolite ID: kdo2lipid4L_c
Compartment: c


Metabolite name: KDO(2)-lipid IV(A) with palmitoleoyl
Metabolite ID: kdo2lipid4p_c
Compartment: c


Metabolite name: 3-Deoxy-D-manno-octulosonate 8-phosphate
Metabolite ID: kdo8p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / Recycling3-deoxy -D-manno-octulosonic -acid 8-phosphate synthaseKDOPSara5p_c + pep_c + h2o_c ⇋ kdo8p_c + pi_c010000.190.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate-8-phosphataseKDOPPh2o_c + kdo8p_c ⇋ kdo_c + pi_c010000.19-0.19

Metabolite name: KDO-lipid IV(A)
Metabolite ID: kdolipid4_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOATckdo_c + lipidA_c ⇋ kdolipid4_c + cmp_c + h_c010000.0960.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOAT2ckdo_c + kdolipid4_c ⇋ h_c + cmp_c + kdo2lipid4_c010000.096-0.096

Metabolite name: kdo-phospho-heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA
Metabolite ID: kphphhlipa_c
Compartment: c


Metabolite name: D-Lactate
Metabolite ID: lac_D_c
Compartment: c


Metabolite name: L-Lactate
Metabolite ID: lac_L_c
Compartment: c


Metabolite name: D-Lactaldehyde
Metabolite ID: lald_D_c
Compartment: c


Metabolite name: L-Lactaldehyde
Metabolite ID: lald_L_c
Compartment: c


Metabolite name: Lactose
Metabolite ID: lcts_c
Compartment: c


Metabolite name: L-Leucine
Metabolite ID: leu_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismleucine transaminase (irreversible)LEUTAiglu_L_c + 4mop_c ⇋ leu_L_c + akg_c010002.22.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-2.2

Metabolite name: L-Leucyl-tRNA(Leu)
Metabolite ID: leutrna_c
Compartment: c


Metabolite name: (R)-S-Lactoylglutathione
Metabolite ID: lgt_S_c
Compartment: c


Metabolite name: KDO(2)-lipid (A)
Metabolite ID: lipa_c
Compartment: c


Metabolite name: cold adapted KDO(2)-lipid (A)
Metabolite ID: lipa_cold_c
Compartment: c


Metabolite name: 2,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
Metabolite ID: lipidA_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingTetraacyldisaccharide 4'kinaseTDSKlipidAds_c + atp_c ⇋ adp_c + h_c + lipidA_c010000.0960.096
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-D-manno-octulosonic acid transferaseMOATckdo_c + lipidA_c ⇋ kdolipid4_c + cmp_c + h_c010000.096-0.096

Metabolite name: Lipid A Disaccharide
Metabolite ID: lipidAds_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingLipid A disaccaride synthaseLPADSSu23ga_c + lipidX_c ⇋ udp_c + h_c + lipidAds_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingTetraacyldisaccharide 4'kinaseTDSKlipidAds_c + atp_c ⇋ adp_c + h_c + lipidA_c010000.096-0.096

Metabolite name: 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
Metabolite ID: lipidX_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingUDP-sugar hydrolaseUSHDu23ga_c + h2o_c ⇋ ump_c + 2 h_c + lipidX_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingLipid A disaccaride synthaseLPADSSu23ga_c + lipidX_c ⇋ udp_c + h_c + lipidAds_c010000.096-0.096

Metabolite name: lipoyl-AMP
Metabolite ID: lipoamp_c
Compartment: c


Metabolite name: Lipoate
Metabolite ID: lipoate_c
Compartment: c


Metabolite name: lipoate (protein bound)
Metabolite ID: lipopb_c
Compartment: c


Metabolite name: L-Lysine
Metabolite ID: lys_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismdiaminopimelate decarboxylaseDAPDCh_c + 26dap_M_c ⇋ co2_c + lys_L_c010001.71.7
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.7

Metabolite name: L-Lysine-tRNA (Lys)
Metabolite ID: lystrna_c
Compartment: c


Metabolite name: L-Lyxose
Metabolite ID: lyx_L_c
Compartment: c


Metabolite name: D-Malate
Metabolite ID: mal_D_c
Compartment: c


Metabolite name: L-Malate
Metabolite ID: mal_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Citric Acid CyclefumaraseFUMh2o_c + fum_c ⇋ mal_L_c-100010005.15.1
Anaplerotic Reactionsmalate synthaseMALSglx_c + accoa_c + h2o_c ⇋ coa_c + h_c + mal_L_c010000.00330.0033
Citric Acid Cyclemalate oxidaseMOXo2_c + mal_L_c ⇋ h2o2_c + oaa_c-100010000.0069-0.0069
Citric Acid Cyclemalate dehydrogenaseMDHnad_c + mal_L_c ⇋ nadh_c + h_c + oaa_c-100010005.1-5.1

Metabolite name: Malonyl-[acyl-carrier protein]
Metabolite ID: malACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid MetabolismMalonyl-CoA-ACP transacylaseMCOATAACP_c + malcoa_c ⇋ coa_c + malACP_c-100010000.380.38
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-06-9.9e-06
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0)3OAS140ddcaACP_c + h_c + malACP_c ⇋ ACP_c + 3omrsACP_c + co2_c010000.38-0.38

Metabolite name: Malonyl-CoA
Metabolite ID: malcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.380.38
Cofactor and Prosthetic Group BiosynthesisMalonyl-CoA methyltransferaseMALCOAMTamet_c + malcoa_c ⇋ ahcys_c + malcoame_c010009.9e-06-9.9e-06
Membrane Lipid MetabolismMalonyl-CoA-ACP transacylaseMCOATAACP_c + malcoa_c ⇋ coa_c + malACP_c-100010000.38-0.38

Metabolite name: malonyl-CoA methyl ester
Metabolite ID: malcoame_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisMalonyl-CoA methyltransferaseMALCOAMTamet_c + malcoa_c ⇋ ahcys_c + malcoame_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-06-9.9e-06

Metabolite name: Maltose
Metabolite ID: malt_c
Compartment: c


Metabolite name: Maltose 6'-phosphate
Metabolite ID: malt6p_c
Compartment: c


Metabolite name: Maltoheptaose
Metabolite ID: malthp_c
Compartment: c


Metabolite name: Maltohexaose
Metabolite ID: malthx_c
Compartment: c


Metabolite name: Maltopentaose
Metabolite ID: maltpt_c
Compartment: c


Metabolite name: Maltotriose
Metabolite ID: malttr_c
Compartment: c


Metabolite name: Maltotetraose
Metabolite ID: maltttr_c
Compartment: c


Metabolite name: D-Mannose
Metabolite ID: man_c
Compartment: c


Metabolite name: D-Mannose 1-phosphate
Metabolite ID: man1p_c
Compartment: c


Metabolite name: D-Mannose 6-phosphate
Metabolite ID: man6p_c
Compartment: c


Metabolite name: 2(alpha-D-Mannosyl-6-phosphate)-D-glycerate
Metabolite ID: man6pglyc_c
Compartment: c


Metabolite name: D-Mannonate
Metabolite ID: mana_c
Compartment: c


Metabolite name: (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one
Metabolite ID: mdhdhf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolism4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)DHPTDCs2dhptd_c ⇋ mdhdhf_c010000.00220.0022
Methionine Metabolism(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)MTHTHFSsh2o_c + mdhdhf_c ⇋ mththf_c010000.0022-0.0022

Metabolite name: Melibiose
Metabolite ID: melib_c
Compartment: c


Metabolite name: Methanol
Metabolite ID: meoh_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisPimeloyl-[ACP] methyl ester esterasePMEACPEh2o_c + pmeACP_c ⇋ pimACP_c + meoh_c010009.9e-069.9e-06
Transport, Inner MembraneMethanol reversible transport via diffusion (periplasm)MEOHtrppmeoh_c ⇋ meoh_p-100010009.9e-06-9.9e-06

Metabolite name: Mercaptopyruvate
Metabolite ID: mercppyr_c
Compartment: c


Metabolite name: D-Methionine
Metabolite ID: met_D_c
Compartment: c


Metabolite name: L-Methionine
Metabolite ID: met_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolismmethionine synthaseMETShcys_L_c + 5mthf_c ⇋ h_c + met_L_c + thf_c010000.760.76
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisBiotin synthaseBTS52fe2s_c + amet_c + dtbt_c ⇋ 2fe1s_c + met_L_c + h_c + btn_c + dad_5_c010009.9e-069.9e-06
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.0044-0.0044
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.76

Metabolite name: 5,10-Methenyltetrahydrofolate
Metabolite ID: methf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate Metabolismmethylenetetrahydrofolate dehydrogenase (NADP)MTHFDnadp_c + mlthf_c ⇋ nadph_c + methf_c-100010004.94.9
Folate Metabolismmethenyltetrahydrofolate cyclohydrolaseMTHFCmethf_c + h2o_c ⇋ h_c + 10fthf_c-100010004.9-4.9

Metabolite name: L-methionine-R-sulfoxide
Metabolite ID: metsox_R_L_c
Compartment: c


Metabolite name: L-Methionine Sulfoxide
Metabolite ID: metsox_S_L_c
Compartment: c


Metabolite name: L-Methionyl-tRNA (Met)
Metabolite ID: mettrna_c
Compartment: c


Metabolite name: magnesium
Metabolite ID: mg2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismmagnesium (Mg+2) transport in/out via proton antiport (periplasm)MG2t3_2pp2 h_c + mg2_p ⇋ mg2_c + 2 h_p-100010000.0430.043
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.043

Metabolite name: 1D-myo-Inositol 1-phosphate
Metabolite ID: mi1p_D_c
Compartment: c


Metabolite name: methylisocitrate
Metabolite ID: micit_c
Compartment: c


Metabolite name: 5,10-Methylenetetrahydrofolate
Metabolite ID: mlthf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c010006363
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Cofactor and Prosthetic Group Biosynthesis3-methyl-2-oxobutanoate hydroxymethyltransferaseMOHMT3mob_c + mlthf_c + h2o_c ⇋ thf_c + 2dhp_c010000.0028-0.0028
Nucleotide Salvage Pathwaythymidylate synthaseTMDSmlthf_c + dump_c ⇋ dhf_c + dtmp_c010000.13-0.13
Folate Metabolism5,10-methylenetetrahydrofolate reductase (NADH)MTHFR2nadh_c + mlthf_c + 2 h_c ⇋ nad_c + 5mthf_c010000.76-0.76
Folate Metabolismmethylenetetrahydrofolate dehydrogenase (NADP)MTHFDnadp_c + mlthf_c ⇋ nadph_c + methf_c-100010004.9-4.9
Glycine and Serine Metabolismglycine hydroxymethyltransferase, reversibleGHMT2rgly_c + mlthf_c + h2o_c ⇋ thf_c + ser_L_c-1000100057-57

Metabolite name: (S)-Methylmalonyl-CoA
Metabolite ID: mmcoa_S_c
Compartment: c


Metabolite name: S-Methyl-L-methionine
Metabolite ID: mmet_c
Compartment: c


Metabolite name: Mn2+
Metabolite ID: mn2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismmanganese transport in via permease (no H+)MN2tppmn2_p ⇋ mn2_c010000.00340.0034
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0034

Metabolite name: D-Mannitol 1-phosphate
Metabolite ID: mnl1p_c
Compartment: c


Metabolite name: MoaD Protein with bound AMP
Metabolite ID: moadamp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthase sulfurylaseMPTSSmoadcoo_c + h_c + atp_c ⇋ ppi_c + moadamp_c010000.00240.0024
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.0024-0.0024

Metabolite name: MoaD Protein with carboxylate
Metabolite ID: moadcoo_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.00120.0024
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthase sulfurylaseMPTSSmoadcoo_c + h_c + atp_c ⇋ ppi_c + moadamp_c010000.0024-0.0024

Metabolite name: MoaD Protein with thiocarboxylate
Metabolite ID: moadcosh_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.00240.0024
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.0012-0.0024

Metabolite name: Molybdate
Metabolite ID: mobd_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.000640.00064
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-3.5e-05
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.0006-0.0006

Metabolite name: molybdenum cofactor
Metabolite ID: moco_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdenum cofactor synthaseBMOCOSmptamp_c + moco_c ⇋ bmoco_c + cu2_c + amp_c010000.0006-0.0006

Metabolite name: molybdopterin cytosine dinucleotide
Metabolite ID: mococdp_c
Compartment: c


Metabolite name: molybdopterin guanine dinucleotide
Metabolite ID: mocogdp_c
Compartment: c


Metabolite name: molybdopterin
Metabolite ID: mpt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthaseMPTS2 moadcosh_c + cu2_c + cpmp_c ⇋ mpt_c + 5 h_c + 2 moadcoo_c010000.00120.0012
Cofactor and Prosthetic Group Biosynthesismolybdopterin adenylyltransferaseMPTATmpt_c + h_c + atp_c ⇋ mptamp_c + ppi_c010000.0012-0.0012

Metabolite name: adenylated molybdopterin
Metabolite ID: mptamp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesismolybdopterin adenylyltransferaseMPTATmpt_c + h_c + atp_c ⇋ mptamp_c + ppi_c010000.00120.0012
Cofactor and Prosthetic Group Biosynthesisbis-molybdenum cofactor synthaseBMOCOSmptamp_c + moco_c ⇋ bmoco_c + cu2_c + amp_c010000.0006-0.0006
Cofactor and Prosthetic Group Biosynthesismolybdenum cofactor synthaseMOCOSmptamp_c + mobd_c + 2 h_c ⇋ h2o_c + amp_c + moco_c + cu2_c010000.0006-0.0006

Metabolite name: Menaquinol 8
Metabolite ID: mql8_c
Compartment: c


Metabolite name: Menaquinone 8
Metabolite ID: mqn8_c
Compartment: c


Metabolite name: Malonate semialdehyde
Metabolite ID: msa_c
Compartment: c


Metabolite name: methanesulfonate
Metabolite ID: mso3_c
Compartment: c


Metabolite name: Methylglyoxal
Metabolite ID: mthgxl_c
Compartment: c


Metabolite name: (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran
Metabolite ID: mththf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolism(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)MTHTHFSsh2o_c + mdhdhf_c ⇋ mththf_c010000.00220.0022
Sink needed to allow (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran to leave systemDM_MTHTHFmththf_c ⇋ 010000.0022-0.0022

Metabolite name: Myristoyl-ACP (n-C14:0ACP)
Metabolite ID: myrsACP_c
Compartment: c


Metabolite name: Nitrous oxide
Metabolite ID: n2o_c
Compartment: c


Metabolite name: N8-Acetylspermidine
Metabolite ID: n8aspmd_c
Compartment: c


Metabolite name: Sodium
Metabolite ID: na1_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneNa+/Proline-L symporter (periplasm)PROt4ppna1_p + pro_L_p ⇋ pro_L_c + na1_c010000.0260.026
Inorganic Ion Transport and Metabolismcalcium / sodium antiporter (1:1)CAt6ppca2_p + na1_c ⇋ na1_p + ca2_c-100010000.026-0.026

Metabolite name: N-3-aminopropyl-1,5-diaminopentane
Metabolite ID: na15dap_c
Compartment: c


Metabolite name: Nicotinate
Metabolite ID: nac_c
Compartment: c


Metabolite name: Nicotinamide adenine dinucleotide
Metabolite ID: nad_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+025.7e+02
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+025.3e+02
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-100010007171
Cofactor and Prosthetic Group BiosynthesisFAD reductaseFADRxnadh_c + fad_c + h_c ⇋ nad_c + fadh2_c010001111
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)HACD4nadh_c + h_c + 3odcoa_c ⇋ 3hdcoa_c + nad_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)HACD53oddcoa_c + h_c + nadh_c ⇋ nad_c + 3hddcoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)HACD1nadh_c + aacoa_c + h_c ⇋ 3hbcoa_c + nad_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)HACD2nadh_c + 3ohcoa_c + h_c ⇋ nad_c + 3hhcoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)HACD3nadh_c + h_c + 3oocoa_c ⇋ nad_c + 3hocoa_c-100010001.81.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)HACD63otdcoa_c + nadh_c + h_c ⇋ nad_c + 3htdcoa_c-100010001.41.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)HACD7nadh_c + 3ohdcoa_c + h_c ⇋ 3hhdcoa_c + nad_c-100010001.41.4
Folate Metabolism5,10-methylenetetrahydrofolate reductase (NADH)MTHFR2nadh_c + mlthf_c + 2 h_c ⇋ nad_c + 5mthf_c010000.760.76
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.010.01
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.00240.0024
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisErythronate 4-phosphate (4per) dehydrogenasePERDnad_c + 4per_c ⇋ nadh_c + h_c + ohpb_c-100010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin dehydrogenase (NAD)SHCHD2dscl_c + nad_c ⇋ nadh_c + scl_c + h_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.0011-0.0011
Cofactor and Prosthetic Group BiosynthesisNAD kinaseNADKnad_c + atp_c ⇋ nadp_c + adp_c + h_c010000.0022-0.0022
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.0033-0.0033
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.009
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydrogenasePPNDnad_c + pphn_c ⇋ nadh_c + co2_c + 34hpp_c010000.68-0.68
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.47-0.93
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.2-1.2
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrogenaseIPMDnad_c + 3c2hmp_c ⇋ nadh_c + h_c + 3c4mop_c010002.2-2.2
Citric Acid Cyclemalate dehydrogenaseMDHnad_c + mal_L_c ⇋ nadh_c + h_c + oaa_c-100010005.1-5.1
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c0100063-63
Glycine and Serine MetabolismL-threonine dehydrogenaseTHRDnad_c + thr_L_c ⇋ nadh_c + h_c + 2aobut_c010001.3e+02-1.3e+02
free_eREDnad_c ⇋ nadh_c010001e+03-1e+03

Metabolite name: Nicotinamide adenine dinucleotide - reduced
Metabolite ID: nadh_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
free_eREDnad_c ⇋ nadh_c010001e+031e+03
Glycine and Serine MetabolismL-threonine dehydrogenaseTHRDnad_c + thr_L_c ⇋ nadh_c + h_c + 2aobut_c010001.3e+021.3e+02
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c010006363
Citric Acid Cyclemalate dehydrogenaseMDHnad_c + mal_L_c ⇋ nadh_c + h_c + oaa_c-100010005.15.1
Valine, Leucine, and Isoleucine Metabolism3-isopropylmalate dehydrogenaseIPMDnad_c + 3c2hmp_c ⇋ nadh_c + h_c + 3c4mop_c010002.22.2
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.21.2
Histidine Metabolismhistidinol dehydrogenaseHISTDhistd_c + 2 nad_c + h2o_c ⇋ 2 nadh_c + his_L_c + 3 h_c010000.470.93
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydrogenasePPNDnad_c + pphn_c ⇋ nadh_c + co2_c + 34hpp_c010000.680.68
Folate MetabolismGlycolaldehyde dehydrogenaseGCALDDnad_c + h2o_c + gcald_c ⇋ nadh_c + glyclt_c + 2 h_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisErythronate 4-phosphate (4per) dehydrogenasePERDnad_c + 4per_c ⇋ nadh_c + h_c + ohpb_c-100010000.00110.0011
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin dehydrogenase (NAD)SHCHD2dscl_c + nad_c ⇋ nadh_c + scl_c + h_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisErythrose 4-phosphate dehydrogenaseE4PDnad_c + h2o_c + e4p_c ⇋ nadh_c + 4per_c + 2 h_c-100010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis4-amino-2-methyl-5-phosphomethylpyrimidine synthetaseAMPMS2nad_c + air_c + h2o_c ⇋ 4ampm_c + 2 for_c + 3 h_c + nadh_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)DMPPSh_c + h2mb4p_c + nadh_c ⇋ dmpp_c + nad_c + h2o_c010000.0014-0.0014
Cofactor and Prosthetic Group BiosynthesisMoaD sulfuration (nadh, assumed)MOADSUxnadh_c + iscssh_c + moadamp_c ⇋ amp_c + nad_c + iscs_c + moadcosh_c010000.0024-0.0024
Cofactor and Prosthetic Group Biosynthesis1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)IPDPSnadh_c + h_c + h2mb4p_c ⇋ ipdp_c + nad_c + h2o_c010000.01-0.01
Folate Metabolism5,10-methylenetetrahydrofolate reductase (NADH)MTHFR2nadh_c + mlthf_c + 2 h_c ⇋ nad_c + 5mthf_c010000.76-0.76
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)HACD63otdcoa_c + nadh_c + h_c ⇋ nad_c + 3htdcoa_c-100010001.4-1.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)HACD7nadh_c + 3ohdcoa_c + h_c ⇋ 3hhdcoa_c + nad_c-100010001.4-1.4
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)HACD4nadh_c + h_c + 3odcoa_c ⇋ 3hdcoa_c + nad_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)HACD53oddcoa_c + h_c + nadh_c ⇋ nad_c + 3hddcoa_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)HACD1nadh_c + aacoa_c + h_c ⇋ 3hbcoa_c + nad_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)HACD2nadh_c + 3ohcoa_c + h_c ⇋ nad_c + 3hhcoa_c-100010001.8-1.8
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)HACD3nadh_c + h_c + 3oocoa_c ⇋ nad_c + 3hocoa_c-100010001.8-1.8
Cofactor and Prosthetic Group BiosynthesisFAD reductaseFADRxnadh_c + fad_c + h_c ⇋ nad_c + fadh2_c0100011-11
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-1000100071-71
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+02-5.3e+02
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+02-5.7e+02

Metabolite name: Nicotinamide adenine dinucleotide phosphate
Metabolite ID: nadp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+021.6e+02
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+021.3e+02
Threonine and Lysine Metabolismhomoserine dehydrogenase (NADPH)HSDyaspsa_c + nadph_c + h_c ⇋ hom_L_c + nadp_c-100010001.3e+021.3e+02
Unassignedflavodoxin reductase (NADPH)FLDR22 flxso_c + nadph_c ⇋ h_c + nadp_c + 2 flxr_c010001e+021e+02
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)KARA1h_c + alac_S_c + nadph_c ⇋ 23dhmb_c + nadp_c-100010004.34.3
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.23.7
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate dehydrogenaseSHK3Drh_c + 3dhsk_c + nadph_c ⇋ skm_c + nadp_c-100010001.91.9
Threonine and Lysine Metabolismdihydrodipicolinate reductase (NADPH)DHDPRy23dhdp_c + h_c + nadph_c ⇋ nadp_c + thdp_c010001.81.8
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.51.5
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2-Acetolactate)KARA22ahbut_c + h_c + nadph_c ⇋ 23dhmp_c + nadp_c-100010001.41.4
Oxidative Phosphorylationthioredoxin reductase (NADPH)TRDRh_c + trdox_c + nadph_c ⇋ nadp_c + trdrd_c010001.41.4
Arginine and Proline Metabolismpyrroline-5-carboxylate reductaseP5CR1pyr5c_c + 2 h_c + nadph_c ⇋ nadp_c + pro_L_c010001.11.1
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.11.1
Alternate Carbon Metabolismglycerol-3-phosphate dehydrogenase (NADP)G3PD2h_c + nadph_c + dhap_c ⇋ glyc3p_c + nadp_c-100010000.690.69
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)3OAR1403omrsACP_c + h_c + nadph_c ⇋ nadp_c + 3hmrsACP_c-100010000.380.38
Cell Envelope BiosynthesisUDP-N-acetylenolpyruvoylglucosamine reductaseUAPGRnadph_c + h_c + uaccg_c ⇋ nadp_c + uamr_c010000.140.14
Cofactor and Prosthetic Group Biosynthesisdihydrofolate reductaseDHFRh_c + dhf_c + nadph_c ⇋ nadp_c + thf_c-100010000.130.13
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.0180.018
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose reductoisomeraseDXPRIidxyl5p_c + h_c + nadph_c ⇋ 2me4p_c + nadp_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesis2-dehydropantoate 2-reductaseDPR2dhp_c + h_c + nadph_c ⇋ pant_R_c + nadp_c010000.00280.0028
Cofactor and Prosthetic Group BiosynthesisNAD kinaseNADKnad_c + atp_c ⇋ nadp_c + adp_c + h_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesis5-amino-6-(5-phosphoribosylamino)uracil reductaseAPRAURnadph_c + h_c + 5apru_c ⇋ nadp_c + 5aprbu_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester reductaseOPMEACPRh_c + nadph_c + opmeACP_c ⇋ nadp_c + hpmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester reductaseOGMEACPRogmeACP_c + h_c + nadph_c ⇋ hgmeACP_c + nadp_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylglutaryl-[ACP] methyl ester reductaseEGMEACPRegmeACP_c + h_c + nadph_c ⇋ nadp_c + gmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylpimeloyl-[ACP] methyl ester reductaseEPMEACPRh_c + epmeACP_c + nadph_c ⇋ nadp_c + pmeACP_c010009.9e-069.9e-06
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0022
Folate Metabolismmethylenetetrahydrofolate dehydrogenase (NADP)MTHFDnadp_c + mlthf_c ⇋ nadph_c + methf_c-100010004.9-4.9
Citric Acid Cycleisocitrate dehydrogenase (NADP)ICDHyrnadp_c + icit_c ⇋ akg_c + nadph_c + co2_c-100010005.3-5.3
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+02-5.3e+02

Metabolite name: Nicotinamide adenine dinucleotide phosphate - reduced
Metabolite ID: nadph_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+025.3e+02
Citric Acid Cycleisocitrate dehydrogenase (NADP)ICDHyrnadp_c + icit_c ⇋ akg_c + nadph_c + co2_c-100010005.35.3
Folate Metabolismmethylenetetrahydrofolate dehydrogenase (NADP)MTHFDnadp_c + mlthf_c ⇋ nadph_c + methf_c-100010004.94.9
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester reductaseOPMEACPRh_c + nadph_c + opmeACP_c ⇋ nadp_c + hpmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester reductaseOGMEACPRogmeACP_c + h_c + nadph_c ⇋ hgmeACP_c + nadp_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylglutaryl-[ACP] methyl ester reductaseEGMEACPRegmeACP_c + h_c + nadph_c ⇋ nadp_c + gmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group BiosynthesisEnoylpimeloyl-[ACP] methyl ester reductaseEPMEACPRh_c + epmeACP_c + nadph_c ⇋ nadp_c + pmeACP_c010009.9e-06-9.9e-06
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesis5-amino-6-(5-phosphoribosylamino)uracil reductaseAPRAURnadph_c + h_c + 5apru_c ⇋ nadp_c + 5aprbu_c010000.0022-0.0022
Cofactor and Prosthetic Group Biosynthesis2-dehydropantoate 2-reductaseDPR2dhp_c + h_c + nadph_c ⇋ pant_R_c + nadp_c010000.0028-0.0028
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose reductoisomeraseDXPRIidxyl5p_c + h_c + nadph_c ⇋ 2me4p_c + nadp_c010000.012-0.012
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.018-0.018
Cofactor and Prosthetic Group Biosynthesisdihydrofolate reductaseDHFRh_c + dhf_c + nadph_c ⇋ nadp_c + thf_c-100010000.13-0.13
Cell Envelope BiosynthesisUDP-N-acetylenolpyruvoylglucosamine reductaseUAPGRnadph_c + h_c + uaccg_c ⇋ nadp_c + uamr_c010000.14-0.14
Cell Envelope Biosynthesis3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0)3OAR1403omrsACP_c + h_c + nadph_c ⇋ nadp_c + 3hmrsACP_c-100010000.38-0.38
Alternate Carbon Metabolismglycerol-3-phosphate dehydrogenase (NADP)G3PD2h_c + nadph_c + dhap_c ⇋ glyc3p_c + nadp_c-100010000.69-0.69
Arginine and Proline Metabolismpyrroline-5-carboxylate reductaseP5CR1pyr5c_c + 2 h_c + nadph_c ⇋ nadp_c + pro_L_c010001.1-1.1
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.1-1.1
Oxidative Phosphorylationthioredoxin reductase (NADPH)TRDRh_c + trdox_c + nadph_c ⇋ nadp_c + trdrd_c010001.4-1.4
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2-Acetolactate)KARA22ahbut_c + h_c + nadph_c ⇋ 23dhmp_c + nadp_c-100010001.4-1.4
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.5-1.5
Threonine and Lysine Metabolismdihydrodipicolinate reductase (NADPH)DHDPRy23dhdp_c + h_c + nadph_c ⇋ nadp_c + thdp_c010001.8-1.8
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate dehydrogenaseSHK3Drh_c + 3dhsk_c + nadph_c ⇋ skm_c + nadp_c-100010001.9-1.9
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.2-3.7
Valine, Leucine, and Isoleucine Metabolismketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)KARA1h_c + alac_S_c + nadph_c ⇋ 23dhmb_c + nadp_c-100010004.3-4.3
Unassignedflavodoxin reductase (NADPH)FLDR22 flxso_c + nadph_c ⇋ h_c + nadp_c + 2 flxr_c010001e+02-1e+02
Threonine and Lysine Metabolismhomoserine dehydrogenase (NADPH)HSDyaspsa_c + nadph_c + h_c ⇋ hom_L_c + nadp_c-100010001.3e+02-1.3e+02
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+02-1.3e+02
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+02-1.6e+02

Metabolite name: Nicotinamide
Metabolite ID: ncam_c
Compartment: c


Metabolite name: Ammonium
Metabolite ID: nh4_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c010006363
Glycine and Serine MetabolismL-serine deaminaseSERD_Lser_L_c ⇋ pyr_c + nh4_c010005454
Inorganic Ion Transport and Metabolismammonia reversible transport (periplasm)NH4tppnh4_p ⇋ nh4_c-100010005353
Valine, Leucine, and Isoleucine MetabolismL-threonine deaminaseTHRD_Lthr_L_c ⇋ 2obut_c + nh4_c010001.41.4
Methionine Metabolismcystathionine b-lyaseCYSTLcyst_L_c + h2o_c ⇋ pyr_c + hcys_L_c + nh4_c010000.760.76
Cofactor and Prosthetic Group Biosynthesishydroxymethylbilane synthaseHMBSh2o_c + 4 ppbng_c ⇋ hmbil_c + 4 nh4_c010000.00220.0088
Cofactor and Prosthetic Group Biosynthesisdiaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)DHPPDA2h_c + 25drapp_c + h2o_c ⇋ 5apru_c + nh4_c010000.00220.0022
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.011-0.011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.064
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.2-1.2
UnassignedCarbamate kinaseCBMKrnh4_c + co2_c + atp_c ⇋ cbp_c + 2 h_c + adp_c-100010003.1-3.1
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.9-8.9
Glutamate Metabolismglutamate dehydrogenase (NADP)GLUDyh_c + akg_c + nadph_c + nh4_c ⇋ nadp_c + h2o_c + glu_L_c-100010001.6e+02-1.6e+02

Metabolite name: nickel
Metabolite ID: ni2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismnickel (+2) transport in via permease (no H+)NI2tppni2_p ⇋ ni2_c010000.00160.0016
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0016

Metabolite name: Nicotinate D-ribonucleotide
Metabolite ID: nicrnt_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.0110.011
Nucleotide Salvage Pathwaynicotinate-nucleotide adenylyltransferaseNNATrnicrnt_c + h_c + atp_c ⇋ ppi_c + dnad_c-100010000.011-0.011

Metabolite name: NMN
Metabolite ID: nmn_c
Compartment: c


Metabolite name: Nitric oxide
Metabolite ID: no_c
Compartment: c


Metabolite name: Nitrite
Metabolite ID: no2_c
Compartment: c


Metabolite name: Nitrate
Metabolite ID: no3_c
Compartment: c


Metabolite name: O16 antigen undecaprenyl diphosphate
Metabolite ID: o16aund_c
Compartment: c


Metabolite name: O2
Metabolite ID: o2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismo2 transport via diffusion (periplasm)O2tppo2_p ⇋ o2_c-100010002.9e+022.9e+02
Cofactor and Prosthetic Group Biosynthesis2-Octaprenylphenol hydroxylaseOPHHX0.5 o2_c + 2oph_c ⇋ 2ohph_c010000.0011-0.00055
Cofactor and Prosthetic Group Biosynthesispyridoxine 5'-phosphate oxidasePDX5POipdx5p_c + o2_c ⇋ h2o2_c + pydx5p_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.0011-0.0011
Citric Acid Cyclemalate oxidaseMOXo2_c + mal_L_c ⇋ h2o2_c + oaa_c-100010000.0069-0.0069
Cofactor and Prosthetic Group BiosynthesisL-aspartate oxidaseASPO6o2_c + asp_L_c ⇋ h_c + iasp_c + h2o2_c010000.011-0.011
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+02-2.9e+02

Metabolite name: Superoxide anion
Metabolite ID: o2s_c
Compartment: c


Metabolite name: Oxaloacetate
Metabolite ID: oaa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+021.4e+02
Citric Acid Cyclemalate dehydrogenaseMDHnad_c + mal_L_c ⇋ nadh_c + h_c + oaa_c-100010005.15.1
Citric Acid Cyclemalate oxidaseMOXo2_c + mal_L_c ⇋ h2o2_c + oaa_c-100010000.00690.0069
Citric Acid Cyclecitrate synthaseCSh2o_c + oaa_c + accoa_c ⇋ coa_c + cit_c + h_c010005.3-5.3
Alanine and Aspartate Metabolismaspartate transaminaseASPTAglu_L_c + oaa_c ⇋ akg_c + asp_L_c-100010001.4e+02-1.4e+02

Metabolite name: trans-Oct-2-enoyl-CoA
Metabolite ID: oc2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)ECOAH33hocoa_c ⇋ h2o_c + oc2coa_c-100010001.81.8
Membrane Lipid Metabolismacyl-CoA dehydrogenase (octanoyl-CoA)ACOAD3ffadh2_c + oc2coa_c ⇋ occoa_c + fad_c-100010001.8-1.8

Metabolite name: Octanoyl-ACP (n-C8:0ACP)
Metabolite ID: ocACP_c
Compartment: c


Metabolite name: Octanoyl-CoA (n-C8:0CoA)
Metabolite ID: occoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (octanoyl-CoA)ACOAD3ffadh2_c + oc2coa_c ⇋ occoa_c + fad_c-100010001.81.8
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (octanoyl-CoA) (r)ACACT4roccoa_c + accoa_c ⇋ 3odcoa_c + coa_c-100010001.8-1.8

Metabolite name: octadecanoate (n-C18:0)
Metabolite ID: ocdca_c
Compartment: c


Metabolite name: Octadecanoyl-ACP (n-C18:0ACP)
Metabolite ID: ocdcaACP_c
Compartment: c


Metabolite name: Octadecanoyl-phosphate (n-C18:0)
Metabolite ID: ocdcap_c
Compartment: c


Metabolite name: octadecenoate (n-C18:1)
Metabolite ID: ocdcea_c
Compartment: c


Metabolite name: Octadecanoyl-phosphate (n-C18:1)
Metabolite ID: ocdceap_c
Compartment: c


Metabolite name: octanoate (n-C8:0)
Metabolite ID: octa_c
Compartment: c


Metabolite name: octanoate (protein bound)
Metabolite ID: octapb_c
Compartment: c


Metabolite name: all-trans-Octaprenyl diphosphate
Metabolite ID: octdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisOctaprenyl pyrophosphate synthaseOCTDPS5 ipdp_c + frdp_c ⇋ octdp_c + 5 ppi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisHydroxybenzoate octaprenyltransferaseHBZOPT4hbz_c + octdp_c ⇋ 3ophb_c + ppi_c010000.0011-0.0011

Metabolite name: cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)
Metabolite ID: octeACP_c
Compartment: c


Metabolite name: trans-Octadec-2-enoyl-CoA
Metabolite ID: od2coa_c
Compartment: c


Metabolite name: Octadecenoyl-CoA (n-C18:1CoA)
Metabolite ID: odecoa_c
Compartment: c


Metabolite name: 3-Oxo-glutaryl-[acyl-carrier protein] methyl ester
Metabolite ID: ogmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester synthaseOGMEACPSh_c + malACP_c + malcoame_c ⇋ ogmeACP_c + co2_c + coa_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-glutaryl-[ACP] methyl ester reductaseOGMEACPRogmeACP_c + h_c + nadph_c ⇋ hgmeACP_c + nadp_c010009.9e-06-9.9e-06

Metabolite name: 2-Oxo-3-hydroxy-4-phosphobutanoate
Metabolite ID: ohpb_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisErythronate 4-phosphate (4per) dehydrogenasePERDnad_c + 4per_c ⇋ nadh_c + h_c + ohpb_c-100010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisO-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferaseOHPBATglu_L_c + ohpb_c ⇋ akg_c + phthr_c-100010000.0011-0.0011

Metabolite name: 2-Oxopent-4-enoate
Metabolite ID: op4en_c
Compartment: c


Metabolite name: 3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester
Metabolite ID: opmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester synthaseOPMEACPSgmeACP_c + h_c + malACP_c ⇋ ACP_c + opmeACP_c + co2_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis3-Oxo-pimeloyl-[ACP] methyl ester reductaseOPMEACPRh_c + nadph_c + opmeACP_c ⇋ nadp_c + hpmeACP_c010009.9e-06-9.9e-06

Metabolite name: Ornithine
Metabolite ID: orn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismacetylornithine deacetylaseACODAacorn_c + h2o_c ⇋ ac_c + orn_c010001.51.5
Arginine and Proline Metabolismornithine carbamoyltransferaseOCBTcbp_c + orn_c ⇋ citr_L_c + h_c + pi_c-100010001.5-1.5

Metabolite name: Orotate
Metabolite ID: orot_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisdihydoorotic acid dehydrogenase (quinone8)DHORD2q8_c + dhor_S_c ⇋ orot_c + q8h2_c010001.61.6
Purine and Pyrimidine Biosynthesisorotate phosphoribosyltransferaseORPTorot_c + prpp_c ⇋ orot5p_c + ppi_c-100010001.6-1.6

Metabolite name: Orotidine 5'-phosphate
Metabolite ID: orot5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisorotate phosphoribosyltransferaseORPTorot_c + prpp_c ⇋ orot5p_c + ppi_c-100010001.61.6
Purine and Pyrimidine Biosynthesisorotidine-5'-phosphate decarboxylaseOMPDCh_c + orot5p_c ⇋ co2_c + ump_c010001.6-1.6

Metabolite name: Oxalate
Metabolite ID: oxa_c
Compartment: c


Metabolite name: 3-Oxoadipyl-CoA
Metabolite ID: oxadpcoa_c
Compartment: c


Metabolite name: Oxalyl-CoA
Metabolite ID: oxalcoa_c
Compartment: c


Metabolite name: Oxamate
Metabolite ID: oxam_c
Compartment: c


Metabolite name: Oxalureate
Metabolite ID: oxur_c
Compartment: c


Metabolite name: 1,2-didodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa120_c
Compartment: c


Metabolite name: 1,2-ditetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa140_c
Compartment: c


Metabolite name: 1,2-ditetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa141_c
Compartment: c


Metabolite name: 1,2-dihexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa160_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid Metabolism1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)AGPAT160palmACP_c + 1hdecg3p_c ⇋ ACP_c + pa160_c010000.310.31
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:0)DASYN160pa160_c + ctp_c + h_c ⇋ ppi_c + cdpdhdecg_c010000.31-0.31

Metabolite name: 1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa161_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid Metabolism1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)AGPAT161hdeACP_c + 1hdec9eg3p_c ⇋ ACP_c + pa161_c010000.370.37
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:1)DASYN161pa161_c + ctp_c + h_c ⇋ ppi_c + cdpdhdec9eg_c010000.37-0.37

Metabolite name: 1,2-dioctadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa180_c
Compartment: c


Metabolite name: 1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa181_c
Compartment: c


Metabolite name: Phenylacetic acid
Metabolite ID: pac_c
Compartment: c


Metabolite name: Phenylacetaldehyde
Metabolite ID: pacald_c
Compartment: c


Metabolite name: Palmitoyl-ACP (n-C16:0ACP)
Metabolite ID: palmACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.630.63
Glycerophospholipid Metabolism1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)AGPAT160palmACP_c + 1hdecg3p_c ⇋ ACP_c + pa160_c010000.31-0.31
Glycerophospholipid Metabolismglycerol-3-phosphate acyltransferase (C16:0)G3PAT160palmACP_c + glyc3p_c ⇋ ACP_c + 1hdecg3p_c010000.31-0.31

Metabolite name: Pantetheine 4'-phosphate
Metabolite ID: pan4p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisphosphopantothenoylcysteine decarboxylasePPCDC4ppcys_c + h_c ⇋ co2_c + pan4p_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantetheine-phosphate adenylyltransferasePTPATih_c + atp_c + pan4p_c ⇋ ppi_c + dpcoa_c010000.0028-0.0028

Metabolite name: (R)-Pantoate
Metabolite ID: pant_R_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesis2-dehydropantoate 2-reductaseDPR2dhp_c + h_c + nadph_c ⇋ pant_R_c + nadp_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.0028-0.0028

Metabolite name: Adenosine 3',5'-bisphosphate
Metabolite ID: pap_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.21.2
Cysteine Metabolism3',5'-bisphosphate nucleotidaseBPNTpap_c + h2o_c ⇋ amp_c + pi_c010001.2-1.2

Metabolite name: 3'-Phosphoadenylyl sulfate
Metabolite ID: paps_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismadenylyl-sulfate kinaseADSKatp_c + aps_c ⇋ paps_c + adp_c + h_c010001.21.2
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.2-1.2

Metabolite name: Pyridoxine 5'-phosphate
Metabolite ID: pdx5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesispyridoxine 5'-phosphate oxidasePDX5POipdx5p_c + o2_c ⇋ h2o2_c + pydx5p_c010000.0011-0.0011

Metabolite name: phosphatidylethanolamine (didodecanoyl, n-C12:0)
Metabolite ID: pe120_c
Compartment: c


Metabolite name: phosphatidylethanolamine (ditetradecanoyl, n-C14:0)
Metabolite ID: pe140_c
Compartment: c


Metabolite name: phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pe141_c
Compartment: c


Metabolite name: phosphatidylethanolamine (dihexadecanoyl, n-C16:0)
Metabolite ID: pe160_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:0)PSD160h_c + ps160_c ⇋ pe160_c + co2_c010000.310.31
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.088
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.23-0.23

Metabolite name: phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)
Metabolite ID: pe161_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:1)PSD161ps161_c + h_c ⇋ co2_c + pe161_c010000.370.37
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.1-0.1
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.27

Metabolite name: phosphatidylethanolamine (dioctadecanoyl, n-C18:0)
Metabolite ID: pe180_c
Compartment: c


Metabolite name: phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pe181_c
Compartment: c


Metabolite name: Phosphoenolpyruvate
Metabolite ID: pep_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+021.4e+02
Cell Envelope BiosynthesisUDP-N-acetylglucosamine 1-carboxyvinyltransferaseUAGCVTuacgam_c + pep_c ⇋ pi_c + uaccg_c010000.14-0.14
Lipopolysaccharide Biosynthesis / Recycling3-deoxy -D-manno-octulosonic -acid 8-phosphate synthaseKDOPSara5p_c + pep_c + h2o_c ⇋ kdo8p_c + pi_c010000.19-0.19
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-deoxy-D-arabino-heptulosonate 7-phosphate synthetaseDDPAe4p_c + h2o_c + pep_c ⇋ 2dda7p_c + pi_c010001.9-1.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-phosphoshikimate 1-carboxyvinyltransferasePSCVTskm5p_c + pep_c ⇋ 3psme_c + pi_c-100010001.9-1.9
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+02-1.4e+02

Metabolite name: Phosphatidylglycerol (didodecanoyl, n-C12:0)
Metabolite ID: pg120_c
Compartment: c


Metabolite name: Phosphatidylglycerol (ditetradecanoyl, n-C14:0)
Metabolite ID: pg140_c
Compartment: c


Metabolite name: Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pg141_c
Compartment: c


Metabolite name: Phosphatidylglycerol (dihexadecanoyl, n-C16:0)
Metabolite ID: pg160_c
Compartment: c


Metabolite name: Phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: pg161_c
Compartment: c


Metabolite name: Phosphatidylglycerol (dioctadecanoyl, n-C18:0)
Metabolite ID: pg180_c
Compartment: c


Metabolite name: Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pg181_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)
Metabolite ID: pgp120_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)
Metabolite ID: pgp140_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pgp141_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)
Metabolite ID: pgp160_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: pgp161_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)
Metabolite ID: pgp180_c
Compartment: c


Metabolite name: Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pgp181_c
Compartment: c


Metabolite name: Phenylacetyl-CoA
Metabolite ID: phaccoa_c
Compartment: c


Metabolite name: L-Phenylalanine
Metabolite ID: phe_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismphenylalanine transaminasePHETA1glu_L_c + phpyr_c ⇋ phe_L_c + akg_c-100010000.910.91
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.91

Metabolite name: Protoheme
Metabolite ID: pheme_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisFerrochelataseFCLTppp9_c + fe2_c ⇋ 2 h_c + pheme_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011

Metabolite name: L-Phenylalanyl-tRNA(Phe)
Metabolite ID: phetrna_c
Compartment: c


Metabolite name: phospho-heptosyl-heptosyl-kdo2-lipidA
Metabolite ID: phhlipa_c
Compartment: c


Metabolite name: O-Phospho-L-homoserine
Metabolite ID: phom_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismhomoserine kinaseHSKhom_L_c + atp_c ⇋ phom_c + adp_c + h_c010001.3e+021.3e+02
Threonine and Lysine Metabolismthreonine synthaseTHRSh2o_c + phom_c ⇋ pi_c + thr_L_c010001.3e+02-1.3e+02

Metabolite name: phospho-heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA
Metabolite ID: phphhlipa_c
Compartment: c


Metabolite name: Phenylpyruvate
Metabolite ID: phpyr_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydratasePPNDHh_c + pphn_c ⇋ phpyr_c + co2_c + h2o_c010000.910.91
Tyrosine, Tryptophan, and Phenylalanine Metabolismphenylalanine transaminasePHETA1glu_L_c + phpyr_c ⇋ phe_L_c + akg_c-100010000.91-0.91

Metabolite name: O-Phospho-4-hydroxy-L-threonine
Metabolite ID: phthr_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisO-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferaseOHPBATglu_L_c + ohpb_c ⇋ akg_c + phthr_c-100010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.0011-0.0011

Metabolite name: Phosphate
Metabolite ID: pi_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.92.7e+02
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+021.4e+02
Anaplerotic Reactionsphosphoenolpyruvate carboxylasePPCh2o_c + co2_c + pep_c ⇋ h_c + pi_c + oaa_c010001.4e+021.4e+02
Threonine and Lysine Metabolismaspartate-semialdehyde dehydrogenaseASADh_c + nadph_c + 4pasp_c ⇋ aspsa_c + nadp_c + pi_c-100010001.3e+021.3e+02
Threonine and Lysine Metabolismthreonine synthaseTHRSh2o_c + phom_c ⇋ pi_c + thr_L_c010001.3e+021.3e+02
Glycolysis/Gluconeogenesisglyceraldehyde-3-phosphate dehydrogenaseGAPDnadh_c + h_c + 13dpg_c ⇋ g3p_c + pi_c + nad_c-100010007171
Glycolysis/Gluconeogenesisfructose-bisphosphataseFBPh2o_c + fdp_c ⇋ pi_c + f6p_c010002828
Oxidative Phosphorylationpolyphosphate kinasePPKrppi_c + adp_c ⇋ atp_c + pi_c-100010001717
Glutamate Metabolismglutamine synthetaseGLNSatp_c + glu_L_c + nh4_c ⇋ h_c + adp_c + pi_c + gln_L_c010008.98.9
Inorganic Ion Transport and Metabolismphosphate reversible transport via symport (periplasm)PIt2rpppi_p + h_p ⇋ h_c + pi_c-100010004.84.8
Pyruvate MetabolismphosphotransacetylasePTArcoa_c + actp_c ⇋ pi_c + accoa_c-100010002.92.9
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.62.6
Purine and Pyrimidine Biosynthesisphosphoribosylformylglycinamidine synthasePRFGSfgam_c + atp_c + gln_L_c + h2o_c ⇋ adp_c + fpram_c + h_c + glu_L_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole synthasePRAISfpram_c + atp_c ⇋ air_c + adp_c + pi_c + 2 h_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazole carboxylaseAIRC2hco3_c + air_c + atp_c ⇋ 5caiz_c + adp_c + h_c + pi_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolesuccinocarboxamide synthasePRASCSiasp_L_c + 5aizc_c + atp_c ⇋ adp_c + 25aics_c + h_c + pi_c010002.22.2
Tyrosine, Tryptophan, and Phenylalanine Metabolismchorismate synthaseCHORS3psme_c ⇋ chor_c + pi_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-phosphoshikimate 1-carboxyvinyltransferasePSCVTskm5p_c + pep_c ⇋ 3psme_c + pi_c-100010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-deoxy-D-arabino-heptulosonate 7-phosphate synthetaseDDPAe4p_c + h2o_c + pep_c ⇋ 2dda7p_c + pi_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-dehydroquinate synthaseDHQS2dda7p_c ⇋ pi_c + 3dhq_c010001.91.9
Purine and Pyrimidine Biosynthesisaspartate carbamoyltransferaseASPCTcbp_c + asp_L_c ⇋ h_c + pi_c + cbasp_c010001.61.6
Purine and Pyrimidine Biosynthesisadenylosuccinate synthaseADSSasp_L_c + gtp_c + imp_c ⇋ 2 h_c + dcamp_c + pi_c + gdp_c010001.51.5
Arginine and Proline Metabolismornithine carbamoyltransferaseOCBTcbp_c + orn_c ⇋ citr_L_c + h_c + pi_c-100010001.51.5
Arginine and Proline MetabolismN-acetyl-g-glutamyl-phosphate reductaseAGPRacg5p_c + h_c + nadph_c ⇋ nadp_c + acg5sa_c + pi_c-100010001.51.5
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.21.2
Cysteine Metabolism3',5'-bisphosphate nucleotidaseBPNTpap_c + h2o_c ⇋ amp_c + pi_c010001.21.2
Arginine and Proline Metabolismglutamate-5-semialdehyde dehydrogenaseG5SDglu5p_c + h_c + nadph_c ⇋ glu5sa_c + nadp_c + pi_c010001.11.1
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.790.79
Histidine Metabolismhistidinol-phosphataseHISTPhisp_c + h2o_c ⇋ histd_c + pi_c010000.470.47
Membrane Lipid Metabolismacetyl-CoA carboxylaseACCOAChco3_c + atp_c + accoa_c ⇋ adp_c + h_c + malcoa_c + pi_c010000.380.38
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.230.23
Lipopolysaccharide Biosynthesis / Recycling3-deoxy -D-manno-octulosonic -acid 8-phosphate synthaseKDOPSara5p_c + pep_c + h2o_c ⇋ kdo8p_c + pi_c010000.190.19
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate-8-phosphataseKDOPPh2o_c + kdo8p_c ⇋ kdo_c + pi_c010000.190.19
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.140.14
Cell Envelope Biosynthesisundecaprenyl-diphosphataseUDCPDPh2o_c + udcpdp_c ⇋ udcpp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisD-alanine-D-alanine ligase (reversible)ALAALAratp_c + 2 ala_D_c ⇋ adp_c + h_c + pi_c + alaala_c-100010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylglucosamine 1-carboxyvinyltransferaseUAGCVTuacgam_c + pep_c ⇋ pi_c + uaccg_c010000.140.14
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.10.1
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.0960.096
Purine and Pyrimidine BiosynthesisGAR transformylase-TGARTgar_c + for_c + atp_c ⇋ fgam_c + adp_c + h_c + pi_c010000.0120.012
Cofactor and Prosthetic Group Biosynthesisquinolinate synthaseQULNSdhap_c + iasp_c ⇋ quln_c + pi_c + 2 h2o_c010000.0110.011
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.00440.0044
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSadb4p_c + 4r5au_c ⇋ dmlz_c + pi_c + 2 h2o_c010000.00440.0044
Nucleotide Salvage Pathwaypurine-nucleoside phosphorylase (Adenosine)PUNP1ade_c + r1p_c ⇋ pi_c + adn_c-100010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin monophosphate dephosphorylaseDNMPPAdhpmp_c + h2o_c ⇋ dhnpt_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydrofolate synthaseDHFSglu_L_c + atp_c + dhpt_c ⇋ h_c + dhf_c + adp_c + pi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesispyrimidine phosphatasePMDPHTh2o_c + 5aprbu_c ⇋ pi_c + 4r5au_c010000.00220.0022
Cofactor and Prosthetic Group BiosynthesisPyridoxine 5'-phosphate synthasePDX5PSnad_c + dxyl5p_c + phthr_c ⇋ nadh_c + pdx5p_c + co2_c + h_c + 2 h2o_c + pi_c010000.00110.0011
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.000640.00064
Cofactor and Prosthetic Group Biosynthesisdethiobiotin synthaseDBTSdann_c + co2_c + atp_c ⇋ adp_c + 3 h_c + pi_c + dtbt_c010009.9e-069.9e-06
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+02-9.8e+02

Metabolite name: Pimeloyl-[acyl-carrier protein]
Metabolite ID: pimACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisPimeloyl-[ACP] methyl ester esterasePMEACPEh2o_c + pmeACP_c ⇋ pimACP_c + meoh_c010009.9e-069.9e-06
Cofactor and Prosthetic Group Biosynthesis8-amino-7-oxononanoate synthaseAOXSr2pimACP_c + ala_L_c ⇋ ACP_c + co2_c + 8aonn_c010009.9e-06-9.9e-06

Metabolite name: Pimeloyl-[acyl-carrier protein] methyl ester
Metabolite ID: pmeACP_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group BiosynthesisEnoylpimeloyl-[ACP] methyl ester reductaseEPMEACPRh_c + epmeACP_c + nadph_c ⇋ nadp_c + pmeACP_c010009.9e-069.9e-06
Cofactor and Prosthetic Group BiosynthesisPimeloyl-[ACP] methyl ester esterasePMEACPEh2o_c + pmeACP_c ⇋ pimACP_c + meoh_c010009.9e-06-9.9e-06

Metabolite name: Palmitoyl-CoA (n-C16:0CoA)
Metabolite ID: pmtcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (hexadecanoyl-CoA)ACOAD7fhdd2coa_c + fadh2_c ⇋ pmtcoa_c + fad_c-100010000.630.63
Cell Envelope Biosynthesisfatty-acid-CoA thioesterase (hexadecanoate)FACOAE160pmtcoa_c + h2o_c ⇋ coa_c + h_c + hdca_c010000.63-0.63

Metabolite name: (R)-Pantothenate
Metabolite ID: pnto_R_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantothenate kinasePNTKpnto_R_c + atp_c ⇋ h_c + 4ppan_c + adp_c010000.0028-0.0028

Metabolite name: Peroxyaminoacrylate
Metabolite ID: poaac_c
Compartment: c


Metabolite name: Propionate (n-C3:0)
Metabolite ID: ppa_c
Compartment: c


Metabolite name: Propanal
Metabolite ID: ppal_c
Compartment: c


Metabolite name: Propanoyl phosphate
Metabolite ID: ppap_c
Compartment: c


Metabolite name: Porphobilinogen
Metabolite ID: ppbng_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisporphobilinogen synthasePPBNGS2 5aop_c ⇋ 2 h2o_c + ppbng_c + h_c010000.00880.0088
Cofactor and Prosthetic Group Biosynthesishydroxymethylbilane synthaseHMBSh2o_c + 4 ppbng_c ⇋ hmbil_c + 4 nh4_c010000.0022-0.0088

Metabolite name: Propanoyl-CoA
Metabolite ID: ppcoa_c
Compartment: c


Metabolite name: Guanosine 3',5'-bis(diphosphate)
Metabolite ID: ppgpp_c
Compartment: c


Metabolite name: Prephenate
Metabolite ID: pphn_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismchorismate mutaseCHORMchor_c ⇋ pphn_c010001.61.6
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydrogenasePPNDnad_c + pphn_c ⇋ nadh_c + co2_c + 34hpp_c010000.68-0.68
Tyrosine, Tryptophan, and Phenylalanine Metabolismprephenate dehydratasePPNDHh_c + pphn_c ⇋ phpyr_c + co2_c + h2o_c010000.91-0.91

Metabolite name: Diphosphate
Metabolite ID: ppi_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.93.8
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.22.2
Purine and Pyrimidine Biosynthesisorotate phosphoribosyltransferaseORPTorot_c + prpp_c ⇋ orot5p_c + ppi_c-100010001.61.6
Arginine and Proline Metabolismargininosuccinate synthaseARGSSasp_L_c + citr_L_c + atp_c ⇋ amp_c + argsuc_c + h_c + ppi_c010001.51.5
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.21.2
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.21.2
Alanine and Aspartate Metabolismasparagine synthetaseASNS2nh4_c + asp_L_c + atp_c ⇋ ppi_c + h_c + asn_L_c + amp_c010001.21.2
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:1)AACPS4ACP_c + hdcea_c + atp_c ⇋ ppi_c + hdeACP_c + amp_c010000.740.74
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C16:0)AACPS3ACP_c + atp_c + hdca_c ⇋ ppi_c + palmACP_c + amp_c010000.630.63
Histidine Metabolismphosphoribosyl-ATP pyrophosphatasePRATPPprbatp_c + h2o_c ⇋ ppi_c + prbamp_c + h_c010000.470.47
Histidine MetabolismATP phosphoribosyltransferaseATPPRTatp_c + prpp_c ⇋ prbatp_c + ppi_c010000.470.47
Cell Envelope BiosynthesisUDP-N-acetylglucosamine diphosphorylaseUAGDPutp_c + h_c + acgam1p_c ⇋ ppi_c + uacgam_c010000.470.47
Cell Envelope Biosynthesisacyl-[acyl-carrier-protein] synthetase (n-C12:0)AACPS7ACP_c + ddca_c + atp_c ⇋ ddcaACP_c + ppi_c + amp_c010000.380.38
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:1)DASYN161pa161_c + ctp_c + h_c ⇋ ppi_c + cdpdhdec9eg_c010000.370.37
Glycerophospholipid MetabolismCDP-diacylglycerol synthetase (n-C16:0)DASYN160pa160_c + ctp_c + h_c ⇋ ppi_c + cdpdhdecg_c010000.310.31
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate phosphoribosyltransferaseANPRTprpp_c + anth_c ⇋ ppi_c + pran_c010000.280.28
Lipopolysaccharide Biosynthesis / Recycling3-deoxy-manno-octulosonate cytidylyltransferaseKDOCT2ctp_c + kdo_c ⇋ ckdo_c + ppi_c010000.190.19
Nucleotide Salvage PathwaydUTP diphosphataseDUTPDPh2o_c + dutp_c ⇋ ppi_c + dump_c + h_c010000.130.13
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.0180.018
Cofactor and Prosthetic Group Biosynthesis2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseMEPCT2me4p_c + h_c + ctp_c ⇋ 4c2me_c + ppi_c010000.0120.012
Cofactor and Prosthetic Group BiosynthesisNAD synthase (nh3)NADS1nh4_c + dnad_c + atp_c ⇋ h_c + nad_c + ppi_c + amp_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.0110.011
Nucleotide Salvage Pathwaynicotinate-nucleotide adenylyltransferaseNNATrnicrnt_c + h_c + atp_c ⇋ ppi_c + dnad_c-100010000.0110.011
Cofactor and Prosthetic Group BiosynthesisOctaprenyl pyrophosphate synthaseOCTDPS5 ipdp_c + frdp_c ⇋ octdp_c + 5 ppi_c010000.00110.0055
Methionine Metabolismmethionine adenosyltransferaseMETATmet_L_c + atp_c + h2o_c ⇋ amet_c + ppi_c + pi_c010000.00440.0044
Cofactor and Prosthetic Group BiosynthesisDihydroneopterin triphosphate pyrophosphataseDNTPPAahdt_c + h2o_c ⇋ ppi_c + dhpmp_c + h_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesisdihydropteroate synthaseDHPS26hmhptpp_c + 4abz_c ⇋ dhpt_c + ppi_c010000.00330.0033
Cofactor and Prosthetic Group Biosynthesispantothenate synthasePANTSpant_R_c + atp_c + ala_B_c ⇋ pnto_R_c + h_c + amp_c + ppi_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesispantetheine-phosphate adenylyltransferasePTPATih_c + atp_c + pan4p_c ⇋ ppi_c + dpcoa_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesisphosphopantothenate-cysteine ligasePPNCL2cys_L_c + 4ppan_c + ctp_c ⇋ 4ppcys_c + ppi_c + cmp_c + h_c010000.00280.0028
Cofactor and Prosthetic Group Biosynthesismolybdopterin synthase sulfurylaseMPTSSmoadcoo_c + h_c + atp_c ⇋ ppi_c + moadamp_c010000.00240.0024
Cofactor and Prosthetic Group BiosynthesisGTP cyclohydrolase II (25drapp)GTPCII2gtp_c + 3 h2o_c ⇋ ppi_c + 25drapp_c + for_c + 2 h_c010000.00220.0022
Cofactor and Prosthetic Group BiosynthesisUndecaprenyl diphosphate synthaseUDCPDPS8 ipdp_c + frdp_c ⇋ 8 ppi_c + udcpdp_c010000.000270.0022
Cofactor and Prosthetic Group BiosynthesisgeranyltranstransferaseGRTTipdp_c + grdp_c ⇋ frdp_c + ppi_c010000.00140.0014
Cofactor and Prosthetic Group BiosynthesisdimethylallyltranstransferaseDMATTdmpp_c + ipdp_c ⇋ grdp_c + ppi_c010000.00140.0014
Cofactor and Prosthetic Group Biosynthesiscyclic pyranopterin monophosphate synthaseCPMPSgtp_c + h2o_c ⇋ ppi_c + cpmp_c010000.00120.0012
Cofactor and Prosthetic Group Biosynthesismolybdopterin adenylyltransferaseMPTATmpt_c + h_c + atp_c ⇋ mptamp_c + ppi_c010000.00120.0012
Cofactor and Prosthetic Group BiosynthesisFMN adenylyltransferaseFMNATh_c + atp_c + fmn_c ⇋ fad_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisHydroxybenzoate octaprenyltransferaseHBZOPT4hbz_c + octdp_c ⇋ 3ophb_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiazole phosphate synthesisTHZPSN3dhgly_c + nadph_c + iscssh_c + dxyl5p_c + atp_c + h_c ⇋ nadp_c + 4mpetz_c + co2_c + 2 h2o_c + iscs_c + amp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate diphosphorylaseTMPPP4mpetz_c + 2mahmp_c + h_c ⇋ thmmp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthase (single GDP)BMOGDS1bmoco_c + h_c + gtp_c ⇋ bmoco1gdp_c + ppi_c010000.00060.0006
Cofactor and Prosthetic Group Biosynthesisbis-molybdopterin guanine dinucleotide synthaseBMOGDS2bmoco1gdp_c + h_c + gtp_c ⇋ ppi_c + bmocogdp_c010000.00060.0006
Oxidative Phosphorylationpolyphosphate kinasePPKrppi_c + adp_c ⇋ atp_c + pi_c-1000100017-17

Metabolite name: Protoporphyrin
Metabolite ID: ppp9_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisprotoporphyrinogen oxidase (anaerobic)PPPGO3pppg9_c + 3 fum_c ⇋ ppp9_c + 3 succ_c010000.00110.0011
Cofactor and Prosthetic Group BiosynthesisFerrochelataseFCLTppp9_c + fe2_c ⇋ 2 h_c + pheme_c010000.0011-0.0011

Metabolite name: Protoporphyrinogen IX
Metabolite ID: pppg9_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesiscoproporphyrinogen oxidase (O2 required)CPPPGOo2_c + 2 h_c + cpppg3_c ⇋ pppg9_c + 2 co2_c + 2 h2o_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisprotoporphyrinogen oxidase (anaerobic)PPPGO3pppg9_c + 3 fum_c ⇋ ppp9_c + 3 succ_c010000.0011-0.0011

Metabolite name: Inorganic triphosphate
Metabolite ID: pppi_c
Compartment: c


Metabolite name: Phenylpropanoate
Metabolite ID: pppn_c
Compartment: c


Metabolite name: 5-Phospho-beta-D-ribosylamine
Metabolite ID: pram_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.22.2
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide synthasePRAGSrgly_c + pram_c + atp_c ⇋ adp_c + h_c + gar_c + pi_c-100010002.2-2.2

Metabolite name: N-(5-Phospho-D-ribosyl)anthranilate
Metabolite ID: pran_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate phosphoribosyltransferaseANPRTprpp_c + anth_c ⇋ ppi_c + pran_c010000.280.28
Tyrosine, Tryptophan, and Phenylalanine Metabolismphosphoribosylanthranilate isomerase (irreversible)PRAIipran_c ⇋ 2cpr5p_c010000.28-0.28

Metabolite name: 1-(5-Phosphoribosyl)-AMP
Metabolite ID: prbamp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismphosphoribosyl-ATP pyrophosphatasePRATPPprbatp_c + h2o_c ⇋ ppi_c + prbamp_c + h_c010000.470.47
Histidine Metabolismphosphoribosyl-AMP cyclohydrolasePRAMPCprbamp_c + h2o_c ⇋ prfp_c010000.47-0.47

Metabolite name: 1-(5-Phosphoribosyl)-ATP
Metabolite ID: prbatp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine MetabolismATP phosphoribosyltransferaseATPPRTatp_c + prpp_c ⇋ prbatp_c + ppi_c010000.470.47
Histidine Metabolismphosphoribosyl-ATP pyrophosphatasePRATPPprbatp_c + h2o_c ⇋ ppi_c + prbamp_c + h_c010000.47-0.47

Metabolite name: 7-cyano-7-carbaguanine
Metabolite ID: preq0_c
Compartment: c


Metabolite name: 7-aminomethyl-7-deazaguanine
Metabolite ID: preq1_c
Compartment: c


Metabolite name: 1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide
Metabolite ID: prfp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismphosphoribosyl-AMP cyclohydrolasePRAMPCprbamp_c + h2o_c ⇋ prfp_c010000.470.47
Histidine Metabolism1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerasePRMICIprfp_c ⇋ prlp_c-100010000.47-0.47

Metabolite name: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide
Metabolite ID: prlp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolism1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerasePRMICIprfp_c ⇋ prlp_c-100010000.470.47
Histidine MetabolismImidazole-glycerol-3-phosphate synthaseIG3PSprlp_c + gln_L_c ⇋ eig3p_c + glu_L_c + h_c + aicar_c010000.47-0.47

Metabolite name: L-Proline
Metabolite ID: pro_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Arginine and Proline Metabolismpyrroline-5-carboxylate reductaseP5CR1pyr5c_c + 2 h_c + nadph_c ⇋ nadp_c + pro_L_c010001.11.1
Transport, Inner MembraneNa+/Proline-L symporter (periplasm)PROt4ppna1_p + pro_L_p ⇋ pro_L_c + na1_c010000.0260.026
Transport, Inner MembraneL-proline reversible transport via proton symport (periplasm)PROt2rpph_c + pro_L_c ⇋ pro_L_p + h_p-100010000.026-0.026
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.1

Metabolite name: L-Prolinylglycine
Metabolite ID: progly_c
Compartment: c


Metabolite name: L-Prolyl-tRNA(Pro)
Metabolite ID: protrna_c
Compartment: c


Metabolite name: 5-Phospho-alpha-D-ribose 1-diphosphate
Metabolite ID: prpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Histidine Metabolismphosphoribosylpyrophosphate synthetasePRPPSatp_c + r5p_c ⇋ amp_c + h_c + prpp_c-100010004.64.6
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.011-0.011
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate phosphoribosyltransferaseANPRTprpp_c + anth_c ⇋ ppi_c + pran_c010000.28-0.28
Histidine MetabolismATP phosphoribosyltransferaseATPPRTatp_c + prpp_c ⇋ prbatp_c + ppi_c010000.47-0.47
Purine and Pyrimidine Biosynthesisorotate phosphoribosyltransferaseORPTorot_c + prpp_c ⇋ orot5p_c + ppi_c-100010001.6-1.6
Purine and Pyrimidine Biosynthesisglutamine phosphoribosyldiphosphate amidotransferaseGLUPRTgln_L_c + prpp_c + h2o_c ⇋ ppi_c + glu_L_c + pram_c010002.2-2.2

Metabolite name: phosphatidylserine (didodecanoyl, n-C12:0)
Metabolite ID: ps120_c
Compartment: c


Metabolite name: phosphatidylserine (ditetradecanoyl, n-C14:0)
Metabolite ID: ps140_c
Compartment: c


Metabolite name: phosphatidylserine (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: ps141_c
Compartment: c


Metabolite name: phosphatidylserine (dihexadecanoyl, n-C16:0)
Metabolite ID: ps160_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:0)PSSA160cdpdhdecg_c + ser_L_c ⇋ ps160_c + cmp_c + h_c010000.310.31
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:0)PSD160h_c + ps160_c ⇋ pe160_c + co2_c010000.31-0.31

Metabolite name: phosphatidylserine (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: ps161_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:1)PSSA161cdpdhdec9eg_c + ser_L_c ⇋ cmp_c + ps161_c + h_c010000.370.37
Glycerophospholipid MetabolismPhosphatidylserine decarboxylase (n-C16:1)PSD161ps161_c + h_c ⇋ co2_c + pe161_c010000.37-0.37

Metabolite name: phosphatidylserine (dioctadecanoyl, n-C18:0)
Metabolite ID: ps180_c
Compartment: c


Metabolite name: phosphatidylserine (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: ps181_c
Compartment: c


Metabolite name: psicoselysine
Metabolite ID: psclys_c
Compartment: c


Metabolite name: O-Phospho-L-serine
Metabolite ID: pser_L_c
Compartment: c


Metabolite name: Putrescine
Metabolite ID: ptrc_c
Compartment: c


Metabolite name: Pyridoxamine 5'-phosphate
Metabolite ID: pyam5p_c
Compartment: c


Metabolite name: Pyridoxamine
Metabolite ID: pydam_c
Compartment: c


Metabolite name: Pyridoxal
Metabolite ID: pydx_c
Compartment: c


Metabolite name: Pyridoxal 5'-phosphate
Metabolite ID: pydx5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesispyridoxine 5'-phosphate oxidasePDX5POipdx5p_c + o2_c ⇋ h2o2_c + pydx5p_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011

Metabolite name: Pyridoxine
Metabolite ID: pydxn_c
Compartment: c


Metabolite name: Pyruvate
Metabolite ID: pyr_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pyruvate Metabolismpyruvate synthasePOR5h_c + 2 flxr_c + co2_c + accoa_c ⇋ coa_c + 2 flxso_c + pyr_c-100010001e+021e+02
Glycine and Serine MetabolismL-serine deaminaseSERD_Lser_L_c ⇋ pyr_c + nh4_c010005454
Methionine Metabolismcystathionine b-lyaseCYSTLcyst_L_c + h2o_c ⇋ pyr_c + hcys_L_c + nh4_c010000.760.76
Tyrosine, Tryptophan, and Phenylalanine Metabolismanthranilate synthaseANSchor_c + gln_L_c ⇋ pyr_c + h_c + anth_c + glu_L_c010000.280.28
Cofactor and Prosthetic Group Biosynthesis4-aminobenzoate synthaseADCL4adcho_c ⇋ h_c + 4abz_c + pyr_c010000.00330.0033
Cofactor and Prosthetic Group BiosynthesisChorismate pyruvate lyaseCHRPLchor_c ⇋ 4hbz_c + pyr_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesis1-deoxy-D-xylulose 5-phosphate synthaseDXPSpyr_c + g3p_c + h_c ⇋ dxyl5p_c + co2_c010000.014-0.014
Valine, Leucine, and Isoleucine Metabolism2-aceto-2-hydroxybutanoate synthaseACHBSpyr_c + 2obut_c + h_c ⇋ 2ahbut_c + co2_c010001.4-1.4
Threonine and Lysine Metabolismdihydrodipicolinate synthaseDHDPSpyr_c + aspsa_c ⇋ h_c + 2 h2o_c + 23dhdp_c010001.8-1.8
Alanine and Aspartate MetabolismL-alanine transaminaseALATA_Lpyr_c + glu_L_c ⇋ ala_L_c + akg_c-100010002.9-2.9
Valine, Leucine, and Isoleucine Metabolismacetolactate synthaseACLSh_c + 2 pyr_c ⇋ alac_S_c + co2_c010004.3-8.6
Glycolysis/Gluconeogenesisphosphoenolpyruvate synthasePPSpyr_c + h2o_c + atp_c ⇋ amp_c + pep_c + 2 h_c + pi_c010001.4e+02-1.4e+02

Metabolite name: Ubiquinone-8
Metabolite ID: q8_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+025.7e+02
Oxidative Phosphorylationsuccinate dehydrogenase (irreversible)SUCDiq8_c + succ_c ⇋ fum_c + q8h2_c010000.0033-0.0033
Alternate Carbon MetabolismGlycolate oxidaseGLYCTO2q8_c + glyclt_c ⇋ q8h2_c + glx_c010000.0033-0.0033
Purine and Pyrimidine Biosynthesisdihydoorotic acid dehydrogenase (quinone8)DHORD2q8_c + dhor_S_c ⇋ orot_c + q8h2_c010001.6-1.6
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+02-5.7e+02

Metabolite name: Ubiquinol-8
Metabolite ID: q8h2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+025.7e+02
Purine and Pyrimidine Biosynthesisdihydoorotic acid dehydrogenase (quinone8)DHORD2q8_c + dhor_S_c ⇋ orot_c + q8h2_c010001.61.6
Alternate Carbon MetabolismGlycolate oxidaseGLYCTO2q8_c + glyclt_c ⇋ q8h2_c + glx_c010000.00330.0033
Oxidative Phosphorylationsuccinate dehydrogenase (irreversible)SUCDiq8_c + succ_c ⇋ fum_c + q8h2_c010000.00330.0033
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+02-5.7e+02

Metabolite name: Quinate
Metabolite ID: quin_c
Compartment: c


Metabolite name: Quinolinate
Metabolite ID: quln_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisquinolinate synthaseQULNSdhap_c + iasp_c ⇋ quln_c + pi_c + 2 h2o_c010000.0110.011
Cofactor and Prosthetic Group Biosynthesisnicotinate-nucleotide diphosphorylase (carboxylating)NNDPRquln_c + 2 h_c + prpp_c ⇋ nicrnt_c + ppi_c + co2_c010000.011-0.011

Metabolite name: D-Ribose 1,5-bisphosphate
Metabolite ID: r15bp_c
Compartment: c


Metabolite name: alpha-D-Ribose 1-phosphate
Metabolite ID: r1p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Alternate Carbon MetabolismphosphopentomutasePPMr5p_c ⇋ r1p_c-100010000.00330.0033
Nucleotide Salvage Pathwaypurine-nucleoside phosphorylase (Adenosine)PUNP1ade_c + r1p_c ⇋ pi_c + adn_c-100010000.0033-0.0033

Metabolite name: alpha-D-Ribose 5-phosphate
Metabolite ID: r5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pentose Phosphate Pathwaytransketolase1TKT1g3p_c + s7p_c ⇋ r5p_c + xu5p_D_c-100010001313
Alternate Carbon MetabolismphosphopentomutasePPMr5p_c ⇋ r1p_c-100010000.0033-0.0033
Histidine Metabolismphosphoribosylpyrophosphate synthetasePRPPSatp_c + r5p_c ⇋ amp_c + h_c + prpp_c-100010004.6-4.6
Pentose Phosphate Pathwayribose-5-phosphate isomeraseRPIr5p_c ⇋ ru5p_D_c-100010008.2-8.2

Metabolite name: rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate
Metabolite ID: ragund_c
Compartment: c


Metabolite name: Reduced riboflavin
Metabolite ID: rbflvrd_c
Compartment: c


Metabolite name: L-Ribulose
Metabolite ID: rbl_L_c
Compartment: c


Metabolite name: N1-(alpha-D-ribosyl)-5,6-dimethylbenzimidazole
Metabolite ID: rdmbzi_c
Compartment: c


Metabolite name: Ring 1,2-epoxyphenylacetyl-CoA
Metabolite ID: rephaccoa_c
Compartment: c


Metabolite name: S-Ribosyl-L-homocysteine
Metabolite ID: rhcys_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine MetabolismS-adenosylhomocysteine nucleosidaseAHCYSNSh2o_c + ahcys_c ⇋ ade_c + rhcys_c010000.00220.0022
Methionine MetabolismS-ribosylhomocysteine cleavage enzymeRHCCErhcys_c ⇋ dhptd_c + hcys_L_c010000.0022-0.0022

Metabolite name: D-Ribose
Metabolite ID: rib_D_c
Compartment: c


Metabolite name: Riboflavin
Metabolite ID: ribflv_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisriboflavin synthaseRBFSb2 dmlz_c ⇋ 4r5au_c + ribflv_c010000.00220.0022
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Cofactor and Prosthetic Group Biosynthesisriboflavin kinaseRBFKatp_c + ribflv_c ⇋ adp_c + h_c + fmn_c010000.0011-0.0011

Metabolite name: L-Rhamnulose
Metabolite ID: rml_c
Compartment: c


Metabolite name: L-Rhamnulose 1-phosphate
Metabolite ID: rml1p_c
Compartment: c


Metabolite name: L-Rhamnose
Metabolite ID: rmn_c
Compartment: c


Metabolite name: D-Ribulose 5-phosphate
Metabolite ID: ru5p_D_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pentose Phosphate Pathwayribulose 5-phosphate 3-epimeraseRPExu5p_D_c ⇋ ru5p_D_c-100010002828
Pentose Phosphate Pathwayribose-5-phosphate isomeraseRPIr5p_c ⇋ ru5p_D_c-100010008.28.2
Cofactor and Prosthetic Group Biosynthesis3,4-Dihydroxy-2-butanone-4-phosphate synthaseDB4PSru5p_D_c ⇋ db4p_c + for_c + h_c010000.0044-0.0044
Alternate Carbon Metabolismarabinose-5-phosphate isomeraseA5PISOru5p_D_c ⇋ ara5p_c-100010000.19-0.19
PRK+RuBisCOPRK+RBCco2_c + atp_c + ru5p_D_c + h2o_c ⇋ 3 h_c + adp_c + 2 3pg_c0100036-36

Metabolite name: L-Ribulose 5-phosphate
Metabolite ID: ru5p_L_c
Compartment: c


Metabolite name: Sedoheptulose 1,7-bisphosphate
Metabolite ID: s17bp_c
Compartment: c


Metabolite name: Sedoheptulose 7-phosphate
Metabolite ID: s7p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pentose Phosphate PathwaytransaldolaseTALAf6p_c + e4p_c ⇋ g3p_c + s7p_c-100010001313
Pentose Phosphate Pathwaytransketolase1TKT1g3p_c + s7p_c ⇋ r5p_c + xu5p_D_c-1000100013-13

Metabolite name: Sarcosine
Metabolite ID: sarcs_c
Compartment: c


Metabolite name: D-Sorbitol 6-phosphate
Metabolite ID: sbt6p_c
Compartment: c


Metabolite name: O-Succinylbenzoyl-CoA
Metabolite ID: sbzcoa_c
Compartment: c


Metabolite name: sirohydrochlorin
Metabolite ID: scl_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin dehydrogenase (NAD)SHCHD2dscl_c + nad_c ⇋ nadh_c + scl_c + h_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin ferrochelataseSHCHFscl_c + fe2_c ⇋ sheme_c + 3 h_c010000.0011-0.0011

Metabolite name: L-Selenocysteinyl-tRNA(Sec)
Metabolite ID: sectrna_c
Compartment: c


Metabolite name: Selenate
Metabolite ID: sel_c
Compartment: c


Metabolite name: Selenide
Metabolite ID: seln_c
Compartment: c


Metabolite name: Selenophosphate
Metabolite ID: selnp_c
Compartment: c


Metabolite name: D-Serine
Metabolite ID: ser_D_c
Compartment: c


Metabolite name: L-Serine
Metabolite ID: ser_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycine and Serine Metabolismglycine hydroxymethyltransferase, reversibleGHMT2rgly_c + mlthf_c + h2o_c ⇋ thf_c + ser_L_c-100010005757
Tyrosine, Tryptophan, and Phenylalanine Metabolismtryptophan synthase (indoleglycerol phosphate)TRPS1ser_L_c + 3ig3p_c ⇋ g3p_c + trp_L_c + h2o_c010000.28-0.28
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:0)PSSA160cdpdhdecg_c + ser_L_c ⇋ ps160_c + cmp_c + h_c010000.31-0.31
Glycerophospholipid MetabolismPhosphatidylserine syntase (n-C16:1)PSSA161cdpdhdec9eg_c + ser_L_c ⇋ cmp_c + ps161_c + h_c010000.37-0.37
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.1
Cysteine Metabolismserine O-acetyltransferaseSERATaccoa_c + ser_L_c ⇋ acser_c + coa_c-100010001.2-1.2
Glycine and Serine MetabolismL-serine deaminaseSERD_Lser_L_c ⇋ pyr_c + nh4_c0100054-54

Metabolite name: L-seryl-AMP
Metabolite ID: seramp_c
Compartment: c


Metabolite name: L-Seryl-tRNA(Ser)
Metabolite ID: sertrna_c
Compartment: c


Metabolite name: L-Seryl-tRNA(Sec)
Metabolite ID: sertrna_LSQBKT_sec_RSQBKT__c
Compartment: c


Metabolite name: Siroheme
Metabolite ID: sheme_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesissirohydrochlorin ferrochelataseSHCHFscl_c + fe2_c ⇋ sheme_c + 3 h_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011

Metabolite name: Shikimate
Metabolite ID: skm_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate dehydrogenaseSHK3Drh_c + 3dhsk_c + nadph_c ⇋ skm_c + nadp_c-100010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate kinaseSHKKskm_c + atp_c ⇋ skm5p_c + adp_c + h_c010001.9-1.9

Metabolite name: Shikimate 5-phosphate
Metabolite ID: skm5p_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismshikimate kinaseSHKKskm_c + atp_c ⇋ skm5p_c + adp_c + h_c010001.91.9
Tyrosine, Tryptophan, and Phenylalanine Metabolism3-phosphoshikimate 1-carboxyvinyltransferasePSCVTskm5p_c + pep_c ⇋ 3psme_c + pi_c-100010001.9-1.9

Metabolite name: N-Succinyl-LL-2,6-diaminoheptanedioate
Metabolite ID: sl26da_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismsuccinyldiaminopimelate transaminaseSDPTAglu_L_c + sl2a6o_c ⇋ sl26da_c + akg_c-100010001.81.8
Threonine and Lysine Metabolismsuccinyl-diaminopimelate desuccinylaseSDPDSsl26da_c + h2o_c ⇋ succ_c + 26dap_LL_c010001.8-1.8

Metabolite name: N-Succinyl-2-L-amino-6-oxoheptanedioate
Metabolite ID: sl2a6o_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismtetrahydrodipicolinate succinylaseTHDPSthdp_c + h2o_c + succoa_c ⇋ coa_c + sl2a6o_c010001.81.8
Threonine and Lysine Metabolismsuccinyldiaminopimelate transaminaseSDPTAglu_L_c + sl2a6o_c ⇋ sl26da_c + akg_c-100010001.8-1.8

Metabolite name: selenite
Metabolite ID: slnt_c
Compartment: c


Metabolite name: sulfur dioxide
Metabolite ID: so2_c
Compartment: c


Metabolite name: Sulfite
Metabolite ID: so3_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.21.2
Cysteine Metabolismsulfite reductase (NADPH2)SULRi5 h_c + so3_c + 3 nadph_c ⇋ h2s_c + 3 h2o_c + 3 nadp_c010001.2-1.2

Metabolite name: Sulfate
Metabolite ID: so4_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismsulfate transport in via proton symport (periplasm to cytoplasm)SO4t2ppso4_p + h_p ⇋ h_c + so4_c010001.21.2
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.021
Cysteine MetabolismSulfate adenyltransferaseSADT2so4_c + atp_c + h2o_c + gtp_c ⇋ aps_c + ppi_c + pi_c + gdp_c010001.2-1.2

Metabolite name: Spermidine
Metabolite ID: spmd_c
Compartment: c


Metabolite name: Stearoyl-CoA (n-C18:0CoA)
Metabolite ID: stcoa_c
Compartment: c


Metabolite name: Sucrose 6-phosphate
Metabolite ID: suc6p_c
Compartment: c


Metabolite name: N2-Succinyl-L-arginine
Metabolite ID: sucarg_c
Compartment: c


Metabolite name: o-Succinylbenzoate
Metabolite ID: sucbz_c
Compartment: c


Metabolite name: Succinate
Metabolite ID: succ_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismsuccinyl-diaminopimelate desuccinylaseSDPDSsl26da_c + h2o_c ⇋ succ_c + 26dap_LL_c010001.81.8
Methionine MetabolismO-succinylhomoserine lyase (L-cysteine)SHSL1cys_L_c + suchms_c ⇋ cyst_L_c + h_c + succ_c010000.760.76
Cofactor and Prosthetic Group Biosynthesisprotoporphyrinogen oxidase (anaerobic)PPPGO3pppg9_c + 3 fum_c ⇋ ppp9_c + 3 succ_c010000.00110.0033
Oxidative Phosphorylationsuccinate dehydrogenase (irreversible)SUCDiq8_c + succ_c ⇋ fum_c + q8h2_c010000.0033-0.0033
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.6-2.6

Metabolite name: Succinyl-CoA
Metabolite ID: succoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Citric Acid Cyclesuccinyl-CoA synthetase (ADP-forming)SUCOAScoa_c + atp_c + succ_c ⇋ adp_c + pi_c + succoa_c-100010002.62.6
Methionine Metabolismhomoserine O-succinyltransferaseHSSThom_L_c + succoa_c ⇋ suchms_c + coa_c010000.76-0.76
Threonine and Lysine Metabolismtetrahydrodipicolinate succinylaseTHDPSthdp_c + h2o_c + succoa_c ⇋ coa_c + sl2a6o_c010001.8-1.8

Metabolite name: N2-Succinyl-L-glutamate
Metabolite ID: sucglu_c
Compartment: c


Metabolite name: N2-Succinyl-L-glutamate 5-semialdehyde
Metabolite ID: sucgsa_c
Compartment: c


Metabolite name: O-Succinyl-L-homoserine
Metabolite ID: suchms_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Methionine Metabolismhomoserine O-succinyltransferaseHSSThom_L_c + succoa_c ⇋ suchms_c + coa_c010000.760.76
Methionine MetabolismO-succinylhomoserine lyase (L-cysteine)SHSL1cys_L_c + suchms_c ⇋ cyst_L_c + h_c + succ_c010000.76-0.76

Metabolite name: N2-Succinyl-L-ornithine
Metabolite ID: sucorn_c
Compartment: c


Metabolite name: Succinic semialdehyde
Metabolite ID: sucsal_c
Compartment: c


Metabolite name: SufBCD scaffold complex
Metabolite ID: sufbcd_c
Compartment: c


Metabolite name: SufBCD with bound [2Fe-2S] cluster
Metabolite ID: sufbcd_2fe2s_c
Compartment: c


Metabolite name: SufBCD with two bound [2Fe-2S] clusters
Metabolite ID: sufbcd_2fe2s2_c
Compartment: c


Metabolite name: SufBCD with bound [4Fe-4S] cluster
Metabolite ID: sufbcd_4fe4s_c
Compartment: c


Metabolite name: SufSE sulfur acceptor complex
Metabolite ID: sufse_c
Compartment: c


Metabolite name: SufSE with bound sulfur
Metabolite ID: sufsesh_c
Compartment: c


Metabolite name: sulfoacetate
Metabolite ID: sulfac_c
Compartment: c


Metabolite name: trans-3-cis-11-vacceoyl-[acyl-carrier protein]
Metabolite ID: t3c11vaceACP_c
Compartment: c


Metabolite name: trans-3-cis-5-dodecenoyl-[acyl-carrier protein]
Metabolite ID: t3c5ddeceACP_c
Compartment: c


Metabolite name: trans-3-cis-7-myristoleoyl-[acyl-carrier protein]
Metabolite ID: t3c7mrseACP_c
Compartment: c


Metabolite name: trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]
Metabolite ID: t3c9palmeACP_c
Compartment: c


Metabolite name: D-Tagatose 6-phosphate
Metabolite ID: tag6p_D_c
Compartment: c


Metabolite name: D-Tagatose 1,6-biphosphate
Metabolite ID: tagdp_D_c
Compartment: c


Metabolite name: D-Tagaturonate
Metabolite ID: tagur_c
Compartment: c


Metabolite name: D-tartrate
Metabolite ID: tartr_D_c
Compartment: c


Metabolite name: L-tartrate
Metabolite ID: tartr_L_c
Compartment: c


Metabolite name: Taurine
Metabolite ID: taur_c
Compartment: c


Metabolite name: Thiocyanate
Metabolite ID: tcynt_c
Compartment: c


Metabolite name: trans-Tetradec-2-enoyl-CoA
Metabolite ID: td2coa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolism3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)ECOAH63htdcoa_c ⇋ td2coa_c + h2o_c-100010001.41.4
Membrane Lipid Metabolismacyl-CoA dehydrogenase (tetradecanoyl-CoA)ACOAD6ftd2coa_c + fadh2_c ⇋ tdcoa_c + fad_c-100010001.4-1.4

Metabolite name: Tetradecanoyl-CoA (n-C14:0CoA)
Metabolite ID: tdcoa_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Membrane Lipid Metabolismacyl-CoA dehydrogenase (tetradecanoyl-CoA)ACOAD6ftd2coa_c + fadh2_c ⇋ tdcoa_c + fad_c-100010001.41.4
Membrane Lipid Metabolismacetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)ACACT7rtdcoa_c + accoa_c ⇋ coa_c + 3ohdcoa_c-100010001.4-1.4

Metabolite name: trans-Dodec-2-enoyl-[acyl-carrier protein]
Metabolite ID: tddec2eACP_c
Compartment: c


Metabolite name: cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)
Metabolite ID: tdeACP_c
Compartment: c


Metabolite name: trans-Dec-2-enoyl-[acyl-carrier protein]
Metabolite ID: tdec2eACP_c
Compartment: c


Metabolite name: Tetradecenoyl-CoA (n-C14:1CoA)
Metabolite ID: tdecoa_c
Compartment: c


Metabolite name: 2,3,4,5-Tetrahydrodipicolinate
Metabolite ID: thdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismdihydrodipicolinate reductase (NADPH)DHDPRy23dhdp_c + h_c + nadph_c ⇋ nadp_c + thdp_c010001.81.8
Threonine and Lysine Metabolismtetrahydrodipicolinate succinylaseTHDPSthdp_c + h2o_c + succoa_c ⇋ coa_c + sl2a6o_c010001.8-1.8

Metabolite name: trans-Hex-2-enoyl-[acyl-carrier protein]
Metabolite ID: thex2eACP_c
Compartment: c


Metabolite name: 5,6,7,8-Tetrahydrofolate
Metabolite ID: thf_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Glycine and Serine Metabolismglycine hydroxymethyltransferase, reversibleGHMT2rgly_c + mlthf_c + h2o_c ⇋ thf_c + ser_L_c-100010005757
Purine and Pyrimidine Biosynthesisphosphoribosylaminoimidazolecarboxamide formyltransferaseAICART10fthf_c + aicar_c ⇋ fprica_c + thf_c-100010002.72.7
Purine and Pyrimidine Biosynthesisphosphoribosylglycinamide formyltransferaseGARFT10fthf_c + gar_c ⇋ fgam_c + thf_c + h_c-100010002.22.2
Methionine Metabolismmethionine synthaseMETShcys_L_c + 5mthf_c ⇋ h_c + met_L_c + thf_c010000.760.76
Cofactor and Prosthetic Group Biosynthesisdihydrofolate reductaseDHFRh_c + dhf_c + nadph_c ⇋ nadp_c + thf_c-100010000.130.13
Cofactor and Prosthetic Group Biosynthesis3-methyl-2-oxobutanoate hydroxymethyltransferaseMOHMT3mob_c + mlthf_c + h2o_c ⇋ thf_c + 2dhp_c010000.00280.0028
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011
Folate MetabolismGlycine Cleavage SystemGLYCLgly_c + nad_c + thf_c ⇋ mlthf_c + nadh_c + co2_c + nh4_c0100063-63

Metabolite name: Thiamin
Metabolite ID: thm_c
Compartment: c


Metabolite name: Thiamin monophosphate
Metabolite ID: thmmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate diphosphorylaseTMPPP4mpetz_c + 2mahmp_c + h_c ⇋ thmmp_c + ppi_c010000.00110.0011
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate kinaseTMPKthmmp_c + atp_c ⇋ adp_c + thmpp_c010000.0011-0.0011

Metabolite name: Tetrahydromonapterin
Metabolite ID: thmnp_c
Compartment: c


Metabolite name: Thiamine diphosphate
Metabolite ID: thmpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisthiamine-phosphate kinaseTMPKthmmp_c + atp_c ⇋ adp_c + thmpp_c010000.00110.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0011

Metabolite name: 5,6,7,8-tetrahydropteridine
Metabolite ID: thptdn_c
Compartment: c


Metabolite name: L-Threonine
Metabolite ID: thr_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Threonine and Lysine Metabolismthreonine synthaseTHRSh2o_c + phom_c ⇋ pi_c + thr_L_c010001.3e+021.3e+02
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-1.3
Valine, Leucine, and Isoleucine MetabolismL-threonine deaminaseTHRD_Lthr_L_c ⇋ 2obut_c + nh4_c010001.4-1.4
Glycine and Serine MetabolismL-threonine dehydrogenaseTHRDnad_c + thr_L_c ⇋ nadh_c + h_c + 2aobut_c010001.3e+02-1.3e+02

Metabolite name: L-Threonyl-tRNA(Thr)
Metabolite ID: thrtrna_c
Compartment: c


Metabolite name: Thymine
Metabolite ID: thym_c
Compartment: c


Metabolite name: Thymidine
Metabolite ID: thymd_c
Compartment: c


Metabolite name: trimethylamine
Metabolite ID: tma_c
Compartment: c


Metabolite name: Trimethylamine N-oxide
Metabolite ID: tmao_c
Compartment: c


Metabolite name: trans-Tetradec-2-enoyl-[acyl-carrier protein]
Metabolite ID: tmrs2eACP_c
Compartment: c


Metabolite name: trans-Oct-2-enoyl-[acyl-carrier protein]
Metabolite ID: toct2eACP_c
Compartment: c


Metabolite name: trans-octadec-2-enoyl-[acyl-carrier protein]
Metabolite ID: toctd2eACP_c
Compartment: c


Metabolite name: trans-Hexadec-2-enoyl-[acyl-carrier protein]
Metabolite ID: tpalm2eACP_c
Compartment: c


Metabolite name: Oxidized thioredoxin
Metabolite ID: trdox_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.21.2
Nucleotide Salvage Pathwayribonucleoside-diphosphate reductase (GDP)RNDR2gdp_c + trdrd_c ⇋ dgdp_c + h2o_c + trdox_c010000.130.13
Oxidative Phosphorylationthioredoxin reductase (NADPH)TRDRh_c + trdox_c + nadph_c ⇋ nadp_c + trdrd_c010001.4-1.4

Metabolite name: Reduced thioredoxin
Metabolite ID: trdrd_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative Phosphorylationthioredoxin reductase (NADPH)TRDRh_c + trdox_c + nadph_c ⇋ nadp_c + trdrd_c010001.41.4
Nucleotide Salvage Pathwayribonucleoside-diphosphate reductase (GDP)RNDR2gdp_c + trdrd_c ⇋ dgdp_c + h2o_c + trdox_c010000.13-0.13
Cysteine Metabolismphosphoadenylyl-sulfate reductase (thioredoxin)PAPSRpaps_c + trdrd_c ⇋ 2 h_c + so3_c + pap_c + trdox_c010001.2-1.2

Metabolite name: Trehalose
Metabolite ID: tre_c
Compartment: c


Metabolite name: alpha,alpha'-Trehalose 6-phosphate
Metabolite ID: tre6p_c
Compartment: c


Metabolite name: tRNA(Ala)
Metabolite ID: trnaala_c
Compartment: c


Metabolite name: tRNA(Arg)
Metabolite ID: trnaarg_c
Compartment: c


Metabolite name: tRNA(Asn)
Metabolite ID: trnaasn_c
Compartment: c


Metabolite name: tRNA(Asp)
Metabolite ID: trnaasp_c
Compartment: c


Metabolite name: tRNA(Cys)
Metabolite ID: trnacys_c
Compartment: c


Metabolite name: tRNA(Gln)
Metabolite ID: trnagln_c
Compartment: c


Metabolite name: tRNA (Glu)
Metabolite ID: trnaglu_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisglutamyl-tRNA reductaseGLUTRRglutrna_c + h_c + nadph_c ⇋ glu1sa_c + nadp_c + trnaglu_c010000.0180.018
Cofactor and Prosthetic Group BiosynthesisGlutamyl-tRNA synthetaseGLUTRSglu_L_c + atp_c + trnaglu_c ⇋ glutrna_c + amp_c + ppi_c010000.018-0.018

Metabolite name: tRNA(Gly)
Metabolite ID: trnagly_c
Compartment: c


Metabolite name: tRNA(His)
Metabolite ID: trnahis_c
Compartment: c


Metabolite name: tRNA(Ile)
Metabolite ID: trnaile_c
Compartment: c


Metabolite name: tRNA(Leu)
Metabolite ID: trnaleu_c
Compartment: c


Metabolite name: tRNA(Lys)
Metabolite ID: trnalys_c
Compartment: c


Metabolite name: tRNA(Met)
Metabolite ID: trnamet_c
Compartment: c


Metabolite name: tRNA(Phe)
Metabolite ID: trnaphe_c
Compartment: c


Metabolite name: tRNA(Pro)
Metabolite ID: trnapro_c
Compartment: c


Metabolite name: tRNA(SeCys)
Metabolite ID: trnasecys_c
Compartment: c


Metabolite name: tRNA(Ser)
Metabolite ID: trnaser_c
Compartment: c


Metabolite name: tRNA(Thr)
Metabolite ID: trnathr_c
Compartment: c


Metabolite name: tRNA(Trp)
Metabolite ID: trnatrp_c
Compartment: c


Metabolite name: tRNA(Tyr)
Metabolite ID: trnatyr_c
Compartment: c


Metabolite name: tRNA(Val)
Metabolite ID: trnaval_c
Compartment: c


Metabolite name: L-Tryptophan
Metabolite ID: trp_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismtryptophan synthase (indoleglycerol phosphate)TRPS1ser_L_c + 3ig3p_c ⇋ g3p_c + trp_L_c + h2o_c010000.280.28
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.28

Metabolite name: L-Tryptophanyl-tRNA(Trp)
Metabolite ID: trptrna_c
Compartment: c


Metabolite name: Thiosulfate
Metabolite ID: tsul_c
Compartment: c


Metabolite name: tetradecanoate (n-C14:0)
Metabolite ID: ttdca_c
Compartment: c


Metabolite name: Tetradecanoyl-phosphate (n-C14:0)
Metabolite ID: ttdcap_c
Compartment: c


Metabolite name: tetradecenoate (n-C14:1)
Metabolite ID: ttdcea_c
Compartment: c


Metabolite name: Tetradecanoyl-phosphate (n-C14:1)
Metabolite ID: ttdceap_c
Compartment: c


Metabolite name: tungstate
Metabolite ID: tungs_c
Compartment: c


Metabolite name: L-Tyrosine
Metabolite ID: tyr_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Tyrosine, Tryptophan, and Phenylalanine Metabolismtyrosine transaminaseTYRTA34hpp_c + glu_L_c ⇋ tyr_L_c + akg_c-100010000.680.68
Cofactor and Prosthetic Group Biosynthesistyrosine lyaseTYRLtyr_L_c + amet_c + nadph_c ⇋ dhgly_c + nadp_c + met_L_c + 4crsol_c + dad_5_c + h_c010000.0011-0.0011
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.68

Metabolite name: L-Tyrosyl-tRNA(Tyr)
Metabolite ID: tyrtrna_c
Compartment: c


Metabolite name: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
Metabolite ID: u23ga_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferaseU23GAAT3hmrsACP_c + u3hga_c ⇋ ACP_c + h_c + u23ga_c010000.190.19
Lipopolysaccharide Biosynthesis / RecyclingLipid A disaccaride synthaseLPADSSu23ga_c + lipidX_c ⇋ udp_c + h_c + lipidAds_c010000.096-0.096
Lipopolysaccharide Biosynthesis / RecyclingUDP-sugar hydrolaseUSHDu23ga_c + h2o_c ⇋ ump_c + 2 h_c + lipidX_c010000.096-0.096

Metabolite name: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
Metabolite ID: u3aga_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingUDP-N-acetylglucosamine acyltransferaseUAGAATuacgam_c + 3hmrsACP_c ⇋ ACP_c + u3aga_c-100010000.190.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-acetylglucosamine deacetylaseUHGADAh2o_c + u3aga_c ⇋ ac_c + u3hga_c010000.19-0.19

Metabolite name: UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
Metabolite ID: u3hga_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-acetylglucosamine deacetylaseUHGADAh2o_c + u3aga_c ⇋ ac_c + u3hga_c010000.190.19
Lipopolysaccharide Biosynthesis / RecyclingUDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferaseU23GAAT3hmrsACP_c + u3hga_c ⇋ ACP_c + h_c + u23ga_c010000.19-0.19

Metabolite name: undecaprenyl phosphate-4-amino-4-formyl-L-arabinose
Metabolite ID: uLa4fn_c
Compartment: c


Metabolite name: undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose
Metabolite ID: uLa4n_c
Compartment: c


Metabolite name: Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-ala-D-glu-meso-2,6-diaminopimeloyl-D-ala-D-ala
Metabolite ID: uaagmda_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUAGPT3uacgam_c + uagmda_c ⇋ udp_c + h_c + uaagmda_c010000.140.14
Murein Biosynthesismurein polymerizing transglycosylaseMPTG2 uaagmda_c ⇋ 2 h_c + murein5p5p_p + 2 udcpdp_c010000.068-0.14

Metabolite name: UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine
Metabolite ID: uaccg_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylglucosamine 1-carboxyvinyltransferaseUAGCVTuacgam_c + pep_c ⇋ pi_c + uaccg_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylenolpyruvoylglucosamine reductaseUAPGRnadph_c + h_c + uaccg_c ⇋ nadp_c + uamr_c010000.14-0.14

Metabolite name: UDP-N-acetyl-D-glucosamine
Metabolite ID: uacgam_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylglucosamine diphosphorylaseUAGDPutp_c + h_c + acgam1p_c ⇋ ppi_c + uacgam_c010000.470.47
Cell Envelope BiosynthesisUDP-N-acetylglucosamine 1-carboxyvinyltransferaseUAGCVTuacgam_c + pep_c ⇋ pi_c + uaccg_c010000.14-0.14
Cell Envelope BiosynthesisUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUAGPT3uacgam_c + uagmda_c ⇋ udp_c + h_c + uaagmda_c010000.14-0.14
Lipopolysaccharide Biosynthesis / RecyclingUDP-N-acetylglucosamine acyltransferaseUAGAATuacgam_c + 3hmrsACP_c ⇋ ACP_c + u3aga_c-100010000.19-0.19

Metabolite name: UDP-N-acetyl-D-mannosamine
Metabolite ID: uacmam_c
Compartment: c


Metabolite name: UDP-N-acetyl-D-mannosaminouronate
Metabolite ID: uacmamu_c
Compartment: c


Metabolite name: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
Metabolite ID: uagmda_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisphospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)PAPPT3ugmda_c + udcpp_c ⇋ ump_c + uagmda_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUAGPT3uacgam_c + uagmda_c ⇋ udp_c + h_c + uaagmda_c010000.14-0.14

Metabolite name: UDP-N-acetylmuramoyl-L-alanine
Metabolite ID: uama_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.14-0.14

Metabolite name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
Metabolite ID: uamag_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUAMAGSuama_c + atp_c + glu_D_c ⇋ uamag_c + h_c + adp_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.14-0.14

Metabolite name: UDP-N-acetylmuramate
Metabolite ID: uamr_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylenolpyruvoylglucosamine reductaseUAPGRnadph_c + h_c + uaccg_c ⇋ nadp_c + uamr_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanine synthetaseUAMASuamr_c + ala_L_c + atp_c ⇋ uama_c + adp_c + h_c + pi_c010000.14-0.14

Metabolite name: Undecaprenyl diphosphate
Metabolite ID: udcpdp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Murein Biosynthesismurein polymerizing transglycosylaseMPTG2 uaagmda_c ⇋ 2 h_c + murein5p5p_p + 2 udcpdp_c010000.0680.14
Cofactor and Prosthetic Group BiosynthesisUndecaprenyl diphosphate synthaseUDCPDPS8 ipdp_c + frdp_c ⇋ 8 ppi_c + udcpdp_c010000.000270.00027
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.00027
Cell Envelope Biosynthesisundecaprenyl-diphosphataseUDCPDPh2o_c + udcpdp_c ⇋ udcpp_c + h_c + pi_c010000.14-0.14

Metabolite name: Undecaprenyl phosphate
Metabolite ID: udcpp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope Biosynthesisundecaprenyl-diphosphataseUDCPDPh2o_c + udcpdp_c ⇋ udcpp_c + h_c + pi_c010000.140.14
Cell Envelope Biosynthesisphospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)PAPPT3ugmda_c + udcpp_c ⇋ ump_c + uagmda_c010000.14-0.14

Metabolite name: UDP
Metabolite ID: udp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage PathwayUMP kinaseUMPKatp_c + ump_c ⇋ udp_c + adp_c-100010001.91.9
Cell Envelope BiosynthesisUDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUAGPT3uacgam_c + uagmda_c ⇋ udp_c + h_c + uaagmda_c010000.140.14
Lipopolysaccharide Biosynthesis / RecyclingLipid A disaccaride synthaseLPADSSu23ga_c + lipidX_c ⇋ udp_c + h_c + lipidAds_c010000.0960.096
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:UDP)NDPK2udp_c + atp_c ⇋ adp_c + utp_c-100010002.1-2.1

Metabolite name: uridine 5''-diphospho-{beta}-4-deoxy-4-formamido-L-arabinose
Metabolite ID: udpLa4fn_c
Compartment: c


Metabolite name: uridine 5''-diphospho-{beta}-4-deoxy-4-amino-L-arabinose
Metabolite ID: udpLa4n_c
Compartment: c


Metabolite name: UDP-4-keto-pyranose
Metabolite ID: udpLa4o_c
Compartment: c


Metabolite name: UDPglucose
Metabolite ID: udpg_c
Compartment: c


Metabolite name: UDPgalactose
Metabolite ID: udpgal_c
Compartment: c


Metabolite name: UDP-D-galacto-1,4-furanose
Metabolite ID: udpgalfur_c
Compartment: c


Metabolite name: UDP-D-glucuronate
Metabolite ID: udpglcur_c
Compartment: c


Metabolite name: UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate
Metabolite ID: ugmd_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetaseUAAGDSuamag_c + 26dap_M_c + atp_c ⇋ ugmd_c + adp_c + h_c + pi_c010000.140.14
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.14-0.14

Metabolite name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
Metabolite ID: ugmda_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cell Envelope BiosynthesisUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetaseUGMDDSugmd_c + alaala_c + atp_c ⇋ adp_c + h_c + pi_c + ugmda_c010000.140.14
Cell Envelope Biosynthesisphospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)PAPPT3ugmda_c + udcpp_c ⇋ ump_c + uagmda_c010000.14-0.14

Metabolite name: UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine
Metabolite ID: um4p_c
Compartment: c


Metabolite name: UMP
Metabolite ID: ump_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine Biosynthesisorotidine-5'-phosphate decarboxylaseOMPDCh_c + orot5p_c ⇋ co2_c + ump_c010001.61.6
Cell Envelope Biosynthesisphospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)PAPPT3ugmda_c + udcpp_c ⇋ ump_c + uagmda_c010000.140.14
Lipopolysaccharide Biosynthesis / RecyclingUDP-sugar hydrolaseUSHDu23ga_c + h2o_c ⇋ ump_c + 2 h_c + lipidX_c010000.0960.096
Nucleotide Salvage PathwayUMP kinaseUMPKatp_c + ump_c ⇋ udp_c + adp_c-100010001.9-1.9

Metabolite name: Undecaprenyl diphospho N-acetyl-glucosamine
Metabolite ID: unaga_c
Compartment: c


Metabolite name: Undecaprenyl-diphospho-N-acetylglucosamine-N-acetylmannosaminuronate
Metabolite ID: unagamu_c
Compartment: c


Metabolite name: Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose
Metabolite ID: unagamuf_c
Compartment: c


Metabolite name: Uroporphyrinogen III
Metabolite ID: uppg3_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen-III synthaseUPP3Shmbil_c ⇋ h2o_c + uppg3_c010000.00220.0022
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen methyltransferaseUPP3MTuppg3_c + 2 amet_c ⇋ dscl_c + 2 ahcys_c + h_c010000.0011-0.0011
Cofactor and Prosthetic Group Biosynthesisuroporphyrinogen decarboxylase (uroporphyrinogen III)UPPDC1uppg3_c + 4 h_c ⇋ cpppg3_c + 4 co2_c010000.0011-0.0011

Metabolite name: Uracil
Metabolite ID: ura_c
Compartment: c


Metabolite name: Ureidoacrylate peracid
Metabolite ID: uracp_c
Compartment: c


Metabolite name: Urate
Metabolite ID: urate_c
Compartment: c


Metabolite name: (-)-Ureidoglycolate
Metabolite ID: urdglyc_c
Compartment: c


Metabolite name: Urea
Metabolite ID: urea_c
Compartment: c


Metabolite name: Uridine
Metabolite ID: uri_c
Compartment: c


Metabolite name: UTP
Metabolite ID: utp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Nucleotide Salvage Pathwaynucleoside-diphosphate kinase (ATP:UDP)NDPK2udp_c + atp_c ⇋ adp_c + utp_c-100010002.12.1
Nucleotide Salvage Pathwayribonucleoside-triphosphate reductase (UTP) (flavodoxin)RNTR4c22 h_c + utp_c + 2 flxr_c ⇋ h2o_c + 2 flxso_c + dutp_c010000.13-0.13
Cell Envelope BiosynthesisUDP-N-acetylglucosamine diphosphorylaseUAGDPutp_c + h_c + acgam1p_c ⇋ ppi_c + uacgam_c010000.47-0.47
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.71
Purine and Pyrimidine BiosynthesisCTP synthase (glutamine)CTPS2utp_c + atp_c + gln_L_c + h2o_c ⇋ glu_L_c + adp_c + 2 h_c + ctp_c + pi_c010000.79-0.79

Metabolite name: L-Valine
Metabolite ID: val_L_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Valine, Leucine, and Isoleucine Metabolismvaline transaminaseVALTA3mob_c + glu_L_c ⇋ akg_c + val_L_c-100010002.12.1
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-2.1

Metabolite name: L-Valyl-tRNA(Val)
Metabolite ID: valtrna_c
Compartment: c


Metabolite name: tungsten binding cofactor
Metabolite ID: wco_c
Compartment: c


Metabolite name: Xanthine
Metabolite ID: xan_c
Compartment: c


Metabolite name: XDP
Metabolite ID: xdp_c
Compartment: c


Metabolite name: Xanthosine 5'-phosphate
Metabolite ID: xmp_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Purine and Pyrimidine BiosynthesisIMP dehydrogenaseIMPDnad_c + h2o_c + imp_c ⇋ nadh_c + h_c + xmp_c010001.21.2
Purine and Pyrimidine BiosynthesisGMP synthaseGMPS2gln_L_c + h2o_c + xmp_c + atp_c ⇋ glu_L_c + gmp_c + ppi_c + amp_c + 2 h_c010001.2-1.2

Metabolite name: XTP
Metabolite ID: xtp_c
Compartment: c


Metabolite name: Xanthosine
Metabolite ID: xtsn_c
Compartment: c


Metabolite name: D-Xylulose 5-phosphate
Metabolite ID: xu5p_D_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Pentose Phosphate Pathwaytransketolase2TKT2g3p_c + f6p_c ⇋ xu5p_D_c + e4p_c-100010001515
Pentose Phosphate Pathwaytransketolase1TKT1g3p_c + s7p_c ⇋ r5p_c + xu5p_D_c-100010001313
Pentose Phosphate Pathwayribulose 5-phosphate 3-epimeraseRPExu5p_D_c ⇋ ru5p_D_c-1000100028-28

Metabolite name: L-Xylulose 5-phosphate
Metabolite ID: xu5p_L_c
Compartment: c


Metabolite name: D-Xylose
Metabolite ID: xyl_D_c
Compartment: c


Metabolite name: D-Xylulose
Metabolite ID: xylu_D_c
Compartment: c


Metabolite name: L-Xylulose
Metabolite ID: xylu_L_c
Compartment: c


Metabolite name: Zinc
Metabolite ID: zn2_c
Compartment: c

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismzinc transport in via permease (no H+)ZN2tppzn2_p ⇋ zn2_c010000.00170.0017
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.0017

Metabolite name: (R)-Propane-1,2-diol
Metabolite ID: 12ppd_R_e
Compartment: e


Metabolite name: (S)-Propane-1,2-diol
Metabolite ID: 12ppd_S_e
Compartment: e


Metabolite name: 1,4-alpha-D-glucan
Metabolite ID: 14glucan_e
Compartment: e


Metabolite name: 1,5-Diaminopentane
Metabolite ID: 15dap_e
Compartment: e


Metabolite name: 2',3'-Cyclic AMP
Metabolite ID: 23camp_e
Compartment: e


Metabolite name: 2',3'-Cyclic CMP
Metabolite ID: 23ccmp_e
Compartment: e


Metabolite name: 2',3'-Cyclic GMP
Metabolite ID: 23cgmp_e
Compartment: e


Metabolite name: 2',3'-Cyclic UMP
Metabolite ID: 23cump_e
Compartment: e


Metabolite name: 2,3-diaminopropionate
Metabolite ID: 23dappa_e
Compartment: e


Metabolite name: meso-2,6-Diaminoheptanedioate
Metabolite ID: 26dap_M_e
Compartment: e


Metabolite name: 2-Dehydro-3-deoxy-D-gluconate
Metabolite ID: 2ddglcn_e
Compartment: e


Metabolite name: 3,4-Dihydroxyphenylacetaldehyde
Metabolite ID: 34dhpac_e
Compartment: e


Metabolite name: 3'-AMP
Metabolite ID: 3amp_e
Compartment: e


Metabolite name: 3'-cmp
Metabolite ID: 3cmp_e
Compartment: e


Metabolite name: 3'-GMP
Metabolite ID: 3gmp_e
Compartment: e


Metabolite name: 3-hydroxycinnamic acid
Metabolite ID: 3hcinnm_e
Compartment: e


Metabolite name: 3-Hydroxypropanoate
Metabolite ID: 3hpp_e
Compartment: e


Metabolite name: 3-(3-hydroxy-phenyl)propionate
Metabolite ID: 3hpppn_e
Compartment: e


Metabolite name: 3'-UMP
Metabolite ID: 3ump_e
Compartment: e


Metabolite name: 4-Aminobutanoate
Metabolite ID: 4abut_e
Compartment: e


Metabolite name: 4-Hydroxyphenylacetaldehyde
Metabolite ID: 4hoxpacd_e
Compartment: e


Metabolite name: 5-Dehydro-D-gluconate
Metabolite ID: 5dglcn_e
Compartment: e


Metabolite name: 5-Methylthio-D-ribose
Metabolite ID: 5mtr_e
Compartment: e


Metabolite name: L-alanine-D-glutamate
Metabolite ID: LalaDglu_e
Compartment: e


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate
Metabolite ID: LalaDgluMdap_e
Compartment: e


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine
Metabolite ID: LalaDgluMdapDala_e
Compartment: e


Metabolite name: L-alanine-L-glutamate
Metabolite ID: LalaLglu_e
Compartment: e


Metabolite name: Acetate
Metabolite ID: ac_e
Compartment: e


Metabolite name: Acetoacetate
Metabolite ID: acac_e
Compartment: e


Metabolite name: Acetaldehyde
Metabolite ID: acald_e
Compartment: e


Metabolite name: N-Acetyl-D-galactosamine
Metabolite ID: acgal_e
Compartment: e


Metabolite name: N-Acetyl-D-galactosamine 1-phosphate
Metabolite ID: acgal1p_e
Compartment: e


Metabolite name: N-Acetyl-D-glucosamine
Metabolite ID: acgam_e
Compartment: e


Metabolite name: N-Acetyl-D-glucosamine 1-phosphate
Metabolite ID: acgam1p_e
Compartment: e


Metabolite name: N-Acetyl-D-mannosamine
Metabolite ID: acmana_e
Compartment: e


Metabolite name: N-Acetylmuramate
Metabolite ID: acmum_e
Compartment: e


Metabolite name: N-Acetylneuraminate
Metabolite ID: acnam_e
Compartment: e


Metabolite name: 4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A
Metabolite ID: acolipa_e
Compartment: e


Metabolite name: O-Acetyl-L-serine
Metabolite ID: acser_e
Compartment: e


Metabolite name: Adenine
Metabolite ID: ade_e
Compartment: e


Metabolite name: Adenosine
Metabolite ID: adn_e
Compartment: e


Metabolite name: Adenosylcobalamin
Metabolite ID: adocbl_e
Compartment: e


Metabolite name: silver
Metabolite ID: ag_e
Compartment: e


Metabolite name: Agmatine
Metabolite ID: agm_e
Compartment: e


Metabolite name: 2-Oxoglutarate
Metabolite ID: akg_e
Compartment: e


Metabolite name: beta-Alanine
Metabolite ID: ala_B_e
Compartment: e


Metabolite name: D-Alanine
Metabolite ID: ala_D_e
Compartment: e


Metabolite name: L-Alanine
Metabolite ID: ala_L_e
Compartment: e


Metabolite name: D-Alanyl-D-alanine
Metabolite ID: alaala_e
Compartment: e


Metabolite name: D-Allose
Metabolite ID: all_D_e
Compartment: e


Metabolite name: Allantoin
Metabolite ID: alltn_e
Compartment: e


Metabolite name: AMP
Metabolite ID: amp_e
Compartment: e


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
Metabolite ID: anhgm_e
Compartment: e


Metabolite name: L-Arabinose
Metabolite ID: arab_L_e
Compartment: e


Metabolite name: Arbutin
Metabolite ID: arbt_e
Compartment: e


Metabolite name: aerobactin minus Fe3
Metabolite ID: arbtn_e
Compartment: e


Metabolite name: Aerobactin
Metabolite ID: arbtn_fe3_e
Compartment: e


Metabolite name: L-Arginine
Metabolite ID: arg_L_e
Compartment: e


Metabolite name: L-Ascorbate
Metabolite ID: ascb_L_e
Compartment: e


Metabolite name: L-Asparagine
Metabolite ID: asn_L_e
Compartment: e


Metabolite name: arsenite
Metabolite ID: aso3_e
Compartment: e


Metabolite name: L-Aspartate
Metabolite ID: asp_L_e
Compartment: e


Metabolite name: Biotin
Metabolite ID: btn_e
Compartment: e


Metabolite name: Butyrate (n-C4:0)
Metabolite ID: but_e
Compartment: e


Metabolite name: butanesulfonate
Metabolite ID: butso3_e
Compartment: e


Metabolite name: Calcium
Metabolite ID: ca2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Calcium exchangeEX_ca2_e ⇋ ca2_e-100010000.0260.026
Transport, Outer Membrane Porincalcium (Ca+2) transport via diffusion (extracellular to periplasm)CA2texca2_e ⇋ ca2_p-100010000.026-0.026

Metabolite name: Cobinamide
Metabolite ID: cbi_e
Compartment: e


Metabolite name: Cob(I)alamin
Metabolite ID: cbl1_e
Compartment: e


Metabolite name: Cadmium
Metabolite ID: cd2_e
Compartment: e


Metabolite name: Cys-Gly
Metabolite ID: cgly_e
Compartment: e


Metabolite name: Choline
Metabolite ID: chol_e
Compartment: e


Metabolite name: N,N'-diacetylchitobiose
Metabolite ID: chtbs_e
Compartment: e


Metabolite name: Citrate
Metabolite ID: cit_e
Compartment: e


Metabolite name: Chloride
Metabolite ID: cl_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Chloride exchangeEX_cl_e ⇋ cl_e-100010000.0260.026
Transport, Outer Membrane Porinchloride (Cl-1) transport via diffusion (extracellular to periplasm)CLtexcl_e ⇋ cl_p-100010000.026-0.026

Metabolite name: Chloramphenicol
Metabolite ID: cm_e
Compartment: e


Metabolite name: CMP
Metabolite ID: cmp_e
Compartment: e


Metabolite name: CO2
Metabolite ID: co2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
CO2 exchangeEX_co2_e ⇋ co2_e-100010002e+022e+02
Transport, Outer Membrane PorinCO2 transport via diffusion (extracellular to periplasm)CO2texco2_e ⇋ co2_p-100010002e+02-2e+02

Metabolite name: Co2+
Metabolite ID: cobalt2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Co2+ exchangeEX_cobalt2_e ⇋ cobalt2_e-100010000.000120.00012
Transport, Outer Membrane Porincobalt (Co+2) transport via diffusion (extracellular to periplasm)COBALT2texcobalt2_e ⇋ cobalt2_p-100010000.00012-0.00012

Metabolite name: core oligosaccharide lipid A
Metabolite ID: colipa_e
Compartment: e


Metabolite name: core oligosaccharide lipid A diphosphate
Metabolite ID: colipap_e
Compartment: e


Metabolite name: coprogen
Metabolite ID: cpgn_e
Compartment: e


Metabolite name: coprogen unloaded (no Fe(III))
Metabolite ID: cpgn_un_e
Compartment: e


Metabolite name: L-Carnitine
Metabolite ID: crn_e
Compartment: e


Metabolite name: D-Carnitine
Metabolite ID: crn_D_e
Compartment: e


Metabolite name: Cytosine
Metabolite ID: csn_e
Compartment: e


Metabolite name: Cu+
Metabolite ID: cu_e
Compartment: e


Metabolite name: Cu2+
Metabolite ID: cu2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Cu2+ exchangeEX_cu2_e ⇋ cu2_e-100010000.00350.0035
Transport, Outer Membrane Porincopper (Cu+2) transport via diffusion (extracellular to periplasm)CU2texcu2_e ⇋ cu2_p-100010000.0035-0.0035

Metabolite name: Hydrogen cyanide
Metabolite ID: cyan_e
Compartment: e


Metabolite name: Cyanate
Metabolite ID: cynt_e
Compartment: e


Metabolite name: D-Cysteine
Metabolite ID: cys_D_e
Compartment: e


Metabolite name: L-Cysteine
Metabolite ID: cys_L_e
Compartment: e


Metabolite name: Cytidine
Metabolite ID: cytd_e
Compartment: e


Metabolite name: Deoxyadenosine
Metabolite ID: dad_2_e
Compartment: e


Metabolite name: dAMP
Metabolite ID: damp_e
Compartment: e


Metabolite name: Decanoate (n-C10:0)
Metabolite ID: dca_e
Compartment: e


Metabolite name: dCMP
Metabolite ID: dcmp_e
Compartment: e


Metabolite name: Deoxycytidine
Metabolite ID: dcyt_e
Compartment: e


Metabolite name: Dodecanoate (n-C12:0)
Metabolite ID: ddca_e
Compartment: e


Metabolite name: dGMP
Metabolite ID: dgmp_e
Compartment: e


Metabolite name: Deoxyguanosine
Metabolite ID: dgsn_e
Compartment: e


Metabolite name: Dihydroxyacetone
Metabolite ID: dha_e
Compartment: e


Metabolite name: dIMP
Metabolite ID: dimp_e
Compartment: e


Metabolite name: Deoxyinosine
Metabolite ID: din_e
Compartment: e


Metabolite name: Dimethyl sulfide
Metabolite ID: dms_e
Compartment: e


Metabolite name: Dimethyl sulfoxide
Metabolite ID: dmso_e
Compartment: e


Metabolite name: Dopamine
Metabolite ID: dopa_e
Compartment: e


Metabolite name: doxorubicin
Metabolite ID: doxrbcn_e
Compartment: e


Metabolite name: dTMP
Metabolite ID: dtmp_e
Compartment: e


Metabolite name: dUMP
Metabolite ID: dump_e
Compartment: e


Metabolite name: Deoxyuridine
Metabolite ID: duri_e
Compartment: e


Metabolite name: (enterobacterial common antigen)x4 core oligosaccharide lipid A
Metabolite ID: eca4colipa_e
Compartment: e


Metabolite name: phosphoethanolamine KDO(2)-lipid (A)
Metabolite ID: enlipa_e
Compartment: e


Metabolite name: Enterochelin
Metabolite ID: enter_e
Compartment: e


Metabolite name: Ethanolamine
Metabolite ID: etha_e
Compartment: e


Metabolite name: ethanesulfonate
Metabolite ID: ethso3_e
Compartment: e


Metabolite name: Ethanol
Metabolite ID: etoh_e
Compartment: e


Metabolite name: D-Fructose 6-phosphate
Metabolite ID: f6p_e
Compartment: e


Metabolite name: Formaldehyde
Metabolite ID: fald_e
Compartment: e


Metabolite name: Fe2+
Metabolite ID: fe2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Fe2+ exchangeEX_fe2_e ⇋ fe2_e-100010000.0790.079
Transport, Outer Membrane Poriniron (II) transport via diffusion (extracellular to periplasm)FE2texfe2_e ⇋ fe2_p-100010000.079-0.079

Metabolite name: Fe3+
Metabolite ID: fe3_e
Compartment: e


Metabolite name: Fe(III)dicitrate
Metabolite ID: fe3dcit_e
Compartment: e


Metabolite name: ferric 2,3-dihydroxybenzoylserine
Metabolite ID: fe3dhbzs_e
Compartment: e


Metabolite name: Fe(III)hydroxamate
Metabolite ID: fe3hox_e
Compartment: e


Metabolite name: Fe(III)hydoxamate, unloaded
Metabolite ID: fe3hox_un_e
Compartment: e


Metabolite name: Ferrichrome
Metabolite ID: fecrm_e
Compartment: e


Metabolite name: Ferrichrome minus Fe(III)
Metabolite ID: fecrm_un_e
Compartment: e


Metabolite name: Fe-enterobactin
Metabolite ID: feenter_e
Compartment: e


Metabolite name: ferroxamine
Metabolite ID: feoxam_e
Compartment: e


Metabolite name: ferroxamine minus Fe(3)
Metabolite ID: feoxam_un_e
Compartment: e


Metabolite name: Formate
Metabolite ID: for_e
Compartment: e


Metabolite name: D-Fructose
Metabolite ID: fru_e
Compartment: e


Metabolite name: fructoselysine
Metabolite ID: frulys_e
Compartment: e


Metabolite name: D-Fructuronate
Metabolite ID: fruur_e
Compartment: e


Metabolite name: L-Fucose
Metabolite ID: fuc_L_e
Compartment: e


Metabolite name: Fumarate
Metabolite ID: fum_e
Compartment: e


Metabolite name: fusidic acid
Metabolite ID: fusa_e
Compartment: e


Metabolite name: D-Glucose 1-phosphate
Metabolite ID: g1p_e
Compartment: e


Metabolite name: sn-Glycero-3-phosphocholine
Metabolite ID: g3pc_e
Compartment: e


Metabolite name: sn-Glycero-3-phosphoethanolamine
Metabolite ID: g3pe_e
Compartment: e


Metabolite name: Glycerophosphoglycerol
Metabolite ID: g3pg_e
Compartment: e


Metabolite name: sn-Glycero-3-phospho-1-inositol
Metabolite ID: g3pi_e
Compartment: e


Metabolite name: Glycerophosphoserine
Metabolite ID: g3ps_e
Compartment: e


Metabolite name: D-Glucose 6-phosphate
Metabolite ID: g6p_e
Compartment: e


Metabolite name: D-Galactose
Metabolite ID: gal_e
Compartment: e


Metabolite name: beta D-Galactose
Metabolite ID: gal_bD_e
Compartment: e


Metabolite name: alpha-D-Galactose 1-phosphate
Metabolite ID: gal1p_e
Compartment: e


Metabolite name: D-Galactarate
Metabolite ID: galct_D_e
Compartment: e


Metabolite name: D-Galactonate
Metabolite ID: galctn_D_e
Compartment: e


Metabolite name: L-Galactonate
Metabolite ID: galctn_L_e
Compartment: e


Metabolite name: Galactitol
Metabolite ID: galt_e
Compartment: e


Metabolite name: D-Galacturonate
Metabolite ID: galur_e
Compartment: e


Metabolite name: D-Glucosamine
Metabolite ID: gam_e
Compartment: e


Metabolite name: D-Glucosamine 6-phosphate
Metabolite ID: gam6p_e
Compartment: e


Metabolite name: gamma-butyrobetaine
Metabolite ID: gbbtn_e
Compartment: e


Metabolite name: GDP
Metabolite ID: gdp_e
Compartment: e


Metabolite name: D-Glucose
Metabolite ID: glc_D_e
Compartment: e


Metabolite name: D-Gluconate
Metabolite ID: glcn_e
Compartment: e


Metabolite name: D-Glucarate
Metabolite ID: glcr_e
Compartment: e


Metabolite name: D-Glucuronate
Metabolite ID: glcur_e
Compartment: e


Metabolite name: D-Glucuronate 1-phosphate
Metabolite ID: glcur1p_e
Compartment: e


Metabolite name: L-Glutamine
Metabolite ID: gln_L_e
Compartment: e


Metabolite name: L-Glutamate
Metabolite ID: glu_L_e
Compartment: e


Metabolite name: Glycine
Metabolite ID: gly_e
Compartment: e


Metabolite name: D-Glyceraldehyde
Metabolite ID: glyald_e
Compartment: e


Metabolite name: Glycine betaine
Metabolite ID: glyb_e
Compartment: e


Metabolite name: Glycerol
Metabolite ID: glyc_e
Compartment: e


Metabolite name: (R)-Glycerate
Metabolite ID: glyc_R_e
Compartment: e


Metabolite name: Glycerol 2-phosphate
Metabolite ID: glyc2p_e
Compartment: e


Metabolite name: Glycerol 3-phosphate
Metabolite ID: glyc3p_e
Compartment: e


Metabolite name: Glycolate
Metabolite ID: glyclt_e
Compartment: e


Metabolite name: GMP
Metabolite ID: gmp_e
Compartment: e


Metabolite name: Guanosine
Metabolite ID: gsn_e
Compartment: e


Metabolite name: Oxidized glutathione
Metabolite ID: gthox_e
Compartment: e


Metabolite name: Reduced glutathione
Metabolite ID: gthrd_e
Compartment: e


Metabolite name: GTP
Metabolite ID: gtp_e
Compartment: e


Metabolite name: Guanine
Metabolite ID: gua_e
Compartment: e


Metabolite name: H+
Metabolite ID: h_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
H+ exchangeEX_h_e ⇋ h_e-100010009.5e+029.5e+02
Transport, Outer Membrane Porinproton transport via diffusion (extracellular to periplasm)Htexh_e ⇋ h_p-100010009.5e+02-9.5e+02

Metabolite name: H2
Metabolite ID: h2_e
Compartment: e


Metabolite name: H2O
Metabolite ID: h2o_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane PorinH2O transport via diffusion (extracellular to periplasm)H2Otexh2o_p ⇋ h2o_e-100010009.3e+029.3e+02
H2O exchangeEX_h2o_eh2o_e ⇋ -100010009.3e+02-9.3e+02

Metabolite name: Hydrogen peroxide
Metabolite ID: h2o2_e
Compartment: e


Metabolite name: Hydrogen sulfide
Metabolite ID: h2s_e
Compartment: e


Metabolite name: hepta-acylated core oligosaccharide lipid A (E. coli)
Metabolite ID: hacolipa_e
Compartment: e


Metabolite name: hepta-acylated KDO(2)-lipid (A)
Metabolite ID: halipa_e
Compartment: e


Metabolite name: Hexadecanoate (n-C16:0)
Metabolite ID: hdca_e
Compartment: e


Metabolite name: Hexadecenoate (n-C16:1)
Metabolite ID: hdcea_e
Compartment: e


Metabolite name: Hg2+
Metabolite ID: hg2_e
Compartment: e


Metabolite name: L-Histidine
Metabolite ID: his_L_e
Compartment: e


Metabolite name: L-Homoserine
Metabolite ID: hom_L_e
Compartment: e


Metabolite name: Hexanoate (n-C6:0)
Metabolite ID: hxa_e
Compartment: e


Metabolite name: Hypoxanthine
Metabolite ID: hxan_e
Compartment: e


Metabolite name: L-Idonate
Metabolite ID: idon_L_e
Compartment: e


Metabolite name: L-Isoleucine
Metabolite ID: ile_L_e
Compartment: e


Metabolite name: IMP
Metabolite ID: imp_e
Compartment: e


Metabolite name: Indole
Metabolite ID: indole_e
Compartment: e


Metabolite name: myo-Inositol
Metabolite ID: inost_e
Compartment: e


Metabolite name: Inosine
Metabolite ID: ins_e
Compartment: e


Metabolite name: Isethionic acid
Metabolite ID: isetac_e
Compartment: e


Metabolite name: potassium
Metabolite ID: k_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
K+ exchangeEX_k_e ⇋ k_e-100010000.960.96
Transport, Outer Membrane Porinpotassium transport via diffusion (extracellular to periplasm)Ktexk_e ⇋ k_p-100010000.96-0.96

Metabolite name: KDO(2)-lipid IV(A)
Metabolite ID: kdo2lipid4_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.0960.096
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.096

Metabolite name: D-Lactate
Metabolite ID: lac_D_e
Compartment: e


Metabolite name: L-Lactate
Metabolite ID: lac_L_e
Compartment: e


Metabolite name: Lactose
Metabolite ID: lcts_e
Compartment: e


Metabolite name: L-Leucine
Metabolite ID: leu_L_e
Compartment: e


Metabolite name: KDO(2)-lipid (A)
Metabolite ID: lipa_e
Compartment: e


Metabolite name: cold adapted KDO(2)-lipid (A)
Metabolite ID: lipa_cold_e
Compartment: e


Metabolite name: Lipoate
Metabolite ID: lipoate_e
Compartment: e


Metabolite name: L-Lysine
Metabolite ID: lys_L_e
Compartment: e


Metabolite name: L-Lyxose
Metabolite ID: lyx_L_e
Compartment: e


Metabolite name: D-Malate
Metabolite ID: mal_D_e
Compartment: e


Metabolite name: L-Malate
Metabolite ID: mal_L_e
Compartment: e


Metabolite name: Maltose
Metabolite ID: malt_e
Compartment: e


Metabolite name: Maltohexaose
Metabolite ID: malthx_e
Compartment: e


Metabolite name: Maltopentaose
Metabolite ID: maltpt_e
Compartment: e


Metabolite name: Maltotriose
Metabolite ID: malttr_e
Compartment: e


Metabolite name: Maltotetraose
Metabolite ID: maltttr_e
Compartment: e


Metabolite name: D-Mannose
Metabolite ID: man_e
Compartment: e


Metabolite name: D-Mannose 6-phosphate
Metabolite ID: man6p_e
Compartment: e


Metabolite name: 2(alpha-D-Mannosyl)-D-glycerate
Metabolite ID: manglyc_e
Compartment: e


Metabolite name: Melibiose
Metabolite ID: melib_e
Compartment: e


Metabolite name: Methanol
Metabolite ID: meoh_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane PorinMethanol transport via diffusion (extracellular to periplasm)MEOHtexmeoh_p ⇋ meoh_e-100010009.9e-069.9e-06
methanol exchangeEX_meoh_emeoh_e ⇋ 010009.9e-06-9.9e-06

Metabolite name: D-Methionine
Metabolite ID: met_D_e
Compartment: e


Metabolite name: L-Methionine
Metabolite ID: met_L_e
Compartment: e


Metabolite name: L-methionine-R-sulfoxide
Metabolite ID: metsox_R_L_e
Compartment: e


Metabolite name: L-Methionine Sulfoxide
Metabolite ID: metsox_S_L_e
Compartment: e


Metabolite name: magnesium
Metabolite ID: mg2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Mg exchangeEX_mg2_e ⇋ mg2_e-100010000.0430.043
Transport, Outer Membrane Porinmagnesium (Mg+2) transport via diffusion (extracellular to periplasm)MG2texmg2_e ⇋ mg2_p-100010000.043-0.043

Metabolite name: minocycline
Metabolite ID: mincyc_e
Compartment: e


Metabolite name: myo-Inositol hexakisphosphate
Metabolite ID: minohp_e
Compartment: e


Metabolite name: S-Methyl-L-methionine
Metabolite ID: mmet_e
Compartment: e


Metabolite name: Mn2+
Metabolite ID: mn2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Mn2+ exchangeEX_mn2_e ⇋ mn2_e-100010000.00340.0034
Transport, Outer Membrane PorinManganese (Mn+2) transport via diffusion (extracellular to periplasm)MNtexmn2_e ⇋ mn2_p-100010000.0034-0.0034

Metabolite name: D-Mannitol
Metabolite ID: mnl_e
Compartment: e


Metabolite name: Molybdate
Metabolite ID: mobd_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Molybdate exchangeEX_mobd_e ⇋ mobd_e-100010000.000640.00064
Transport, Outer Membrane Porinmolybdate transport via diffusion (extracellular to periplasm)MOBDtexmobd_e ⇋ mobd_p-100010000.00064-0.00064

Metabolite name: methanesulfonate
Metabolite ID: mso3_e
Compartment: e


Metabolite name: Nitrous oxide
Metabolite ID: n2o_e
Compartment: e


Metabolite name: Sodium
Metabolite ID: na1_e
Compartment: e


Metabolite name: Nicotinate
Metabolite ID: nac_e
Compartment: e


Metabolite name: Ammonium
Metabolite ID: nh4_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Ammonia exchangeEX_nh4_e ⇋ nh4_e-100010005353
Transport, Outer Membrane Porinammonia transport via diffusion (extracellular to periplasm)NH4texnh4_e ⇋ nh4_p-1000100053-53

Metabolite name: nickel
Metabolite ID: ni2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Ni2+ exchangeEX_ni2_e ⇋ ni2_e-100010000.00160.0016
Transport, Outer Membrane Porinnickel transport via diffusion (extracellular to periplasm)NI2texni2_e ⇋ ni2_p-100010000.0016-0.0016

Metabolite name: NMN
Metabolite ID: nmn_e
Compartment: e


Metabolite name: Nitric oxide
Metabolite ID: no_e
Compartment: e


Metabolite name: Nitrite
Metabolite ID: no2_e
Compartment: e


Metabolite name: Nitrate
Metabolite ID: no3_e
Compartment: e


Metabolite name: novobiocin
Metabolite ID: novbcn_e
Compartment: e


Metabolite name: (O16 antigen)x4 core oligosaccharide lipid A
Metabolite ID: o16a4colipa_e
Compartment: e


Metabolite name: O2
Metabolite ID: o2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
O2 exchangeEX_o2_e ⇋ o2_e-100010002.9e+022.9e+02
Transport, Outer Membrane Porinoxygen transport via diffusion (extracellular to periplasm)O2texo2_e ⇋ o2_p-100010002.9e+02-2.9e+02

Metabolite name: Superoxide anion
Metabolite ID: o2s_e
Compartment: e


Metabolite name: octadecanoate (n-C18:0)
Metabolite ID: ocdca_e
Compartment: e


Metabolite name: octadecenoate (n-C18:1)
Metabolite ID: ocdcea_e
Compartment: e


Metabolite name: octanoate (n-C8:0)
Metabolite ID: octa_e
Compartment: e


Metabolite name: Ornithine
Metabolite ID: orn_e
Compartment: e


Metabolite name: Orotate
Metabolite ID: orot_e
Compartment: e


Metabolite name: Phenylacetaldehyde
Metabolite ID: pacald_e
Compartment: e


Metabolite name: Phenethylamine
Metabolite ID: peamn_e
Compartment: e


Metabolite name: L-Phenylalanine
Metabolite ID: phe_L_e
Compartment: e


Metabolite name: Protoheme
Metabolite ID: pheme_e
Compartment: e


Metabolite name: Phosphate
Metabolite ID: pi_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Phosphate exchangeEX_pi_e ⇋ pi_e-100010004.84.8
Transport, Outer Membrane Porinphosphate transport via diffusion (extracellular to periplasm)PItexpi_e ⇋ pi_p-100010004.8-4.8

Metabolite name: (R)-Pantothenate
Metabolite ID: pnto_R_e
Compartment: e


Metabolite name: Propionate (n-C3:0)
Metabolite ID: ppa_e
Compartment: e


Metabolite name: Propanal
Metabolite ID: ppal_e
Compartment: e


Metabolite name: Phenylpropanoate
Metabolite ID: pppn_e
Compartment: e


Metabolite name: Phosphonate
Metabolite ID: ppt_e
Compartment: e


Metabolite name: L-Proline
Metabolite ID: pro_L_e
Compartment: e


Metabolite name: L-Prolinylglycine
Metabolite ID: progly_e
Compartment: e


Metabolite name: psicoselysine
Metabolite ID: psclys_e
Compartment: e


Metabolite name: O-Phospho-L-serine
Metabolite ID: pser_L_e
Compartment: e


Metabolite name: Putrescine
Metabolite ID: ptrc_e
Compartment: e


Metabolite name: Pyridoxamine
Metabolite ID: pydam_e
Compartment: e


Metabolite name: Pyridoxal
Metabolite ID: pydx_e
Compartment: e


Metabolite name: Pyridoxine
Metabolite ID: pydxn_e
Compartment: e


Metabolite name: Pyruvate
Metabolite ID: pyr_e
Compartment: e


Metabolite name: Quinate
Metabolite ID: quin_e
Compartment: e


Metabolite name: alpha-D-Ribose 5-phosphate
Metabolite ID: r5p_e
Compartment: e


Metabolite name: rifampin
Metabolite ID: rfamp_e
Compartment: e


Metabolite name: D-Ribose
Metabolite ID: rib_D_e
Compartment: e


Metabolite name: L-Rhamnose
Metabolite ID: rmn_e
Compartment: e


Metabolite name: D-Sorbitol
Metabolite ID: sbt_D_e
Compartment: e


Metabolite name: Selenate
Metabolite ID: sel_e
Compartment: e


Metabolite name: D-Serine
Metabolite ID: ser_D_e
Compartment: e


Metabolite name: L-Serine
Metabolite ID: ser_L_e
Compartment: e


Metabolite name: Shikimate
Metabolite ID: skm_e
Compartment: e


Metabolite name: selenite
Metabolite ID: slnt_e
Compartment: e


Metabolite name: sulfur dioxide
Metabolite ID: so2_e
Compartment: e


Metabolite name: Sulfite
Metabolite ID: so3_e
Compartment: e


Metabolite name: Sulfate
Metabolite ID: so4_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Sulfate exchangeEX_so4_e ⇋ so4_e-100010001.21.2
Transport, Outer Membrane Porinsulfate transport via diffusion (extracellular to periplasm)SO4texso4_e ⇋ so4_p-100010001.2-1.2

Metabolite name: Spermidine
Metabolite ID: spmd_e
Compartment: e


Metabolite name: Succinate
Metabolite ID: succ_e
Compartment: e


Metabolite name: Sucrose
Metabolite ID: sucr_e
Compartment: e


Metabolite name: sulfoacetate
Metabolite ID: sulfac_e
Compartment: e


Metabolite name: D-tartrate
Metabolite ID: tartr_D_e
Compartment: e


Metabolite name: L-tartrate
Metabolite ID: tartr_L_e
Compartment: e


Metabolite name: Taurine
Metabolite ID: taur_e
Compartment: e


Metabolite name: Thiocyanate
Metabolite ID: tcynt_e
Compartment: e


Metabolite name: Thiamin
Metabolite ID: thm_e
Compartment: e


Metabolite name: L-Threonine
Metabolite ID: thr_L_e
Compartment: e


Metabolite name: L-Threonine O-3-phosphate
Metabolite ID: thrp_e
Compartment: e


Metabolite name: Thymine
Metabolite ID: thym_e
Compartment: e


Metabolite name: Thymidine
Metabolite ID: thymd_e
Compartment: e


Metabolite name: trimethylamine
Metabolite ID: tma_e
Compartment: e


Metabolite name: Trimethylamine N-oxide
Metabolite ID: tmao_e
Compartment: e


Metabolite name: Trehalose
Metabolite ID: tre_e
Compartment: e


Metabolite name: L-Tryptophan
Metabolite ID: trp_L_e
Compartment: e


Metabolite name: Thiosulfate
Metabolite ID: tsul_e
Compartment: e


Metabolite name: tetradecanoate (n-C14:0)
Metabolite ID: ttdca_e
Compartment: e


Metabolite name: tetradecenoate (n-C14:1)
Metabolite ID: ttdcea_e
Compartment: e


Metabolite name: tetracycline
Metabolite ID: ttrcyc_e
Compartment: e


Metabolite name: tungstate
Metabolite ID: tungs_e
Compartment: e


Metabolite name: Tyramine
Metabolite ID: tym_e
Compartment: e


Metabolite name: L-Tyrosine
Metabolite ID: tyr_L_e
Compartment: e


Metabolite name: Phosphotyrosine
Metabolite ID: tyrp_e
Compartment: e


Metabolite name: UDP-N-acetyl-D-glucosamine
Metabolite ID: uacgam_e
Compartment: e


Metabolite name: UDP-N-acetyl-D-galactosamine
Metabolite ID: udpacgal_e
Compartment: e


Metabolite name: UDPglucose
Metabolite ID: udpg_e
Compartment: e


Metabolite name: UDPgalactose
Metabolite ID: udpgal_e
Compartment: e


Metabolite name: UDP-D-glucuronate
Metabolite ID: udpglcur_e
Compartment: e


Metabolite name: UMP
Metabolite ID: ump_e
Compartment: e


Metabolite name: Uracil
Metabolite ID: ura_e
Compartment: e


Metabolite name: Urea
Metabolite ID: urea_e
Compartment: e


Metabolite name: Uridine
Metabolite ID: uri_e
Compartment: e


Metabolite name: L-Valine
Metabolite ID: val_L_e
Compartment: e


Metabolite name: Xanthine
Metabolite ID: xan_e
Compartment: e


Metabolite name: Xanthosine 5'-phosphate
Metabolite ID: xmp_e
Compartment: e


Metabolite name: Xanthosine
Metabolite ID: xtsn_e
Compartment: e


Metabolite name: D-Xylose
Metabolite ID: xyl_D_e
Compartment: e


Metabolite name: L-Xylulose
Metabolite ID: xylu_L_e
Compartment: e


Metabolite name: Zinc
Metabolite ID: zn2_e
Compartment: e

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Zinc exchangeEX_zn2_e ⇋ zn2_e-100010000.00170.0017
Transport, Outer Membrane Porinzinc (Zn+2) transport via diffusion (extracellular to periplasm)Zn2texzn2_e ⇋ zn2_p-100010000.0017-0.0017

Metabolite name: 1,2-Diacyl-sn-glycerol (didodecanoyl, n-C12:0)
Metabolite ID: 12dgr120_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (ditetradecanoyl, n-C14:0)
Metabolite ID: 12dgr140_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: 12dgr141_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (dihexadecanoyl, n-C16:0)
Metabolite ID: 12dgr160_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: 12dgr161_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)
Metabolite ID: 12dgr180_p
Compartment: p


Metabolite name: 1,2-Diacyl-sn-glycerol (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: 12dgr181_p
Compartment: p


Metabolite name: (R)-Propane-1,2-diol
Metabolite ID: 12ppd_R_p
Compartment: p


Metabolite name: (S)-Propane-1,2-diol
Metabolite ID: 12ppd_S_p
Compartment: p


Metabolite name: 1,4-alpha-D-glucan
Metabolite ID: 14glucan_p
Compartment: p


Metabolite name: 1,5-Diaminopentane
Metabolite ID: 15dap_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0)
Metabolite ID: 1agpe120_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0)
Metabolite ID: 1agpe140_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)
Metabolite ID: 1agpe141_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)
Metabolite ID: 1agpe160_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)
Metabolite ID: 1agpe161_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)
Metabolite ID: 1agpe180_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)
Metabolite ID: 1agpe181_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)
Metabolite ID: 1agpg120_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)
Metabolite ID: 1agpg140_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)
Metabolite ID: 1agpg141_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)
Metabolite ID: 1agpg160_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)
Metabolite ID: 1agpg161_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)
Metabolite ID: 1agpg180_p
Compartment: p


Metabolite name: 1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)
Metabolite ID: 1agpg181_p
Compartment: p


Metabolite name: 1-dodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1ddecg3p_p
Compartment: p


Metabolite name: 1-hexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1hdec9eg3p_p
Compartment: p


Metabolite name: 1-hexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1hdecg3p_p
Compartment: p


Metabolite name: 1-octadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1odec11eg3p_p
Compartment: p


Metabolite name: 1-octadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1odecg3p_p
Compartment: p


Metabolite name: 1-tetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 1tdec7eg3p_p
Compartment: p


Metabolite name: 1-tetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 1tdecg3p_p
Compartment: p


Metabolite name: 2',3'-Cyclic AMP
Metabolite ID: 23camp_p
Compartment: p


Metabolite name: 2',3'-Cyclic CMP
Metabolite ID: 23ccmp_p
Compartment: p


Metabolite name: 2',3'-Cyclic GMP
Metabolite ID: 23cgmp_p
Compartment: p


Metabolite name: 2',3'-Cyclic UMP
Metabolite ID: 23cump_p
Compartment: p


Metabolite name: 2,3-diaminopropionate
Metabolite ID: 23dappa_p
Compartment: p


Metabolite name: meso-2,6-Diaminoheptanedioate
Metabolite ID: 26dap_M_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0)
Metabolite ID: 2agpe120_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0)
Metabolite ID: 2agpe140_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)
Metabolite ID: 2agpe141_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)
Metabolite ID: 2agpe160_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)
Metabolite ID: 2agpe161_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)
Metabolite ID: 2agpe180_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)
Metabolite ID: 2agpe181_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)
Metabolite ID: 2agpg120_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)
Metabolite ID: 2agpg140_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)
Metabolite ID: 2agpg141_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)
Metabolite ID: 2agpg160_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)
Metabolite ID: 2agpg161_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)
Metabolite ID: 2agpg180_p
Compartment: p


Metabolite name: 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)
Metabolite ID: 2agpg181_p
Compartment: p


Metabolite name: 2-dodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2ddecg3p_p
Compartment: p


Metabolite name: 2-Dehydro-3-deoxy-D-gluconate
Metabolite ID: 2ddglcn_p
Compartment: p


Metabolite name: 2-hexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2hdec9eg3p_p
Compartment: p


Metabolite name: 2-hexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2hdecg3p_p
Compartment: p


Metabolite name: 2-octadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2odec11eg3p_p
Compartment: p


Metabolite name: 2-octadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2odecg3p_p
Compartment: p


Metabolite name: 2-tetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: 2tdec7eg3p_p
Compartment: p


Metabolite name: 2-tetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: 2tdecg3p_p
Compartment: p


Metabolite name: 3,4-Dihydroxyphenylacetaldehyde
Metabolite ID: 34dhpac_p
Compartment: p


Metabolite name: 3'-AMP
Metabolite ID: 3amp_p
Compartment: p


Metabolite name: 3'-cmp
Metabolite ID: 3cmp_p
Compartment: p


Metabolite name: 3'-GMP
Metabolite ID: 3gmp_p
Compartment: p


Metabolite name: 3-hydroxycinnamic acid
Metabolite ID: 3hcinnm_p
Compartment: p


Metabolite name: 3-Hydroxypropanoate
Metabolite ID: 3hpp_p
Compartment: p


Metabolite name: 3-(3-hydroxy-phenyl)propionate
Metabolite ID: 3hpppn_p
Compartment: p


Metabolite name: 3'-UMP
Metabolite ID: 3ump_p
Compartment: p


Metabolite name: 4-Aminobutanoate
Metabolite ID: 4abut_p
Compartment: p


Metabolite name: 4-Hydroxyphenylacetaldehyde
Metabolite ID: 4hoxpacd_p
Compartment: p


Metabolite name: 5-Dehydro-D-gluconate
Metabolite ID: 5dglcn_p
Compartment: p


Metabolite name: 5-Methylthio-D-ribose
Metabolite ID: 5mtr_p
Compartment: p


Metabolite name: L-alanine-D-glutamate
Metabolite ID: LalaDglu_p
Compartment: p


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate
Metabolite ID: LalaDgluMdap_p
Compartment: p


Metabolite name: L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine
Metabolite ID: LalaDgluMdapDala_p
Compartment: p


Metabolite name: L-alanine-L-glutamate
Metabolite ID: LalaLglu_p
Compartment: p


Metabolite name: Acetate
Metabolite ID: ac_p
Compartment: p


Metabolite name: Acetoacetate
Metabolite ID: acac_p
Compartment: p


Metabolite name: Acetaldehyde
Metabolite ID: acald_p
Compartment: p


Metabolite name: N-Acetyl-D-galactosamine
Metabolite ID: acgal_p
Compartment: p


Metabolite name: N-Acetyl-D-galactosamine 1-phosphate
Metabolite ID: acgal1p_p
Compartment: p


Metabolite name: N-Acetyl-D-glucosamine
Metabolite ID: acgam_p
Compartment: p


Metabolite name: N-Acetyl-D-glucosamine 1-phosphate
Metabolite ID: acgam1p_p
Compartment: p


Metabolite name: N-Acetyl-D-mannosamine
Metabolite ID: acmana_p
Compartment: p


Metabolite name: N-Acetylmuramate
Metabolite ID: acmum_p
Compartment: p


Metabolite name: N-Acetylneuraminate
Metabolite ID: acnam_p
Compartment: p


Metabolite name: 4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A
Metabolite ID: acolipa_p
Compartment: p


Metabolite name: O-Acetyl-L-serine
Metabolite ID: acser_p
Compartment: p


Metabolite name: Adenine
Metabolite ID: ade_p
Compartment: p


Metabolite name: Adenosine
Metabolite ID: adn_p
Compartment: p


Metabolite name: Adenosylcobalamin
Metabolite ID: adocbl_p
Compartment: p


Metabolite name: Agmatine
Metabolite ID: agm_p
Compartment: p


Metabolite name: 2-Oxoglutarate
Metabolite ID: akg_p
Compartment: p


Metabolite name: beta-Alanine
Metabolite ID: ala_B_p
Compartment: p


Metabolite name: D-Alanine
Metabolite ID: ala_D_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Murein Biosynthesismurein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)MCTP1Appmurein5p5p_p ⇋ ala_D_p + murein5px4p_p010000.0680.068
Transport, Inner MembraneD-alanine transport in via proton symport (periplasm)DALAt2ppala_D_p + h_p ⇋ ala_D_c + h_c010000.068-0.068

Metabolite name: L-Alanine
Metabolite ID: ala_L_p
Compartment: p


Metabolite name: D-Alanyl-D-alanine
Metabolite ID: alaala_p
Compartment: p


Metabolite name: D-Allose
Metabolite ID: all_D_p
Compartment: p


Metabolite name: Allantoin
Metabolite ID: alltn_p
Compartment: p


Metabolite name: applipoprotein
Metabolite ID: alpp_p
Compartment: p


Metabolite name: AMP
Metabolite ID: amp_p
Compartment: p


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
Metabolite ID: anhgm_p
Compartment: p


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide
Metabolite ID: anhgm3p_p
Compartment: p


Metabolite name: N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide
Metabolite ID: anhgm4p_p
Compartment: p


Metabolite name: L-Arabinose
Metabolite ID: arab_L_p
Compartment: p


Metabolite name: Arbutin
Metabolite ID: arbt_p
Compartment: p


Metabolite name: aerobactin minus Fe3
Metabolite ID: arbtn_p
Compartment: p


Metabolite name: Aerobactin
Metabolite ID: arbtn_fe3_p
Compartment: p


Metabolite name: L-Arginine
Metabolite ID: arg_L_p
Compartment: p


Metabolite name: L-Ascorbate
Metabolite ID: ascb_L_p
Compartment: p


Metabolite name: L-Asparagine
Metabolite ID: asn_L_p
Compartment: p


Metabolite name: arsenite
Metabolite ID: aso3_p
Compartment: p


Metabolite name: L-Aspartate
Metabolite ID: asp_L_p
Compartment: p


Metabolite name: Biotin
Metabolite ID: btn_p
Compartment: p


Metabolite name: Butyrate (n-C4:0)
Metabolite ID: but_p
Compartment: p


Metabolite name: butanesulfonate
Metabolite ID: butso3_p
Compartment: p


Metabolite name: Calcium
Metabolite ID: ca2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porincalcium (Ca+2) transport via diffusion (extracellular to periplasm)CA2texca2_e ⇋ ca2_p-100010000.0260.026
Inorganic Ion Transport and Metabolismcalcium / sodium antiporter (1:1)CAt6ppca2_p + na1_c ⇋ na1_p + ca2_c-100010000.026-0.026

Metabolite name: Cobinamide
Metabolite ID: cbi_p
Compartment: p


Metabolite name: Cob(I)alamin
Metabolite ID: cbl1_p
Compartment: p


Metabolite name: Cadmium
Metabolite ID: cd2_p
Compartment: p


Metabolite name: Cys-Gly
Metabolite ID: cgly_p
Compartment: p


Metabolite name: Choline
Metabolite ID: chol_p
Compartment: p


Metabolite name: N,N'-diacetylchitobiose
Metabolite ID: chtbs_p
Compartment: p


Metabolite name: Citrate
Metabolite ID: cit_p
Compartment: p


Metabolite name: Chloride
Metabolite ID: cl_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinchloride (Cl-1) transport via diffusion (extracellular to periplasm)CLtexcl_e ⇋ cl_p-100010000.0260.026
Inorganic Ion Transport and Metabolismchloride transport out via proton antiport (2:1) (periplasm)CLt3_2pph_c + 2 cl_p ⇋ h_p + 2 cl_c010000.013-0.026

Metabolite name: cardiolipin (tetradodecanoyl, n-C12:0)
Metabolite ID: clpn120_p
Compartment: p


Metabolite name: cardiolipin (tetratetradecanoyl, n-C14:0)
Metabolite ID: clpn140_p
Compartment: p


Metabolite name: cardiolipin (tetratetradec-7-enoyl, n-C14:1)
Metabolite ID: clpn141_p
Compartment: p


Metabolite name: cardiolipin (tetrahexadecanoyl, n-C16:0)
Metabolite ID: clpn160_p
Compartment: p


Metabolite name: cardiolipin (tetrahexadec-9-enoyl, n-C16:1)
Metabolite ID: clpn161_p
Compartment: p


Metabolite name: cardiolipin (tetraoctadecanoyl, n-C18:0)
Metabolite ID: clpn180_p
Compartment: p


Metabolite name: cardiolipin (tetraoctadec-11-enoyl, n-C18:1)
Metabolite ID: clpn181_p
Compartment: p


Metabolite name: Chloramphenicol
Metabolite ID: cm_p
Compartment: p


Metabolite name: CMP
Metabolite ID: cmp_p
Compartment: p


Metabolite name: CO2
Metabolite ID: co2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane PorinCO2 transport via diffusion (extracellular to periplasm)CO2texco2_e ⇋ co2_p-100010002e+022e+02
Transport, Inner MembraneCO2 transporter via diffusion (periplasm)CO2tppco2_p ⇋ co2_c-100010002e+02-2e+02

Metabolite name: Co2+
Metabolite ID: cobalt2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porincobalt (Co+2) transport via diffusion (extracellular to periplasm)COBALT2texcobalt2_e ⇋ cobalt2_p-100010000.000120.00012
Inorganic Ion Transport and Metabolismcobalt transport in via permease (no H+)COBALT2tppcobalt2_p ⇋ cobalt2_c010000.00012-0.00012

Metabolite name: core oligosaccharide lipid A
Metabolite ID: colipa_p
Compartment: p


Metabolite name: core oligosaccharide lipid A diphosphate
Metabolite ID: colipap_p
Compartment: p


Metabolite name: coprogen
Metabolite ID: cpgn_p
Compartment: p


Metabolite name: coprogen unloaded (no Fe(III))
Metabolite ID: cpgn_un_p
Compartment: p


Metabolite name: L-Carnitine
Metabolite ID: crn_p
Compartment: p


Metabolite name: D-Carnitine
Metabolite ID: crn_D_p
Compartment: p


Metabolite name: Cytosine
Metabolite ID: csn_p
Compartment: p


Metabolite name: crotonobetaine
Metabolite ID: ctbt_p
Compartment: p


Metabolite name: Cu+
Metabolite ID: cu_p
Compartment: p


Metabolite name: Cu2+
Metabolite ID: cu2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porincopper (Cu+2) transport via diffusion (extracellular to periplasm)CU2texcu2_e ⇋ cu2_p-100010000.00350.0035
Inorganic Ion Transport and Metabolismcopper transport in via permease (no H+)CU2tppcu2_p ⇋ cu2_c010000.0035-0.0035

Metabolite name: Hydrogen cyanide
Metabolite ID: cyan_p
Compartment: p


Metabolite name: Cyanate
Metabolite ID: cynt_p
Compartment: p


Metabolite name: D-Cysteine
Metabolite ID: cys_D_p
Compartment: p


Metabolite name: L-Cysteine
Metabolite ID: cys_L_p
Compartment: p


Metabolite name: Cytidine
Metabolite ID: cytd_p
Compartment: p


Metabolite name: Deoxyadenosine
Metabolite ID: dad_2_p
Compartment: p


Metabolite name: dAMP
Metabolite ID: damp_p
Compartment: p


Metabolite name: Decanoate (n-C10:0)
Metabolite ID: dca_p
Compartment: p


Metabolite name: dCMP
Metabolite ID: dcmp_p
Compartment: p


Metabolite name: Deoxycytidine
Metabolite ID: dcyt_p
Compartment: p


Metabolite name: Dodecanoate (n-C12:0)
Metabolite ID: ddca_p
Compartment: p


Metabolite name: dGMP
Metabolite ID: dgmp_p
Compartment: p


Metabolite name: Deoxyguanosine
Metabolite ID: dgsn_p
Compartment: p


Metabolite name: Dihydroxyacetone
Metabolite ID: dha_p
Compartment: p


Metabolite name: dIMP
Metabolite ID: dimp_p
Compartment: p


Metabolite name: Deoxyinosine
Metabolite ID: din_p
Compartment: p


Metabolite name: Dimethyl sulfide
Metabolite ID: dms_p
Compartment: p


Metabolite name: Dimethyl sulfoxide
Metabolite ID: dmso_p
Compartment: p


Metabolite name: Dopamine
Metabolite ID: dopa_p
Compartment: p


Metabolite name: doxorubicin
Metabolite ID: doxrbcn_p
Compartment: p


Metabolite name: periplasmic protein disulfide isomerase I (oxidized)
Metabolite ID: dsbaox_p
Compartment: p


Metabolite name: periplasmic protein disulfide isomerase I (reduced)
Metabolite ID: dsbard_p
Compartment: p


Metabolite name: protein disulfide isomerase II (oxidized)
Metabolite ID: dsbcox_p
Compartment: p


Metabolite name: protein disulfide isomerase II (reduced)
Metabolite ID: dsbcrd_p
Compartment: p


Metabolite name: periplasmic disulfide isomerase/thiol-disulphide oxidase (oxidized)
Metabolite ID: dsbgox_p
Compartment: p


Metabolite name: periplasmic disulfide isomerase/thiol-disulphide oxidase (reduced)
Metabolite ID: dsbgrd_p
Compartment: p


Metabolite name: dTMP
Metabolite ID: dtmp_p
Compartment: p


Metabolite name: dUMP
Metabolite ID: dump_p
Compartment: p


Metabolite name: Deoxyuridine
Metabolite ID: duri_p
Compartment: p


Metabolite name: (enterobacterial common antigen)x2 undecaprenyl-diphosphate
Metabolite ID: eca2und_p
Compartment: p


Metabolite name: (enterobacterial common antigen)x3 undecaprenyl-diphosphate
Metabolite ID: eca3und_p
Compartment: p


Metabolite name: (enterobacterial common antigen)x4 core oligosaccharide lipid A
Metabolite ID: eca4colipa_p
Compartment: p


Metabolite name: (enterobacterial common antigen)x4 undecaprenyl-diphosphate
Metabolite ID: eca4und_p
Compartment: p


Metabolite name: phosphoethanolamine KDO(2)-lipid (A)
Metabolite ID: enlipa_p
Compartment: p


Metabolite name: Enterochelin
Metabolite ID: enter_p
Compartment: p


Metabolite name: Ethanolamine
Metabolite ID: etha_p
Compartment: p


Metabolite name: ethanesulfonate
Metabolite ID: ethso3_p
Compartment: p


Metabolite name: Ethanol
Metabolite ID: etoh_p
Compartment: p


Metabolite name: D-Fructose 6-phosphate
Metabolite ID: f6p_p
Compartment: p


Metabolite name: Formaldehyde
Metabolite ID: fald_p
Compartment: p


Metabolite name: Fe2+
Metabolite ID: fe2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Poriniron (II) transport via diffusion (extracellular to periplasm)FE2texfe2_e ⇋ fe2_p-100010000.0790.079
Inorganic Ion Transport and Metabolismiron (+2) transport in via permease (no H+)FE2tppfe2_p ⇋ fe2_c010000.079-0.079

Metabolite name: Fe3+
Metabolite ID: fe3_p
Compartment: p


Metabolite name: Fe(III)dicitrate
Metabolite ID: fe3dcit_p
Compartment: p


Metabolite name: ferric 2,3-dihydroxybenzoylserine
Metabolite ID: fe3dhbzs_p
Compartment: p


Metabolite name: Fe(III)hydroxamate
Metabolite ID: fe3hox_p
Compartment: p


Metabolite name: Fe(III)hydoxamate, unloaded
Metabolite ID: fe3hox_un_p
Compartment: p


Metabolite name: Ferrichrome
Metabolite ID: fecrm_p
Compartment: p


Metabolite name: Ferrichrome minus Fe(III)
Metabolite ID: fecrm_un_p
Compartment: p


Metabolite name: Fe-enterobactin
Metabolite ID: feenter_p
Compartment: p


Metabolite name: ferroxamine
Metabolite ID: feoxam_p
Compartment: p


Metabolite name: ferroxamine minus Fe(3)
Metabolite ID: feoxam_un_p
Compartment: p


Metabolite name: Formate
Metabolite ID: for_p
Compartment: p


Metabolite name: D-Fructose
Metabolite ID: fru_p
Compartment: p


Metabolite name: fructoselysine
Metabolite ID: frulys_p
Compartment: p


Metabolite name: D-Fructuronate
Metabolite ID: fruur_p
Compartment: p


Metabolite name: L-Fucose
Metabolite ID: fuc_L_p
Compartment: p


Metabolite name: Fumarate
Metabolite ID: fum_p
Compartment: p


Metabolite name: fusidic acid
Metabolite ID: fusa_p
Compartment: p


Metabolite name: D-Glucose 1-phosphate
Metabolite ID: g1p_p
Compartment: p


Metabolite name: sn-Glycero-3-phosphocholine
Metabolite ID: g3pc_p
Compartment: p


Metabolite name: sn-Glycero-3-phosphoethanolamine
Metabolite ID: g3pe_p
Compartment: p


Metabolite name: Glycerophosphoglycerol
Metabolite ID: g3pg_p
Compartment: p


Metabolite name: sn-Glycero-3-phospho-1-inositol
Metabolite ID: g3pi_p
Compartment: p


Metabolite name: Glycerophosphoserine
Metabolite ID: g3ps_p
Compartment: p


Metabolite name: D-Glucose 6-phosphate
Metabolite ID: g6p_p
Compartment: p


Metabolite name: D-Galactose
Metabolite ID: gal_p
Compartment: p


Metabolite name: beta D-Galactose
Metabolite ID: gal_bD_p
Compartment: p


Metabolite name: alpha-D-Galactose 1-phosphate
Metabolite ID: gal1p_p
Compartment: p


Metabolite name: D-Galactarate
Metabolite ID: galct_D_p
Compartment: p


Metabolite name: D-Galactonate
Metabolite ID: galctn_D_p
Compartment: p


Metabolite name: L-Galactonate
Metabolite ID: galctn_L_p
Compartment: p


Metabolite name: Galactitol
Metabolite ID: galt_p
Compartment: p


Metabolite name: D-Galacturonate
Metabolite ID: galur_p
Compartment: p


Metabolite name: D-Glucosamine
Metabolite ID: gam_p
Compartment: p


Metabolite name: D-Glucosamine 6-phosphate
Metabolite ID: gam6p_p
Compartment: p


Metabolite name: gamma-butyrobetaine
Metabolite ID: gbbtn_p
Compartment: p


Metabolite name: GDP
Metabolite ID: gdp_p
Compartment: p


Metabolite name: D-Glucose
Metabolite ID: glc_D_p
Compartment: p


Metabolite name: D-Gluconate
Metabolite ID: glcn_p
Compartment: p


Metabolite name: D-Glucarate
Metabolite ID: glcr_p
Compartment: p


Metabolite name: D-Glucuronate
Metabolite ID: glcur_p
Compartment: p


Metabolite name: D-Glucuronate 1-phosphate
Metabolite ID: glcur1p_p
Compartment: p


Metabolite name: L-Glutamine
Metabolite ID: gln_L_p
Compartment: p


Metabolite name: L-Glutamate
Metabolite ID: glu_L_p
Compartment: p


Metabolite name: Glycine
Metabolite ID: gly_p
Compartment: p


Metabolite name: D-Glyceraldehyde
Metabolite ID: glyald_p
Compartment: p


Metabolite name: Glycine betaine
Metabolite ID: glyb_p
Compartment: p


Metabolite name: Glycerol
Metabolite ID: glyc_p
Compartment: p


Metabolite name: (R)-Glycerate
Metabolite ID: glyc_R_p
Compartment: p


Metabolite name: Glycerol 2-phosphate
Metabolite ID: glyc2p_p
Compartment: p


Metabolite name: Glycerol 3-phosphate
Metabolite ID: glyc3p_p
Compartment: p


Metabolite name: Glycolate
Metabolite ID: glyclt_p
Compartment: p


Metabolite name: GMP
Metabolite ID: gmp_p
Compartment: p


Metabolite name: Guanosine
Metabolite ID: gsn_p
Compartment: p


Metabolite name: Oxidized glutathione
Metabolite ID: gthox_p
Compartment: p


Metabolite name: Reduced glutathione
Metabolite ID: gthrd_p
Compartment: p


Metabolite name: GTP
Metabolite ID: gtp_p
Compartment: p


Metabolite name: Guanine
Metabolite ID: gua_p
Compartment: p


Metabolite name: H+
Metabolite ID: h_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Oxidative Phosphorylationcytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)CYTBO3_4pp0.5 o2_c + q8h2_c + 4 h_c ⇋ h2o_c + q8_c + 4 h_p010005.7e+022.3e+03
Oxidative PhosphorylationNADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)NADH16ppnadh_c + 4 h_c + q8_c ⇋ nad_c + 3 h_p + q8h2_c010005.7e+021.7e+03
Transport, Outer Membrane Porinproton transport via diffusion (extracellular to periplasm)Htexh_e ⇋ h_p-100010009.5e+029.5e+02
Inorganic Ion Transport and Metabolismmagnesium (Mg+2) transport in/out via proton antiport (periplasm)MG2t3_2pp2 h_c + mg2_p ⇋ mg2_c + 2 h_p-100010000.0430.086
Transport, Inner MembraneL-proline reversible transport via proton symport (periplasm)PROt2rpph_c + pro_L_c ⇋ pro_L_p + h_p-100010000.0260.026
Inorganic Ion Transport and Metabolismchloride transport out via proton antiport (2:1) (periplasm)CLt3_2pph_c + 2 cl_p ⇋ h_p + 2 cl_c010000.0130.013
Transport, Inner MembraneD-alanine transport in via proton symport (periplasm)DALAt2ppala_D_p + h_p ⇋ ala_D_c + h_c010000.068-0.068
Inorganic Ion Transport and Metabolismpotassium transport in via proton symport (periplasm)Kt2ppk_p + h_p ⇋ h_c + k_c010000.96-0.96
Inorganic Ion Transport and Metabolismsulfate transport in via proton symport (periplasm to cytoplasm)SO4t2ppso4_p + h_p ⇋ h_c + so4_c010001.2-1.2
Inorganic Ion Transport and Metabolismphosphate reversible transport via symport (periplasm)PIt2rpppi_p + h_p ⇋ h_c + pi_c-100010004.8-4.8
Oxidative PhosphorylationNAD(P) transhydrogenase (periplasm)THD2ppnadh_c + nadp_c + 2 h_p ⇋ nad_c + nadph_c + 2 h_c010005.3e+02-1.1e+03
Oxidative PhosphorylationATP synthase (four protons for one ATP) (periplasm)ATPS4rppadp_c + pi_c + 4 h_p ⇋ 3 h_c + atp_c + h2o_c-100010009.8e+02-3.9e+03

Metabolite name: H2
Metabolite ID: h2_p
Compartment: p


Metabolite name: H2O
Metabolite ID: h2o_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneH2O transport via diffusion (periplasm)H2Otpph2o_c ⇋ h2o_p-100010009.3e+029.3e+02
Transport, Outer Membrane PorinH2O transport via diffusion (extracellular to periplasm)H2Otexh2o_p ⇋ h2o_e-100010009.3e+02-9.3e+02

Metabolite name: Hydrogen peroxide
Metabolite ID: h2o2_p
Compartment: p


Metabolite name: Hydrogen sulfide
Metabolite ID: h2s_p
Compartment: p


Metabolite name: Hexadecanoate (n-C16:0)
Metabolite ID: hdca_p
Compartment: p


Metabolite name: Hexadecenoate (n-C16:1)
Metabolite ID: hdcea_p
Compartment: p


Metabolite name: Hg2+
Metabolite ID: hg2_p
Compartment: p


Metabolite name: L-Histidine
Metabolite ID: his_L_p
Compartment: p


Metabolite name: L-Homoserine
Metabolite ID: hom_L_p
Compartment: p


Metabolite name: Hexanoate (n-C6:0)
Metabolite ID: hxa_p
Compartment: p


Metabolite name: Hypoxanthine
Metabolite ID: hxan_p
Compartment: p


Metabolite name: L-Idonate
Metabolite ID: idon_L_p
Compartment: p


Metabolite name: L-Isoleucine
Metabolite ID: ile_L_p
Compartment: p


Metabolite name: IMP
Metabolite ID: imp_p
Compartment: p


Metabolite name: Indole
Metabolite ID: indole_p
Compartment: p


Metabolite name: myo-Inositol
Metabolite ID: inost_p
Compartment: p


Metabolite name: Inosine
Metabolite ID: ins_p
Compartment: p


Metabolite name: Isethionic acid
Metabolite ID: isetac_p
Compartment: p


Metabolite name: potassium
Metabolite ID: k_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinpotassium transport via diffusion (extracellular to periplasm)Ktexk_e ⇋ k_p-100010000.960.96
Inorganic Ion Transport and Metabolismpotassium transport in via proton symport (periplasm)Kt2ppk_p + h_p ⇋ h_c + k_c010000.96-0.96

Metabolite name: KDO(2)-lipid IV(A)
Metabolite ID: kdo2lipid4_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneKDO(2)-lipid IV A transport via ABC system (periplasm)K2L4Aabcppkdo2lipid4_c + atp_c + h2o_c ⇋ h_c + adp_c + kdo2lipid4_p + pi_c010000.0960.096
Lipopolysaccharide Biosynthesis / RecyclingKDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)K2L4Aabctexkdo2lipid4_p + h2o_c + atp_c ⇋ kdo2lipid4_e + adp_c + h_c + pi_c010000.096-0.096

Metabolite name: D-Lactate
Metabolite ID: lac_D_p
Compartment: p


Metabolite name: L-Lactate
Metabolite ID: lac_L_p
Compartment: p


Metabolite name: Lactose
Metabolite ID: lcts_p
Compartment: p


Metabolite name: L-Leucine
Metabolite ID: leu_L_p
Compartment: p


Metabolite name: KDO(2)-lipid (A)
Metabolite ID: lipa_p
Compartment: p


Metabolite name: cold adapted KDO(2)-lipid (A)
Metabolite ID: lipa_cold_p
Compartment: p


Metabolite name: Lipoate
Metabolite ID: lipoate_p
Compartment: p


Metabolite name: lipoprotein
Metabolite ID: lpp_p
Compartment: p


Metabolite name: L-Lysine
Metabolite ID: lys_L_p
Compartment: p


Metabolite name: L-Lyxose
Metabolite ID: lyx_L_p
Compartment: p


Metabolite name: D-Malate
Metabolite ID: mal_D_p
Compartment: p


Metabolite name: L-Malate
Metabolite ID: mal_L_p
Compartment: p


Metabolite name: Maltose
Metabolite ID: malt_p
Compartment: p


Metabolite name: Maltohexaose
Metabolite ID: malthx_p
Compartment: p


Metabolite name: Maltopentaose
Metabolite ID: maltpt_p
Compartment: p


Metabolite name: Maltotriose
Metabolite ID: malttr_p
Compartment: p


Metabolite name: Maltotetraose
Metabolite ID: maltttr_p
Compartment: p


Metabolite name: D-Mannose
Metabolite ID: man_p
Compartment: p


Metabolite name: D-Mannose 6-phosphate
Metabolite ID: man6p_p
Compartment: p


Metabolite name: 2(alpha-D-Mannosyl)-D-glycerate
Metabolite ID: manglyc_p
Compartment: p


Metabolite name: Melibiose
Metabolite ID: melib_p
Compartment: p


Metabolite name: Methanol
Metabolite ID: meoh_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneMethanol reversible transport via diffusion (periplasm)MEOHtrppmeoh_c ⇋ meoh_p-100010009.9e-069.9e-06
Transport, Outer Membrane PorinMethanol transport via diffusion (extracellular to periplasm)MEOHtexmeoh_p ⇋ meoh_e-100010009.9e-06-9.9e-06

Metabolite name: D-Methionine
Metabolite ID: met_D_p
Compartment: p


Metabolite name: L-Methionine
Metabolite ID: met_L_p
Compartment: p


Metabolite name: L-methionine-R-sulfoxide
Metabolite ID: metsox_R_L_p
Compartment: p


Metabolite name: L-Methionine Sulfoxide
Metabolite ID: metsox_S_L_p
Compartment: p


Metabolite name: magnesium
Metabolite ID: mg2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinmagnesium (Mg+2) transport via diffusion (extracellular to periplasm)MG2texmg2_e ⇋ mg2_p-100010000.0430.043
Inorganic Ion Transport and Metabolismmagnesium (Mg+2) transport in/out via proton antiport (periplasm)MG2t3_2pp2 h_c + mg2_p ⇋ mg2_c + 2 h_p-100010000.043-0.043

Metabolite name: minocycline
Metabolite ID: mincyc_p
Compartment: p


Metabolite name: myo-Inositol hexakisphosphate
Metabolite ID: minohp_p
Compartment: p


Metabolite name: S-Methyl-L-methionine
Metabolite ID: mmet_p
Compartment: p


Metabolite name: Mn2+
Metabolite ID: mn2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane PorinManganese (Mn+2) transport via diffusion (extracellular to periplasm)MNtexmn2_e ⇋ mn2_p-100010000.00340.0034
Inorganic Ion Transport and Metabolismmanganese transport in via permease (no H+)MN2tppmn2_p ⇋ mn2_c010000.0034-0.0034

Metabolite name: D-Mannitol
Metabolite ID: mnl_p
Compartment: p


Metabolite name: Molybdate
Metabolite ID: mobd_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinmolybdate transport via diffusion (extracellular to periplasm)MOBDtexmobd_e ⇋ mobd_p-100010000.000640.00064
Inorganic Ion Transport and Metabolismmolybdate transport via ABC system (periplasm)MOBDabcppmobd_p + atp_c + h2o_c ⇋ mobd_c + adp_c + h_c + pi_c010000.00064-0.00064

Metabolite name: methanesulfonate
Metabolite ID: mso3_p
Compartment: p


Metabolite name: two linked disacharide tripeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein3p3p_p
Compartment: p


Metabolite name: two disacharide linked murein units, tripeptide crosslinked tripeptide (A2pm->A2pm) (middle of chain)
Metabolite ID: murein3px3p_p
Compartment: p


Metabolite name: two disacharide linked murein units, tripeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)
Metabolite ID: murein3px4p_p
Compartment: p


Metabolite name: two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein4p3p_p
Compartment: p


Metabolite name: two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein4p4p_p
Compartment: p


Metabolite name: two disacharide linked murein units, tetrapeptide corsslinked tetrapeptide (A2pm->D-ala) (middle of chain)
Metabolite ID: murein4px4p_p
Compartment: p


Metabolite name: three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala), one uncrosslinked tetrapaptide) (middle of chain)
Metabolite ID: murein4px4p4p_p
Compartment: p


Metabolite name: three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)
Metabolite ID: murein4px4px4p_p
Compartment: p


Metabolite name: two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein5p3p_p
Compartment: p


Metabolite name: two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein5p4p_p
Compartment: p


Metabolite name: two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein5p5p_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Murein Biosynthesismurein polymerizing transglycosylaseMPTG2 uaagmda_c ⇋ 2 h_c + murein5p5p_p + 2 udcpdp_c010000.0680.068
Murein Biosynthesismurein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)MCTP1Appmurein5p5p_p ⇋ ala_D_p + murein5px4p_p010000.068-0.068

Metabolite name: three linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)
Metabolite ID: murein5p5p5p_p
Compartment: p


Metabolite name: two disacharide linked murein units, pentapeptide corsslinked tripeptide (A2pm->A2pm) (middle of chain)
Metabolite ID: murein5px3p_p
Compartment: p


Metabolite name: two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)
Metabolite ID: murein5px4p_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Murein Biosynthesismurein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)MCTP1Appmurein5p5p_p ⇋ ala_D_p + murein5px4p_p010000.0680.068
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.068

Metabolite name: three disacharide linked murein units (pentapeptide crosslinked tetrapeptide (A2pm->D-ala) tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)
Metabolite ID: murein5px4px4p_p
Compartment: p


Metabolite name: Nitrous oxide
Metabolite ID: n2o_p
Compartment: p


Metabolite name: Sodium
Metabolite ID: na1_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Inorganic Ion Transport and Metabolismcalcium / sodium antiporter (1:1)CAt6ppca2_p + na1_c ⇋ na1_p + ca2_c-100010000.0260.026
Transport, Inner MembraneNa+/Proline-L symporter (periplasm)PROt4ppna1_p + pro_L_p ⇋ pro_L_c + na1_c010000.026-0.026

Metabolite name: Nicotinate
Metabolite ID: nac_p
Compartment: p


Metabolite name: Ammonium
Metabolite ID: nh4_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinammonia transport via diffusion (extracellular to periplasm)NH4texnh4_e ⇋ nh4_p-100010005353
Inorganic Ion Transport and Metabolismammonia reversible transport (periplasm)NH4tppnh4_p ⇋ nh4_c-1000100053-53

Metabolite name: nickel
Metabolite ID: ni2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinnickel transport via diffusion (extracellular to periplasm)NI2texni2_e ⇋ ni2_p-100010000.00160.0016
Inorganic Ion Transport and Metabolismnickel (+2) transport in via permease (no H+)NI2tppni2_p ⇋ ni2_c010000.0016-0.0016

Metabolite name: NMN
Metabolite ID: nmn_p
Compartment: p


Metabolite name: Nitric oxide
Metabolite ID: no_p
Compartment: p


Metabolite name: Nitrite
Metabolite ID: no2_p
Compartment: p


Metabolite name: Nitrate
Metabolite ID: no3_p
Compartment: p


Metabolite name: novobiocin
Metabolite ID: novbcn_p
Compartment: p


Metabolite name: (O16 antigen)x2 undecaprenyl diphosphate
Metabolite ID: o16a2und_p
Compartment: p


Metabolite name: (O16 antigen)x3 undecaprenyl diphosphate
Metabolite ID: o16a3und_p
Compartment: p


Metabolite name: (O16 antigen)x4 core oligosaccharide lipid A
Metabolite ID: o16a4colipa_p
Compartment: p


Metabolite name: (O16 antigen)x4 undecaprenyl diphosphate
Metabolite ID: o16a4und_p
Compartment: p


Metabolite name: O16 antigen undecaprenyl diphosphate
Metabolite ID: o16aund_p
Compartment: p


Metabolite name: O2
Metabolite ID: o2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinoxygen transport via diffusion (extracellular to periplasm)O2texo2_e ⇋ o2_p-100010002.9e+022.9e+02
Inorganic Ion Transport and Metabolismo2 transport via diffusion (periplasm)O2tppo2_p ⇋ o2_c-100010002.9e+02-2.9e+02

Metabolite name: Superoxide anion
Metabolite ID: o2s_p
Compartment: p


Metabolite name: octadecanoate (n-C18:0)
Metabolite ID: ocdca_p
Compartment: p


Metabolite name: octadecenoate (n-C18:1)
Metabolite ID: ocdcea_p
Compartment: p


Metabolite name: octanoate (n-C8:0)
Metabolite ID: octa_p
Compartment: p


Metabolite name: Ornithine
Metabolite ID: orn_p
Compartment: p


Metabolite name: Orotate
Metabolite ID: orot_p
Compartment: p


Metabolite name: 1,2-didodecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa120_p
Compartment: p


Metabolite name: 1,2-ditetradecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa140_p
Compartment: p


Metabolite name: 1,2-ditetradec-7-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa141_p
Compartment: p


Metabolite name: 1,2-dihexadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa160_p
Compartment: p


Metabolite name: 1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa161_p
Compartment: p


Metabolite name: 1,2-dioctadecanoyl-sn-glycerol 3-phosphate
Metabolite ID: pa180_p
Compartment: p


Metabolite name: 1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate
Metabolite ID: pa181_p
Compartment: p


Metabolite name: Phenylacetaldehyde
Metabolite ID: pacald_p
Compartment: p


Metabolite name: phosphatidylethanolamine (didodecanoyl, n-C12:0)
Metabolite ID: pe120_p
Compartment: p


Metabolite name: phosphatidylethanolamine (ditetradecanoyl, n-C14:0)
Metabolite ID: pe140_p
Compartment: p


Metabolite name: phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pe141_p
Compartment: p


Metabolite name: phosphatidylethanolamine (dihexadecanoyl, n-C16:0)
Metabolite ID: pe160_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)PE160abcpph2o_c + pe160_c + atp_c ⇋ pe160_p + adp_c + h_c + pi_c010000.230.23
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.23

Metabolite name: phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)
Metabolite ID: pe161_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner Membranephosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)PE161abcpph2o_c + pe161_c + atp_c ⇋ adp_c + h_c + pi_c + pe161_p010000.10.1
E. coli biomass objective function (iJO1366) - core - with 53.95 GAM estimateEc_biomass_iJO1366_core_53p95M0.290529 ile_L_c + 0.027017 dctp_c + 0.000223 sheme_c + 0.000691 mn2_c + 0.215096 gtp_c + 0.26316 gln_L_c + 0.00026 4fe4s_c + 0.423162 val_L_c + 0.133508 ctp_c + 54.1248 atp_c + 5.5e-05 udcpdp_c + 0.000223 ribflv_c + 0.221055 pro_L_c + 0.000223 amet_c + 0.000341 zn2_c + 0.343161 lys_L_c + 0.001831 nad_c + 2.5e-05 cobalt2_c + 48.6015 h2o_c + 0.09158 cys_L_c + 0.056843 trp_L_c + 0.195193 k_c + 0.026166 dttp_c + 0.000223 pydx5p_c + 0.017868 pe160_c + 0.000323 ni2_c + 0.215792 ser_L_c + 0.450531 leu_L_c + 0.013013 nh4_c + 0.008675 mg2_c + 0.094738 his_L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.054154 pe161_c + 0.000223 mlthf_c + 0.000223 fad_c + 0.02106 pe161_p + 0.137896 tyr_L_c + 0.000223 pheme_c + 0.513689 ala_L_c + 0.295792 arg_L_c + 0.019456 kdo2lipid4_e + 0.000447 nadp_c + 0.000122 bmocogdp_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.013894 murein5px4p_p + 0.000576 coa_c + 0.005205 ca2_c + 0.241055 asn_L_c + 0.185265 phe_L_c + 0.612638 gly_c + 0.045946 pe160_p + 0.000223 thmpp_c + 0.26316 glu_L_c + 0.253687 thr_L_c + 0.153686 met_L_c + 0.027017 dgtp_c + 0.000223 thf_c + 0.007808 fe3_c + 7e-06 mobd_c + 0.026166 datp_c + 0.000709 cu2_c + 0.241055 asp_L_c + 2e-06 btn_c + 0.006715 fe2_c + 0.005205 cl_c + 0.144104 utp_c ⇋ 53.95 h_c + 53.95 adp_c + 0.773903 ppi_c + 53.9457 pi_c0.110004.9-0.1

Metabolite name: phosphatidylethanolamine (dioctadecanoyl, n-C18:0)
Metabolite ID: pe180_p
Compartment: p


Metabolite name: phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pe181_p
Compartment: p


Metabolite name: Phenethylamine
Metabolite ID: peamn_p
Compartment: p


Metabolite name: Phosphatidylglycerol (didodecanoyl, n-C12:0)
Metabolite ID: pg120_p
Compartment: p


Metabolite name: Phosphatidylglycerol (ditetradecanoyl, n-C14:0)
Metabolite ID: pg140_p
Compartment: p


Metabolite name: Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pg141_p
Compartment: p


Metabolite name: Phosphatidylglycerol (dihexadecanoyl, n-C16:0)
Metabolite ID: pg160_p
Compartment: p


Metabolite name: Phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: pg161_p
Compartment: p


Metabolite name: Phosphatidylglycerol (dioctadecanoyl, n-C18:0)
Metabolite ID: pg180_p
Compartment: p


Metabolite name: Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pg181_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)
Metabolite ID: pgp120_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)
Metabolite ID: pgp140_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)
Metabolite ID: pgp141_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)
Metabolite ID: pgp160_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)
Metabolite ID: pgp161_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)
Metabolite ID: pgp180_p
Compartment: p


Metabolite name: Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)
Metabolite ID: pgp181_p
Compartment: p


Metabolite name: L-Phenylalanine
Metabolite ID: phe_L_p
Compartment: p


Metabolite name: Protoheme
Metabolite ID: pheme_p
Compartment: p


Metabolite name: Phosphate
Metabolite ID: pi_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinphosphate transport via diffusion (extracellular to periplasm)PItexpi_e ⇋ pi_p-100010004.84.8
Inorganic Ion Transport and Metabolismphosphate reversible transport via symport (periplasm)PIt2rpppi_p + h_p ⇋ h_c + pi_c-100010004.8-4.8

Metabolite name: (R)-Pantothenate
Metabolite ID: pnto_R_p
Compartment: p


Metabolite name: Propionate (n-C3:0)
Metabolite ID: ppa_p
Compartment: p


Metabolite name: Propanal
Metabolite ID: ppal_p
Compartment: p


Metabolite name: Phenylpropanoate
Metabolite ID: pppn_p
Compartment: p


Metabolite name: Phosphonate
Metabolite ID: ppt_p
Compartment: p


Metabolite name: L-Proline
Metabolite ID: pro_L_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Inner MembraneL-proline reversible transport via proton symport (periplasm)PROt2rpph_c + pro_L_c ⇋ pro_L_p + h_p-100010000.0260.026
Transport, Inner MembraneNa+/Proline-L symporter (periplasm)PROt4ppna1_p + pro_L_p ⇋ pro_L_c + na1_c010000.026-0.026

Metabolite name: L-Prolinylglycine
Metabolite ID: progly_p
Compartment: p


Metabolite name: psicoselysine
Metabolite ID: psclys_p
Compartment: p


Metabolite name: O-Phospho-L-serine
Metabolite ID: pser_L_p
Compartment: p


Metabolite name: Putrescine
Metabolite ID: ptrc_p
Compartment: p


Metabolite name: Pyridoxamine
Metabolite ID: pydam_p
Compartment: p


Metabolite name: Pyridoxal
Metabolite ID: pydx_p
Compartment: p


Metabolite name: Pyridoxine
Metabolite ID: pydxn_p
Compartment: p


Metabolite name: Pyruvate
Metabolite ID: pyr_p
Compartment: p


Metabolite name: Quinate
Metabolite ID: quin_p
Compartment: p


Metabolite name: alpha-D-Ribose 5-phosphate
Metabolite ID: r5p_p
Compartment: p


Metabolite name: rifampin
Metabolite ID: rfamp_p
Compartment: p


Metabolite name: D-Ribose
Metabolite ID: rib_D_p
Compartment: p


Metabolite name: L-Rhamnose
Metabolite ID: rmn_p
Compartment: p


Metabolite name: D-Sorbitol
Metabolite ID: sbt_D_p
Compartment: p


Metabolite name: Selenate
Metabolite ID: sel_p
Compartment: p


Metabolite name: D-Serine
Metabolite ID: ser_D_p
Compartment: p


Metabolite name: L-Serine
Metabolite ID: ser_L_p
Compartment: p


Metabolite name: Shikimate
Metabolite ID: skm_p
Compartment: p


Metabolite name: selenite
Metabolite ID: slnt_p
Compartment: p


Metabolite name: sulfur dioxide
Metabolite ID: so2_p
Compartment: p


Metabolite name: Sulfite
Metabolite ID: so3_p
Compartment: p


Metabolite name: Sulfate
Metabolite ID: so4_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinsulfate transport via diffusion (extracellular to periplasm)SO4texso4_e ⇋ so4_p-100010001.21.2
Inorganic Ion Transport and Metabolismsulfate transport in via proton symport (periplasm to cytoplasm)SO4t2ppso4_p + h_p ⇋ h_c + so4_c010001.2-1.2

Metabolite name: Spermidine
Metabolite ID: spmd_p
Compartment: p


Metabolite name: Succinate
Metabolite ID: succ_p
Compartment: p


Metabolite name: Sucrose
Metabolite ID: sucr_p
Compartment: p


Metabolite name: sulfoacetate
Metabolite ID: sulfac_p
Compartment: p


Metabolite name: D-tartrate
Metabolite ID: tartr_D_p
Compartment: p


Metabolite name: L-tartrate
Metabolite ID: tartr_L_p
Compartment: p


Metabolite name: Taurine
Metabolite ID: taur_p
Compartment: p


Metabolite name: Thiocyanate
Metabolite ID: tcynt_p
Compartment: p


Metabolite name: Thiamin
Metabolite ID: thm_p
Compartment: p


Metabolite name: L-Threonine
Metabolite ID: thr_L_p
Compartment: p


Metabolite name: L-Threonine O-3-phosphate
Metabolite ID: thrp_p
Compartment: p


Metabolite name: Thymine
Metabolite ID: thym_p
Compartment: p


Metabolite name: Thymidine
Metabolite ID: thymd_p
Compartment: p


Metabolite name: trimethylamine
Metabolite ID: tma_p
Compartment: p


Metabolite name: Trimethylamine N-oxide
Metabolite ID: tmao_p
Compartment: p


Metabolite name: Trehalose
Metabolite ID: tre_p
Compartment: p


Metabolite name: L-Tryptophan
Metabolite ID: trp_L_p
Compartment: p


Metabolite name: Thiosulfate
Metabolite ID: tsul_p
Compartment: p


Metabolite name: tetradecanoate (n-C14:0)
Metabolite ID: ttdca_p
Compartment: p


Metabolite name: tetradecenoate (n-C14:1)
Metabolite ID: ttdcea_p
Compartment: p


Metabolite name: tetracycline
Metabolite ID: ttrcyc_p
Compartment: p


Metabolite name: tungstate
Metabolite ID: tungs_p
Compartment: p


Metabolite name: Tyramine
Metabolite ID: tym_p
Compartment: p


Metabolite name: L-Tyrosine
Metabolite ID: tyr_L_p
Compartment: p


Metabolite name: Phosphotyrosine
Metabolite ID: tyrp_p
Compartment: p


Metabolite name: undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose
Metabolite ID: uLa4n_p
Compartment: p


Metabolite name: UDP-N-acetyl-D-glucosamine
Metabolite ID: uacgam_p
Compartment: p


Metabolite name: Undecaprenyl diphosphate
Metabolite ID: udcpdp_p
Compartment: p


Metabolite name: Undecaprenyl phosphate
Metabolite ID: udcpp_p
Compartment: p


Metabolite name: UDP-N-acetyl-D-galactosamine
Metabolite ID: udpacgal_p
Compartment: p


Metabolite name: UDPglucose
Metabolite ID: udpg_p
Compartment: p


Metabolite name: UDPgalactose
Metabolite ID: udpgal_p
Compartment: p


Metabolite name: UDP-D-glucuronate
Metabolite ID: udpglcur_p
Compartment: p


Metabolite name: UMP
Metabolite ID: ump_p
Compartment: p


Metabolite name: Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose
Metabolite ID: unagamuf_p
Compartment: p


Metabolite name: Uracil
Metabolite ID: ura_p
Compartment: p


Metabolite name: Urea
Metabolite ID: urea_p
Compartment: p


Metabolite name: Uridine
Metabolite ID: uri_p
Compartment: p


Metabolite name: L-Valine
Metabolite ID: val_L_p
Compartment: p


Metabolite name: Xanthine
Metabolite ID: xan_p
Compartment: p


Metabolite name: Xanthosine 5'-phosphate
Metabolite ID: xmp_p
Compartment: p


Metabolite name: Xanthosine
Metabolite ID: xtsn_p
Compartment: p


Metabolite name: D-Xylose
Metabolite ID: xyl_D_p
Compartment: p


Metabolite name: L-Xylulose
Metabolite ID: xylu_L_p
Compartment: p


Metabolite name: Zinc
Metabolite ID: zn2_p
Compartment: p

Sub SystemReaction NameReaction IDReactionLBUBReaction FluxNet Flux
Transport, Outer Membrane Porinzinc (Zn+2) transport via diffusion (extracellular to periplasm)Zn2texzn2_e ⇋ zn2_p-100010000.00170.0017
Inorganic Ion Transport and Metabolismzinc transport in via permease (no H+)ZN2tppzn2_p ⇋ zn2_c010000.0017-0.0017